Daan Noordermeer lab
@daannoordermeerlab.bsky.social
We are the Noordermeer lab at the Institute for Integrative Biology of the Cell - Université Paris-Saclay. Interested in 3D genome organization, enhancer-promoter contacts, epigenetics, genomic imprinting, loop extrusion and everything CTCF.
It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation
November 14, 2025 at 7:09 PM
It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation
Reposted by Daan Noordermeer lab
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 5, 2025 at 10:59 AM
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
Reposted by Daan Noordermeer lab
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
The newly announced ERC Synergy Grant includes research on:
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
buff.ly
November 6, 2025 at 11:40 AM
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
Reposted by Daan Noordermeer lab
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Daan Noordermeer lab
We’re pleased to share our new bioRxiv preprint:
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
October 27, 2025 at 10:15 AM
We’re pleased to share our new bioRxiv preprint:
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
Reposted by Daan Noordermeer lab
The TArgeted Cohesin Loader (TACL) paper was just published. Happy that we were able to contribute to this really exciting project!
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
Characterization of induced cohesin loop extrusion trajectories in living cells
Nature Genetics - This study introduces a system called TArgeted Cohesin Loader (TACL) that recruits cohesin complexes at defined genomic regions and induces loop extrusion events in living cells,...
rdcu.be
October 16, 2025 at 8:17 PM
The TArgeted Cohesin Loader (TACL) paper was just published. Happy that we were able to contribute to this really exciting project!
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
Reposted by Daan Noordermeer lab
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Daan Noordermeer lab
If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳
🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
October 8, 2025 at 5:05 PM
If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳
Reposted by Daan Noordermeer lab
🚨🚨🚨🧪 H1B scientists who are traveling outside the USA. Please be aware that current advice is to return to the USA IMMEDIATELY
This is not my normal content, but given that I have friends and followers this affects, this is the advice one large tech company is giving about H1B visas and the exec order set to go into place on the 21st.
September 20, 2025 at 3:46 AM
🚨🚨🚨🧪 H1B scientists who are traveling outside the USA. Please be aware that current advice is to return to the USA IMMEDIATELY
Reposted by Daan Noordermeer lab
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 2:09 PM
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Reposted by Daan Noordermeer lab
Trainees: Struggling to find the best figure arrangement for a manuscript draft? Do the 🧪 equivalent of an arts and crafts project:
1. Print draft figures and cut each panel into its own square.
2. Find a big table.
3. Move the panels around until you see the story.
This is your paper. 🤓
1. Print draft figures and cut each panel into its own square.
2. Find a big table.
3. Move the panels around until you see the story.
This is your paper. 🤓
September 18, 2025 at 7:56 PM
Trainees: Struggling to find the best figure arrangement for a manuscript draft? Do the 🧪 equivalent of an arts and crafts project:
1. Print draft figures and cut each panel into its own square.
2. Find a big table.
3. Move the panels around until you see the story.
This is your paper. 🤓
1. Print draft figures and cut each panel into its own square.
2. Find a big table.
3. Move the panels around until you see the story.
This is your paper. 🤓
Reposted by Daan Noordermeer lab
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
September 18, 2025 at 1:20 PM
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
Reposted by Daan Noordermeer lab
1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis
During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial...
doi.org
September 17, 2025 at 8:41 AM
1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
Reposted by Daan Noordermeer lab
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
🚨 Happy to see this collaborative work out in @embojournal.org. How is spindle pole detachment at mitotic exit regulated and what happens to nuclear & chromosome organization when it goes wrong? Hint: chromosomes look like kidney beans! 🌮🌯 Tour-de-force by @spindlebehavior.bsky.social and team!
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
September 13, 2025 at 9:50 AM
🚨 Happy to see this collaborative work out in @embojournal.org. How is spindle pole detachment at mitotic exit regulated and what happens to nuclear & chromosome organization when it goes wrong? Hint: chromosomes look like kidney beans! 🌮🌯 Tour-de-force by @spindlebehavior.bsky.social and team!
Reposted by Daan Noordermeer lab
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:15 AM
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Reposted by Daan Noordermeer lab
We are looking for a student to continue our work on chromatin evolution:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.
More info: recruitment.crg.eu/content/jobs...
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.
More info: recruitment.crg.eu/content/jobs...
July 15, 2025 at 11:30 AM
We are looking for a student to continue our work on chromatin evolution:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.
More info: recruitment.crg.eu/content/jobs...
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.
More info: recruitment.crg.eu/content/jobs...
Reposted by Daan Noordermeer lab
The “problem” with vaccines? They so effective at preventing deaths that they create generations of people that question whether disease was a problem in the first place because they have never experienced the horrors of a world without vaccines.
September 4, 2025 at 7:44 PM
The “problem” with vaccines? They so effective at preventing deaths that they create generations of people that question whether disease was a problem in the first place because they have never experienced the horrors of a world without vaccines.
Reposted by Daan Noordermeer lab
🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
May 16, 2025 at 3:06 PM
🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Daan Noordermeer lab
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
August 18, 2025 at 1:00 PM
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
Reposted by Daan Noordermeer lab
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Reposted by Daan Noordermeer lab
Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
---
Gain deeper insights into gene regulation; epigenometech.com
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
---
Gain deeper insights into gene regulation; epigenometech.com
The molecular basis of lamin-specific chromatin interactions - Nature Structural & Molecular Biology
Wang, Kronenberg-Tenga, Rosti and colleagues use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome dens...
go.nature.com
August 4, 2025 at 1:11 PM
Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
---
Gain deeper insights into gene regulation; epigenometech.com
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
---
Gain deeper insights into gene regulation; epigenometech.com
Reposted by Daan Noordermeer lab
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 2:56 PM
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Daan Noordermeer lab
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
RNA Pol II-based regulations of chromosome folding
The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. St…
www.sciencedirect.com
August 11, 2025 at 12:32 PM
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Daan Noordermeer lab
Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
RNA Pol II-based regulations of chromosome folding
How transcription and cohesin complexes interact to regulate 3D genome organization
remains unclear. Chapard et al. dissect their respective contributions and their interplay
in shaping the genome arc...
www.cell.com
August 9, 2025 at 10:47 AM
Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!