Olivier Namy 🧬🧪
@onamy.bsky.social
Phd, director of research, RNA Biology & Ribosome, former president Section 21 #CNRS, #RNA and #ribosome fan, specialist in translation regulations at #I2BC
ORCID: 0000-0002-1143-5961
ORCID: 0000-0002-1143-5961
Pinned
The newly announced ERC Synergy Grant includes research on:
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
buff.ly
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
Waouh translational termination depends on circadian cycle!
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Lamb et al. show that the circadian clock rhythmically remodels ribosome composition in Neurospora crassa. Clock-regulated incorporation of the ribosomal protein eL31 is required for rhythmic translation and translation fidelity, linking temporal ribosome remodeling to daily changes in proteome diversity.
dlvr.it
November 8, 2025 at 9:28 PM
Waouh translational termination depends on circadian cycle!
Reposted by Olivier Namy 🧬🧪
Leoš Valášek, Julius Lukeš, Olivier Namy (@onamy.bsky.social) and Mark Osborn are among the winners of 2025 Synergy Grants.
They'll investigate premature termination codons, the genetic 'stop signals' that cut production of proteins short causing disorders. 🧬🔬
👉 buff.ly/ZQhLp4h
#ERCSyG
They'll investigate premature termination codons, the genetic 'stop signals' that cut production of proteins short causing disorders. 🧬🔬
👉 buff.ly/ZQhLp4h
#ERCSyG
November 7, 2025 at 8:43 AM
Leoš Valášek, Julius Lukeš, Olivier Namy (@onamy.bsky.social) and Mark Osborn are among the winners of 2025 Synergy Grants.
They'll investigate premature termination codons, the genetic 'stop signals' that cut production of proteins short causing disorders. 🧬🔬
👉 buff.ly/ZQhLp4h
#ERCSyG
They'll investigate premature termination codons, the genetic 'stop signals' that cut production of proteins short causing disorders. 🧬🔬
👉 buff.ly/ZQhLp4h
#ERCSyG
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
The newly announced ERC Synergy Grant includes research on:
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
✴️ genetic drug design
✴️ the Big Bang's first microseconds
✴️ crowd movement
✴️ nature-society interactions
👉 buff.ly/ZQhLp4h
Congrats to the 66 awarded research teams!
#FrontierResearch
buff.ly
November 6, 2025 at 11:40 AM
I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr
Reposted by Olivier Namy 🧬🧪
🎃 Trick or transcript?
Bacteria rewire their RNA world under stress & infection. tRNA mods as dual-function sensors, phage tRNA slashers, hibernating ribosomes & haunted translation hubs.
🧬🧪 Full November 1st issue → #RNAmod #Epitranscriptomics #HalloweenScience
#rnasky #microsky
Bacteria rewire their RNA world under stress & infection. tRNA mods as dual-function sensors, phage tRNA slashers, hibernating ribosomes & haunted translation hubs.
🧬🧪 Full November 1st issue → #RNAmod #Epitranscriptomics #HalloweenScience
#rnasky #microsky
📰 🎃 RNA Modifications Newsletter – October 31st - November 1st, 2025
Issue #5
rnamodifupdates.substack.com
October 31, 2025 at 8:14 PM
🎃 Trick or transcript?
Bacteria rewire their RNA world under stress & infection. tRNA mods as dual-function sensors, phage tRNA slashers, hibernating ribosomes & haunted translation hubs.
🧬🧪 Full November 1st issue → #RNAmod #Epitranscriptomics #HalloweenScience
#rnasky #microsky
Bacteria rewire their RNA world under stress & infection. tRNA mods as dual-function sensors, phage tRNA slashers, hibernating ribosomes & haunted translation hubs.
🧬🧪 Full November 1st issue → #RNAmod #Epitranscriptomics #HalloweenScience
#rnasky #microsky
Reposted by Olivier Namy 🧬🧪
Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago
October 24, 2025 at 10:32 PM
Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago
Reposted by Olivier Namy 🧬🧪
Pelota, a ribosome rescue factor, unlocks the secret to longevity and age-defying health across species. This discovery sheds light on how quality control in protein synthesis can combat ...
🧵 Thread below
Full analysis: https://helixbrief.com/article/a2e1736b-7031-4cdb-98d7-78309181890c
🧵 Thread below
Full analysis: https://helixbrief.com/article/a2e1736b-7031-4cdb-98d7-78309181890c
October 17, 2025 at 4:36 PM
Pelota, a ribosome rescue factor, unlocks the secret to longevity and age-defying health across species. This discovery sheds light on how quality control in protein synthesis can combat ...
