Wai-Hong Tham
@thamlab.bsky.social
🇲🇾 scientist in 🇦🇺 | 🦟 🩸 #malaria |🦙 #nanobodies | Prof @WEHI_research @ourANU | on Wurundjeri, Ngunnawal & Ngambri lands | views my own 🏃🏻♀️ 🍜
Reposted by Wai-Hong Tham
I'm hiring!
If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply!
WEHI is a great place to work with access to state-of-the art cryo-EM facilities.
Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...
If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply!
WEHI is a great place to work with access to state-of-the art cryo-EM facilities.
Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...
Research Officer
Job Title Research Officer Job Description An excellent opportunity is available for a Research Officer/Senior Research Officer to join the Callegari Lab in the Ubiquitin Signalling Division at Austra...
wehi.wd3.myworkdayjobs.com
February 11, 2026 at 10:56 AM
I'm hiring!
If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply!
WEHI is a great place to work with access to state-of-the art cryo-EM facilities.
Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...
If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply!
WEHI is a great place to work with access to state-of-the art cryo-EM facilities.
Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...
Reposted by Wai-Hong Tham
It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details.
Don't miss out, register now! www.lorneinfectionimmunity.org/registration
#lorneiandi
Don't miss out, register now! www.lorneinfectionimmunity.org/registration
#lorneiandi
February 9, 2026 at 6:01 AM
It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details.
Don't miss out, register now! www.lorneinfectionimmunity.org/registration
#lorneiandi
Don't miss out, register now! www.lorneinfectionimmunity.org/registration
#lorneiandi
Reposted by Wai-Hong Tham
Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪
February 6, 2026 at 4:54 PM
Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪
Reposted by Wai-Hong Tham
Really happy to see this work out!
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology
Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...
doi.org
February 5, 2026 at 7:12 PM
Really happy to see this work out!
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
Reposted by Wai-Hong Tham
Been on multiple search committees
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
You can read more about that experience here: www.nature.com/articles/s41...
Preprints as tools to advance careers - Nature Reviews Cancer
The practice of posting preprint manuscripts on servers such as bioRxiv has become increasingly common. In this Comment, Hindle and Sever explore the utility of preprints for advancing researchers…
www.nature.com
February 5, 2026 at 8:05 PM
Been on multiple search committees
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
Reposted by Wai-Hong Tham
Have I ever mentioned how surreal it is to be an Editor-in-Chief of a journal called Vaccine right now?
www.science.org/content/arti...
It’s pretty wild, at least by typical academic journal editorial office standards.
www.science.org/content/arti...
It’s pretty wild, at least by typical academic journal editorial office standards.
Controversial Danish vaccine research group faces new allegations
Researchers say they couldn’t find complete data for 10 trials that together enrolled tens of thousands of children in Guinea-Bissau
www.science.org
February 6, 2026 at 6:14 AM
Have I ever mentioned how surreal it is to be an Editor-in-Chief of a journal called Vaccine right now?
www.science.org/content/arti...
It’s pretty wild, at least by typical academic journal editorial office standards.
www.science.org/content/arti...
It’s pretty wild, at least by typical academic journal editorial office standards.
Alpseq - open source software to process and analyse NGS data for nanobody discovery 🦙 🧬
Led by Kathleen Zeglinski and @qgouil.bsky.social to provide a great solution to processing & analysing millions of nanobody reads from phage display campaigns to make the most of your sequence information!
Led by Kathleen Zeglinski and @qgouil.bsky.social to provide a great solution to processing & analysing millions of nanobody reads from phage display campaigns to make the most of your sequence information!
Alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing
Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability and remarkable binding specificity. Next-Generation Sequencing (NGS) enable...
www.tandfonline.com
February 6, 2026 at 2:46 AM
Alpseq - open source software to process and analyse NGS data for nanobody discovery 🦙 🧬
Led by Kathleen Zeglinski and @qgouil.bsky.social to provide a great solution to processing & analysing millions of nanobody reads from phage display campaigns to make the most of your sequence information!
Led by Kathleen Zeglinski and @qgouil.bsky.social to provide a great solution to processing & analysing millions of nanobody reads from phage display campaigns to make the most of your sequence information!
