Daan Noordermeer lab
@daannoordermeerlab.bsky.social
We are the Noordermeer lab at the Institute for Integrative Biology of the Cell - Université Paris-Saclay. Interested in 3D genome organization, enhancer-promoter contacts, epigenetics, genomic imprinting, loop extrusion and everything CTCF.
Reposted by Daan Noordermeer lab
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 10:37 AM
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Thank you Max, I’ll transmit the message 😃
February 2, 2026 at 5:12 PM
Thank you Max, I’ll transmit the message 😃
That looked like an excellent visit!
January 22, 2026 at 10:48 AM
That looked like an excellent visit!
Reposted by Daan Noordermeer lab
New paper from the Feil lab! congratulations🍾👏
Great thread below ⤵️
@agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support
@cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social
#epigenetics
Great thread below ⤵️
@agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support
@cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social
#epigenetics
🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains - Nature Communications
It is not fully understood why genomic loci show asynchronous DNA replication. Here, the authors show that two imprinted gene domains replicate asynchronously between the parental chromosomes due to d...
www.nature.com
January 22, 2026 at 9:57 AM
New paper from the Feil lab! congratulations🍾👏
Great thread below ⤵️
@agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support
@cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social
#epigenetics
Great thread below ⤵️
@agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support
@cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social
#epigenetics
This has been an exciting collab with (all non-BS): Yui Imaizumi in Robert Feil’s lab (@igmm-montpel.bsky.social ), Francois Charon and Benoit Moindrot from @i2bcparissaclay.bsky.social and Jean-Charles Cadoret (@ijmonod.bsky.social) and others. Thanks to @agencerecherche.bsky.social for funding.
January 21, 2026 at 8:57 PM
This has been an exciting collab with (all non-BS): Yui Imaizumi in Robert Feil’s lab (@igmm-montpel.bsky.social ), Francois Charon and Benoit Moindrot from @i2bcparissaclay.bsky.social and Jean-Charles Cadoret (@ijmonod.bsky.social) and others. Thanks to @agencerecherche.bsky.social for funding.
How about 3D organization? Correlations emerge at larger scale, but our high-res allelic data has poor overlap, both for timing and for boundaries between repli domains and TADs. At imprinted domains, regulators that desynchronize replication timing also uncouple links with genome organization (4/n)
January 21, 2026 at 8:54 PM
How about 3D organization? Correlations emerge at larger scale, but our high-res allelic data has poor overlap, both for timing and for boundaries between repli domains and TADs. At imprinted domains, regulators that desynchronize replication timing also uncouple links with genome organization (4/n)
(2) perturbing lncRNA expression on the early chromosome delays replication, but further away. Methylation and lncRNA expression thus provide means to locally override the intrinsic replication program (3/n)
January 21, 2026 at 8:54 PM
(2) perturbing lncRNA expression on the early chromosome delays replication, but further away. Methylation and lncRNA expression thus provide means to locally override the intrinsic replication program (3/n)
Imprinted domains can replicate asynchronously, making them excellent study objects. High-res allelic Capture Repli-seq reveals unexpected outcomes: (1) removal of DNA methylation from the tiny Imprinting Control Region on the late replicating chromosome advances replication over 100s of kbs (2/n)
January 21, 2026 at 8:53 PM
Imprinted domains can replicate asynchronously, making them excellent study objects. High-res allelic Capture Repli-seq reveals unexpected outcomes: (1) removal of DNA methylation from the tiny Imprinting Control Region on the late replicating chromosome advances replication over 100s of kbs (2/n)
🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains - Nature Communications
It is not fully understood why genomic loci show asynchronous DNA replication. Here, the authors show that two imprinted gene domains replicate asynchronously between the parental chromosomes due to d...
www.nature.com
January 21, 2026 at 8:53 PM
🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
Bravo Anne and colleagues!
January 12, 2026 at 6:43 AM
Bravo Anne and colleagues!
Reposted by Daan Noordermeer lab
Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...
Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
January 11, 2026 at 7:43 PM
Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...
Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
What a nice start of the year!
January 6, 2026 at 12:08 PM
What a nice start of the year!
Reposted by Daan Noordermeer lab
We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...
Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488
We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...
www.nature.com
January 2, 2026 at 8:12 AM
We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...
Reposted by Daan Noordermeer lab
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 6:33 AM
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Great to see this out Agnese. It’s a very interesting mechanism. Congratulations to all authors!
December 17, 2025 at 5:40 AM
Great to see this out Agnese. It’s a very interesting mechanism. Congratulations to all authors!
Thank you Vicky. We’re looking forward to an exciting 5 years ahead of us!
December 16, 2025 at 8:34 PM
Thank you Vicky. We’re looking forward to an exciting 5 years ahead of us!
Reposted by Daan Noordermeer lab
Reposted by Daan Noordermeer lab
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation
November 14, 2025 at 7:09 PM
It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation
Reposted by Daan Noordermeer lab
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 5, 2025 at 10:59 AM
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
Reposted by Daan Noordermeer lab
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
The newly announced ERC Synergy Grant includes research on:
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
buff.ly
November 6, 2025 at 11:40 AM
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
Reposted by Daan Noordermeer lab
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Daan Noordermeer lab
We’re pleased to share our new bioRxiv preprint:
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
October 27, 2025 at 10:15 AM
We’re pleased to share our new bioRxiv preprint:
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
“The Pre-clinical Animal Network (PCAN)...t”
www.biorxiv.org/content/10.1...
#PraderWilliSyndrome #MouseGenetics #Phenotyping #FPWR #TranslationalResearch #OpenScience #DigitalTwin #IMPC #INFRAFRONTIER #MRC #RareDisease
Reposted by Daan Noordermeer lab
The TArgeted Cohesin Loader (TACL) paper was just published. Happy that we were able to contribute to this really exciting project!
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
Characterization of induced cohesin loop extrusion trajectories in living cells
Nature Genetics - This study introduces a system called TArgeted Cohesin Loader (TACL) that recruits cohesin complexes at defined genomic regions and induces loop extrusion events in living cells,...
rdcu.be
October 16, 2025 at 8:17 PM
The TArgeted Cohesin Loader (TACL) paper was just published. Happy that we were able to contribute to this really exciting project!
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5