Raquel Fueyo
@fueyoraquel.bsky.social
Incoming Group Leader @molgen | Postdoc in the Wysocka Lab at @ Stanford. @ EMBO, @ CancerResearch, and @ Leading Edge fellow.
Gene regulation | Transposons | Human embryo development
Gene regulation | Transposons | Human embryo development
Pinned
Raquel Fueyo
@fueyoraquel.bsky.social
· Oct 1
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Raquel Fueyo
Happy to share our paper now out in @cp-cellreports.bsky.social - and check out our thread about the findings at bsky.app/profile/vale...
In vivo differentiation of embryonic cells devoid of key reprogramming factors
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.
dlvr.it
November 13, 2025 at 12:34 AM
Happy to share our paper now out in @cp-cellreports.bsky.social - and check out our thread about the findings at bsky.app/profile/vale...
Reposted by Raquel Fueyo
We have a new lab photo. Busy times in the Delas Lab!
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
November 12, 2025 at 2:04 PM
We have a new lab photo. Busy times in the Delas Lab!
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
70s Glam-Rock phenotype! I love this story! Congrats to all the team 🍾
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A
Insertion of an invading retrovirus regulates a novel color trait in swordtail fish
For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...
shorturl.at
November 12, 2025 at 9:00 PM
70s Glam-Rock phenotype! I love this story! Congrats to all the team 🍾
So many memories and feelings cleaning up boxes... Where do the unfinished projects go? Are the amount of plastic tubes used worth the discoveries? Also, this picture could serve as my CV...
November 11, 2025 at 3:32 PM
So many memories and feelings cleaning up boxes... Where do the unfinished projects go? Are the amount of plastic tubes used worth the discoveries? Also, this picture could serve as my CV...
Reposted by Raquel Fueyo
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
November 10, 2025 at 9:46 PM
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Reposted by Raquel Fueyo
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Raquel Fueyo
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
November 6, 2025 at 6:37 PM
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
Thrilled to start my Group Leader adventure with these and other great scientists!
We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Three new research groups joining the MPIMG
www.molgen.mpg.de
November 6, 2025 at 8:11 PM
Thrilled to start my Group Leader adventure with these and other great scientists!
Reposted by Raquel Fueyo
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice - Nature Communications
KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealin...
www.nature.com
November 6, 2025 at 9:40 AM
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Reposted by Raquel Fueyo
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
November 5, 2025 at 5:48 PM
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
Reposted by Raquel Fueyo
🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
November 3, 2025 at 12:03 PM
🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Raquel Fueyo
Join us to hear about writing and re-writing the central dogma! Looking forward to hosting Samuel Sternberg @sternberglab.bsky.social from @columbiauniversity.bsky.social for our Dahlem Colloquium Seminar at the MPI for Molecular Genetics @molgen.mpg.de - see below 👇
November 2, 2025 at 11:18 PM
Join us to hear about writing and re-writing the central dogma! Looking forward to hosting Samuel Sternberg @sternberglab.bsky.social from @columbiauniversity.bsky.social for our Dahlem Colloquium Seminar at the MPI for Molecular Genetics @molgen.mpg.de - see below 👇
Reposted by Raquel Fueyo
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:25 AM
Reposted by Raquel Fueyo
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Reposted by Raquel Fueyo
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
Check out @jaguilarrod.bsky.social and @petrovadmitri.bsky.social thought provoking work! If like me, you feel this work may be out of your comfort zone, make sure to read Jose's bluetorial, clearly explained! Congratulations!
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 23, 2025 at 9:32 PM
Check out @jaguilarrod.bsky.social and @petrovadmitri.bsky.social thought provoking work! If like me, you feel this work may be out of your comfort zone, make sure to read Jose's bluetorial, clearly explained! Congratulations!
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
[2026] – Endogenous retroviruses in human embryogenesis
www.molgen.mpg.de
October 23, 2025 at 8:31 PM
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
Congratulations @katerinakraft.bsky.social, @sedonamurphy.bsky.social and @mattjones.bsky.social ! Very cool!
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
www.nature.com
October 21, 2025 at 4:35 PM
Congratulations @katerinakraft.bsky.social, @sedonamurphy.bsky.social and @mattjones.bsky.social ! Very cool!
Reposted by Raquel Fueyo
🎃We are ready & excited for the new #FragileNucleosome seminar session tomorrow with @alicelaigle.bsky.social and @seungsookim.bsky.social ! How about you ?
October 21, 2025 at 2:42 PM
🎃We are ready & excited for the new #FragileNucleosome seminar session tomorrow with @alicelaigle.bsky.social and @seungsookim.bsky.social ! How about you ?
Reposted by Raquel Fueyo
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
October 17, 2025 at 7:58 PM
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
Reposted by Raquel Fueyo
📢 We are hiring!
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
October 15, 2025 at 3:00 PM
📢 We are hiring!
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
Reposted by Raquel Fueyo
even more results in the #preprint!
Our interpretation (TL;DR)
We think that the promoter-proximal cis-regulatory element acts like a #facilitator that helps to filter and relay long-range enhancer activity to the core promoter!
Our interpretation (TL;DR)
We think that the promoter-proximal cis-regulatory element acts like a #facilitator that helps to filter and relay long-range enhancer activity to the core promoter!
October 16, 2025 at 3:06 PM
even more results in the #preprint!
Our interpretation (TL;DR)
We think that the promoter-proximal cis-regulatory element acts like a #facilitator that helps to filter and relay long-range enhancer activity to the core promoter!
Our interpretation (TL;DR)
We think that the promoter-proximal cis-regulatory element acts like a #facilitator that helps to filter and relay long-range enhancer activity to the core promoter!
Reposted by Raquel Fueyo
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Raquel Fueyo
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...