5um dot size, 20um step.
Max resolution is 4um as far as I know

It was such an exciting experience to learn about the cutting edge science at the VIB! Thank you for having me!

Amazing work Gioele et al. Your talk about the lipid brain atlas and how it connects within a grand vision, this morning at VIB.ai, was truly spectacular. We were honoured to hear the story on the day of the preprint :)

With this reference atlas, we can embark on new missions to track how disease, aging, diet, and drugs reshape the brain lipidome at the resolution where change happens.

Through the lipidome, we bring into sharp focus cell-type-specific metabolism and membrane biochemistry, and also glimpse developmental history and connectivity patterns.

- Biochemical zonation of the choroid plexus and ventricular linings.

- Pregnancy triggers coordinated membrane adaptations from cortex to white matter.

- Sex differences in white matter sphingolipids are amplified during pregnancy.

- The lipidome alone can predict 3D coordinates of brain tissue.

- Oligodendrocytes are lipidomically heterogeneous in the corpus callosum.

- In the gray matter, many lipizones capture cell-type territories.

- Lipid signatures connect cell bodies to distant axon terminals across the brain.

@epfl-brainmind.bsky.social @neuroxepfl.bsky.social

!!!We found that lipids act as zip codes for fine-grained brain anatomy!!!

✨ Specifically, we discovered:

- #LIPIZONES: brain territories defined purely by lipid composition, no anatomical priors needed.

I dedicate the achievement to my family, whose patience and support through every creative burst made this possible.

Proud of these advances, achieved in great company @EPFL : @giodang.bsky.social (co-PI), with Halima Schede & Leila Alieh leading the project, and the Oates lab bringing their zebrafish expertise [2/2]