Miki Ebisuya
@ebisuyamiki.bsky.social
Synthetic developmental biologist at PoL TU Dresden. Cross-species comparison and manipulation of the ORGANOID ZOO.
https://physics-of-life.tu-dresden.de/team/pol-groups/ebisuya
https://physics-of-life.tu-dresden.de/team/pol-groups/ebisuya
Pinned
Miki Ebisuya
@ebisuyamiki.bsky.social
· Oct 8
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
Reposted by Miki Ebisuya
“substantial phenotypic diversity already existed in early Holocene dogs” nice #domestixation study by @gregerlarson.bsky.social & collaborators in @science.org 🧪🐶🐾
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The emergence and diversification of dog morphology
Dogs exhibit an exceptional range of morphological diversity as a result of their long-term association with humans. Attempts to identify when dog morphological variation began to expand have been con...
www.science.org
November 14, 2025 at 12:32 PM
“substantial phenotypic diversity already existed in early Holocene dogs” nice #domestixation study by @gregerlarson.bsky.social & collaborators in @science.org 🧪🐶🐾
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Miki Ebisuya
Carnivorous 'death-ball' among odd deep-sea finds. 🧪 www.bbc.co.uk/news/article...
Carnivorous 'death-ball' sponge is team's oddest deep-sea find
The unusual creature lurks more than two miles (3.2km) deep in a trench in the Southern Ocean.
www.bbc.co.uk
November 11, 2025 at 6:56 AM
Carnivorous 'death-ball' among odd deep-sea finds. 🧪 www.bbc.co.uk/news/article...
Reposted by Miki Ebisuya
What is the origin of diversity in allometric laws scaling across species? Check our new paper led by Andrea Tabi where
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
November 9, 2025 at 2:39 AM
What is the origin of diversity in allometric laws scaling across species? Check our new paper led by Andrea Tabi where
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
Reposted by Miki Ebisuya
And you can of course also go through to the q.e.d website: www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
www.qedscience.com
November 6, 2025 at 3:05 PM
And you can of course also go through to the q.e.d website: www.qedscience.com
Reposted by Miki Ebisuya
“If your heart is beating really strong and fast, and you’re in a fear state, you don’t want to be sensitive to pain. You want to be able to run over broken twigs and glass to escape the threat,” said neuroscientist Sarah Garfinkel. www.quantamagazine.org/how-your-hea...
October 31, 2025 at 10:59 PM
“If your heart is beating really strong and fast, and you’re in a fear state, you don’t want to be sensitive to pain. You want to be able to run over broken twigs and glass to escape the threat,” said neuroscientist Sarah Garfinkel. www.quantamagazine.org/how-your-hea...
Reposted by Miki Ebisuya
🌟 Countdown to Nov 4 (11:59pm MT)! Submit your short talk or scholarship app for #KSEmbryology26: Stem Cell Models in Embryology. Join @jun-wu-lab.bsky.social, @ebisuyamiki.bsky.social & global experts
🎥 youtu.be/hKhc2VrbFj0
🔗 keysym.us/KSEmbryology26
#KSEmbryology26 #embryology #stemcells
🎥 youtu.be/hKhc2VrbFj0
🔗 keysym.us/KSEmbryology26
#KSEmbryology26 #embryology #stemcells
KSQA: Dr. Jun Wu (Stem Cell Models in Embryology)
YouTube video by KeystoneSymposia
youtu.be
October 31, 2025 at 5:07 PM
🌟 Countdown to Nov 4 (11:59pm MT)! Submit your short talk or scholarship app for #KSEmbryology26: Stem Cell Models in Embryology. Join @jun-wu-lab.bsky.social, @ebisuyamiki.bsky.social & global experts
🎥 youtu.be/hKhc2VrbFj0
🔗 keysym.us/KSEmbryology26
#KSEmbryology26 #embryology #stemcells
🎥 youtu.be/hKhc2VrbFj0
🔗 keysym.us/KSEmbryology26
#KSEmbryology26 #embryology #stemcells
Despite higher cell numbers and longer lifespans, large animals don’t have a higher cancer rate: Peto’s paradox. Elephants carry extra copies of tumor suppressor genes, while whales rely on enhanced DNA repair mechanisms! It’s fascinating that nature found different solutions to the same problem
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/4oNJSAG
go.nature.com/4oNJSAG
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
go.nature.com
October 30, 2025 at 12:26 PM
Despite higher cell numbers and longer lifespans, large animals don’t have a higher cancer rate: Peto’s paradox. Elephants carry extra copies of tumor suppressor genes, while whales rely on enhanced DNA repair mechanisms! It’s fascinating that nature found different solutions to the same problem
Reposted by Miki Ebisuya
From the nine-inch pygmy shark to a whale shark, the largest living fish, all sharks have the same surface area to volume ratio: a metric that might be a universal proportion across the natural world.
