Hannah Long
@hannahlong.bsky.social
Group Leader @mrc_hgu investigating gene regulation in development & human disease
Pinned
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Hannah Long
Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested
non-coding regulatory elements, predicts enhancer activity directly from DNA sequence
and identifies nucleotides ess...
www.cell.com
November 20, 2025 at 9:38 AM
Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
Reposted by Hannah Long
Researchers have identified gene-regulatory variants that might have contributed to Neanderthals’ beefy jaws — offering a window on how the human face developed
go.nature.com/3Ke6StJ
go.nature.com/3Ke6StJ
Neanderthal DNA reveals how human faces form
Subtle genomic variations between humans and Neanderthals provide clues to how DNA shapes our facial features.
go.nature.com
November 20, 2025 at 5:07 PM
Researchers have identified gene-regulatory variants that might have contributed to Neanderthals’ beefy jaws — offering a window on how the human face developed
go.nature.com/3Ke6StJ
go.nature.com/3Ke6StJ
Congratulations!
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
November 19, 2025 at 11:56 AM
Congratulations!
Reposted by Hannah Long
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Reposted by Hannah Long
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD.
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
November 5, 2025 at 10:28 AM
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD.
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
Reposted by Hannah Long
Neanderthal DNA enhances our understanding of face development
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
November 10, 2025 at 1:04 PM
Neanderthal DNA enhances our understanding of face development
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
Reposted by Hannah Long
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Hannah Long
To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah Jüllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....
doi.org/10.1242/dev....
November 10, 2025 at 1:04 PM
To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah Jüllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Hannah Long
Excited to share our new paper out today in Development! Check out Hannah’s fantastic post below for a summary of the findings ✨
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 2:37 PM
Excited to share our new paper out today in Development! Check out Hannah’s fantastic post below for a summary of the findings ✨
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Hannah Long
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
November 6, 2025 at 6:37 PM
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
Reposted by Hannah Long
🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
November 3, 2025 at 12:03 PM
🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Hannah Long
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
October 6, 2025 at 1:46 PM
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
Reposted by Hannah Long
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency
In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...
www.biorxiv.org
October 3, 2025 at 3:09 PM
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Reposted by Hannah Long
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 18, 2025 at 6:59 PM
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Looking forward to listening!
In this episode of the Epigenetics Podcast, we talked with @em6wong.bsky.social from the University of New South Wales in Sydney about her work on how evolution shapes mammalian genes. #podcast #epigenetics #chromatin
Listen here: www.activemotif.com/podcasts-emi...
Listen here: www.activemotif.com/podcasts-emi...
September 19, 2025 at 7:48 AM
Looking forward to listening!
Reposted by Hannah Long
deadline tomorrow, Sept 19! www.csh-asia.org?content/2767
WELCOME-Meetings-Cold Spring Harbor Asia
www.csh-asia.org
September 18, 2025 at 5:43 AM
deadline tomorrow, Sept 19! www.csh-asia.org?content/2767
Reposted by Hannah Long
RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648
#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion
By Williamson et al.
➡️ https://tinyurl.com/gd352648
#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion
September 15, 2025 at 3:04 PM
RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648
#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion
By Williamson et al.
➡️ https://tinyurl.com/gd352648
#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion
Reposted by Hannah Long
New online! Is enhancer-driven gene regulation all wrapped up?
Is enhancer-driven gene regulation all wrapped up?
Nature Reviews Genetics, Published online: 16 September 2025; doi:10.1038/s41576-025-00880-9In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
www.nature.com
September 16, 2025 at 3:31 PM
New online! Is enhancer-driven gene regulation all wrapped up?
Amazing evolutionary gene regulatory story about dorsoventral limb and fin patterning! Congratulations to all the team 🙌
We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
September 2, 2025 at 4:43 PM
Amazing evolutionary gene regulatory story about dorsoventral limb and fin patterning! Congratulations to all the team 🙌
Reposted by Hannah Long
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by Hannah Long
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
August 28, 2025 at 12:48 PM
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
Reposted by Hannah Long
Super excited that our latest work is out!
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 27, 2025 at 10:52 AM
Super excited that our latest work is out!
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
Reposted by Hannah Long
Denisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
August 27, 2025 at 1:05 PM
Denisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Hannah Long
Eva Nogales @nogaleslab.bsky.social introducing the 2025 CSH Mechanisms of Eukaryotic Transcription Meeting. Co-organizing with Wendy Bickmore @wbickmor.bsky.social and Joanna Wysocka. Will intermittently try to update as allowed
August 26, 2025 at 11:32 PM
Eva Nogales @nogaleslab.bsky.social introducing the 2025 CSH Mechanisms of Eukaryotic Transcription Meeting. Co-organizing with Wendy Bickmore @wbickmor.bsky.social and Joanna Wysocka. Will intermittently try to update as allowed