Karin Prummel
@kprummel.bsky.social
SNSF and EMBO Postdoctoral fellow at EMBL | PhD in Dev Bio from University of Zurich | Utrecht University alumni | climbing | cycling | piano
Reposted by Karin Prummel
As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive.
I hope you like it!
www.biorxiv.org/content/10.1...
I hope you like it!
www.biorxiv.org/content/10.1...
Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells
Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...
www.biorxiv.org
September 23, 2025 at 10:49 PM
As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive.
I hope you like it!
www.biorxiv.org/content/10.1...
I hope you like it!
www.biorxiv.org/content/10.1...
Reposted by Karin Prummel
Join EMBL as a research group leader in AI in biology. EMBL AI is our new initiative aiming to exploit the full potential of ML/AI-based approaches to advance our understanding of the most complex system in the known universe - life on Earth.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
(1/3)
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
(1/3)
September 9, 2025 at 10:07 AM
Join EMBL as a research group leader in AI in biology. EMBL AI is our new initiative aiming to exploit the full potential of ML/AI-based approaches to advance our understanding of the most complex system in the known universe - life on Earth.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
(1/3)
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
(1/3)
Reposted by Karin Prummel
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 8:22 AM
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
We are searching for a research technician in our group at EMBL Heidelberg! 🧫🧬🔬
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Research Technician
We are looking for a highly motivated research technician to join the Zaugg group at EMBL Heidelberg, an interdisciplinary team of experimental and computational scientists. Our research combines larg...
embl.wd103.myworkdayjobs.com
September 1, 2025 at 7:37 AM
We are searching for a research technician in our group at EMBL Heidelberg! 🧫🧬🔬
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Karin Prummel
🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab)
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
August 21, 2025 at 2:34 PM
🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab)
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
Reposted by Karin Prummel
Looking for a #postdoc opportunity? Funded positions available @cuanschutz.bsky.social to advance our #zebrafish transgenesis tools - and to look into developmental origins of congenital disease!
#devbio
#devbio
Grateful to receive an R24 NOA from NIH/ORIP to advance phiC31-based transgenesis tools in #zebrafish. 🐟
Collab with @aburger2009.bsky.social & Breuss labs @cuanschutz.bsky.social. 🧬
...and: big THX to everyone who already helped w/ sharing #pIGLET reagents! 🐽
#ShareYourTools #MakeMoreTransgenics
Collab with @aburger2009.bsky.social & Breuss labs @cuanschutz.bsky.social. 🧬
...and: big THX to everyone who already helped w/ sharing #pIGLET reagents! 🐽
#ShareYourTools #MakeMoreTransgenics
piglet from winnie the pooh says thank you
ALT: piglet from winnie the pooh says thank you
media.tenor.com
August 15, 2025 at 8:44 PM
Looking for a #postdoc opportunity? Funded positions available @cuanschutz.bsky.social to advance our #zebrafish transgenesis tools - and to look into developmental origins of congenital disease!
#devbio
#devbio
Reposted by Karin Prummel
Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
August 7, 2025 at 11:24 AM
Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
Reposted by Karin Prummel
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Karin Prummel
Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
July 24, 2025 at 4:28 PM
Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
Reposted by Karin Prummel
🥁 New article 📢: #Mechanobiology of #development during #Drosophila #gastrulation using #Brillouin microscopy, now in @natcomms.nature.com : rdcu.be/ev6ZX
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social
July 15, 2025 at 2:12 PM
🥁 New article 📢: #Mechanobiology of #development during #Drosophila #gastrulation using #Brillouin microscopy, now in @natcomms.nature.com : rdcu.be/ev6ZX
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social
Reposted by Karin Prummel
SUM-seq: New single-cell method by @biomedizin.unibas.ch , @embl.org , @au.dk and Tampere university enables large-scale analysis of gene activity & DNA accessibility across millions of cells.
Congrats Prof. Zaugg & collaborators!
🔗 www.nature.com/articles/s41...
Congrats Prof. Zaugg & collaborators!
🔗 www.nature.com/articles/s41...
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods
This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...
www.nature.com
May 26, 2025 at 2:20 PM
SUM-seq: New single-cell method by @biomedizin.unibas.ch , @embl.org , @au.dk and Tampere university enables large-scale analysis of gene activity & DNA accessibility across millions of cells.
Congrats Prof. Zaugg & collaborators!
🔗 www.nature.com/articles/s41...
Congrats Prof. Zaugg & collaborators!
🔗 www.nature.com/articles/s41...
Looking for an ultra-high-throughput single-cell RNA+ATAC method? 🎆
Check out our SUM-seq method, now officially out! 🧬
Showcased on macrophages, T cells, and iPSC-derived embryoid bodies; more cell types and tissues to come! 🧫
Reach out for the detailed protocol! 📝 ✨
Check out our SUM-seq method, now officially out! 🧬
Showcased on macrophages, T cells, and iPSC-derived embryoid bodies; more cell types and tissues to come! 🧫
Reach out for the detailed protocol! 📝 ✨
SUM-seq out @natmethods.nature.com !