www.quantamagazine.org/shark-data-s...
www.quantamagazine.org/shark-data-s...
Shark Data Suggests Animals Scale Like Geometric Objects | Quanta Magazine
Despite their wide variety of sizes, niches and shapes, sharks scale geometrically, pointing to possible fundamental constraints on evolution.
www.quantamagazine.org
October 27, 2025 at 3:00 PM
From the nine-inch pygmy shark to a whale shark, the largest living fish, all sharks have the same surface area to volume ratio: a metric that might be a universal proportion across the natural world.
www.quantamagazine.org/shark-data-s...
www.quantamagazine.org/shark-data-s...
Reposted by Miki Ebisuya
Join us @ #IETS2026 for our CANDES Precon keynote speaker, Miki Ebisuya, PhD (Physics of Life Dresden) 🎉.
“Stem cell zoo: A platform for exploring species-specific biological time” 🔬⏰
Don't miss out—register by Dec 15 📆 to lock in early bird pricing!
🔗 https://bit.ly/3ILbB5r
“Stem cell zoo: A platform for exploring species-specific biological time” 🔬⏰
Don't miss out—register by Dec 15 📆 to lock in early bird pricing!
🔗 https://bit.ly/3ILbB5r
October 27, 2025 at 2:01 PM
Join us @ #IETS2026 for our CANDES Precon keynote speaker, Miki Ebisuya, PhD (Physics of Life Dresden) 🎉.
“Stem cell zoo: A platform for exploring species-specific biological time” 🔬⏰
Don't miss out—register by Dec 15 📆 to lock in early bird pricing!
🔗 https://bit.ly/3ILbB5r
“Stem cell zoo: A platform for exploring species-specific biological time” 🔬⏰
Don't miss out—register by Dec 15 📆 to lock in early bird pricing!
🔗 https://bit.ly/3ILbB5r
Reposted by Miki Ebisuya
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
October 26, 2025 at 2:01 AM
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Reposted by Miki Ebisuya
#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel!
📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.
Apply to attend by 12/12: alleninstitute.org/events/aics-...
📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.
Apply to attend by 12/12: alleninstitute.org/events/aics-...
2026 Lake Conference: Modeling Life from Cells to Tissues
Join the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...
alleninstitute.org
October 20, 2025 at 9:33 PM
#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel!
📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.
Apply to attend by 12/12: alleninstitute.org/events/aics-...
📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.
Apply to attend by 12/12: alleninstitute.org/events/aics-...
Reposted by Miki Ebisuya
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
October 24, 2025 at 10:57 AM
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
Reposted by Miki Ebisuya
mStayRose is published in JBC 🥳🎉
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric green fluorescent protein recently
monomerised through sequence engi...
www.jbc.org
October 22, 2025 at 4:58 PM
mStayRose is published in JBC 🥳🎉
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Reposted by Miki Ebisuya
🚨 Late preprint alert!
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
October 22, 2025 at 10:29 AM
🚨 Late preprint alert!
