Petr Cejka
@cejkalab.bsky.social
Research group leader. Interested in DNA repair.
November magic in Graubünden
November 8, 2025 at 6:48 PM
November magic in Graubünden
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 1:12 PM
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lake Como with plenty of fall sunshine today
October 26, 2025 at 5:29 PM
Lake Como with plenty of fall sunshine today
Golden October in its glory. Mountains in Ticino today.
October 18, 2025 at 4:55 PM
Golden October in its glory. Mountains in Ticino today.
Trip to Greina plateau, northern Ticino
September 20, 2025 at 3:00 PM
Trip to Greina plateau, northern Ticino
Last hike in August with first snow
August 31, 2025 at 1:20 PM
Last hike in August with first snow
Hiking in Switzerland today, Val Poschiavo
May 31, 2025 at 6:11 PM
Hiking in Switzerland today, Val Poschiavo
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
May 5, 2025 at 7:22 AM
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
Nice weekend everyone from sunny Bellinzona
April 11, 2025 at 3:00 PM
Nice weekend everyone from sunny Bellinzona
Spring is here. Valleys and lakesides are green, and snow is melting fast in the mountains.
April 5, 2025 at 8:05 PM
Spring is here. Valleys and lakesides are green, and snow is melting fast in the mountains.
An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...
March 26, 2025 at 9:45 AM
An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
March 25, 2025 at 4:00 PM
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
Como Lake in winter
February 15, 2025 at 12:38 PM
Como Lake in winter
I was great to host Alessandro Vindigni @vindignilab.bsky.social in Bellinzona. We are excited about our collaborations!
December 16, 2024 at 9:36 AM
I was great to host Alessandro Vindigni @vindignilab.bsky.social in Bellinzona. We are excited about our collaborations!
The Cejka lab holiday dinner yesterday
December 5, 2024 at 12:11 PM
The Cejka lab holiday dinner yesterday
Amazing weather in the mountains of Ticino continues!
November 17, 2024 at 9:09 AM
Amazing weather in the mountains of Ticino continues!
My first post here, completely non-scientific, photos from a hike last weekend. I hope to reconnect with as as many of you as possible! Anyone wants to move to Switzerland these days?
November 13, 2024 at 1:56 PM
My first post here, completely non-scientific, photos from a hike last weekend. I hope to reconnect with as as many of you as possible! Anyone wants to move to Switzerland these days?