Biophysical Journal
@biophysj.bsky.social
The premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research. Editor-in-Chief: Vasanthi Jayaraman.
#OPENACCESS: How protein hydration depends on amino acid composition, peptide conformation, and force fields. Johanna-Barbara Linse, Tobias M. Fischbach, and Jochen S. Hub.
www.cell.com
January 16, 2026 at 9:45 PM
#OPENACCESS: How protein hydration depends on amino acid composition, peptide conformation, and force fields. Johanna-Barbara Linse, Tobias M. Fischbach, and Jochen S. Hub.
#OPENACCESS: Dynamics of excitability in axonal trees. Laurie D. Cohen, Tamar Galateanu, and Shimon Marom.
www.cell.com
January 16, 2026 at 7:30 PM
#OPENACCESS: Dynamics of excitability in axonal trees. Laurie D. Cohen, Tamar Galateanu, and Shimon Marom.
#OPENACCESS: The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction. Ruichen Sui, Nicolae Moise, and Seth H. Weinberg.
www.cell.com
January 16, 2026 at 5:05 PM
#OPENACCESS: The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction. Ruichen Sui, Nicolae Moise, and Seth H. Weinberg.
Special issue call for papers: Viral Biophysics.
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January 16, 2026 at 2:31 PM
Special issue call for papers: Viral Biophysics.
In the New and Notable "Deciphering the mechanics of spindle positioning,"
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
www.cell.com
January 15, 2026 at 7:01 PM
In the New and Notable "Deciphering the mechanics of spindle positioning,"
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
Dechang Li highlights the paper "A Constitutive Model Deciphers the Viscoelastic Mechanics of Metaphase Spindle Positioning."
Like tiny “energy carts” in a factory shifting to busy assembly lines when orders (glucose) flood in, mitochondria in beta cells move toward the edge on glucose cues to power insulin release!
www.cell.com
January 15, 2026 at 3:04 PM
Like tiny “energy carts” in a factory shifting to busy assembly lines when orders (glucose) flood in, mitochondria in beta cells move toward the edge on glucose cues to power insulin release!
Experimental determination of backbone conformational change entropy on helix formation by model peptides—a step to better understand protein folding.
www.cell.com
January 14, 2026 at 7:01 PM
Experimental determination of backbone conformational change entropy on helix formation by model peptides—a step to better understand protein folding.
Fast adaptation in hearing? A viscoelastic model validated by experiments, explains receptor-current sensitivity, hysteresis, phase leads, high-pass filtering, and dynamic range in outer hair bundles.
www.cell.com
January 14, 2026 at 3:04 PM
Fast adaptation in hearing? A viscoelastic model validated by experiments, explains receptor-current sensitivity, hysteresis, phase leads, high-pass filtering, and dynamic range in outer hair bundles.
#OPENACCESS: Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell. Luis Perez, Xue Wen Ng, Michael Mohs, David W. Piston, and Shankar Mukherji.
www.cell.com
January 13, 2026 at 8:03 PM
#OPENACCESS: Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell. Luis Perez, Xue Wen Ng, Michael Mohs, David W. Piston, and Shankar Mukherji.
In the New and Notable "3D cellular scaffolds reveal a hidden sensitivity to fluid-solid coupling," Samantha Cheung and X. Wendy Gu highlight the article, "Biphasic Mechanical Loading Disrupts Cytoskeletal Symmetry in 3D Architected Scaffolds."
January 13, 2026 at 5:30 PM
In the New and Notable "3D cellular scaffolds reveal a hidden sensitivity to fluid-solid coupling," Samantha Cheung and X. Wendy Gu highlight the article, "Biphasic Mechanical Loading Disrupts Cytoskeletal Symmetry in 3D Architected Scaffolds."
In the New and Notable "Counting conformations by calorimetry," Hue Sun Chan highlights the paper, "Backbone conformational entropy change in helix folding."
www.cell.com
January 13, 2026 at 3:03 PM
In the New and Notable "Counting conformations by calorimetry," Hue Sun Chan highlights the paper, "Backbone conformational entropy change in helix folding."
Like dancers adjusting moves on a crowded 3D dance floor— fibroblasts sense subtle collagen “floor texture” and reshuffle their steps, but without Caveolin-1 they lose rhythm and can’t feel the groove at the cell-matrix interface!
www.cell.com
January 12, 2026 at 8:03 PM
Like dancers adjusting moves on a crowded 3D dance floor— fibroblasts sense subtle collagen “floor texture” and reshuffle their steps, but without Caveolin-1 they lose rhythm and can’t feel the groove at the cell-matrix interface!
The authors decode the formation of liquid-liquid phase separation in proteins and highlight that the specific vs non-specific interactions between the coiled-coil proteins play a direct role in propensity of LLPS.
www.cell.com
January 12, 2026 at 5:04 PM
The authors decode the formation of liquid-liquid phase separation in proteins and highlight that the specific vs non-specific interactions between the coiled-coil proteins play a direct role in propensity of LLPS.
