Nick Riley
@nmriley.bsky.social
Assistant Professor, University of Washington, Dept. of Chemistry. PI of the Riley Research Group, @riley-research.bsky.social. Glyco, mass spec, chembio. Sports, food, travel, dogs. riley-research.com
Not only did Kayla do a great job with her #HUPO2025 presentation, but she also was recognized this afternoon as one of the winners of the competitive 2025 Quantitative Proteomics Grant from Thermo Fisher Scientific.
Way to go, Kayla!
Way to go, Kayla!
November 10, 2025 at 10:21 PM
Not only did Kayla do a great job with her #HUPO2025 presentation, but she also was recognized this afternoon as one of the winners of the competitive 2025 Quantitative Proteomics Grant from Thermo Fisher Scientific.
Way to go, Kayla!
Way to go, Kayla!
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
November 9, 2025 at 10:34 PM
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
My poster on our recent work informatics tools is on Monday afternoon too. See you there!
#glycotime
NP enrichment also helped O-glycopeptide characterization, but MAX enrichment was less beneficial.
We looked into CSF, too. We think this is one of the first applications of Seer's NPs to CSF, so we did proteomics and glycoproteomics.
Be sure to check out the pre-print if this sounds interesting!
We looked into CSF, too. We think this is one of the first applications of Seer's NPs to CSF, so we did proteomics and glycoproteomics.
Be sure to check out the pre-print if this sounds interesting!
September 24, 2025 at 1:52 PM
NP enrichment also helped O-glycopeptide characterization, but MAX enrichment was less beneficial.
We looked into CSF, too. We think this is one of the first applications of Seer's NPs to CSF, so we did proteomics and glycoproteomics.
Be sure to check out the pre-print if this sounds interesting!
We looked into CSF, too. We think this is one of the first applications of Seer's NPs to CSF, so we did proteomics and glycoproteomics.
Be sure to check out the pre-print if this sounds interesting!
It's rare that a single LC-MS/MS can provide IDs for all glycopeptides in a mixture, so we ran enrich enrichment multiple times on the instrument.
This allowed us to capture as much of the population of glycopeptides that we could -- an important thing when exploring how enrichment methods differ!
This allowed us to capture as much of the population of glycopeptides that we could -- an important thing when exploring how enrichment methods differ!
September 24, 2025 at 1:46 PM
It's rare that a single LC-MS/MS can provide IDs for all glycopeptides in a mixture, so we ran enrich enrichment multiple times on the instrument.
This allowed us to capture as much of the population of glycopeptides that we could -- an important thing when exploring how enrichment methods differ!
This allowed us to capture as much of the population of glycopeptides that we could -- an important thing when exploring how enrichment methods differ!
Large dynamic range in biofluids is an issue for glycoproteomics just like with proteomics. We saw that Seer's NP mixtures (A and B) combined with MAX enrichment provided a boost in N-glycopeptide IDs relative to no nanoparticles (NP0), with the majority of IDs being unique to the NP enrichments.
September 24, 2025 at 1:40 PM
Large dynamic range in biofluids is an issue for glycoproteomics just like with proteomics. We saw that Seer's NP mixtures (A and B) combined with MAX enrichment provided a boost in N-glycopeptide IDs relative to no nanoparticles (NP0), with the majority of IDs being unique to the NP enrichments.
@riley-research.bsky.social had a great time catching up with local research at the Cascadia Proteomics Symposium last week. The lineup featured talks from Katie Kothlow and Haley Schramm, and a lightning talk/poster from @emmajays.bsky.social
Congrats to Emmajay for her 2nd-place poster award too!
Congrats to Emmajay for her 2nd-place poster award too!
July 23, 2025 at 2:55 PM
@riley-research.bsky.social had a great time catching up with local research at the Cascadia Proteomics Symposium last week. The lineup featured talks from Katie Kothlow and Haley Schramm, and a lightning talk/poster from @emmajays.bsky.social
Congrats to Emmajay for her 2nd-place poster award too!
Congrats to Emmajay for her 2nd-place poster award too!
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
June 2, 2025 at 11:55 AM
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
On Tuesday, our poster presentations include work from @timveth.bsky.social, Katie Kothlow, and @vishnutejus.bsky.social. Vishnu just gave a great presentation during the undergraduate poster competition tonight, too!
On Thursday, Dr. Haley Schramm will present a poster and I will give a talk.
On Thursday, Dr. Haley Schramm will present a poster and I will give a talk.
June 2, 2025 at 2:54 AM
On Tuesday, our poster presentations include work from @timveth.bsky.social, Katie Kothlow, and @vishnutejus.bsky.social. Vishnu just gave a great presentation during the undergraduate poster competition tonight, too!
On Thursday, Dr. Haley Schramm will present a poster and I will give a talk.