🧵 Thread below
Full analysis: https://helixbrief.com/article/a2e1736b-7031-4cdb-98d7-78309181890c
🧵 Thread below
Full analysis: https://helixbrief.com/article/a2e1736b-7031-4cdb-98d7-78309181890c
Probably one of the best European lab if you are interested in ribosome structure! Go go go
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...
www.uni-hamburg.de/en/stellenan...
Job advertisement
www.uni-hamburg.de
October 16, 2025 at 9:13 PM
Probably one of the best European lab if you are interested in ribosome structure! Go go go
Reposted by Olivier Namy 🧬🧪
A new family of ribosome hibernation factors in Archaea https://www.biorxiv.org/content/10.1101/2025.10.11.676729v1
October 12, 2025 at 4:16 AM
A new family of ribosome hibernation factors in Archaea https://www.biorxiv.org/content/10.1101/2025.10.11.676729v1
Reposted by Olivier Namy 🧬🧪
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 3, 2025 at 11:02 AM
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
Reposted by Olivier Namy 🧬🧪
New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
Nature Structural & Molecular Biology, Published online: 19 September 2025; doi:10.1038/s41594-025-01676-5By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.
go.nature.com
September 19, 2025 at 10:12 AM
New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
Reposted by Olivier Namy 🧬🧪
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features.
In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
September 12, 2025 at 7:23 PM
Reposted by Olivier Namy 🧬🧪
A large consortium of researchers introduces the term 'translon' to denote any transcriptome region that is decoded by ribosomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Translon: a single term for translated regions - Nature Methods
Nature Methods - Translon: a single term for translated regions
www.nature.com
September 5, 2025 at 1:30 PM
A large consortium of researchers introduces the term 'translon' to denote any transcriptome region that is decoded by ribosomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Olivier Namy 🧬🧪
Protocol for Disome-seq to identify transcriptome-wide ribosome collisions in yeast cells #protocol #starprotocols #cellpress
Protocol for Disome-seq to identify transcriptome-wide ribosome collisions in yeast cells
When translation elongation is hindered, stalled ribosomes can collide with trailing ribosomes and form ribosome collision complexes also known as disomes. Disomes are sensed in the cell to trigger signaling events, and therefore it is important to determine their frequency and distribution across transcripts. Here, we provide the protocol for Disome-seq in Saccharomyces cerevisiae (yeast) cells to enable transcriptome-wide detection of disomes. We describe the steps for yeast growth and isolati...
dlvr.it
August 27, 2025 at 3:09 PM
Protocol for Disome-seq to identify transcriptome-wide ribosome collisions in yeast cells #protocol #starprotocols #cellpress
Reposted by Olivier Namy 🧬🧪
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting #rnasky #microsky 🦠 m1G (TrmD) at position 37 modulates tRNA conformation on ribosome and suppresses +1 FS induced by tRNA-Pro (four base pair codon-anticodon)💫 smFRET & cryo doi.org/10.1038/s414...
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting - Nature Communications
tRNAs contain many chemical modifications that regulate their function. Integrating smFRET and cryo-EM approaches, this work demonstrates that m1G37 in tRNAProL stabilizes its conformation in the ribo...
doi.org
August 18, 2025 at 12:42 PM
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting #rnasky #microsky 🦠 m1G (TrmD) at position 37 modulates tRNA conformation on ribosome and suppresses +1 FS induced by tRNA-Pro (four base pair codon-anticodon)💫 smFRET & cryo doi.org/10.1038/s414...
Reposted by Olivier Namy 🧬🧪
🦠 Launching a bimonthly digest on RNA modifications and related topics in bacteria!🤩 First issue: Summer 2025. Shared here + by email, future ones will be quicker reads! 😅 #rnasky #microsky #ribosome Subscribe and share if you are interested! rnamodifupdates.substack.com/p/rna-modifi...
RNA modifications digest Summer 2025
Bimonthly newsletter: RNA modifications and related topics, mostly in bacteria. Summer 2025, first issue!
rnamodifupdates.substack.com
August 15, 2025 at 9:30 AM
🦠 Launching a bimonthly digest on RNA modifications and related topics in bacteria!🤩 First issue: Summer 2025. Shared here + by email, future ones will be quicker reads! 😅 #rnasky #microsky #ribosome Subscribe and share if you are interested! rnamodifupdates.substack.com/p/rna-modifi...
Reposted by Olivier Namy 🧬🧪
"C5 methylation of C1407 functions as a kinetic regulator in the E. coli rRNA to properly adjust the time frame for the selection of the correct tRNA–mRNA interaction" #rnasky #microsky #ribosome 🦠 pubs.acs.org/doi/10.1021/...