New study introduces a demons algorithm-based approach for traction force microscopy, achieving faster and more accurate force measurements with reduced sensitivity to image blur.
www.cell.com
January 12, 2026 at 2:02 PM
New study introduces a demons algorithm-based approach for traction force microscopy, achieving faster and more accurate force measurements with reduced sensitivity to image blur.
Special issue call for papers: Viral Biophysics.
January 9, 2026 at 8:30 PM
Special issue call for papers: Viral Biophysics.
#OPENACCESS: All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level. Jean-Sébastien Rougier, Eugene Glushkov, Sabrina Guichard, Jan Kucera, Vadim Zeeb, and Hugues Abriel.
www.cell.com
January 9, 2026 at 7:02 PM
#OPENACCESS: All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level. Jean-Sébastien Rougier, Eugene Glushkov, Sabrina Guichard, Jan Kucera, Vadim Zeeb, and Hugues Abriel.
#OPENACCESS: Tracking the morphological evolution of neuronal dendrites by first-passage analysis. Fabian H. Kreten, Barbara A. Niemeyer, Ludger Santen, and Reza Shaebani.
www.cell.com
January 9, 2026 at 4:30 PM
#OPENACCESS: Tracking the morphological evolution of neuronal dendrites by first-passage analysis. Fabian H. Kreten, Barbara A. Niemeyer, Ludger Santen, and Reza Shaebani.
#OPENACCESS: Does amyloid fibril nucleation occur at surfaces only? Jon Pallbo, Sara Linse, and Ulf Olsson.
www.cell.com
January 9, 2026 at 3:02 PM
#OPENACCESS: Does amyloid fibril nucleation occur at surfaces only? Jon Pallbo, Sara Linse, and Ulf Olsson.
#OPENACCESS: Like adding food coloring to water slightly changes how sound ripples through it, staining cells (e.g., calcein) tweaks their acoustic fingerprint — a 2.7% dip in impedance in MCF-7 cells!
www.cell.com
January 8, 2026 at 7:01 PM
#OPENACCESS: Like adding food coloring to water slightly changes how sound ripples through it, staining cells (e.g., calcein) tweaks their acoustic fingerprint — a 2.7% dip in impedance in MCF-7 cells!
In the New and Notable "Plectin: The cytoskeletal cross-linker that shields the cell from mechanical damage," Farhan Chowdhury highlights the paper, "Plectin affects cell viscoelasticity at small and large deformations."
www.cell.com
January 8, 2026 at 3:01 PM
In the New and Notable "Plectin: The cytoskeletal cross-linker that shields the cell from mechanical damage," Farhan Chowdhury highlights the paper, "Plectin affects cell viscoelasticity at small and large deformations."
#OPENACCESS: Biomolecular condensates as cellular memory modules: Thermodynamic principles and plant stress adaptation. Sukhendu Maity and Panagiotis Nikolaou Moschou.
www.cell.com
January 7, 2026 at 9:30 PM
#OPENACCESS: Biomolecular condensates as cellular memory modules: Thermodynamic principles and plant stress adaptation. Sukhendu Maity and Panagiotis Nikolaou Moschou.
In the New and Notable "Glucose-driven mitochondrial transport adds a new dimension to mitochondrial heterogeneity," Abdul Haseeb Khan and Tatsuhisa Tsuboi highlight the paper "Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell."
January 7, 2026 at 7:00 PM
In the New and Notable "Glucose-driven mitochondrial transport adds a new dimension to mitochondrial heterogeneity," Abdul Haseeb Khan and Tatsuhisa Tsuboi highlight the paper "Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell."
NMR and MD simulations-based study shows that the conformational preferences of an RNA internal loop are dictated by the base pairs flanking the loop.
www.cell.com
January 7, 2026 at 4:45 PM
NMR and MD simulations-based study shows that the conformational preferences of an RNA internal loop are dictated by the base pairs flanking the loop.
#OPENACCESS: Strong yet flexible, how do cells manage both? Conboy et al. use single-cell compression measurements to show that the cross-linker protein plectin stiffens fibroblasts and organizes actin–vimentin networks to shield cells from mechanical damage.
www.cell.com
January 7, 2026 at 3:01 PM
#OPENACCESS: Strong yet flexible, how do cells manage both? Conboy et al. use single-cell compression measurements to show that the cross-linker protein plectin stiffens fibroblasts and organizes actin–vimentin networks to shield cells from mechanical damage.
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/the-whi...
The Whispers between the Cell and the Matrix: Fibroblasts Entrapped in a Collagen Network
Our research focuses on the interaction between fibroblasts and the surrounding 3D matrix at the cell–extracellular matrix (ECM) interphase. Using confocal reflectance microscopy, we quantitatively as...
www.biophysics.org
January 6, 2026 at 3:38 PM
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/the-whi...