OUTLOOK: The two faces of MyoD: repressor and activator of gene expression during myogenesis
By Carmen Birchmeier
➡️ https://genesdev.cshlp.org/content/39/21-22/1269.full

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1299.abstract

#transcription #muscle #stemcells #openaccess

RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
➡️ https://genesdev.cshlp.org/content/39/21-22/1355.full

Eric Conway
Adrian Bracken

#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover

REVIEW: Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation
By Mishra et al. and Lingbo Zhang
➡️ https://genesdev.cshlp.org/content/39/21-22/1271.abstract

#cancer #metabolism #vitamin #cancertherapy #cancermetabolism #immune

RESEARCH PAPER: Mouse cortical cellular diversification through lineage progression of radial glia
By Yang et al., and Xiaosu Li
➡️ https://genesdev.cshlp.org/content/39/21-22/1338.abstract

#glia #braindevelopment #neuron #neurodevelopment #neuronalprogenitor #neuralstemcell #epigenetics

RESEARCH PAPER: MYOD represses gene expression from non-E-box motifs
By Nicoletti, Massenet et al., Luca Caputo and Pier Lorenzo Puri
➡️ https://genesdev.cshlp.org/content/39/21-22/1299.abstract

#transcription #trancriptionfactor #epigenetics #muscle #stemcells

🎥 G&D Tapes 🎥

G&D author, Haoming Yu tells us about their new study in #genesdev that uses epigenetic editing to probe the role of H3K4me3 at intergenic regulatory elements.

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full

Bluma Lesch
@haomingyu.bsky.social

RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full

Bluma Lesch
@haomingyu.bsky.social

#transcription #epigenetics #histones #histonePTMs #methylation #enhancers

🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research articles online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/21-22.toc

RESOURCE/METHODOLOGY: A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change
By Turn et al. and Peter Jackson

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1241.abstract

RESEARCH PAPER: A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family
By Sakhawala et al. and Katherine McJunkin

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1198.abstract

RESEARCH PAPER: SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly
By He et al. and Michael Matunis

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1182.abstract

RESEARCH PAPER: Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus
By Briggs et al. and James Burke

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1162.abstract

RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif
By Alegrio-Louro et al. and Andres Leschziner

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full

REVIEW: Modeling and targeting general and chromosome-specific aneuploidy in cancer.
By Aleah Goldberg, Maria Trifas and Teresa Davoli

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1132.abstract

📽️ G&D Tapes 📽️

G&D Author, Aishwarya Pawar, tells us about their new study showing that PHF6 and PHIP function together to suppress stemness programs and leukemia progression.
@aishwarya2510.bsky.social
@paralkarlab.bsky.social

Learn more here:
➡️ genesdev.cshlp.org/content/39/1...

OUTLOOK: A new link in the leukemia genetic puzzle
By Xiaodi Wu and Ross Levine

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1129.full

G&D's Editor-in-Chief, Andrew Dillin, will be at #FusionAging25
If you’d like to chat about publishing your work with #genesdev, feel free to reach out to dillin[at]berkeley[dot]edu

RESEARCH PAPER: Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness
By Pawar et al. and Vikram Paralkar
Aishwarya Pawar
Vikram Paralkar

Learn more here:
 ➡️ https://genesdev.cshlp.org/content/39/19-20/1219.abstract

🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research Papers online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/19-20.toc

How does the brain connect with each muscle to control the body? Check out new videos from @columbiamed.bsky.social & @zuckermanbrain.bsky.social that reveal two key molecules behind this vital process in fruit flies. @genesdev.bsky.social

zuckermaninstitute.columbia.edu/microscopic-...

🧠💪🪰

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

G&D will be at Biology of Cancer 2025 #cshlcancer this week. Come find us in Grace Lobby or schedule an appointment below if you'd like to chat about your work or learn more about publishing with us.

<a href="https://bsky.app/profile/did:plc:4gb34vaxz2lzseq4bqsngavr" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@cshlmeetings.bsky.social <a href="https://bsky.app/profile/did:plc:vmgobpps53ca6r3b5ylzmt3p" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@genesdev.bsky.social

➡️ https://tinyurl.com/GenesDev-MeetTheEditors

RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648

#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion

OUTLOOK: Lineage rewiring in lung adenocarcinoma via HNF4α and NKX2-1 dynamics
By Alice Feng, Alena Yermalovich, and Matthew Meyerson
➡️ https://tinyurl.com/gd353142

Read the paper:
➡️ https://tinyurl.com/gd352742

#KRAS #hybrididentity #lineage #plasticity #lungcancer #cancertherapy

G&D's Editor-in-Chief, Andrew Dillin will be at the 2025 Frontiers in Metabolism – Mechanisms of Metabolic Disease meeting at the Morgridge Institute for Research @<a href="https://uwmadison.bsky.social." class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">uwmadison.bsky.social. If you’d like to chat about publishing your work with us, feel free to reach out to dillin<a href="https://bsky.app/profile/did:plc:berkeley.edu" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@berkeley.edu