Nick Riley
@nmriley.bsky.social
Assistant Professor, University of Washington, Dept. of Chemistry. PI of the Riley Research Group, @riley-research.bsky.social. Glyco, mass spec, chembio. Sports, food, travel, dogs. riley-research.com
Pinned
Nick Riley
@nmriley.bsky.social
· Apr 18
SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025
Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or …
searlescholars.org
I still can't quite believe I am included in the 2025 Searle Scholars cohort. Feeling especially thankful for all who have supported me. I am most excited about the science @riley-research.bsky.social gets to pursue and the support this award provides for my group
searlescholars.org/2025/04/14/s...
searlescholars.org/2025/04/14/s...
Reposted by Nick Riley
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry:
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona
Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...
pubs.acs.org
February 10, 2026 at 3:59 PM
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry:
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry:
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona
Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...
pubs.acs.org
February 10, 2026 at 3:59 PM
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry:
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Reposted by Nick Riley
2025 ended with this paper being accepted by Analytical Chemistry! 😁
Please check out our article in its new home and learn how these multinanoparticle protein coronas grant us a deeper insight into the glycoproteome of different biofluids:
pubs.acs.org/doi/10.1021/...
Please check out our article in its new home and learn how these multinanoparticle protein coronas grant us a deeper insight into the glycoproteome of different biofluids:
pubs.acs.org/doi/10.1021/...
January 9, 2026 at 4:32 PM
2025 ended with this paper being accepted by Analytical Chemistry! 😁
Please check out our article in its new home and learn how these multinanoparticle protein coronas grant us a deeper insight into the glycoproteome of different biofluids:
pubs.acs.org/doi/10.1021/...
Please check out our article in its new home and learn how these multinanoparticle protein coronas grant us a deeper insight into the glycoproteome of different biofluids:
pubs.acs.org/doi/10.1021/...
Reposted by Nick Riley
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
go.nature.com
December 16, 2025 at 3:40 PM
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
Reposted by Nick Riley
A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...
December 16, 2025 at 3:11 PM
A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...
It was a great meeting at OHSU, and it’s always fun to connect with @carolynbertozzi.bskyverified.social alum!
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
December 14, 2025 at 7:21 PM
It was a great meeting at OHSU, and it’s always fun to connect with @carolynbertozzi.bskyverified.social alum!
Reposted by Nick Riley
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
December 14, 2025 at 1:54 PM
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
Reposted by Nick Riley
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...
www.biorxiv.org
December 8, 2025 at 2:32 AM
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Nick Riley
Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings?
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Awards for Undergraduate Students
Visit the post for more.
acsanalytical.org
November 25, 2025 at 8:27 PM
Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings?
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Reposted by Nick Riley
And of course thanks to all co-authors and hopefully reaching out to future users @gundrylab.bsky.social @nmriley.bsky.social @khookh.bsky.social @cashwood.proteaglyco.com @wandalllab.bsky.social @glyconet.bsky.social and so many I cannot include...
Cannot hide my joy, relief, excitement being able to share the outcome of persevering (to say the least) collaborative work. So... the MS glyco(proteomics) guidelines are published!! www.mcponline.org/article/S153...
Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss
Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss
Update and new implementation of the MIRAGE reporting guidelines for mass spectrometry experiments in glycoscience
The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for
mass spectrometry (MS) data were initially developed to standardize the reporting
of instrumentation, data acquisiti...
www.mcponline.org
November 25, 2025 at 9:46 AM
And of course thanks to all co-authors and hopefully reaching out to future users @gundrylab.bsky.social @nmriley.bsky.social @khookh.bsky.social @cashwood.proteaglyco.com @wandalllab.bsky.social @glyconet.bsky.social and so many I cannot include...
Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings?
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Awards for Undergraduate Students
Visit the post for more.
acsanalytical.org
November 25, 2025 at 8:27 PM
Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings?
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.
acsanalytical.org/undergraduat...
Reposted by Nick Riley
Know an inspiring early-career chemist? Nominate an early-career chemist for the 2026 Talented 12 at cen.acs.org/sections/tal...
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
November 19, 2025 at 4:37 PM
Know an inspiring early-career chemist? Nominate an early-career chemist for the 2026 Talented 12 at cen.acs.org/sections/tal...
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
Submit your nomination by January 20, 2026.
#CENT12 #MassSpec #Chemistry
Reposted by Nick Riley
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.
youtu.be/LutI8YqJkqM?...
youtu.be/LutI8YqJkqM?...
November 17, 2025 at 6:31 AM
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.
youtu.be/LutI8YqJkqM?...
youtu.be/LutI8YqJkqM?...
Reposted by Nick Riley
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
November 13, 2025 at 8:34 PM
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
Reposted by Nick Riley
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
www.science.org
November 12, 2025 at 9:57 PM
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
Reposted by Nick Riley
Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...
us-hupo.org/Computationa...
US HUPO - Computational Proteomics Award
us-hupo.org
November 12, 2025 at 5:14 PM
Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...
us-hupo.org/Computationa...
Reposted by Nick Riley
Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...
us-hupo.org/Distinguishe...
US HUPO - Distinguished Contribution Award
us-hupo.org
November 12, 2025 at 5:12 PM
Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...
us-hupo.org/Distinguishe...
Reposted by Nick Riley
Have fun with the poster presentation today @timveth.bsky.social!
@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity
November 11, 2025 at 4:30 PM
Have fun with the poster presentation today @timveth.bsky.social!
Reposted by Nick Riley
The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego.
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
November 10, 2025 at 9:15 PM
The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego.
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
Reposted by Nick Riley
@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity
November 10, 2025 at 9:15 PM
@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity
Not only did Kayla do a great job with her #HUPO2025 presentation, but she also was recognized this afternoon as one of the winners of the competitive 2025 Quantitative Proteomics Grant from Thermo Fisher Scientific.
Way to go, Kayla!
Way to go, Kayla!
November 10, 2025 at 10:21 PM
Not only did Kayla do a great job with her #HUPO2025 presentation, but she also was recognized this afternoon as one of the winners of the competitive 2025 Quantitative Proteomics Grant from Thermo Fisher Scientific.
Way to go, Kayla!
Way to go, Kayla!
The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego.
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
November 10, 2025 at 9:15 PM
The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego.
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
Reposted by Nick Riley
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
November 9, 2025 at 10:34 PM
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
November 9, 2025 at 10:34 PM
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
Reposted by Nick Riley
Understanding m/z range settings for MS/MS scans: a case study with intact glycopeptides chemrxiv.org/engage/...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
October 22, 2025 at 6:40 PM
Understanding m/z range settings for MS/MS scans: a case study with intact glycopeptides chemrxiv.org/engage/...
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#proteomics #prot-preprint
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#proteomics #prot-preprint