On Thursday, Dr. Haley Schramm will present a poster and I will give a talk.
On Monday, our poster presentations include work from Kayla Markuson, @jacobrussell02.bsky.social, Ruby Zhang, Dr. @emmajays.bsky.social, and Anna Duboff.
June 2, 2025 at 2:54 AM
On Monday, our poster presentations include work from Kayla Markuson, @jacobrussell02.bsky.social, Ruby Zhang, Dr. @emmajays.bsky.social, and Anna Duboff.
@riley-research.bsky.social is excited for #ASMS2025 in Baltimore!
We made sure to capitalize on some of the classics, like a crab dinner at LP Steamers and an Orioles game, before the conference festivities kicked off.
Come hear what we have been up to!
We made sure to capitalize on some of the classics, like a crab dinner at LP Steamers and an Orioles game, before the conference festivities kicked off.
Come hear what we have been up to!
June 2, 2025 at 2:54 AM
@riley-research.bsky.social is excited for #ASMS2025 in Baltimore!
We made sure to capitalize on some of the classics, like a crab dinner at LP Steamers and an Orioles game, before the conference festivities kicked off.
Come hear what we have been up to!
We made sure to capitalize on some of the classics, like a crab dinner at LP Steamers and an Orioles game, before the conference festivities kicked off.
Come hear what we have been up to!
Welcome! You picked a great week to be here. Don’t forget to check out the views up on main campus if you can. Took these on my walks to/from work this week
April 17, 2025 at 5:10 AM
Welcome! You picked a great week to be here. Don’t forget to check out the views up on main campus if you can. Took these on my walks to/from work this week
We heard of an interest in tutorial style manuscripts, so we (@timveth.bsky.social, Katie Kothlow) took an opportunity to explore the implications for glycopeptide analysis of the "5-10-15" rule of thumb used to set the m/z range for tandem MS. A pre-print is here:
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
April 16, 2025 at 4:20 PM
We heard of an interest in tutorial style manuscripts, so we (@timveth.bsky.social, Katie Kothlow) took an opportunity to explore the implications for glycopeptide analysis of the "5-10-15" rule of thumb used to set the m/z range for tandem MS. A pre-print is here:
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Here is a screenshot of the poster about GlyCounter I am presenting at this week's Glycobiology Gordon Research Conference to give you an overview of analyses we include in the pre-print.
March 26, 2025 at 11:28 AM
Here is a screenshot of the poster about GlyCounter I am presenting at this week's Glycobiology Gordon Research Conference to give you an overview of analyses we include in the pre-print.
Finally, congratulations to the newly elected 2027 GRS Co-Chairs, Andrew Alexander and @lornamilne.bsky.social! Looking forward to the great meeting you plan in CA.
Overall, it was a group of impressive group of early career researchers from 14+ countries. The future of #glycotome is in good hands
Overall, it was a group of impressive group of early career researchers from 14+ countries. The future of #glycotome is in good hands
March 23, 2025 at 8:19 PM
Finally, congratulations to the newly elected 2027 GRS Co-Chairs, Andrew Alexander and @lornamilne.bsky.social! Looking forward to the great meeting you plan in CA.
Overall, it was a group of impressive group of early career researchers from 14+ countries. The future of #glycotome is in good hands
Overall, it was a group of impressive group of early career researchers from 14+ countries. The future of #glycotome is in good hands
Congratulations to our poster winners, Eva Maria Stork and Lorenzo Rossi!
Also congratulations to poster honorable mention presentations from Taryn Lucas, Katrin Nuẞbaumer, Til Schlotter, Sandhya Sridhar, Natalie Stewart, Bożena Szulc!
Also congratulations to poster honorable mention presentations from Taryn Lucas, Katrin Nuẞbaumer, Til Schlotter, Sandhya Sridhar, Natalie Stewart, Bożena Szulc!
March 23, 2025 at 8:19 PM
Congratulations to our poster winners, Eva Maria Stork and Lorenzo Rossi!
Also congratulations to poster honorable mention presentations from Taryn Lucas, Katrin Nuẞbaumer, Til Schlotter, Sandhya Sridhar, Natalie Stewart, Bożena Szulc!
Also congratulations to poster honorable mention presentations from Taryn Lucas, Katrin Nuẞbaumer, Til Schlotter, Sandhya Sridhar, Natalie Stewart, Bożena Szulc!
A big thank you to @docgatordawg1.bsky.social, Stacy Malaker, @elisafadda.bsky.social, @glycocode.bsky.social, and @glyco.me for participating in our GRS Mentorship Session on Careers in Glycoscience.
March 23, 2025 at 8:19 PM
A big thank you to @docgatordawg1.bsky.social, Stacy Malaker, @elisafadda.bsky.social, @glycocode.bsky.social, and @glyco.me for participating in our GRS Mentorship Session on Careers in Glycoscience.