Reposted by Wai-Hong Tham
The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Mass Spectrometry Platform Manager
Institute for Molecular Bioscience Full-time (100%), permanent position Base salary will be in the range $117,958.12 - $132,247.57+ 17% Superannuation (HEW Level 8) Based at our St Lucia Campus About ...
uq.wd3.myworkdayjobs.com
February 5, 2026 at 12:20 AM
The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Reposted by Wai-Hong Tham
Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
February 2, 2026 at 10:30 PM
Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...
portlandpress.com
February 2, 2026 at 10:51 PM
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...
journals.plos.org
February 2, 2026 at 8:36 AM
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Reposted by Wai-Hong Tham
Thrilled to share our latest work @luptoncj.bsky.social @drellisdon.bsky.social @drmlhalls.bsky.social.
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.
🧪🔬#cryoEM
Now online @cellpress.bsky.social.
doi.org/10.1016/j.ce...
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.
🧪🔬#cryoEM
Now online @cellpress.bsky.social.
doi.org/10.1016/j.ce...
January 8, 2026 at 7:39 PM
Thrilled to share our latest work @luptoncj.bsky.social @drellisdon.bsky.social @drmlhalls.bsky.social.
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.
🧪🔬#cryoEM
Now online @cellpress.bsky.social.
doi.org/10.1016/j.ce...
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.
🧪🔬#cryoEM
Now online @cellpress.bsky.social.
doi.org/10.1016/j.ce...
Reposted by Wai-Hong Tham
Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪
1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?
authors.elsevier.com/sd/article/S...
1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?
authors.elsevier.com/sd/article/S...
January 6, 2026 at 11:07 AM
Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪
1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?
authors.elsevier.com/sd/article/S...
1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?
authors.elsevier.com/sd/article/S...
🎉Graduation Day! Congratulations to Dr Jaison D Sa @jaisondsa.bsky.social who was awarded his PhD from University of Melbourne
Wonderful to celebrate with his family, the lab and his co-supervisor Phillip Pymm 💕🎓 @wehi-research.bsky.social
Wonderful to celebrate with his family, the lab and his co-supervisor Phillip Pymm 💕🎓 @wehi-research.bsky.social
December 18, 2025 at 9:03 AM
🎉Graduation Day! Congratulations to Dr Jaison D Sa @jaisondsa.bsky.social who was awarded his PhD from University of Melbourne
Wonderful to celebrate with his family, the lab and his co-supervisor Phillip Pymm 💕🎓 @wehi-research.bsky.social
Wonderful to celebrate with his family, the lab and his co-supervisor Phillip Pymm 💕🎓 @wehi-research.bsky.social
Reposted by Wai-Hong Tham
ARC says they’ll announce Centres of Excellence outcomes tomorrow (Tuesday 9th Dec).
This is more than 2 months late, most likely due to the new security checking requirements for ARC grants. Centres of Excellence grants also need to have been approved by the Minister.
This is more than 2 months late, most likely due to the new security checking requirements for ARC grants. Centres of Excellence grants also need to have been approved by the Minister.
December 8, 2025 at 2:05 AM
ARC says they’ll announce Centres of Excellence outcomes tomorrow (Tuesday 9th Dec).
This is more than 2 months late, most likely due to the new security checking requirements for ARC grants. Centres of Excellence grants also need to have been approved by the Minister.
This is more than 2 months late, most likely due to the new security checking requirements for ARC grants. Centres of Excellence grants also need to have been approved by the Minister.
Reposted by Wai-Hong Tham
MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks.
More info: t1p.de/nag2v
@bosse-lab.bsky.social
More info: t1p.de/nag2v
@bosse-lab.bsky.social
December 3, 2025 at 11:17 AM
MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks.
More info: t1p.de/nag2v
@bosse-lab.bsky.social
More info: t1p.de/nag2v
@bosse-lab.bsky.social
HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...
www.biorxiv.org
December 3, 2025 at 11:27 AM
HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Reposted by Wai-Hong Tham
#ARCschedule Dec25
Outcomes expected … at some point, for Centres of Excellence – now 5 weeks late!
Other events:
🔹Close: Discovery Projects Expressions of Interest
🔹Take a damn break; you’ve more than earned it!
Data ▶️ docs.google.com/spreadsheets...
Outcomes expected … at some point, for Centres of Excellence – now 5 weeks late!
Other events:
🔹Close: Discovery Projects Expressions of Interest
🔹Take a damn break; you’ve more than earned it!
Data ▶️ docs.google.com/spreadsheets...
December 2, 2025 at 10:33 PM
#ARCschedule Dec25
Outcomes expected … at some point, for Centres of Excellence – now 5 weeks late!
Other events:
🔹Close: Discovery Projects Expressions of Interest
🔹Take a damn break; you’ve more than earned it!
Data ▶️ docs.google.com/spreadsheets...
Outcomes expected … at some point, for Centres of Excellence – now 5 weeks late!
