Nichollas E. Scott

Nature Chemical Biology @natchembio.nature.com · 14h

Monoclonal antibodies against pseudaminic acid (Pse) – present in bacterial LPS, capsular polysaccharides, and glycoproteins – have been developed that enable Pse glycoproteome profiling and show therapeutic potential #glycotime

www.nature.com/articles/s41...

Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

www.nature.com

Nichollas Scott @nickescott.bsky.social · 1d

Really happy to see this work out!

Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).

Ethan Goddard-Borger @ethangbaus.bsky.social · 2d

🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...

This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.

1/6

Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

doi.org

Ben Parker Lab @benparkerlab.bsky.social · 1d

Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. www.nature.com/articles/s41...

Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator - Nature Communications

Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insul...

www.nature.com

Ethan Goddard-Borger @ethangbaus.bsky.social · 2d

🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...

This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.

1/6

Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

doi.org

Ben Parker Lab @benparkerlab.bsky.social · Jan 6

Protein:protein interactions are incredibly dynamic so how do we quantify and discover changes in native tissues? Our new study uses qXL-MS and PCP-MS to study dynamic remodeling of interactions following skeletal muscle insulin resistance. #MyoBlue #Proteomics www.biorxiv.org/content/10.6...

Quantitative interactome mapping of skeletal muscle insulin resistance

Protein-protein interactions (PPIs) are dynamic and critical to adaptive homeostasis. While there have been massive efforts to catalogue proteome-wide PPIs, global quantification of changes remains a ...

www.biorxiv.org

Cellular Bioenergetics Laboratory @cellbioenerglab.bsky.social · Dec 18

🎉 We are pleased to announce @sarahehancock.bsky.social's latest publication in Analytical Chemistry: "Epoxidation-Enhanced Charge-Switch Derivatization for Rapid Profiling of Monounsaturated Fatty Acid Isomers"

Read the paper here 👉 pubs.acs.org/doi/full/10....

Epoxidation-Enhanced Charge-Switch Derivatization for Rapid Profiling of Monounsaturated Fatty Acid Isomers

Structural isomerism in monounsaturated fatty acids (MUFAs) presents a persistent challenge in lipidomics due to limited chromatographic resolution and indistinguishable mass spectral profiles. Moreov...

pubs.acs.org

Nichollas Scott @nickescott.bsky.social · Dec 8

Welcome to the club, what instrument are you generating the data on (QE?) can provide guidance, drop me an email.... Looking at the raw data, upping your AGC and using stepped nce is going to be your friend here

homer simpson and bart simpson are sitting on a couch

ALT: homer simpson and bart simpson are sitting on a couch

media.tenor.com

Nik Fortelny @nikfortelny.bsky.social · Sep 19

Postdoc position open!
Digital Pathology: Therapy-response prediction using spatial biology
University of Salzburg
Deadline: October 26th, 2025

We look forward to hearing from you!

www.plus.ac.at/biowissensch...

Alexey Nesvizhskii @nesvilab.bsky.social · Aug 1

Conventional proteomics searches struggle with many modifications and fully open searches may be difficult to interpret. We introduce a "detailed" mass offset search in #MSFragger boosting interpretability and localization especially in complex cases (e.g. FPOP data): www.biorxiv.org/content/10.1...

Mike Goodwin @massspecpro.bsky.social · Jun 12

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...

Alan Marshall: A scientist and a Gentleman - MagLab

Meet one of the greatest innovators in the history of mass spectrometry, hard at work.

nationalmaglab.org

Nichollas Scott @nickescott.bsky.social · May 23

Really nice to see this work finally out in print. This has been a long term project (> 3 years) in the lab to understand why we couldn't make a few mutants in the burkholderia o-linked glycan biosynthesis pathway. Special shout out to Leila who drove most of this work! www.jbc.org/article/S002...

The late-stage steps of Burkholderia cenocepacia protein O-linked glycan biosynthesis are conditionally essential

Periplasmic O-linked protein glycosylation is a highly conserved process observed across the Burkholderia genus. Within Burkholderia, protein glycosylation requires the five-gene cluster known as the ...

www.jbc.org

Nichollas Scott @nickescott.bsky.social · Mar 25

Wait is that supposed to be a cid spectra (no charge reduction so doesn't look like a ExD)... I'm seeing z ions annotated...