🚀 Ultra-high-throughput Multiplexed snATAC+RNA
Used to:
⏳ link temporal macrophage GRNs to immune disease genetics
🩸 map T cell regulatory landscapes
🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens
doi.org/10.1038/s41592-025-02700-8
🧵
🚀 Ultra-high-throughput Multiplexed snATAC+RNA
Used to:
⏳ link temporal macrophage GRNs to immune disease genetics
🩸 map T cell regulatory landscapes
🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens
doi.org/10.1038/s41592-025-02700-8
🧵
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods
This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...
doi.org
May 26, 2025 at 10:58 AM
Looking for an ultra-high-throughput single-cell RNA+ATAC method? 🎆
Check out our SUM-seq method, now officially out! 🧬
Showcased on macrophages, T cells, and iPSC-derived embryoid bodies; more cell types and tissues to come! 🧫
Reach out for the detailed protocol! 📝 ✨
Check out our SUM-seq method, now officially out! 🧬
Showcased on macrophages, T cells, and iPSC-derived embryoid bodies; more cell types and tissues to come! 🧫
Reach out for the detailed protocol! 📝 ✨
Reposted by Karin Prummel
/ rant on:
Abbreviating cis-regulatory elements as *CRE* is a terrible abbreviation in a field that uses *Cre* recombinase as major lineage trace tool. 🐭🐟🧬
/ rant off
#devbio #MakeMoreTransgenics #Crelox #enhancers
Abbreviating cis-regulatory elements as *CRE* is a terrible abbreviation in a field that uses *Cre* recombinase as major lineage trace tool. 🐭🐟🧬
/ rant off
#devbio #MakeMoreTransgenics #Crelox #enhancers
March 17, 2025 at 11:08 PM
/ rant on:
Abbreviating cis-regulatory elements as *CRE* is a terrible abbreviation in a field that uses *Cre* recombinase as major lineage trace tool. 🐭🐟🧬
/ rant off
#devbio #MakeMoreTransgenics #Crelox #enhancers
Abbreviating cis-regulatory elements as *CRE* is a terrible abbreviation in a field that uses *Cre* recombinase as major lineage trace tool. 🐭🐟🧬
/ rant off
#devbio #MakeMoreTransgenics #Crelox #enhancers
Reposted by Karin Prummel
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
embl.wd103.myworkdayjobs.com
February 11, 2025 at 9:03 PM
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Reposted by Karin Prummel
Join us next week (Wednesday!) for the next VGZT morning/eastern session ☀️ ☕️ seminar!
We are looking forward to exciting 🪰🪲 talks by:
Juan Manuel Gómez @gomezjm-devmech.bsky.social
and
Wolfram Pönisch @wolframponisch.bsky.social
🗓️ Wednesday, Feb 12
⏰ 18:00 JST / 10:00 CET / 9:00 UTC
We are looking forward to exciting 🪰🪲 talks by:
Juan Manuel Gómez @gomezjm-devmech.bsky.social
and
Wolfram Pönisch @wolframponisch.bsky.social
🗓️ Wednesday, Feb 12
⏰ 18:00 JST / 10:00 CET / 9:00 UTC
February 7, 2025 at 11:22 PM
Join us next week (Wednesday!) for the next VGZT morning/eastern session ☀️ ☕️ seminar!
We are looking forward to exciting 🪰🪲 talks by:
Juan Manuel Gómez @gomezjm-devmech.bsky.social
and
Wolfram Pönisch @wolframponisch.bsky.social
🗓️ Wednesday, Feb 12
⏰ 18:00 JST / 10:00 CET / 9:00 UTC
We are looking forward to exciting 🪰🪲 talks by:
Juan Manuel Gómez @gomezjm-devmech.bsky.social
and
Wolfram Pönisch @wolframponisch.bsky.social
🗓️ Wednesday, Feb 12
⏰ 18:00 JST / 10:00 CET / 9:00 UTC
I am happy to see this awesome collaboration from my PhD times officially out! On the origins of another fun mesoderm-derived structure: our neck muscles!
Congrats to Eglantine and Shahragim for this beautiful evo-devo work 🔬❤️
Congrats to Eglantine and Shahragim for this beautiful evo-devo work 🔬❤️
Where did our neck muscles come from?🧪
Here's our #evodevo #devbio deep dive feat. #zebrafish, mouse, axolotls, & more!
Led by Eglantine Heude & Tajbakhsh lab at Pasteur, the team at National Museum of Natural History France, & lab alumni Karin Prummel & Rob Lalonde.
www.nature.com/articles/s41...
Here's our #evodevo #devbio deep dive feat. #zebrafish, mouse, axolotls, & more!
Led by Eglantine Heude & Tajbakhsh lab at Pasteur, the team at National Museum of Natural History France, & lab alumni Karin Prummel & Rob Lalonde.
www.nature.com/articles/s41...
Co-option of neck muscles supported the vertebrate water-to-land transition - Nature Communications
The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that th...
www.nature.com
December 5, 2024 at 12:33 PM
I am happy to see this awesome collaboration from my PhD times officially out! On the origins of another fun mesoderm-derived structure: our neck muscles!
Congrats to Eglantine and Shahragim for this beautiful evo-devo work 🔬❤️
Congrats to Eglantine and Shahragim for this beautiful evo-devo work 🔬❤️