Biophysical Journal
@biophysj.bsky.social
The premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research. Editor-in-Chief: Vasanthi Jayaraman.
Cells rolling in microvessels = like shopping carts with varying wheel grip. Yonggang Li et al. (2025) link molecular bond dynamics to how fast cells “roll” in blood flow. Tiny stickiness = big traffic effects!
A cross-scale analysis for the determinants of bonding dynamics on the distributions of rolling velocities of cells in microvessels
The interplay between subcellular adhesion dynamics and cellular-scale deformations under shear flow drives key physiological and pathological processes. Whereas both bond kinetics and fluid-cell…
www.cell.com
November 13, 2025 at 7:03 PM
Cells rolling in microvessels = like shopping carts with varying wheel grip. Yonggang Li et al. (2025) link molecular bond dynamics to how fast cells “roll” in blood flow. Tiny stickiness = big traffic effects!
Special issue call for papers: Viral Biophysics.
www.biophysics.org
November 13, 2025 at 2:30 PM
Special issue call for papers: Viral Biophysics.
The authors present initial experimental evidence detailing the biophysical mechanisms by which SARS-CoV-2 interferes with pulmonary surfactant function, highlighting the role of the S2 subunit of the viral spike protein in inducing this inhibition.
Biophysical mechanisms of SARS-CoV-2-induced surfactant inhibition
Surfactant replacement has been studied as a supportive therapy for managing COVID-19-induced acute respiratory distress syndrome. The clinical applications require biophysical understanding of the…
www.cell.com
November 12, 2025 at 7:03 PM
The authors present initial experimental evidence detailing the biophysical mechanisms by which SARS-CoV-2 interferes with pulmonary surfactant function, highlighting the role of the S2 subunit of the viral spike protein in inducing this inhibition.
#OPENACCESS: Reactive oxygen species counteract zebrafish wound contraction and promote wound healing. Chang Ding, Linlin Li, Yueyang Wang, Hong-Anh A. Nguyen, Deva D. Chan, David M. Umulis, Adrian T. Buganza, and Qing Deng.
Reactive oxygen species counteract zebrafish wound contraction and promote wound healing
Reactive oxygen species (ROS) are second messengers that drive wound closure. However, the mechanism by which ROS regulate wound contraction to facilitate wound healing remains unclear. Here, we…
www.cell.com
November 12, 2025 at 3:03 PM
#OPENACCESS: Reactive oxygen species counteract zebrafish wound contraction and promote wound healing. Chang Ding, Linlin Li, Yueyang Wang, Hong-Anh A. Nguyen, Deva D. Chan, David M. Umulis, Adrian T. Buganza, and Qing Deng.
In the New and Notable "Milestone for the interpretation of muscle x-ray diffraction patterns," Anthony L. Hessel highlights the paper "Annotating the X-ray diffraction pattern of vertebrate striated muscle."
Milestone for the interpretation of muscle x-ray diffraction patterns
Research on mammalian cardiac and skeletal muscle spans fields such as exercise physiology, longevity science, and inherited myopathies. Muscle is composed of many repeating contractile units, called…
www.cell.com
November 11, 2025 at 7:04 PM
In the New and Notable "Milestone for the interpretation of muscle x-ray diffraction patterns," Anthony L. Hessel highlights the paper "Annotating the X-ray diffraction pattern of vertebrate striated muscle."
#OPENACCESS: Nayak et al. develop a computational whole-cell model revealing how actin-microtubule crosstalk drives cell polarity, shape, and migration behaviors.
Modeling actin-microtubule crosstalk in migrating cells
Actin-microtubule crosstalk regulates the polarity and morphology of migrating cells and encompasses mechanical interactions, mediated by cross-linkers, molecular motors, and cytoskeletal regulators.…
www.cell.com
November 11, 2025 at 3:04 PM
#OPENACCESS: Nayak et al. develop a computational whole-cell model revealing how actin-microtubule crosstalk drives cell polarity, shape, and migration behaviors.
#OPENACCESS: The study reveals key features of the different structural states of the 5 ‘and 3’ UTRs of the dengue virus during its replication, highlighting the adaptability of the UTR structures and contributing to the development of targeted drugs. buff.ly/dtWrfLJ
Structural dynamics of dengue virus UTRs and their cyclization
The dengue virus (DENV) poses a significant threat to human health, accounting for approximately 400 million infections each year. Its genome features a circular structure that facilitates…
www.cell.com
November 10, 2025 at 7:02 PM
#OPENACCESS: The study reveals key features of the different structural states of the 5 ‘and 3’ UTRs of the dengue virus during its replication, highlighting the adaptability of the UTR structures and contributing to the development of targeted drugs. buff.ly/dtWrfLJ
#OPENACCESS: MreB filaments in the elongasome modulate E. coli membrane curvature. Becca W.A. Baileeves, Anthony D.Q. Hoang, Timothy D.H. Bugg, and Phillip J. Stansfeld.