Methylation of Cytidine 1407 Increases the Lifetimes of the A-Site Ground and Excited States of E. coli 16S Ribosomal RNA
The C5 methylation of cytidine 1407 (C1407) in the E. coli 16S rRNA is a permanent modification. The methylation occurs directly at the A-site internal loop, a known dynamic hotspot in helix 44 (H44) ...
pubs.acs.org
August 13, 2025 at 2:02 PM
"C5 methylation of C1407 functions as a kinetic regulator in the E. coli rRNA to properly adjust the time frame for the selection of the correct tRNA–mRNA interaction" #rnasky #microsky #ribosome 🦠 pubs.acs.org/doi/10.1021/...
Reposted by Olivier Namy 🧬🧪
Frameshifting Stimulatory Sequence Induces Large Structural Change of Ribosomal Proteins When Bound to E. coli Ribosomes pubmed.ncbi.nlm.nih.gov/40788995/ #cryoem
August 12, 2025 at 6:40 PM
Frameshifting Stimulatory Sequence Induces Large Structural Change of Ribosomal Proteins When Bound to E. coli Ribosomes pubmed.ncbi.nlm.nih.gov/40788995/ #cryoem
Reposted by Olivier Namy 🧬🧪
Researchers developed a high-throughput ribosome profiling method using RNA amplification that works with tiny samples.
Applied to 70 COVID-19 patients, it revealed symptom severity links to mitochondrial translation decline and stop codon readthrough.
www.biorxiv.org/content/10.1...
Applied to 70 COVID-19 patients, it revealed symptom severity links to mitochondrial translation decline and stop codon readthrough.
www.biorxiv.org/content/10.1...
Ultra-parallel ribosome profiling platform with RNA-dependent RNA amplification
Translation regulation plays a pivotal role in the diversification of gene expression and the response to intra- and extracellular environmental cues. Ribosome profiling (or Ribo-Seq) serves as a sens...
www.biorxiv.org
August 8, 2025 at 2:13 PM
Researchers developed a high-throughput ribosome profiling method using RNA amplification that works with tiny samples.
Applied to 70 COVID-19 patients, it revealed symptom severity links to mitochondrial translation decline and stop codon readthrough.
www.biorxiv.org/content/10.1...
Applied to 70 COVID-19 patients, it revealed symptom severity links to mitochondrial translation decline and stop codon readthrough.
www.biorxiv.org/content/10.1...
Reposted by Olivier Namy 🧬🧪
Free tRNALeu shows flexible variable arm and CCA end, reshaped by LeuRS and ribosome binding #tRNA #StructuralBiology bit.ly/45PxJF5
July 31, 2025 at 1:51 PM
Free tRNALeu shows flexible variable arm and CCA end, reshaped by LeuRS and ribosome binding #tRNA #StructuralBiology bit.ly/45PxJF5
Reposted by Olivier Namy 🧬🧪
Finally out!
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
July 22, 2025 at 5:12 PM
Reposted by Olivier Namy 🧬🧪
Editor's Pick: Shen, Ye et al. review recent literature on the role of bacterial ribosome heterogeneity on facilitating rapid response to stress.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
July 21, 2025 at 2:37 PM
Editor's Pick: Shen, Ye et al. review recent literature on the role of bacterial ribosome heterogeneity on facilitating rapid response to stress.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Olivier Namy 🧬🧪
Structure of an archaeal ribosome reveals a divergent active site and hibernation factor | Nature Microbiology https://www.nature.com/articles/s41564-025-02065-w
Structure of an archaeal ribosome reveals a divergent active site and hibernation factor - Nature Microbiology
Sequence and structural analyses reveal a divergent peptidyl transferase centre and a hibernation factor in archaea.
www.nature.com
July 17, 2025 at 10:19 PM
Structure of an archaeal ribosome reveals a divergent active site and hibernation factor | Nature Microbiology https://www.nature.com/articles/s41564-025-02065-w
Reposted by Olivier Namy 🧬🧪
Insights on how ribosomal RNA modification distant from drug binding site can still affect drug binding, in mycobacterium 🦠 #rnasky #ribosome #microsky
Distant ribose 2'-O-methylation of 23S rRNA helix 69 pre-orders the capreomycin drug binding pocket at the ribosome subunit interface pubmed.ncbi.nlm.nih.gov/40626557/ #cryoem
July 10, 2025 at 7:33 AM
Reposted by Olivier Namy 🧬🧪
Pan-viral ORFs discovery using massively parallel ribosome profiling www.science.org/doi/10.1126/...
Pan-viral ORFs discovery using massively parallel ribosome profiling
Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...
www.science.org
June 20, 2025 at 6:36 PM
Pan-viral ORFs discovery using massively parallel ribosome profiling www.science.org/doi/10.1126/...
Reposted by Olivier Namy 🧬🧪
