Brett Collins
@brettcollins.bsky.social
Structural biologist studying proteins that move things from A to B. University of Queensland, Institute for Molecular Bioscience. Centre for Cell Biology of Chronic Disease.
He/Him.
https://imb.uq.edu.au/research-groups/collins
He/Him.
https://imb.uq.edu.au/research-groups/collins
Reposted by Brett Collins
#MD blind predictions of water/ions around Tetrahymena ribozyme #RNA matched cryo-EM data better than our baselines! Congrats #CASP16 + @rachael-kretsch.bsky.social + 23 brave groups. Still a ways to go — time for #DeepLearning of water? Community paper: doi.org/10.1002/prot...
November 11, 2025 at 12:53 AM
#MD blind predictions of water/ions around Tetrahymena ribozyme #RNA matched cryo-EM data better than our baselines! Congrats #CASP16 + @rachael-kretsch.bsky.social + 23 brave groups. Still a ways to go — time for #DeepLearning of water? Community paper: doi.org/10.1002/prot...
Reposted by Brett Collins
We have strength across a wide range of neuroscience topics, including ageing and development, brain injury and repair, cognition and behavior, mental health, RNA science, etc.
To clarify, the QBI Director need not be focused on Dementia, this just happens to be one of the sites where the recruiter has posted….
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
November 11, 2025 at 1:39 AM
We have strength across a wide range of neuroscience topics, including ageing and development, brain injury and repair, cognition and behavior, mental health, RNA science, etc.
Reposted by Brett Collins
To clarify, the QBI Director need not be focused on Dementia, this just happens to be one of the sites where the recruiter has posted….
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute - DEMENTIA RESEARCHER
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.
www.dementiaresearcher.nihr.ac.uk
November 11, 2025 at 1:36 AM
To clarify, the QBI Director need not be focused on Dementia, this just happens to be one of the sites where the recruiter has posted….
Reposted by Brett Collins
Special Issue: Macromolecular Assemblies is now live! Explore advances in cryoEM, cryoET, FIB milling, NMR, & AI for structure prediction. Discover cutting-edge insights into the structure & function of biological complexes. #StructuralBiology #CryoEM
spkl.io/63324AwAho
spkl.io/63324AwAho
November 10, 2025 at 1:00 PM
Special Issue: Macromolecular Assemblies is now live! Explore advances in cryoEM, cryoET, FIB milling, NMR, & AI for structure prediction. Discover cutting-edge insights into the structure & function of biological complexes. #StructuralBiology #CryoEM
spkl.io/63324AwAho
spkl.io/63324AwAho
Reposted by Brett Collins
I find this remarkable:
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
November 11, 2025 at 12:49 AM
I find this remarkable:
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
The Dresden Codex, one of the few surviving Mayan manuscripts, contains tables that give highly accurate timings of solar eclipses over more than 700 years, from 350 CE to the 12 century. 🧪🔭
www.science.org/doi/10.1126/...
Reposted by Brett Collins
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration. Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/director...
www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute - DEMENTIA RESEARCHER
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.
www.dementiaresearcher.nihr.ac.uk
November 10, 2025 at 9:05 PM
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration. Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/director...
www.dementiaresearcher.nihr.ac.uk/job/director...
Reposted by Brett Collins
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...
doi.org
November 10, 2025 at 7:06 AM
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Reposted by Brett Collins
Check out our new paper:
🔗 www.cell.com/structure/fu...
We explored how sulfate-reducing bacteria import isethionate, a sulfur-containing molecule found in the environment and produced by microbes in the human gut. We captured a structure of the IseQM TRAP transporter in a substrate-bound state.
🔗 www.cell.com/structure/fu...
We explored how sulfate-reducing bacteria import isethionate, a sulfur-containing molecule found in the environment and produced by microbes in the human gut. We captured a structure of the IseQM TRAP transporter in a substrate-bound state.
Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium
Newton-Vesty et al. used a megabody fiducial to determine the cryo-EM structure of
an isethionate TRAP transporter, revealing the substrate and Na+-binding sites. Transport
is dependent on Na+ and the...
www.cell.com
November 9, 2025 at 8:45 PM
Check out our new paper:
🔗 www.cell.com/structure/fu...
We explored how sulfate-reducing bacteria import isethionate, a sulfur-containing molecule found in the environment and produced by microbes in the human gut. We captured a structure of the IseQM TRAP transporter in a substrate-bound state.
🔗 www.cell.com/structure/fu...
We explored how sulfate-reducing bacteria import isethionate, a sulfur-containing molecule found in the environment and produced by microbes in the human gut. We captured a structure of the IseQM TRAP transporter in a substrate-bound state.
Reposted by Brett Collins
At the time the cultures were so complex it was impossible to tell precisely which organism had the vesicles. The cultures contain many different types of archaea- a real treasure trove, and lots of bacteria with lots of ‘weirdness’.
November 8, 2025 at 12:58 AM
At the time the cultures were so complex it was impossible to tell precisely which organism had the vesicles. The cultures contain many different types of archaea- a real treasure trove, and lots of bacteria with lots of ‘weirdness’.
