Joshua Newson
@joshnewson.bsky.social
Senior postdoctoral research scientist at ETH Zürich. Microbiology, bacterial pathogenesis, host-pathogen interactions, antibiotic persistence, pathogen transmission. Aussie 🇦🇺 expat in Switzerland 🇨🇭. Formerly University of Melbourne.
Excited to share our latest work, where we create Salmonella mutants deficient for cohorts of SPI-2 T3SS effectors. These strains can be used to efficiently identify particular effectors that contribute to SPI-2 phenotypes doi.org/10.1038/s414...
Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization - Nature Communications
Intracellular Salmonella enterica uses a type III secretion system to secrete more than 30 effector proteins into host cells. Here, Newson et al. generate six mutant strains deficient in different set...
doi.org
November 10, 2025 at 8:02 AM
Excited to share our latest work, where we create Salmonella mutants deficient for cohorts of SPI-2 T3SS effectors. These strains can be used to efficiently identify particular effectors that contribute to SPI-2 phenotypes doi.org/10.1038/s414...
Reposted by Joshua Newson
Many of you in #AcademicBsky in the northern hemisphere might not know the dire state of Australian academia. This essay by Andrew Dean is a fair snapshot of the state of the sector.
Thinking today especially of academics in some Aus unis facing mass job cuts ~ 3,000 jobs on the chopping block now.
Thinking today especially of academics in some Aus unis facing mass job cuts ~ 3,000 jobs on the chopping block now.
Dropping out, burning out, tuning out • Andrew Dean
Nobody’s happy about the state of Australian universities, but a seasoned academic has some remedies
insidestory.org.au
August 13, 2025 at 9:55 PM
Many of you in #AcademicBsky in the northern hemisphere might not know the dire state of Australian academia. This essay by Andrew Dean is a fair snapshot of the state of the sector.
Thinking today especially of academics in some Aus unis facing mass job cuts ~ 3,000 jobs on the chopping block now.
Thinking today especially of academics in some Aus unis facing mass job cuts ~ 3,000 jobs on the chopping block now.
Great week of science in New Hampshire at the Salmonella GRS/GRC. Thanks to the chairs for their hard work. Really nice to see a strong Aussie cohort here too. Looking forward to 2027!
August 8, 2025 at 1:25 PM
Great week of science in New Hampshire at the Salmonella GRS/GRC. Thanks to the chairs for their hard work. Really nice to see a strong Aussie cohort here too. Looking forward to 2027!
Excited to be traveling to New Hampshire USA for the GRC Salmonella meeting, looking forward to some great discussion. But, since I'm traveling on Swiss National Day, first a quick farewell Raclette 🇨🇭 🧀 🥂
August 1, 2025 at 2:07 PM
Excited to be traveling to New Hampshire USA for the GRC Salmonella meeting, looking forward to some great discussion. But, since I'm traveling on Swiss National Day, first a quick farewell Raclette 🇨🇭 🧀 🥂
Reposted by Joshua Newson
Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission
Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission
Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse requires intracellular virulence factors and produces clonal populations. Microbiota transfer between hosts blocks pathogen relapse-associated blooms, revealing how the host-pathogen-microbiota axis shapes transmission.
dlvr.it
July 17, 2025 at 11:23 PM
Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission
We're happy to share this example of how antibiotic treatment can promote clonal transmission of an invasive gut pathogen. We also explore the importance of preserving microbiota during treatment. Thanks to everyone who contributed to this paper! #MicroSky #IDSky
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission
Newson et al. show that antibiotics not only reduce Salmonella infection but also
disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister
reservoirs. Relapse require...
www.cell.com
July 14, 2025 at 9:28 AM
We're happy to share this example of how antibiotic treatment can promote clonal transmission of an invasive gut pathogen. We also explore the importance of preserving microbiota during treatment. Thanks to everyone who contributed to this paper! #MicroSky #IDSky
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Really nice to be back in Australia for a couple of weeks, going through Brisbane, Melbourne, and Adelaide. Nice to trade snow for sunshine and catch up with friends, family, and colleagues around the country 🇦🇺 🍻 🌞
December 31, 2024 at 11:30 AM
Really nice to be back in Australia for a couple of weeks, going through Brisbane, Melbourne, and Adelaide. Nice to trade snow for sunshine and catch up with friends, family, and colleagues around the country 🇦🇺 🍻 🌞
Excited to share this story describing new tools for studying Salmonella virulence. We engineered six multimutant strains to be deficient for different sets of SPI-2 T3SS effectors. We think there's lots of potential for new discoveries using these strains www.biorxiv.org/content/10.1...
Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization
Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulatio...
www.biorxiv.org
December 15, 2024 at 3:48 PM
Excited to share this story describing new tools for studying Salmonella virulence. We engineered six multimutant strains to be deficient for different sets of SPI-2 T3SS effectors. We think there's lots of potential for new discoveries using these strains www.biorxiv.org/content/10.1...
Coming to the end of a big week in Liverpool, great to share some of our work on pathogen transmission and antibiotic persistence. Thanks @jayhinton.bsky.social for hosting me at @liverpooluni.bsky.social and thanks to the Microbiology Society for the support to present at #FISHIS24
November 22, 2024 at 12:24 PM
Coming to the end of a big week in Liverpool, great to share some of our work on pathogen transmission and antibiotic persistence. Thanks @jayhinton.bsky.social for hosting me at @liverpooluni.bsky.social and thanks to the Microbiology Society for the support to present at #FISHIS24