Olga Rosspopoff, PhD
@orpsf.bsky.social
Former PhD student @crougeulle.bsky.social // postdoc @trono-lab.bsky.social at EPFL🇨🇭// Future Junior PI at @igbmc.bsky.social 🇫🇷 // Fascinated in the evolution of gene regulatory networks, with a strong interest for transposons 🤘 and embryogenesis 👶
Pinned
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
Reposted by Olga Rosspopoff, PhD
Welcome to Day 3 of #EMBOMobileGenome 🙌🏼
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
November 6, 2025 at 9:48 AM
Welcome to Day 3 of #EMBOMobileGenome 🙌🏼
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
November 5, 2025 at 6:58 PM
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
Reposted by Olga Rosspopoff, PhD
An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
November 4, 2025 at 6:50 PM
An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
Reposted by Olga Rosspopoff, PhD
Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
November 4, 2025 at 1:31 PM
Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
Reposted by Olga Rosspopoff, PhD
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Reposted by Olga Rosspopoff, PhD
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Olga Rosspopoff, PhD
📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social!
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 3:34 PM
📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social!
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
Reposted by Olga Rosspopoff, PhD
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Olga Rosspopoff, PhD
How do embryos develop robustly despite variability in gene expression, cell properties, and tissue growth? In our new review, we explore how optimal selection of coupled parameters can contribute to robustness in development. Have a look at the article:
doi.org/10.1016/j.tc...
doi.org/10.1016/j.tc...
Redirecting
doi.org
October 10, 2025 at 8:18 AM
How do embryos develop robustly despite variability in gene expression, cell properties, and tissue growth? In our new review, we explore how optimal selection of coupled parameters can contribute to robustness in development. Have a look at the article:
doi.org/10.1016/j.tc...
doi.org/10.1016/j.tc...
Reposted by Olga Rosspopoff, PhD
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 9, 2025 at 5:33 AM
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Reposted by Olga Rosspopoff, PhD
We lost another Gem of a scientist:
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
"I was the worst out of 250." John Gurdon, Nobel Prize in Physiology or Medicine 2012
YouTube video by Nobel Prize
www.youtube.com
October 8, 2025 at 5:04 PM
We lost another Gem of a scientist:
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
Reposted by Olga Rosspopoff, PhD
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
Reposted by Olga Rosspopoff, PhD
🔬For the 2025 Fête de la Science, Institut Curie opens its doors to the public! Follow the steps of Marie Curie’s research in Paris and explore the fascinating world of biology.
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
October 1, 2025 at 1:38 PM
🔬For the 2025 Fête de la Science, Institut Curie opens its doors to the public! Follow the steps of Marie Curie’s research in Paris and explore the fascinating world of biology.
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
Reposted by Olga Rosspopoff, PhD
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reposted by Olga Rosspopoff, PhD
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
www.nature.com
October 6, 2025 at 6:57 AM
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Reposted by Olga Rosspopoff, PhD
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
October 3, 2025 at 7:14 AM
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
Reposted by Olga Rosspopoff, PhD
3rd lab meeting I’m presenting at this year! After two during my sabbatical on my experiments (Helaine & Mekalanos labs), today finally in MY OWN lab 🎉
So much fun to share new work done w/ fantastic technicians Laurie, Sandrine, Loriane & bioinformatician Alexandre.
Bonus: cake served by the lab 🍰
So much fun to share new work done w/ fantastic technicians Laurie, Sandrine, Loriane & bioinformatician Alexandre.
Bonus: cake served by the lab 🍰
October 2, 2025 at 12:34 PM
3rd lab meeting I’m presenting at this year! After two during my sabbatical on my experiments (Helaine & Mekalanos labs), today finally in MY OWN lab 🎉
So much fun to share new work done w/ fantastic technicians Laurie, Sandrine, Loriane & bioinformatician Alexandre.
Bonus: cake served by the lab 🍰
So much fun to share new work done w/ fantastic technicians Laurie, Sandrine, Loriane & bioinformatician Alexandre.
Bonus: cake served by the lab 🍰
Reposted by Olga Rosspopoff, PhD
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
September 28, 2025 at 5:50 PM
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Reposted by Olga Rosspopoff, PhD
EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026.
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026
September 28, 2025 at 12:00 AM
EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026.
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026
Reposted by Olga Rosspopoff, PhD
And from other labs’ work this is really cool:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...
www.science.org
September 28, 2025 at 2:56 PM
And from other labs’ work this is really cool:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Olga Rosspopoff, PhD
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers
DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...
www.biorxiv.org
September 20, 2025 at 4:10 PM
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
Reposted by Olga Rosspopoff, PhD
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
First-grader raises $1,000 for axolotl research, meets her scientist hero — and maybe gets taste of what she wants to do when she grows up
kids! science heroes! axolotls! (cuter story than the headline suggests) ꒰(˶• ᴗ •˶)꒱
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
When your research donor is 6 — Harvard Gazette
First-grader raises $1,000 for axolotl research, meets her scientist hero — and maybe gets taste of what she wants to do when she grows up
news.harvard.edu
September 25, 2025 at 7:51 PM
First-grader raises $1,000 for axolotl research, meets her scientist hero — and maybe gets taste of what she wants to do when she grows up
Reposted by Olga Rosspopoff, PhD
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
Reposted by Olga Rosspopoff, PhD
Huge congratulations to Thomas on this well-deserved award. His PhD defense last week was outstanding too - a great moment. He’ll on the lookout for a postdoc position soon…spread the word!
📣 Congratulations to @thomasbalan.bsky.social (@sandraduharcourt.bsky.social Lab) who won the Best Poster Award at the Gordon Research Epigenetics conference “Variation: Mechanisms and Impact across Systems”!
More informations 🔗 buff.ly/NhLWE6G
@cnrs-idf-villejuif.bsky.social @upcite.bsky.social
More informations 🔗 buff.ly/NhLWE6G
@cnrs-idf-villejuif.bsky.social @upcite.bsky.social
September 23, 2025 at 3:25 PM
Huge congratulations to Thomas on this well-deserved award. His PhD defense last week was outstanding too - a great moment. He’ll on the lookout for a postdoc position soon…spread the word!