Moritz Mall
@moritzmall.bsky.social
Research group leader @German Cancer Research Center, reconstructing human development and disease using cell fate engineering
Pinned
Moritz Mall
@moritzmall.bsky.social
· May 16
What keeps cancer cells in check—and can we tame them? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...
Reposted by Moritz Mall
Werden Sie Teil unseres Teams!
Become part of our team!
💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit:
👩🏻🔬Referent∗in👨🔬 (w/m/d)
Bewerbungen als PDF-Datei bis 30.11.2025 an: andrea.leibfried@bioquant.uni-heidelberg.de
adb.zuv.uni-heidelberg.de/info/INFO_FD...
#job
Become part of our team!
💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit:
👩🏻🔬Referent∗in👨🔬 (w/m/d)
Bewerbungen als PDF-Datei bis 30.11.2025 an: andrea.leibfried@bioquant.uni-heidelberg.de
adb.zuv.uni-heidelberg.de/info/INFO_FD...
#job
October 31, 2025 at 9:05 AM
Werden Sie Teil unseres Teams!
Become part of our team!
💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit:
👩🏻🔬Referent∗in👨🔬 (w/m/d)
Bewerbungen als PDF-Datei bis 30.11.2025 an: andrea.leibfried@bioquant.uni-heidelberg.de
adb.zuv.uni-heidelberg.de/info/INFO_FD...
#job
Become part of our team!
💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit:
👩🏻🔬Referent∗in👨🔬 (w/m/d)
Bewerbungen als PDF-Datei bis 30.11.2025 an: andrea.leibfried@bioquant.uni-heidelberg.de
adb.zuv.uni-heidelberg.de/info/INFO_FD...
#job
Reposted by Moritz Mall
Presenting recipients of our 2025 Stimulator Grant:
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
October 13, 2025 at 2:19 PM
Presenting recipients of our 2025 Stimulator Grant:
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
Reposted by Moritz Mall
Looking forward to this collab with @moritzmall.bsky.social and Barbara Treutlein!
We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.
We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.
Presenting recipients of our 2025 Stimulator Grant:
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
October 14, 2025 at 11:42 AM
Looking forward to this collab with @moritzmall.bsky.social and Barbara Treutlein!
We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.
We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.
Reposted by Moritz Mall
Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. @nature.com Neuroscience
t1p.de/hpj1m
t1p.de/hpj1m
No GPS in the head: How the brain flexibly switches between internal maps
Since their discovery in 2004, the grid cells in the brain, which are important for our orientation, have been regarded as a kind of “GPS in the head.” However, scientists at the German Cancer Researc...
t1p.de
September 24, 2025 at 1:54 PM
Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. @nature.com Neuroscience
t1p.de/hpj1m
t1p.de/hpj1m
Reposted by Moritz Mall
🚨 Registration deadline for the EACR conference on #cancerneuroscience is September 15 ‼️
Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠
See you soon!
Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠
See you soon!
Introduction | Cancer Neuroscience | The European Association for Cancer Research
eacr.org
September 10, 2025 at 6:15 AM
🚨 Registration deadline for the EACR conference on #cancerneuroscience is September 15 ‼️
Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠
See you soon!
Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠
See you soon!
Reposted by Moritz Mall
GSCN 2025 Best Publication Award goes to B. Lim, @moritzmall.bsky.social, J. Zaugg, A. Kamal @biomedizin.unibas.ch for joint publication in @naturegenz.bsky.social All infos on www.gscn.org @dkfz.bsky.social @www.helmholtz-munich.de @embl.org @mdc-berlin.bsky.social @bihatcharite.bsky.social
August 22, 2025 at 9:24 AM
GSCN 2025 Best Publication Award goes to B. Lim, @moritzmall.bsky.social, J. Zaugg, A. Kamal @biomedizin.unibas.ch for joint publication in @naturegenz.bsky.social All infos on www.gscn.org @dkfz.bsky.social @www.helmholtz-munich.de @embl.org @mdc-berlin.bsky.social @bihatcharite.bsky.social
Reposted by Moritz Mall
Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏
@gscnoffice.bsky.social
@gscnoffice.bsky.social
August 22, 2025 at 8:37 AM
Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏
@gscnoffice.bsky.social
@gscnoffice.bsky.social
🎉 Herzlichen Dank für den @gscnoffice.bsky.social-Preis „Publication of the Year 2025“ zu unserer @natgenet.nature.com Publikation: www.nature.com/articles/s41...
Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!
Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!