MreB filaments in the elongasome modulate E. coli membrane curvature
MreB, a bacterial actin homolog, plays a pivotal role in defining the shape of rod-shaped bacteria by coordinating peptidoglycan synthesis during cell elongation. It forms filaments that interact…
www.cell.com
November 10, 2025 at 3:04 PM
#OPENACCESS: MreB filaments in the elongasome modulate E. coli membrane curvature. Becca W.A. Baileeves, Anthony D.Q. Hoang, Timothy D.H. Bugg, and Phillip J. Stansfeld.
Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang.
www.biophysics.org
November 7, 2025 at 8:30 PM
Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang.
In the New and Notable "A multimodal glimpse into the amyloid precursor protein intracellular domain ensembles," Veronica Isabel Dodero highlights the paper "Unraveling the conformational landscape of amyloid precursor protein intracellular domain."
A multimodal glimpse into the amyloid precursor protein intracellular domain ensembles
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered protein (IDP) implicated in Alzheimer disease and amyloid lateral sclerosis (1). AICD translocates to the…
www.cell.com
November 7, 2025 at 7:01 PM
In the New and Notable "A multimodal glimpse into the amyloid precursor protein intracellular domain ensembles," Veronica Isabel Dodero highlights the paper "Unraveling the conformational landscape of amyloid precursor protein intracellular domain."
Cells can switch vibes! Lin-Ru Qiao et al. (2025) show single cells shift from fluid-like to solid-like behavior—like going from jelly to jawbreaker depending on mechanical cues.
A transition of dynamic rheological responses of single cells: From fluid-like to solid-like
The mechanical properties of cells are crucial for elucidating various physiological and pathological processes. Cells are found to exhibit a universal power-law rheological behavior at low…
www.cell.com
November 7, 2025 at 3:03 PM
Cells can switch vibes! Lin-Ru Qiao et al. (2025) show single cells shift from fluid-like to solid-like behavior—like going from jelly to jawbreaker depending on mechanical cues.
#OPENACCESS: Unraveling the conformational landscape of amyloid precursor protein intracellular domain. Nabanita Mandal and Marie Skepö.
Unraveling the conformational landscape of amyloid precursor protein intracellular domain
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important…
www.cell.com
November 6, 2025 at 7:02 PM
#OPENACCESS: Unraveling the conformational landscape of amyloid precursor protein intracellular domain. Nabanita Mandal and Marie Skepö.
#OPENACCESS: Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines. Kimberly J. McCabe, María Hernández Mesa, and Padmini Rangamani.
Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines
Spatiotemporal dynamics of calcium regulation in subcellular regions is critical for precise local control of cell signaling. Recent studies have shown that, in addition to biochemical control of…
www.cell.com
November 6, 2025 at 3:01 PM
#OPENACCESS: Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines. Kimberly J. McCabe, María Hernández Mesa, and Padmini Rangamani.
In the New and Notable "Single-cell memory matters in collective migration ," Ruihan Hou and Jinglei Hu highlight the paper "Time-dependent active force drives periodic reversal in collective cell migration."
Single-cell memory matters in collective migration
The coordinated migration of collective cells within confluent tissues is essential for various physiological and pathological processes, including embryogenesis, wound healing, and cancer metastasis…
www.cell.com
November 5, 2025 at 7:01 PM
In the New and Notable "Single-cell memory matters in collective migration ," Ruihan Hou and Jinglei Hu highlight the paper "Time-dependent active force drives periodic reversal in collective cell migration."
#OPENACCESS: OsmoFold it, don’t guess it! New open-source tool predicts how osmolytes affect protein stability and folding.
OsmoFold: A high-throughput tool for predicting the impact of osmolytes on protein structure
Small molecules can affect a protein’s fold and stability. Physical chemistry conceptualizes this effect using Tanford’s transfer model, which describes the change in free energy of a protein upon…
www.cell.com
November 5, 2025 at 3:01 PM
#OPENACCESS: OsmoFold it, don’t guess it! New open-source tool predicts how osmolytes affect protein stability and folding.
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/flexibi...