Australian & New Zealand Society for Mass Spectrometry @anzsms.bsky.social · Mar 10

📣 Calling all students! 📣

Did you know that ANZSMS have travel support for attending ANZSMS conferences and international mass spectrometry conferences? 😮

The deadline for students attending the 30th ANZSMS at AUS-oMicS this year is coming up next week, 18th March! 🚨

Nichollas Scott @nickescott.bsky.social · Mar 8

Congratulations!! Very well deserved!

Australian & New Zealand Society for Mass Spectrometry @anzsms.bsky.social · Feb 24

🎉Announcing our ANZSMS 2025 Medalists 🎉

Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong!

Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆

Read about our medalists here 👉 mailchi.mp/6c90f3d41712...

ANSMS 2025 Medal Recipients.
Morrison Medal, Prof Nicki Packer from Macquarie University.
Bowie Medal, A/Prof Shane Ellis from University of Wollongong.

Michael Steidel @michaelsteidel.bsky.social · Feb 14

Popularity of current DIA data analysis tools (vendor-independent, based on citations of initial publication) Updated for 2024:

Nick Riley @nmriley.bsky.social · Feb 10

Regardless of current events, highlighting trainees as they continue to excel is a joy.

We just added @emmajays.bsky.social's recent J_@asms.org publication about chemical deamidation from common proteomics buffer to our website, too.

Congrats Emmajay! #TeamMassSpec

pubs.acs.org/doi/full/10....

Females in Mass Spectrometry (FeMS+) @femalesinms.bsky.social · Feb 10

Applications are open for the #FeMS+ 2025 Q2 Empowerment Awards! Thanks @brukercorporation.bsky.social for sponsoring!
Apply here: airtable.com/appyGufCIumj...
#TeamMAssSpec #WomenEmpowerment

Nichollas Scott @nickescott.bsky.social · Jan 31

Really cool stuff, this looks super specific to cys. Looking at the ms2 data do labelled peptides show any unique diagnostic ions?

Nichollas Scott @nickescott.bsky.social · Jan 27

Ha! Not my only bright jersey on this trip

Nichollas Scott @nickescott.bsky.social · Jan 27

For those interested in the distance cycled, not bad considering there was two days of travel in there

Nichollas Scott @nickescott.bsky.social · Jan 26

I rarely post personal things on here but it's my birthday and as it's the big 4-0 I've spent the week cycling in south east Asia which has been awesome.. 100% recommend cycling around Siem Reap in Cambodia

Matthew Macauley @siglecdude.bsky.social · Jan 22

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...

Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs

Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...

pubs.acs.org

ANZ Metabolomics Society @anzmetabolomics.bsky.social · Jan 21

⏰ Time’s ticking! Only 2 weeks left to submit your oral presentation abstract for #AUSoMicS 2025!

🗓️ Deadline: Jan 31st, 2025

Submit your abstract here: ausomics.com/abstracts

#metabolomics #proteomics #glycomics #massspectrometry #multiomics
@anzsms.bsky.social @ozglyco.bsky.social

bioRxivpreprint @biorxivpreprint.bsky.social · Jan 14

Polysialylation is a general feature of immune activation https://www.biorxiv.org/content/10.1101/2025.01.10.632476v1

Nichollas Scott @nickescott.bsky.social · Jan 5

not alot of tree cover in those photos but looks beautiful!

Iain Wilson @iainwilsonwien.bsky.social · Dec 26

I’m looking for a postdoc with experience in #glycosyltransferases and/or yeast/insect #proteinexpression
A new EU pathfinder project begins on 1st February 2025.
Contact me if interested!

Nichollas Scott @nickescott.bsky.social · Dec 22

Oh man this hits way too close to me🤣

Trent Peters-Clarke @trentpetersclarke.bsky.social · Dec 22

Coworker: “Wow looks like you’re queuing up a lot of LC-MS runs over the holiday break.”

Me:

Matthew McConaughey meme from his famous chest thumping scene in The Wolf of Wall Street where he says, “I’m not doing it because I want to. I’m doing it because I NEED to!”

Trent Peters-Clarke @trentpetersclarke.bsky.social · Dec 22

Coworker: “Wow looks like you’re queuing up a lot of LC-MS runs over the holiday break.”

Me:

Joshua Newson @joshnewson.bsky.social · Dec 15

Excited to share this story describing new tools for studying Salmonella virulence. We engineered six multimutant strains to be deficient for different sets of SPI-2 T3SS effectors. We think there's lots of potential for new discoveries using these strains www.biorxiv.org/content/10.1...

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulatio...

www.biorxiv.org

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