August 22, 2025 at 4:26 PM
🎉 Herzlichen Dank für den @gscnoffice.bsky.social-Preis „Publication of the Year 2025“ zu unserer @natgenet.nature.com Publikation: www.nature.com/articles/s41...
Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!
Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!
🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab)
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
August 21, 2025 at 2:34 PM
🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab)
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience.
Apply: jobs.dkfz.de/en/jobs/1679...
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
Reposted by Moritz Mall
We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare!
You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.
👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application
You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.
👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application
Application - Helmholtz Information & Data Science Academy
hidss4health.de
August 5, 2025 at 8:08 AM
We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare!
You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.
👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application
You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.
👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application
Hands down the best meeting this year so far! Thanks for the fantastic organization @matlupien.bsky.social @shenhui1986.bsky.social Bonus was a musical finale - who said science cannot be fun :)
May 25, 2025 at 12:36 PM
Hands down the best meeting this year so far! Thanks for the fantastic organization @matlupien.bsky.social @shenhui1986.bsky.social Bonus was a musical finale - who said science cannot be fun :)
What keeps cancer cells in check—and can we tame them? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...
May 16, 2025 at 3:57 PM
What keeps cancer cells in check—and can we tame them? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...
📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1...
📍 Regulatory logic: www.biorxiv.org/content/10.1...
Reposted by Moritz Mall
13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1...
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics
Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...
www.biorxiv.org
May 16, 2025 at 10:05 AM
13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1...
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB
Reposted by Moritz Mall
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
May 16, 2025 at 10:05 AM
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
Reposted by Moritz Mall
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
May 16, 2025 at 11:44 AM
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Thank you, @hlsalliance.bsky.social! Your backing lets junior teams like ours pursue fundamental, high-risk research to better understand cancer. Excited to keep advancing the frontiers together with many collaborations within the Alliance.
👏Congratulations to👏
🎉@moritzmall.bsky.social and
🏆@venkataramanilab.bsky.social at @UKHD for receiving the Hella-Bühler Price for their outstanding contributions to cancer research.
www.uni-heidelberg.de/en/newsroom/...
Their research groups are supported by the @hlsalliance.bsky.social.
🎉@moritzmall.bsky.social and
🏆@venkataramanilab.bsky.social at @UKHD for receiving the Hella-Bühler Price for their outstanding contributions to cancer research.
www.uni-heidelberg.de/en/newsroom/...
Their research groups are supported by the @hlsalliance.bsky.social.
Award for Outstanding Contributions to Cancer Research
www.uni-heidelberg.de
May 16, 2025 at 3:19 PM
Thank you, @hlsalliance.bsky.social! Your backing lets junior teams like ours pursue fundamental, high-risk research to better understand cancer. Excited to keep advancing the frontiers together with many collaborations within the Alliance.
I am very grateful to @uniheidelberg.bsky.social and the Hella Bühler Foundation for this honour. Sharing the prize with the brilliant @venkataramanilab.bsky.social and our amazing teams makes me extremely proud. I am excited to channel this prize into the next wave of cancer-fighting ideas!
Award for Outstanding Contributions to Cancer Research: Dr Dr Varun Venkataramani and Dr Moritz Mall share the 100,000-euro Hella Bühler Prize www.uni-heidelberg.de/en/newsroom/...
Award for Outstanding Contributions to Cancer Research
www.uni-heidelberg.de
May 16, 2025 at 3:14 PM
I am very grateful to @uniheidelberg.bsky.social and the Hella Bühler Foundation for this honour. Sharing the prize with the brilliant @venkataramanilab.bsky.social and our amazing teams makes me extremely proud. I am excited to channel this prize into the next wave of cancer-fighting ideas!
Reposted by Moritz Mall
Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social
👉 t1p.de/1dnqw
👉 t1p.de/1dnqw
May 14, 2025 at 9:12 AM
Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social
👉 t1p.de/1dnqw
👉 t1p.de/1dnqw
Vielen Dank für die große Ehrung und die starke Unterstützung durch das @dkfz.bsky.social
, das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience
, das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience
Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social
👉 t1p.de/1dnqw
👉 t1p.de/1dnqw
May 16, 2025 at 3:02 PM
Vielen Dank für die große Ehrung und die starke Unterstützung durch das @dkfz.bsky.social
, das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience
, das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience
Reposted by Moritz Mall
Do you want to do your #postdoc in #cancerresearch with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses by May 19. Projects in #cellandmolecularbiology #genomics #bioinformatics #immunology #medicaltechnology, #epidemiology.
