Sten Linnarsson
@sten.linnarsson.org
Professor of molecular systems biology at Karolinska Institutet, Sweden. On a mission to delete brain cancer using DNA therapy. Email: sten.linnarsson@ki.se
A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
August 15, 2025 at 9:23 PM
A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
Reposted by Sten Linnarsson
If you were alive in the 1980s, this is among the most wonderful & truly incredible things you have ever witnessed in your lifetime.
July 28, 2025 at 2:15 AM
If you were alive in the 1980s, this is among the most wonderful & truly incredible things you have ever witnessed in your lifetime.
”All contracts with Springer Nature are terminated or no longer active. Precious taxpayer dollars should be [sic] not be used on unused subscriptions to junk science.” the NIH spokesperson said. www.nature.com/articles/d41...
Trump team axes contracts with publishing giant Springer Nature
The action comes as high-ranking US officials criticize top journals as ‘woke’ and ‘corrupt’.
www.nature.com
July 1, 2025 at 4:52 PM
”All contracts with Springer Nature are terminated or no longer active. Precious taxpayer dollars should be [sic] not be used on unused subscriptions to junk science.” the NIH spokesperson said. www.nature.com/articles/d41...
Reposted by Sten Linnarsson
We're looking for a new Assistant Professor in Experimental Tumor Biology to join us at Karolinska Institutet (MTC) @ki.se .
Generous funding package and part of a 20 Assistant Prof recruitment in a wide range of subject areas.
📅 Deadline: Sep 2nd, 2025
ki.varbi.com/en/what:job/...
Generous funding package and part of a 20 Assistant Prof recruitment in a wide range of subject areas.
📅 Deadline: Sep 2nd, 2025
ki.varbi.com/en/what:job/...
Assistant Professor in Experimental Tumor Biology
Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universitie
ki.varbi.com
July 1, 2025 at 12:54 PM
We're looking for a new Assistant Professor in Experimental Tumor Biology to join us at Karolinska Institutet (MTC) @ki.se .
Generous funding package and part of a 20 Assistant Prof recruitment in a wide range of subject areas.
📅 Deadline: Sep 2nd, 2025
ki.varbi.com/en/what:job/...
Generous funding package and part of a 20 Assistant Prof recruitment in a wide range of subject areas.
📅 Deadline: Sep 2nd, 2025
ki.varbi.com/en/what:job/...
Reposted by Sten Linnarsson
1/3 I spent 10 years running a lab in Philadelphia and then decided to return to Europe and continue in a more family friendly environment. Best decision of my life! You can now do the same by applying to one of these 20 assistant professor positions at Karolinska Institutet ki.se/en/about-ki/...
Early-career researcher — join a global community of excellence
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. In 2025, KI will recruit outstanding early-career researchers with particularly e...
ki.se
June 20, 2025 at 7:03 AM
1/3 I spent 10 years running a lab in Philadelphia and then decided to return to Europe and continue in a more family friendly environment. Best decision of my life! You can now do the same by applying to one of these 20 assistant professor positions at Karolinska Institutet ki.se/en/about-ki/...
Reposted by Sten Linnarsson
Come join our department at the Karolinska Institute! ki.varbi.com/what:job/job...
Assistant Professor in Biomedical Science
Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,
ki.varbi.com
June 25, 2025 at 12:51 PM
Come join our department at the Karolinska Institute! ki.varbi.com/what:job/job...
Reposted by Sten Linnarsson
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
June 25, 2025 at 1:59 PM
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:08 AM
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Reposted by Sten Linnarsson
In these turbulent times, beautiful microscopy always cheers me up 😍. Here's a quail neural tube just doing its thing for #FluorescenceFriday. Imaged by the very talented
@vanderspuy.bsky.social
#devbio 🧪🔬👩🔬
@vanderspuy.bsky.social
#devbio 🧪🔬👩🔬
June 20, 2025 at 5:04 AM
In these turbulent times, beautiful microscopy always cheers me up 😍. Here's a quail neural tube just doing its thing for #FluorescenceFriday. Imaged by the very talented
@vanderspuy.bsky.social
#devbio 🧪🔬👩🔬
@vanderspuy.bsky.social
#devbio 🧪🔬👩🔬
Reposted by Sten Linnarsson
🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease @capstantx.bsky.social direct delivery of mRNA-encoded CARs to CD8+ T cells in mouse & NHP models shows tumor control not only in blood, but also tissue. Immune reset seen at B cell recovery www.science.org/doi/10.1126/...
In vivo CAR T cell generation to treat cancer and autoimmune disease
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...
www.science.org
June 19, 2025 at 6:27 PM
🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease @capstantx.bsky.social direct delivery of mRNA-encoded CARs to CD8+ T cells in mouse & NHP models shows tumor control not only in blood, but also tissue. Immune reset seen at B cell recovery www.science.org/doi/10.1126/...
Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
news.ki.se
June 19, 2025 at 5:50 AM
Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.
Very cool work from James Zou. Link to paper: www.nature.com/articles/s41...
May 28, 2025 at 11:44 AM
Very cool work from James Zou. Link to paper: www.nature.com/articles/s41...
Reposted by Sten Linnarsson
⚡️Really thrilled that #textgrad is published in @nature.com today!⚡️
We present a general method for genAI to self-improve via our new *calculus of text*.
We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!
We present a general method for genAI to self-improve via our new *calculus of text*.
We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!
March 19, 2025 at 4:47 PM
⚡️Really thrilled that #textgrad is published in @nature.com today!⚡️
We present a general method for genAI to self-improve via our new *calculus of text*.
We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!
We present a general method for genAI to self-improve via our new *calculus of text*.
We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!
Reposted by Sten Linnarsson
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 10:12 AM
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
Reposted by Sten Linnarsson
Discover aptamers faster! UltraSelex combines partitioning, high-throughput sequencing & computation in 1 step. Revolutionize drug discovery! PMID:40164941, Nat Chem Biol 2025, @nchembio https://doi.org/10.1038/s41589-025-01868-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Single-step discovery of high-affinity RNA ligands by UltraSelex | Nature Chemical Biology
Aptamers, nucleic acid ligands targeting specific molecules, have emerged as drug candidates, sensors, imaging tools and nanotechnology building blocks. The predominant method for their discovery, systematic evolution of ligands by exponential enrichment, while successful, is laborious, time-consuming and often results in candidates enriched for unintended criteria. Here we present UltraSelex, a noniterative method that combines biochemical partitioning, high-throughput sequencing and computational signal-to-background rank modeling for discovering RNA aptamers in about 1 day. UltraSelex identified high-affinity RNA aptamers capable of binding a fluorogenic silicon rhodamine dye and two protein targets, the SARS-CoV-2 RNA-dependent RNA polymerase and HIV reverse transcriptase, enabling live-cell RNA imaging and efficient enzyme inhibition, respectively. From the ranked sequences, minimal aptamer motifs could be easily inferred. UltraSelex provides a rapid route to reveal new drug candi
doi.org
May 27, 2025 at 12:10 AM
Reposted by Sten Linnarsson
New paper out in @pnas.org
We followed cells migrating along signalling gradients in 3D, and found they collectively behave as a living droplet - a self-propelling fluid that grows.
www.pnas.org/doi/10.1073/...
We followed cells migrating along signalling gradients in 3D, and found they collectively behave as a living droplet - a self-propelling fluid that grows.
www.pnas.org/doi/10.1073/...
May 21, 2025 at 10:00 AM
New paper out in @pnas.org
We followed cells migrating along signalling gradients in 3D, and found they collectively behave as a living droplet - a self-propelling fluid that grows.
www.pnas.org/doi/10.1073/...
We followed cells migrating along signalling gradients in 3D, and found they collectively behave as a living droplet - a self-propelling fluid that grows.
www.pnas.org/doi/10.1073/...
Reposted by Sten Linnarsson
Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection https://www.biorxiv.org/content/10.1101/2025.05.19.654765v1
May 25, 2025 at 6:15 AM
Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection https://www.biorxiv.org/content/10.1101/2025.05.19.654765v1
Vibecoding, but for DNA
May 24, 2025 at 7:39 AM
Vibecoding, but for DNA
Reposted by Sten Linnarsson
Reposted by Sten Linnarsson
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
May 16, 2025 at 11:44 AM
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Reposted by Sten Linnarsson
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
April 30, 2025 at 3:12 PM
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
Registration for Single-cell genomics 2025 is now open! This year we’re back in beautiful Stockholm archipelago. We have a special session on clinical applications, but we also invite abstracts from both PIs and trainees, with plenty of slots for selected talks. conferences.weizmann.ac.il/SCG2025/
Single cell genomics 2025 | SCG 2025
conferences.weizmann.ac.il
April 28, 2025 at 1:01 PM
Registration for Single-cell genomics 2025 is now open! This year we’re back in beautiful Stockholm archipelago. We have a special session on clinical applications, but we also invite abstracts from both PIs and trainees, with plenty of slots for selected talks. conferences.weizmann.ac.il/SCG2025/
Spent the last few days stunned by how good ChatGPT ”deep research” is. It takes a detailed science question, thinks for 20 mins and then spits out a well structured, comprehensive and almost completely correct answer, with citations (not hallucinated!). It generated very promising hypoteses for me.
April 27, 2025 at 1:11 PM
Spent the last few days stunned by how good ChatGPT ”deep research” is. It takes a detailed science question, thinks for 20 mins and then spits out a well structured, comprehensive and almost completely correct answer, with citations (not hallucinated!). It generated very promising hypoteses for me.
Reposted by Sten Linnarsson
