Centre for Structural Systems Biology CSSB
@cssbhamburg.bsky.social
New preprint from @carobarisch.bsky.social lab!
🚨 New preprint!
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
February 12, 2026 at 11:43 AM
New preprint from @carobarisch.bsky.social lab!
🎉 Happy International Day of Women and Girls in Science 🔬
Some of our group leaders shared insights into what they love most about their jobs in science. ❤️
CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day.
#WomenInScience @landaulabcssb.bsky.social
Some of our group leaders shared insights into what they love most about their jobs in science. ❤️
CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day.
#WomenInScience @landaulabcssb.bsky.social
February 11, 2026 at 11:04 AM
🎉 Happy International Day of Women and Girls in Science 🔬
Some of our group leaders shared insights into what they love most about their jobs in science. ❤️
CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day.
#WomenInScience @landaulabcssb.bsky.social
Some of our group leaders shared insights into what they love most about their jobs in science. ❤️
CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day.
#WomenInScience @landaulabcssb.bsky.social
Reposted by Centre for Structural Systems Biology CSSB
Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
January 29, 2026 at 4:48 PM
Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
Reposted by Centre for Structural Systems Biology CSSB
New protocol out now! 📕🖊️🔍
A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit.
A must-see if you’re working with RNA structure and CD data.
DOI: 10.1007/978-1-0716-5084-4_12 
A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit.
A must-see if you’re working with RNA structure and CD data.
DOI: 10.1007/978-1-0716-5084-4_12 
January 29, 2026 at 3:22 PM
New protocol out now! 📕🖊️🔍
A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit.
A must-see if you’re working with RNA structure and CD data.
DOI: 10.1007/978-1-0716-5084-4_12 
A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit.
A must-see if you’re working with RNA structure and CD data.
DOI: 10.1007/978-1-0716-5084-4_12 
Reposted by Centre for Structural Systems Biology CSSB
My colleagues have put together a nice book chapter on amyloid polymorphism. Have a look! 🧪🧬🧶
#amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social
#amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social
The Many Lives of a Single Sequence: Functional Plasticity Through Amyloid Polymorphism pubmed.ncbi.nlm.nih.gov/41557242/ #cryoem
January 21, 2026 at 2:37 PM
My colleagues have put together a nice book chapter on amyloid polymorphism. Have a look! 🧪🧬🧶
#amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social
#amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social
Fun in the snow!
January 9, 2026 at 1:32 PM
Fun in the snow!
New Year, New Leadership!
Charlotte Uetrecht is the new Scientific Director of CSSB. Holger Sondermann and Tim Gilberger are Deputy Directors.
Find out more: t1p.de/q6mdg
@carobarisch.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social
Charlotte Uetrecht is the new Scientific Director of CSSB. Holger Sondermann and Tim Gilberger are Deputy Directors.
Find out more: t1p.de/q6mdg
@carobarisch.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social
January 5, 2026 at 2:32 PM
New Year, New Leadership!
Charlotte Uetrecht is the new Scientific Director of CSSB. Holger Sondermann and Tim Gilberger are Deputy Directors.
Find out more: t1p.de/q6mdg
@carobarisch.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social
Charlotte Uetrecht is the new Scientific Director of CSSB. Holger Sondermann and Tim Gilberger are Deputy Directors.
Find out more: t1p.de/q6mdg
@carobarisch.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social
Wishing you peace, joy and happiness this holiday season. Looking forward to 2026!
@leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org @uni-hamburg.de
@leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org @uni-hamburg.de
December 18, 2025 at 10:43 AM
Wishing you peace, joy and happiness this holiday season. Looking forward to 2026!
@leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org @uni-hamburg.de
@leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org @uni-hamburg.de
The 25th issue of our CSSB Connect newsletter is here!
Find out what's been going on at CSSB during the second half of 2025.
t1p.de/352cr
@uni-hamburg.de @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org
Find out what's been going on at CSSB during the second half of 2025.
t1p.de/352cr
@uni-hamburg.de @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org
December 16, 2025 at 8:37 AM
The 25th issue of our CSSB Connect newsletter is here!
Find out what's been going on at CSSB during the second half of 2025.
t1p.de/352cr
@uni-hamburg.de @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org
Find out what's been going on at CSSB during the second half of 2025.
t1p.de/352cr
@uni-hamburg.de @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org
Our next CSSB Connect newsletter is coming out soon!
Make sure it's delivered straight to your inbox by signing up today: t1p.de/hnamq
@landaulabcssb.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social
Make sure it's delivered straight to your inbox by signing up today: t1p.de/hnamq
@landaulabcssb.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social
December 12, 2025 at 10:13 AM
Our next CSSB Connect newsletter is coming out soon!
