Nature Chemical Biology
@natchembio.nature.com
A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
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Our January issue is live!
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system
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January 8, 2026 at 9:01 PM
Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system
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Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime
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January 8, 2026 at 8:58 PM
Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime
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A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms
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January 8, 2026 at 8:55 PM
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms
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A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement
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January 8, 2026 at 8:51 PM
A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement
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The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function
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January 8, 2026 at 8:49 PM
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function
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Our January issue is live!
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
January 8, 2026 at 4:38 PM
Our January issue is live!
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
Reposted by Nature Chemical Biology
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
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More info 👇
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More info 👇
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
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January 7, 2026 at 2:59 PM
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
A new paper developed a deep-learning-based de novo design strategy that enables simultaneous scaffolding of three distinct epitopes and demonstrates the potential of generative models for complex multisite protein engineering
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Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning - Nature Chemical Biology
A deep-learning-based de novo design strategy was developed that enables simultaneous scaffolding of three distinct epitopes derived from respiratory syncytial virus within small single-domain immunog...
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December 12, 2025 at 9:47 PM
A new paper developed a deep-learning-based de novo design strategy that enables simultaneous scaffolding of three distinct epitopes and demonstrates the potential of generative models for complex multisite protein engineering
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Come join our team! The deadline is December 7, but the application is quick. Only a cover letter, CV, and a short Research Highlight are needed #chemsky #chemjob #chembio
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Chemical Biology
Job Title: Associate or Senior Editor, Nature Chemical Biology Organization: Nature Portfolio Location: New York, Washington DC, Jersey City, Beijing or Shanghai – Hybrid working Model Closing date: D...
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December 3, 2025 at 9:22 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
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SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...
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December 3, 2025 at 9:15 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
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Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase
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Dynamic metal coordination controls chemoselectivity in a radical halogenase - Nature Chemical Biology
Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.
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December 3, 2025 at 9:09 PM
Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase
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www.nature.com/articles/s41...
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system
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Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR–Cas system - Nature Chemical Biology
The CorA-associated type III-B CRISPR–Cas system synthesizes S-adenosyl methionine (SAM)-AMP, triggering immune responses. Through structural characterization and biochemical validation, Duan and Jin ...
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December 3, 2025 at 9:04 PM
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system
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Our December issue is live!
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
December 3, 2025 at 8:58 PM
Our December issue is live!
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Chemical Biology
Job Title: Associate or Senior Editor, Nature Chemical Biology Organization: Nature Portfolio Location: New York, Washington DC, Jersey City, Beijing or Shanghai – Hybrid working Model Closing date: D...
springernature.wd3.myworkdayjobs.com
November 20, 2025 at 5:41 PM
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Reposted by Nature Chemical Biology
A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR
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Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap - Nature Chemical Biology
A multiscale photoproximity labeling proteomics workflow captures dynamic neighborhoods of extracellular and intracellular epidermal growth factor (EGF) receptor interactomes during early, middle and ...
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November 19, 2025 at 8:23 PM
A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR
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www.nature.com/articles/s41...
Nitrogen fixation by nitrogenase requires a metallocofactor built by dedicated multiprotein machinery. Structural snapshots of a precursor entering a key maturase reveal the dynamic process of FeMo-cofactor assembly
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Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly - Nature Chemical Biology
Nitrogen fixation by nitrogenase requires a metallocofactor built by a dedicated multiprotein machinery. Here, the authors captured structural snapshots of a precursor entering a key maturase, reveali...
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November 19, 2025 at 8:21 PM
Nitrogen fixation by nitrogenase requires a metallocofactor built by dedicated multiprotein machinery. Structural snapshots of a precursor entering a key maturase reveal the dynamic process of FeMo-cofactor assembly
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases
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Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology
Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...
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November 14, 2025 at 8:51 PM
A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases
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A large-scale metagenomic, single-bacterial sequencing and biochemical study reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts in marine sponges
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Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges - Nature Chemical Biology
Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...
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November 14, 2025 at 8:46 PM
A large-scale metagenomic, single-bacterial sequencing and biochemical study reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts in marine sponges
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www.nature.com/articles/s41...
A new Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand, and water molecules, expanding insights into the protein conformational landscape for drug design
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Unfreezing structural biology for drug discovery - Nature Chemical Biology
This Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand and water molecules, expanding insights into the protein conformational landscape ...
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November 10, 2025 at 2:38 PM
A new Perspective discusses how elevated-temperature crystallography uncovers hidden dynamic states of protein, ligand, and water molecules, expanding insights into the protein conformational landscape for drug design
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology
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Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology
Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...
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November 4, 2025 at 5:26 PM
A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology
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www.nature.com/articles/s41...
A new paper developed a small molecule that exploits the high abundance of mutant p53 and binds p53 Y220C delivering a mitosis blocker, killing TP53 mutant cancer cells while sparing healthy ones
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Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs - Nature Chemical Biology
Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...
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November 4, 2025 at 5:24 PM
A new paper developed a small molecule that exploits the high abundance of mutant p53 and binds p53 Y220C delivering a mitosis blocker, killing TP53 mutant cancer cells while sparing healthy ones
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping oxidatively damaged bases and abasic sites at single-nucleotide resolutions reveals transcription-related strand biases, patterns mirroring cancer mutational signatures, and the action of anticancer drug irofulven
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Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome - Nature Chemical Biology
By mapping oxidatively damaged bases and abasic sites at single-nucleotide resolution in human cells, Takhaveev et al. observed transcription-related strand biases, patterns mirroring cancer mutationa...
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October 31, 2025 at 2:01 PM
Mapping oxidatively damaged bases and abasic sites at single-nucleotide resolutions reveals transcription-related strand biases, patterns mirroring cancer mutational signatures, and the action of anticancer drug irofulven
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new paper reports a tungsten-dependent aldehyde:ferredoxin oxidoreductase as the enzyme responsible for acetate reduction to acetaldehyde for ethanol biosynthesis in the gas-converting bacteria C. autoethanogenum
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www.nature.com/articles/s41...
Carbon-monoxide-driven bioethanol production operates through a tungsten-dependent catalyst - Nature Chemical Biology
Microbial alcohol production from waste gases could enable sustainable carbon cycling. Now, the tungsten-dependent aldehyde:ferredoxin oxidoreductase from the gas-converting bacterium Clostridium auto...
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October 31, 2025 at 2:01 PM
A new paper reports a tungsten-dependent aldehyde:ferredoxin oxidoreductase as the enzyme responsible for acetate reduction to acetaldehyde for ethanol biosynthesis in the gas-converting bacteria C. autoethanogenum
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www.nature.com/articles/s41...
Our November issue is live!
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The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
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The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
October 31, 2025 at 2:00 PM
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
A new paper shows that SIRT1-driven deacetylation of MED1 under stress modifies gene expression by enhancing RNA Pol II action, promoting survival and growth of ER+ breast cancer cells----highlighting a potential therapeutic target
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MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment - Nature Chemical Biology
SIRT1-driven deacetylation of the MED1 subunit of the Mediator complex under stress modifies gene expression by enhancing RNA polymerase II action, promoting survival and growth of estrogen-receptor-p...
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October 27, 2025 at 3:42 PM
A new paper shows that SIRT1-driven deacetylation of MED1 under stress modifies gene expression by enhancing RNA Pol II action, promoting survival and growth of ER+ breast cancer cells----highlighting a potential therapeutic target
www.nature.com/articles/s41...
www.nature.com/articles/s41...