Apply here: t1p.de/nx6tu
Apply here: t1p.de/nx6tu
April 22, 2025 at 1:50 PM
Do you want to do your #postdoc in #cancerresearch with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses by May 19. Projects in #cellandmolecularbiology #genomics #bioinformatics #immunology #medicaltechnology, #epidemiology.
Apply here: t1p.de/nx6tu
Apply here: t1p.de/nx6tu
Reposted by Moritz Mall
Warum sind #Tierversuche in der #Krebsforschung notwendig? Das erklärt Andreas Trumpp, Abteilungsleiter am DKFZ und geschäftsführender Direktor HI-STEM in diesem Video von @tvvde.bsky.social.
Neue Methoden im Fokus: Organoide und Tierversuche in der Krebsforschung
YouTube video by Tierversuche verstehen
www.youtube.com
April 23, 2025 at 8:24 AM
Warum sind #Tierversuche in der #Krebsforschung notwendig? Das erklärt Andreas Trumpp, Abteilungsleiter am DKFZ und geschäftsführender Direktor HI-STEM in diesem Video von @tvvde.bsky.social.
Reposted by Moritz Mall
@michael-platten.bsky.social has been selected and nominated as Ambassador for the ERC network. The @erc.europa.eu & the @ercgrantees.bsky.social launched the new Ambassadors on 28 April. This joint initiative aims to promote investment in frontier research and highlight the importance of #research.
April 30, 2025 at 10:54 AM
@michael-platten.bsky.social has been selected and nominated as Ambassador for the ERC network. The @erc.europa.eu & the @ercgrantees.bsky.social launched the new Ambassadors on 28 April. This joint initiative aims to promote investment in frontier research and highlight the importance of #research.
Reposted by Moritz Mall
Jedes Jahr erkranken in Deutschland etwa 500.000 Menschen an #Krebs. Das Deutsche Krebsforschungszentrum (DKFZ) widmet sich als größte biomedizinische Forschungseinrichtung in Deutschland ganz der Aufgabe, #Krebsforschung zu betreiben.
April 24, 2025 at 12:39 PM
Jedes Jahr erkranken in Deutschland etwa 500.000 Menschen an #Krebs. Das Deutsche Krebsforschungszentrum (DKFZ) widmet sich als größte biomedizinische Forschungseinrichtung in Deutschland ganz der Aufgabe, #Krebsforschung zu betreiben.
Reposted by Moritz Mall
Visit us at the #AACR25 in #Chicago, where we present #CancerResearch in Germany. 👩🏽🔬👨🏽🔬 🇩🇪
📍Exhibition at booth #842 from April 27 to 30
@nct-heidelberg.bsky.social @DKTK @theaacr.bsky.social
📍Exhibition at booth #842 from April 27 to 30
@nct-heidelberg.bsky.social @DKTK @theaacr.bsky.social
April 28, 2025 at 11:44 AM
Visit us at the #AACR25 in #Chicago, where we present #CancerResearch in Germany. 👩🏽🔬👨🏽🔬 🇩🇪
📍Exhibition at booth #842 from April 27 to 30
@nct-heidelberg.bsky.social @DKTK @theaacr.bsky.social
📍Exhibition at booth #842 from April 27 to 30
@nct-heidelberg.bsky.social @DKTK @theaacr.bsky.social
Movement for prevention, nature for inspiration 🌿🌍
Today's @dkfz.bsky.social Lunch Walk took us to the Botanical Garden—a perfect match for #EarthWeek and our goal to promote #CancerPrevention through regular activity. Thanks to all who joined!
#DKFZgeht #HealthyWorkplace #Heidelberg
Today's @dkfz.bsky.social Lunch Walk took us to the Botanical Garden—a perfect match for #EarthWeek and our goal to promote #CancerPrevention through regular activity. Thanks to all who joined!
#DKFZgeht #HealthyWorkplace #Heidelberg
April 25, 2025 at 11:22 AM
Movement for prevention, nature for inspiration 🌿🌍
Today's @dkfz.bsky.social Lunch Walk took us to the Botanical Garden—a perfect match for #EarthWeek and our goal to promote #CancerPrevention through regular activity. Thanks to all who joined!
#DKFZgeht #HealthyWorkplace #Heidelberg
Today's @dkfz.bsky.social Lunch Walk took us to the Botanical Garden—a perfect match for #EarthWeek and our goal to promote #CancerPrevention through regular activity. Thanks to all who joined!
#DKFZgeht #HealthyWorkplace #Heidelberg