Make sure it's delivered straight to your inbox by signing up today: t1p.de/hnamq
@landaulabcssb.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social
Make sure it's delivered straight to your inbox by signing up today: t1p.de/hnamq
@landaulabcssb.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social
Congratulations Julia!
Congratulations, Julia Mahamid!
Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!
#LeibnizPreis
Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!
#LeibnizPreis
Und hier sind sie – die 10 Preisträger*innen des Gottfried Wilhelm #LeibnizPreis' 2026 – ausgezeichnet für ihre exzellenten Forschungsarbeiten und Errungenschaften in der Wissenschaft! 🏆👏
Die Verleihung der Preise feiern wir am 18. März in Berlin.
Einzelheiten & Kurzprofile: sohub.io/1uv1
Die Verleihung der Preise feiern wir am 18. März in Berlin.
Einzelheiten & Kurzprofile: sohub.io/1uv1
December 11, 2025 at 1:02 PM
Congratulations Julia!
Reposted by Centre for Structural Systems Biology CSSB
Congrats to Thomas Mulvaney from the @topf-lab.bsky.social for his Nomination for the Leibniz Association’s Dissertation Award — a great recognition of his innovative work on integrative modeling of proteins and nucleic acids. #ResearchExcellence
@leibnizliv.bsky.social
@cssbhamburg.bsky.social
@leibnizliv.bsky.social
@cssbhamburg.bsky.social
December 5, 2025 at 4:02 PM
Congrats to Thomas Mulvaney from the @topf-lab.bsky.social for his Nomination for the Leibniz Association’s Dissertation Award — a great recognition of his innovative work on integrative modeling of proteins and nucleic acids. #ResearchExcellence
@leibnizliv.bsky.social
@cssbhamburg.bsky.social
@leibnizliv.bsky.social
@cssbhamburg.bsky.social
MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks.
More info: t1p.de/nag2v
@bosse-lab.bsky.social
More info: t1p.de/nag2v
@bosse-lab.bsky.social
December 3, 2025 at 11:17 AM
MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks.
More info: t1p.de/nag2v
@bosse-lab.bsky.social
More info: t1p.de/nag2v
@bosse-lab.bsky.social
CSSB group leader Jens Bosse @bosse-lab.bsky.social @resist-cluster.bsky.social and CSSB associate member Chris Meier @uni-hamburg.de , together with Hans-Achim Wagenknecht from the Karlsruhe Institute of Technology, have developed a new method for live-cell RNA imaging
Find out more: t1p.de/18suk
Find out more: t1p.de/18suk
December 1, 2025 at 12:08 PM
CSSB group leader Jens Bosse @bosse-lab.bsky.social @resist-cluster.bsky.social and CSSB associate member Chris Meier @uni-hamburg.de , together with Hans-Achim Wagenknecht from the Karlsruhe Institute of Technology, have developed a new method for live-cell RNA imaging
Find out more: t1p.de/18suk
Find out more: t1p.de/18suk
Reposted by Centre for Structural Systems Biology CSSB
The Krey lab is hiring! If you are interested in viral glycoproteins, neutralizing antibodies and vaccines - and you want to further study this using structural and biochemical approaches, please apply!
stellenangebote.uni-luebeck.de/jobposting/d...
stellenangebote.uni-luebeck.de/jobposting/d...
December 1, 2025 at 9:05 AM
The Krey lab is hiring! If you are interested in viral glycoproteins, neutralizing antibodies and vaccines - and you want to further study this using structural and biochemical approaches, please apply!
stellenangebote.uni-luebeck.de/jobposting/d...
stellenangebote.uni-luebeck.de/jobposting/d...
Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes.
Apply now: v22.desy.de/e67416/recor...
Apply now: v22.desy.de/e67416/recor...
November 28, 2025 at 2:12 PM
Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes.
Apply now: v22.desy.de/e67416/recor...
Apply now: v22.desy.de/e67416/recor...
An international research team headed by the Bozdech lab at the Nanyang Technological University and the Gilberger lab (BNITM @uni-hamburg.de) at CSSB reveals the global landscape of protein-protein interactions that govern the biology of the malaria parasite.
Find out more: t1p.de/puyln
Find out more: t1p.de/puyln
November 28, 2025 at 10:53 AM
An international research team headed by the Bozdech lab at the Nanyang Technological University and the Gilberger lab (BNITM @uni-hamburg.de) at CSSB reveals the global landscape of protein-protein interactions that govern the biology of the malaria parasite.
Find out more: t1p.de/puyln
Find out more: t1p.de/puyln
Researchers from @topf-lab.bsky.social, @embl.org, and IIT have visualised how a large RNA molecule assembles itself into a functional machine, revealing a dynamic choreography that helps us better understand structural folding and misfolding, almost frame by frame.