Other events:
🔹Close: Discovery Projects Expressions of Interest
🔹Take a damn break; you’ve more than earned it!
Data ▶️ docs.google.com/spreadsheets...
Reposted by Wai-Hong Tham
"We estimate that a 1% increase in annual mining area was associated with a 24% increase in monthly malaria cases in the Yanomami. Also ... an estimated excess of 102,870 malaria cases occurred from 2018 to 2023 due to increased mining activity"
journals.plos.org/plosntds/art...
journals.plos.org/plosntds/art...
Mining and malaria in the Brazilian Amazon and in the Yanomami indigenous land
Author summary The expansion of illegal mining in the Brazilian Amazon, and particularly in indigenous lands, has produced severely negative environmental and health externalities. One major health co...
journals.plos.org
November 29, 2025 at 9:16 PM
"We estimate that a 1% increase in annual mining area was associated with a 24% increase in monthly malaria cases in the Yanomami. Also ... an estimated excess of 102,870 malaria cases occurred from 2018 to 2023 due to increased mining activity"
journals.plos.org/plosntds/art...
journals.plos.org/plosntds/art...
Reposted by Wai-Hong Tham
Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes.
Apply now: v22.desy.de/e67416/recor...
Apply now: v22.desy.de/e67416/recor...
November 28, 2025 at 2:12 PM
Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes.
Apply now: v22.desy.de/e67416/recor...
Apply now: v22.desy.de/e67416/recor...
Fun presenting our malaria work at Stromlo Plant Pathology - thanks @plantpathpete.bsky.social for the invite!
Megan Outram & Grace Jones gave lovely talks on our new work on chytrid fungus @biologyanu.bsky.social 🐸
Lovely to catch up with Barbara Howlett & learning about fungi 🍄🟫
#strompath25
Megan Outram & Grace Jones gave lovely talks on our new work on chytrid fungus @biologyanu.bsky.social 🐸
Lovely to catch up with Barbara Howlett & learning about fungi 🍄🟫
#strompath25
November 27, 2025 at 9:33 PM
Fun presenting our malaria work at Stromlo Plant Pathology - thanks @plantpathpete.bsky.social for the invite!
Megan Outram & Grace Jones gave lovely talks on our new work on chytrid fungus @biologyanu.bsky.social 🐸
Lovely to catch up with Barbara Howlett & learning about fungi 🍄🟫
#strompath25
Megan Outram & Grace Jones gave lovely talks on our new work on chytrid fungus @biologyanu.bsky.social 🐸
Lovely to catch up with Barbara Howlett & learning about fungi 🍄🟫
#strompath25
Reposted by Wai-Hong Tham
Hello UK, West Nile Virus carrying mosquito Culex modestus is coming to a ditch near you! link.springer.com/article/10.1...
Evidence of much wider distribution of the potential West Nile virus vector, Culex modestus, in the UK - Parasites & Vectors
Culex modestus is a primary vector of West Nile virus (WNV) in Europe, feeding on both avian and mammalian hosts. Since its rediscovery in the UK in Kent in 2010, its range has been reported throughou...
link.springer.com
November 25, 2025 at 1:10 PM
Hello UK, West Nile Virus carrying mosquito Culex modestus is coming to a ditch near you! link.springer.com/article/10.1...
Reposted by Wai-Hong Tham
What a day at the Académie des Sciences! 🎉 Honored to receive the Allianz Prize / Institut de France. Huge shoutout to my dream team — none of this happens without you. 🙏🏽💥
@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr
@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr
November 25, 2025 at 6:12 PM
What a day at the Académie des Sciences! 🎉 Honored to receive the Allianz Prize / Institut de France. Huge shoutout to my dream team — none of this happens without you. 🙏🏽💥
@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr
@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr
Reposted by Wai-Hong Tham
Last week we had the CCeMMP Symposium 2025. Fantastic event with an outstanding line-up of speakers. There were 2 poster prizes and 1 oral presentation prize; thrilled that we did a clean sweep! Huge congratulations @tiltedscientist.bsky.social @somavallyd.bsky.social and @lucatroman.bsky.social
November 17, 2025 at 2:17 PM
Last week we had the CCeMMP Symposium 2025. Fantastic event with an outstanding line-up of speakers. There were 2 poster prizes and 1 oral presentation prize; thrilled that we did a clean sweep! Huge congratulations @tiltedscientist.bsky.social @somavallyd.bsky.social and @lucatroman.bsky.social
Reposted by Wai-Hong Tham
Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
November 18, 2025 at 1:26 AM
Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...