Flexibility Matters: Challenges of Binding Disordered Regions
We are excited to share a cover image of the November 4 issue of Biophysical Journal, which captures the dynamic interaction between two proteins central to neurological health: Tau and BIN1. The figu...
www.biophysics.org
November 4, 2025 at 3:42 PM
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/flexibi...
Special issue call for papers: Martin Karplus: In Memoriam.
November 3, 2025 at 2:30 PM
Special issue call for papers: Martin Karplus: In Memoriam.
Special issue call for papers: Viral Biophysics.
www.biophysics.org
October 31, 2025 at 7:30 PM
Special issue call for papers: Viral Biophysics.
#OPENACCESS: An application of segmented fluorescence correlation spectroscopy to investigate the dynamics of the PARP1 protein reveals its reduced mobility at DNA damage sites and unaltered PARP1 diffusion outside the DNA damage region.
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Measuring PARP1 mobility at DNA damage sites by segmented fluorescence correlation spectroscopy
Segmented fluorescence correlation spectroscopy (FCS) improves the accuracy of FCS measurements in cells by analyzing data in short temporal segments. We have recently demonstrated the possibility of…
www.cell.com
October 30, 2025 at 6:03 PM
#OPENACCESS: An application of segmented fluorescence correlation spectroscopy to investigate the dynamics of the PARP1 protein reveals its reduced mobility at DNA damage sites and unaltered PARP1 diffusion outside the DNA damage region.
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New study uses super-resolution imaging to study PIP2 clustering in mast cells, showing that antimicrobial CPC disrupts this organization and inhibits cell function at low (µM) doses.
Nanoscale clustering and dynamics of phosphatidylinositol 4,5-bisphosphate in an immune cell model
Mast cells mediate their immuno- and neuro-modulatory effects by releasing granules containing bioactive substances. Phosphatidylinositol 4,5-bisphosphate (PIP2), enriched at the plasma membrane, is…
www.cell.com
October 29, 2025 at 2:05 PM
New study uses super-resolution imaging to study PIP2 clustering in mast cells, showing that antimicrobial CPC disrupts this organization and inhibits cell function at low (µM) doses.
#OPENACCESS: Think of FCS as filming a hummingbird’s wings—fast, tiny, and hard to see. Pandey et al. tested different super-resolution “slow-motion modes” to see which one turns that blur into crisp frame-by-frame motion. Their guide helps you pick the best mode to catch the flaps!
Super-resolution algorithms for imaging FCS enhancement: A comparative study
Understanding the structure and dynamics of biological systems is often limited by the trade-off between spatial and temporal resolution. Imaging fluorescence correlation spectroscopy (ImFCS) is a…
www.cell.com
October 28, 2025 at 6:05 PM
#OPENACCESS: Think of FCS as filming a hummingbird’s wings—fast, tiny, and hard to see. Pandey et al. tested different super-resolution “slow-motion modes” to see which one turns that blur into crisp frame-by-frame motion. Their guide helps you pick the best mode to catch the flaps!
Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang.
www.biophysics.org
October 28, 2025 at 1:32 PM
Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang.
#OPENACCESS: Assessing the role of all the relevant timescales that affect the observed photon emission, fluorescence lifetimes, rotational correlation times, and the chain dynamics in this integrated approach combining all-atom MD simulations with single-molecule FRET spectroscopy.
Accuracy of distance distributions and dynamics from single-molecule FRET
Single-molecule spectroscopy combined with Förster resonance energy transfer is widely used to quantify distance dynamics and distributions in biomolecules. Most commonly, measurements are…
www.cell.com
October 27, 2025 at 2:06 PM
#OPENACCESS: Assessing the role of all the relevant timescales that affect the observed photon emission, fluorescence lifetimes, rotational correlation times, and the chain dynamics in this integrated approach combining all-atom MD simulations with single-molecule FRET spectroscopy.
#OPENACCESS: Variational calculus approach to Zernike polynomials with application to FCS. Ivan Gligonov and Jörg Enderlein.
Variational calculus approach to Zernike polynomials with application to FCS
Zernike polynomials are a sequence of orthogonal polynomials that play a crucial role in optics and, in particular, modeling microscopy systems. Introduced by Frits Zernike in 1934, they are…
www.cell.com
October 24, 2025 at 2:04 PM
#OPENACCESS: Variational calculus approach to Zernike polynomials with application to FCS. Ivan Gligonov and Jörg Enderlein.
Special issue call for papers: Martin Karplus: In Memoriam.
www.biophysics.org
October 23, 2025 at 7:30 PM
Special issue call for papers: Martin Karplus: In Memoriam.