The Glycobiology Gordon Research Seminar this weekend was a great kickoff to the Glyco GRC this week. ~70 grad students and postdocs shared awesome #glycotime data and built community.
Much appreciation is owed to my co-chair @fionachembot.bsky.social who played a big role in its success.
Much appreciation is owed to my co-chair @fionachembot.bsky.social who played a big role in its success.
March 23, 2025 at 8:19 PM
The Glycobiology Gordon Research Seminar this weekend was a great kickoff to the Glyco GRC this week. ~70 grad students and postdocs shared awesome #glycotime data and built community.
Much appreciation is owed to my co-chair @fionachembot.bsky.social who played a big role in its success.
Much appreciation is owed to my co-chair @fionachembot.bsky.social who played a big role in its success.
Highlights from our week include:
Travel awards for Katie (graduate) and
@vishnutejus.bsky.social (undergraduate) 🎉
Poster presentations by
@emmajays.bsky.social y.social, Haley, Vishnu, and me. We had fun with our poster lightning talks, too!
1st place overall poster award to Katie! 🎉
Travel awards for Katie (graduate) and
@vishnutejus.bsky.social (undergraduate) 🎉
Poster presentations by
@emmajays.bsky.social y.social, Haley, Vishnu, and me. We had fun with our poster lightning talks, too!
1st place overall poster award to Katie! 🎉
March 2, 2025 at 5:10 PM
Highlights from our week include:
Travel awards for Katie (graduate) and
@vishnutejus.bsky.social (undergraduate) 🎉
Poster presentations by
@emmajays.bsky.social y.social, Haley, Vishnu, and me. We had fun with our poster lightning talks, too!
1st place overall poster award to Katie! 🎉
Travel awards for Katie (graduate) and
@vishnutejus.bsky.social (undergraduate) 🎉
Poster presentations by
@emmajays.bsky.social y.social, Haley, Vishnu, and me. We had fun with our poster lightning talks, too!
1st place overall poster award to Katie! 🎉
Despite current events, @riley-research.bsky.social enjoyed @us-hupo.bsky.social last week!
Connecting w/ colleagues was an antidote for the frustration that occupies a lot of my brain space these days
Thanks for the continual motivation to pursue good science and support scientists however we can
Connecting w/ colleagues was an antidote for the frustration that occupies a lot of my brain space these days
Thanks for the continual motivation to pursue good science and support scientists however we can
March 2, 2025 at 5:06 PM
Despite current events, @riley-research.bsky.social enjoyed @us-hupo.bsky.social last week!
Connecting w/ colleagues was an antidote for the frustration that occupies a lot of my brain space these days
Thanks for the continual motivation to pursue good science and support scientists however we can
Connecting w/ colleagues was an antidote for the frustration that occupies a lot of my brain space these days
Thanks for the continual motivation to pursue good science and support scientists however we can
We updated our @riley-research.bsky.social website this weekend, including a new section on our Useful Links page that consolidates materials we found helpful in the current events discourse, re: funding cuts. Hopefully it can be a helpful resource:
www.riley-research.com/useful-links
www.riley-research.com/useful-links
February 10, 2025 at 3:57 PM
We updated our @riley-research.bsky.social website this weekend, including a new section on our Useful Links page that consolidates materials we found helpful in the current events discourse, re: funding cuts. Hopefully it can be a helpful resource:
www.riley-research.com/useful-links
www.riley-research.com/useful-links
Actual picture from a @riley-research.bsky.social group meeting this week
January 31, 2025 at 10:23 PM
Actual picture from a @riley-research.bsky.social group meeting this week
Ruby Zhang joins the RRG as a 1st-year graduate student. Growing up in Los Angeles, CA, Ruby was previously at UC-San Diego, Pfizer, and CalTech before coming to UW. Welcome, Ruby! Read more here: riley-research.com/group-member...
December 22, 2023 at 5:50 PM
Ruby Zhang joins the RRG as a 1st-year graduate student. Growing up in Los Angeles, CA, Ruby was previously at UC-San Diego, Pfizer, and CalTech before coming to UW. Welcome, Ruby! Read more here: riley-research.com/group-member...
Jacob Russell joins the RRG as a 1st-year graduate student. From Columbus, OH, Jacob was previously at the Ohio State University and the Olesik lab before coming to UW. Welcome, Jacob! Read more here: riley-research.com/group-member...
December 22, 2023 at 5:49 PM
Jacob Russell joins the RRG as a 1st-year graduate student. From Columbus, OH, Jacob was previously at the Ohio State University and the Olesik lab before coming to UW. Welcome, Jacob! Read more here: riley-research.com/group-member...