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Why do biological process rates scale nonlinearly with temperature, deviating from the straight line on an Arrhenius plot? The key may lie in their inherent complexity!
More in thread and here: doi.org/10.1101/2025...
Reposted by Miki Ebisuya
This week’s round-up spans species from birds to sheep, and now, fittingly, to dogs!
We dive into a new study from Japanese researchers, who have successfully established culture conditions for #canine iPSCs.
🐕 Article: https://bit.ly/4gA5zkC
🐩 Discussion: https://bit.ly/4qfiME4
We dive into a new study from Japanese researchers, who have successfully established culture conditions for #canine iPSCs.
🐕 Article: https://bit.ly/4gA5zkC
🐩 Discussion: https://bit.ly/4qfiME4
October 20, 2025 at 4:48 PM
This week’s round-up spans species from birds to sheep, and now, fittingly, to dogs!
We dive into a new study from Japanese researchers, who have successfully established culture conditions for #canine iPSCs.
🐕 Article: https://bit.ly/4gA5zkC
🐩 Discussion: https://bit.ly/4qfiME4
We dive into a new study from Japanese researchers, who have successfully established culture conditions for #canine iPSCs.
🐕 Article: https://bit.ly/4gA5zkC
🐩 Discussion: https://bit.ly/4qfiME4
Reposted by Miki Ebisuya
⏰ Last chance! Apply for a scholarship or submit your short talk abstract for Stem Cell Models in Embryology by Oct 21 (11:59pm MT). Join @jun-wu-lab.bsky.social & @ebisuyamiki.bsky.social this Feb for cutting-edge #stemcells & #embryology.
🎥 youtu.be/hKhc2VrbFj0 🔗 keysym.us/KSEmbryology26
🎥 youtu.be/hKhc2VrbFj0 🔗 keysym.us/KSEmbryology26
KSQA: Dr. Jun Wu (Stem Cell Models in Embryology)
YouTube video by KeystoneSymposia
youtu.be
October 20, 2025 at 5:25 PM
⏰ Last chance! Apply for a scholarship or submit your short talk abstract for Stem Cell Models in Embryology by Oct 21 (11:59pm MT). Join @jun-wu-lab.bsky.social & @ebisuyamiki.bsky.social this Feb for cutting-edge #stemcells & #embryology.
🎥 youtu.be/hKhc2VrbFj0 🔗 keysym.us/KSEmbryology26
🎥 youtu.be/hKhc2VrbFj0 🔗 keysym.us/KSEmbryology26
Reposted by Miki Ebisuya
陸上生活に適応する耐圧メカニズム
陸上で生活する四足動物に存在し、足底の皮膚に特異的に発現する因子SLURP1を発見。SLURP1がないと、機械的圧力によって皮膚の過形成性が起きる。SLURP1は分泌されると考えられていたがERでCaレベルを制御
着眼点が面白いです
www.cell.com/cell/fulltex...
陸上で生活する四足動物に存在し、足底の皮膚に特異的に発現する因子SLURP1を発見。SLURP1がないと、機械的圧力によって皮膚の過形成性が起きる。SLURP1は分泌されると考えられていたがERでCaレベルを制御
着眼点が面白いです
www.cell.com/cell/fulltex...
A mechano-resistance mechanism in skin adapts to terrestrial locomotion
An evolutionarily emerged ER-based mechano-resistance mechanism supports epidermal function under mechanical pressure. SLURP1, an ER membrane protein, preserves SERCA2b activity and calcium…
www.cell.com
October 18, 2025 at 10:01 AM
陸上生活に適応する耐圧メカニズム
陸上で生活する四足動物に存在し、足底の皮膚に特異的に発現する因子SLURP1を発見。SLURP1がないと、機械的圧力によって皮膚の過形成性が起きる。SLURP1は分泌されると考えられていたがERでCaレベルを制御
着眼点が面白いです
www.cell.com/cell/fulltex...
