Nature Chemical Biology
@natchembio.nature.com
A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
October 31, 2025 at 2:00 PM
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
‘Pausing for stress’ – Check out the associated News & Views by Amy Strom on how MED1 acetylation tunes transcriptional condensates and RNA Pol II pausing during stress responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 3:44 PM
‘Pausing for stress’ – Check out the associated News & Views by Amy Strom on how MED1 acetylation tunes transcriptional condensates and RNA Pol II pausing during stress responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our October issue is live!
www.nature.com/nchembio/vol...
The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
www.nature.com/nchembio/vol...
The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
September 29, 2025 at 3:58 PM
Our October issue is live!
www.nature.com/nchembio/vol...
The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
www.nature.com/nchembio/vol...
The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
Our September issue is live!
www.nature.com/nchembio/vol...
The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
www.nature.com/nchembio/vol...
The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
August 28, 2025 at 7:21 PM
Our September issue is live!
www.nature.com/nchembio/vol...
The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
www.nature.com/nchembio/vol...
The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
The 21st annual Tri-Institutional Chemical Biology Symposium will be held on Thursday, August 28, 2025, 9:00 am – 6:00 pm, on the campus of Memorial Sloan Kettering Cancer Center. Registration will close on Wednesday, August 20.
August 19, 2025 at 6:51 AM
The 21st annual Tri-Institutional Chemical Biology Symposium will be held on Thursday, August 28, 2025, 9:00 am – 6:00 pm, on the campus of Memorial Sloan Kettering Cancer Center. Registration will close on Wednesday, August 20.
Our August issue is live!
www.nature.com/nchembio/vol...
The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
www.nature.com/nchembio/vol...
The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
July 30, 2025 at 3:06 PM
Our August issue is live!
www.nature.com/nchembio/vol...
The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
www.nature.com/nchembio/vol...
The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
Our July issue is live!
www.nature.com/nchembio/vol...
The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
www.nature.com/nchembio/vol...
The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
June 27, 2025 at 1:59 PM
Our July issue is live!
www.nature.com/nchembio/vol...
The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
www.nature.com/nchembio/vol...
The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
Our June issue is live with a mini-focus on metabolism, featuring an Editorial, Research Highlights, Reviews, and Perspectives on the interplay between chemical biology and metabolism.
www.nature.com/nchembio/vol...
The spotlights in the cover highlight beta cell regeneration in the pancreas
www.nature.com/nchembio/vol...
The spotlights in the cover highlight beta cell regeneration in the pancreas
June 2, 2025 at 4:23 PM
Our June issue is live with a mini-focus on metabolism, featuring an Editorial, Research Highlights, Reviews, and Perspectives on the interplay between chemical biology and metabolism.
www.nature.com/nchembio/vol...
The spotlights in the cover highlight beta cell regeneration in the pancreas
www.nature.com/nchembio/vol...
The spotlights in the cover highlight beta cell regeneration in the pancreas
Our May issue is live!
www.nature.com/nchembio/vol...
The cover image depicts a 3D model of an engineered group I intron set against a background of electronic circuits
www.nature.com/nchembio/vol...
The cover image depicts a 3D model of an engineered group I intron set against a background of electronic circuits
April 30, 2025 at 2:06 PM
Our May issue is live!
www.nature.com/nchembio/vol...
The cover image depicts a 3D model of an engineered group I intron set against a background of electronic circuits
www.nature.com/nchembio/vol...
The cover image depicts a 3D model of an engineered group I intron set against a background of electronic circuits
Our April issue is live!
www.nature.com/nchembio/vol...
The cover features a SEM image of a cluster of MRSA strain NRS21 from the Mobashery group, reporting on inhibitors of the β-lactam-sensing protein BlaR that is key to the β-lactam resistance response in MRSA.
www.nature.com/nchembio/vol...
The cover features a SEM image of a cluster of MRSA strain NRS21 from the Mobashery group, reporting on inhibitors of the β-lactam-sensing protein BlaR that is key to the β-lactam resistance response in MRSA.
March 28, 2025 at 4:27 PM
Our April issue is live!
www.nature.com/nchembio/vol...
The cover features a SEM image of a cluster of MRSA strain NRS21 from the Mobashery group, reporting on inhibitors of the β-lactam-sensing protein BlaR that is key to the β-lactam resistance response in MRSA.
www.nature.com/nchembio/vol...
The cover features a SEM image of a cluster of MRSA strain NRS21 from the Mobashery group, reporting on inhibitors of the β-lactam-sensing protein BlaR that is key to the β-lactam resistance response in MRSA.
Our March issue is live!
www.nature.com/nchembio/vol...
The cover from first-author Rachel Deis features light-reflecting crystals in the zebrafish eye with unique morphology and function that are genetically controlled through tissue-specific expression of paralogs
www.nature.com/nchembio/vol...
The cover from first-author Rachel Deis features light-reflecting crystals in the zebrafish eye with unique morphology and function that are genetically controlled through tissue-specific expression of paralogs
February 28, 2025 at 9:24 PM
Our March issue is live!
www.nature.com/nchembio/vol...
The cover from first-author Rachel Deis features light-reflecting crystals in the zebrafish eye with unique morphology and function that are genetically controlled through tissue-specific expression of paralogs
www.nature.com/nchembio/vol...
The cover from first-author Rachel Deis features light-reflecting crystals in the zebrafish eye with unique morphology and function that are genetically controlled through tissue-specific expression of paralogs
Our February issue is live!
www.nature.com/nchembio/vol...
The cover image is a botanical illustration of a Saponaria plant taken from a book in the rare book collection at the John Innes Centre
www.nature.com/nchembio/vol...
The cover image is a botanical illustration of a Saponaria plant taken from a book in the rare book collection at the John Innes Centre
January 31, 2025 at 2:53 PM
Our February issue is live!
www.nature.com/nchembio/vol...
The cover image is a botanical illustration of a Saponaria plant taken from a book in the rare book collection at the John Innes Centre
www.nature.com/nchembio/vol...
The cover image is a botanical illustration of a Saponaria plant taken from a book in the rare book collection at the John Innes Centre
Our January issue is live and it’s our 20th Anniversary Issue!
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
January 6, 2025 at 7:46 PM
Our January issue is live and it’s our 20th Anniversary Issue!
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
www.nature.com/nchembio/vol...
It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.
Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover.
www.nature.com/nchembio/vol...
www.nature.com/nchembio/vol...
December 19, 2024 at 11:27 AM
Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover.
www.nature.com/nchembio/vol...
www.nature.com/nchembio/vol...