More information: t1p.de/tt2hk
More information: t1p.de/tt2hk
November 27, 2025 at 11:46 AM
Researchers from @topf-lab.bsky.social, @embl.org, and IIT have visualised how a large RNA molecule assembles itself into a functional machine, revealing a dynamic choreography that helps us better understand structural folding and misfolding, almost frame by frame.
More information: t1p.de/tt2hk
More information: t1p.de/tt2hk
📣Join us on December 9 for the Academia-Industry Matchmaking Workshop, focused on innovative solutions for challenges in the Life Sciences.
Registration: indico.desy.de/event/50931/
@landaulabcssb.bsky.social @leibnizliv.bsky.social @uni-hamburg.de @fzborstel.bsky.social
Registration: indico.desy.de/event/50931/
@landaulabcssb.bsky.social @leibnizliv.bsky.social @uni-hamburg.de @fzborstel.bsky.social
November 27, 2025 at 9:55 AM
📣Join us on December 9 for the Academia-Industry Matchmaking Workshop, focused on innovative solutions for challenges in the Life Sciences.
Registration: indico.desy.de/event/50931/
@landaulabcssb.bsky.social @leibnizliv.bsky.social @uni-hamburg.de @fzborstel.bsky.social
Registration: indico.desy.de/event/50931/
@landaulabcssb.bsky.social @leibnizliv.bsky.social @uni-hamburg.de @fzborstel.bsky.social
Using a combination of X-ray crystallography and cryo-EM, a new study from @landaulabcssb.bsky.social shows that amyloids,form different structures that could be useful as a natural mechanism of immune protection.
More info: t1p.de/4n8se
@amyloid-sam.bsky.social @emilgustavsson.bsky.social
More info: t1p.de/4n8se
@amyloid-sam.bsky.social @emilgustavsson.bsky.social
November 26, 2025 at 2:15 PM
Using a combination of X-ray crystallography and cryo-EM, a new study from @landaulabcssb.bsky.social shows that amyloids,form different structures that could be useful as a natural mechanism of immune protection.
More info: t1p.de/4n8se
@amyloid-sam.bsky.social @emilgustavsson.bsky.social
More info: t1p.de/4n8se
@amyloid-sam.bsky.social @emilgustavsson.bsky.social
The Barisch lab held a 2 week practical module called 'Molecular Master Thieves' including an excursion to FZB. It was amazing & inspiring to see the students' enthusiasm & curiosity.
We wish you all the best for your bright careers!
@carobarisch.bsky.social @fzborstel.bsky.social @uni-hamburg.de
We wish you all the best for your bright careers!
@carobarisch.bsky.social @fzborstel.bsky.social @uni-hamburg.de
November 24, 2025 at 12:32 PM
The Barisch lab held a 2 week practical module called 'Molecular Master Thieves' including an excursion to FZB. It was amazing & inspiring to see the students' enthusiasm & curiosity.
We wish you all the best for your bright careers!
@carobarisch.bsky.social @fzborstel.bsky.social @uni-hamburg.de
We wish you all the best for your bright careers!
@carobarisch.bsky.social @fzborstel.bsky.social @uni-hamburg.de
Reposted by Centre for Structural Systems Biology CSSB
New preprint out!📃
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
Clathrin adaptors drive phase separation in endocytosis and trafficking
Liquid-liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize cellular processes, including endocytosis and membrane trafficking. Although LLPS has been impli...
www.biorxiv.org
November 21, 2025 at 10:13 AM
New preprint out!📃
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
On Wednesday afternoon, students who are part of DESY's ELB-Akademie programme visited CSSB. The students learned about our molecular infection research and visited the @landaulabcssb.bsky.social and our ALFM and cryo-EM facilities.
Find out more about the ELB-Akademie: t1p.de/w89j6
Find out more about the ELB-Akademie: t1p.de/w89j6
November 21, 2025 at 9:32 AM
On Wednesday afternoon, students who are part of DESY's ELB-Akademie programme visited CSSB. The students learned about our molecular infection research and visited the @landaulabcssb.bsky.social and our ALFM and cryo-EM facilities.
Find out more about the ELB-Akademie: t1p.de/w89j6
Find out more about the ELB-Akademie: t1p.de/w89j6
Congratulations to the Hamburg iGEM team for winning a gold medal in Paris for their project DeathCapTrap. @uni-hamburg.de @igemhq.bsky.social @igemcommunity.bsky.social
Find out more: t1p.de/dtho1
Find out more: t1p.de/dtho1
November 20, 2025 at 12:23 PM
Congratulations to the Hamburg iGEM team for winning a gold medal in Paris for their project DeathCapTrap. @uni-hamburg.de @igemhq.bsky.social @igemcommunity.bsky.social
Find out more: t1p.de/dtho1
Find out more: t1p.de/dtho1
Reposted by Centre for Structural Systems Biology CSSB
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...