Reposted by Brett Collins
Yes they are! Might have been an oversight, but these cultures were established at UNSW in 2019 in @brendanburns999.bsky.social ‘s lab and funded by Australian research grants. The first tomograms that revealed the exciting internal structures were carried out by @debnathghosal.bsky.social
November 8, 2025 at 12:20 AM
Yes they are! Might have been an oversight, but these cultures were established at UNSW in 2019 in @brendanburns999.bsky.social ‘s lab and funded by Australian research grants. The first tomograms that revealed the exciting internal structures were carried out by @debnathghosal.bsky.social
Reposted by Brett Collins
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Brett Collins
Beautiful and important work. Congrats @tbharat-lab.bsky.social @buzzbaum.bsky.social and colleagues!
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 11:35 AM
Beautiful and important work. Congrats @tbharat-lab.bsky.social @buzzbaum.bsky.social and colleagues!
These are true blue Aussie archaea!
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:49 AM
These are true blue Aussie archaea!
Reposted by Brett Collins
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Brett Collins
Flying Squirrel Loves It Every Time
November 5, 2025 at 11:00 PM
Flying Squirrel Loves It Every Time
Last week to get your Protein onto the Lorne Conference T-shirt!
🕐 One Week Left to Enter the T-Shirt Competition!
Time’s running out to design the next official Lorne Proteins T-shirt 👕
📅 Entries close 10 November 2025
👉 Submit your design: docs.google.com/forms/d/1nPy...
Time’s running out to design the next official Lorne Proteins T-shirt 👕
📅 Entries close 10 November 2025
👉 Submit your design: docs.google.com/forms/d/1nPy...
November 5, 2025 at 9:42 PM
Last week to get your Protein onto the Lorne Conference T-shirt!
Reposted by Brett Collins
Workflow Using a Cryogenic Coincident Fluorescence, Electron, and Ion Beam Microscope for Targeted Milling of Cells pubmed.ncbi.nlm.nih.gov/41182991/ #cryoem
November 5, 2025 at 12:54 AM
Workflow Using a Cryogenic Coincident Fluorescence, Electron, and Ion Beam Microscope for Targeted Milling of Cells pubmed.ncbi.nlm.nih.gov/41182991/ #cryoem
Reposted by Brett Collins
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Brett Collins
#CentresOfExcellence #CE26
ARC has "postponed" announcement of Centres of Excellence outcomes!
It says "due diligence checks" are still being carried out on some applications.
www.arc.gov.au/news-publica...
ARC has "postponed" announcement of Centres of Excellence outcomes!
It says "due diligence checks" are still being carried out on some applications.
www.arc.gov.au/news-publica...
November 3, 2025 at 6:32 AM
#CentresOfExcellence #CE26
ARC has "postponed" announcement of Centres of Excellence outcomes!
It says "due diligence checks" are still being carried out on some applications.
www.arc.gov.au/news-publica...
ARC has "postponed" announcement of Centres of Excellence outcomes!
It says "due diligence checks" are still being carried out on some applications.
www.arc.gov.au/news-publica...
Reposted by Brett Collins
AAAAAAAAAAAAAAAAAHHHHHHHH
November 3, 2025 at 2:40 AM
AAAAAAAAAAAAAAAAAHHHHHHHH
Reposted by Brett Collins
Hey Siri, show me the Frenchiest news story
November 2, 2025 at 9:22 AM
Hey Siri, show me the Frenchiest news story
Reposted by Brett Collins
I promised myself that when I next had a successful grant, I'd share a snapshot of my trail of unfunded submissions.
With gratitude to the ARC, looking forward to next several years of collaboration on effort motivation with @minzlicht.bsky.social, Deena Skolnick Weisberg, and Frederik Anseel!
With gratitude to the ARC, looking forward to next several years of collaboration on effort motivation with @minzlicht.bsky.social, Deena Skolnick Weisberg, and Frederik Anseel!
November 2, 2025 at 2:20 AM
I promised myself that when I next had a successful grant, I'd share a snapshot of my trail of unfunded submissions.
With gratitude to the ARC, looking forward to next several years of collaboration on effort motivation with @minzlicht.bsky.social, Deena Skolnick Weisberg, and Frederik Anseel!
With gratitude to the ARC, looking forward to next several years of collaboration on effort motivation with @minzlicht.bsky.social, Deena Skolnick Weisberg, and Frederik Anseel!
Reposted by Brett Collins
An extraordinary result for ipilimumab immunotherapy given as a first line therapy for glioblastoma
share.google/485XFZxmBm26...
share.google/485XFZxmBm26...
Dad’s aggressive brain cancer vanishes after taking new drug
The NHS is now looking for patients with glioblastoma to take part in a new drug trial
share.google
November 1, 2025 at 9:18 AM
An extraordinary result for ipilimumab immunotherapy given as a first line therapy for glioblastoma
share.google/485XFZxmBm26...
share.google/485XFZxmBm26...
Reposted by Brett Collins
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.