陸上で生活する四足動物に存在し、足底の皮膚に特異的に発現する因子SLURP1を発見。SLURP1がないと、機械的圧力によって皮膚の過形成性が起きる。SLURP1は分泌されると考えられていたがERでCaレベルを制御
着眼点が面白いです
www.cell.com/cell/fulltex...
Reposted by Miki Ebisuya
🇬🇧Are you experienced as an administrative manager and thrive in an #international environment? We would love to hear from you!
Please share with those who might be interested!
🗓️Deadline: 30.10.2025
Apply here: tud.link/f4wf13
Please share with those who might be interested!
🗓️Deadline: 30.10.2025
Apply here: tud.link/f4wf13
🚨 #WeAreHiring! Wir beim Physics of Life suchen für ein/e Verwaltungsleiter/in für unser internationales Team. 🌍 Leite das gerne an deine Kollegen weiter!
Wir freuen uns auf Ihre Bewerbung!
🗓️Frist: 30.10.2025
Alle Infos hier: tud.link/f4wf13
#sachsenjobs #jobalert #admin #jobstelle
Wir freuen uns auf Ihre Bewerbung!
🗓️Frist: 30.10.2025
Alle Infos hier: tud.link/f4wf13
#sachsenjobs #jobalert #admin #jobstelle
October 16, 2025 at 3:30 PM
🇬🇧Are you experienced as an administrative manager and thrive in an #international environment? We would love to hear from you!
Please share with those who might be interested!
🗓️Deadline: 30.10.2025
Apply here: tud.link/f4wf13
Please share with those who might be interested!
🗓️Deadline: 30.10.2025
Apply here: tud.link/f4wf13
Reposted by Miki Ebisuya
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Miki Ebisuya
📢 New in @natbiotech.nature.com!
Scientists have successfully derived #haploid androgenetic #ESCs from cattle and sheep and developed a novel method to generate offspring from these cells.
📖 Read the article: https://go.nature.com/48XR600
🎧 Listen to the discussion: https://bit.ly/4qfiME4
Scientists have successfully derived #haploid androgenetic #ESCs from cattle and sheep and developed a novel method to generate offspring from these cells.
📖 Read the article: https://go.nature.com/48XR600
🎧 Listen to the discussion: https://bit.ly/4qfiME4
October 15, 2025 at 4:13 PM
📢 New in @natbiotech.nature.com!
Scientists have successfully derived #haploid androgenetic #ESCs from cattle and sheep and developed a novel method to generate offspring from these cells.
📖 Read the article: https://go.nature.com/48XR600
🎧 Listen to the discussion: https://bit.ly/4qfiME4
Scientists have successfully derived #haploid androgenetic #ESCs from cattle and sheep and developed a novel method to generate offspring from these cells.
📖 Read the article: https://go.nature.com/48XR600
🎧 Listen to the discussion: https://bit.ly/4qfiME4
Reposted by Miki Ebisuya
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
A quadratic paradigm describes the relationship between phenotype severity and variation - Nature Communications
Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...
www.nature.com
October 15, 2025 at 9:24 AM
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
This meeting will be a significant event for those advancing research in stem cell-based embryo models. Submit your abstract and scholarship application by Oct 21!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
October 15, 2025 at 7:15 AM
This meeting will be a significant event for those advancing research in stem cell-based embryo models. Submit your abstract and scholarship application by Oct 21!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Reposted by Miki Ebisuya
Vertebral skeletal diversity in mammals is remarkable. How do the differences between vertebral size and shape develop and evolve? See how we tackled this question in our paper published in @natcomms.nature.com today!
October 10, 2025 at 6:46 PM
Vertebral skeletal diversity in mammals is remarkable. How do the differences between vertebral size and shape develop and evolve? See how we tackled this question in our paper published in @natcomms.nature.com today!
Reposted by Miki Ebisuya
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 12:50 PM
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Reposted by Miki Ebisuya
Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
October 9, 2025 at 2:32 PM
Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October