Wilson Lab
@wilsonlab.bsky.social
Ribosomes & Translation Regulation; Antibiotics & Resistance Mechanisms; Structural Biology & Cryo-EM; University of Hamburg.
Reposted by Wilson Lab
🎉Thrilled to share that our lab has been awarded an ERC Synergy Grant @erc.europa.eu! Excited for amazing collaborations with the Pertschy (Uni Graz), Henras (CBI Toulouse), and Woodson (Johns Hopkins) labs.
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
November 7, 2025 at 1:50 PM
🎉Thrilled to share that our lab has been awarded an ERC Synergy Grant @erc.europa.eu! Excited for amazing collaborations with the Pertschy (Uni Graz), Henras (CBI Toulouse), and Woodson (Johns Hopkins) labs.
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
Reposted by Wilson Lab
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
codon usage
About the Conference
Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...
sites.google.com
November 5, 2025 at 10:55 PM
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
Reposted by Wilson Lab
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
November 5, 2025 at 1:18 AM
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
Reposted by Wilson Lab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Wilson Lab
#GetTheMessage - Did you know? After 300+ days in the hospital, Baby KJ went home—sitting up, waving, and growing. His parents were once told to consider end-of-life care. Now they're watching him thrive, thanks to mRNA technology.
www.chop.edu/news/worlds-...
www.chop.edu/news/worlds-...
World's First Patient Treated with Personalized CRISPR Gene Editing Therapy at Children’s Hospital of Philadelphia
Landmark study from CHOP and Penn Medicine showcases the power of customized gene editing therapy to treat patient with rare metabolic disease.
www.chop.edu
October 30, 2025 at 4:00 AM
#GetTheMessage - Did you know? After 300+ days in the hospital, Baby KJ went home—sitting up, waving, and growing. His parents were once told to consider end-of-life care. Now they're watching him thrive, thanks to mRNA technology.
www.chop.edu/news/worlds-...
www.chop.edu/news/worlds-...
It was a fantastic mini-ribosome meeting with great science, lots of historical anecdotes and speeches as well as Swedish singing. Nice to catch up with old friends and make new ones! Special thanks to Suparna, Maria Selmer and Magnus Johansson for the organization!
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
October 30, 2025 at 1:32 PM
It was a fantastic mini-ribosome meeting with great science, lots of historical anecdotes and speeches as well as Swedish singing. Nice to catch up with old friends and make new ones! Special thanks to Suparna, Maria Selmer and Magnus Johansson for the organization!
Reposted by Wilson Lab
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
October 30, 2025 at 10:13 AM
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
Reposted by Wilson Lab
EF-G variants (fusA mutants) slow down ribosome translocation only when the ribosome is bound by an aminoglycoside => the antibiotic isn’t displaced, but translation on that ribosome is effectively stalled 🦠 rdcu.be/eNt96
Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Nature Communications - Mutations in elongation factor G protect bacteria from aminoglycoside antibiotics through unknown mechanisms. Here, the authors show that the mutations selectively slow the...
rdcu.be
October 30, 2025 at 1:10 PM
EF-G variants (fusA mutants) slow down ribosome translocation only when the ribosome is bound by an aminoglycoside => the antibiotic isn’t displaced, but translation on that ribosome is effectively stalled 🦠 rdcu.be/eNt96
Reposted by Wilson Lab
25 years on from publishing the structure of the bacterial 30S ribosomal subunit, alumni, collaborators & friends of Venki Ramakrishnan’s group joined us for a symposium celebrating the legacy of this work.
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
October 29, 2025 at 12:11 PM
25 years on from publishing the structure of the bacterial 30S ribosomal subunit, alumni, collaborators & friends of Venki Ramakrishnan’s group joined us for a symposium celebrating the legacy of this work.
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
Reposted by Wilson Lab
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
October 29, 2025 at 5:22 PM
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
Reposted by Wilson Lab
Finally out in print! Long time project with @olexandr.bsky.social and the PHENIX group. Refinement of X-ray and CryoEM structures, using Machine Learned Potentials as the back end to help fitting. This fulfills the old dream of doing QM refinement, but very very cheap www.nature.com/articles/s41...
AQuaRef: machine learning accelerated quantum refinement of protein structures - Nature Communications
AQuaRef employs machine learning to refine protein structures from cryo-EM and X-ray data in Phenix. It achieves quantum-level precision, improving model geometry and fit to the data while reducing ov...
www.nature.com
October 23, 2025 at 3:20 PM
Finally out in print! Long time project with @olexandr.bsky.social and the PHENIX group. Refinement of X-ray and CryoEM structures, using Machine Learned Potentials as the back end to help fitting. This fulfills the old dream of doing QM refinement, but very very cheap www.nature.com/articles/s41...
Reposted by Wilson Lab
End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC https://www.biorxiv.org/content/10.1101/2025.10.17.682689v1
October 20, 2025 at 1:47 PM
End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC https://www.biorxiv.org/content/10.1101/2025.10.17.682689v1
Reposted by Wilson Lab
🚨 Abstract submission extended to Oct 21!
Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹
Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna.
👉 cryoem-symposium.pages.ist.ac.at
Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹
Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna.
👉 cryoem-symposium.pages.ist.ac.at
October 17, 2025 at 1:51 PM
🚨 Abstract submission extended to Oct 21!
Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹
Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna.
👉 cryoem-symposium.pages.ist.ac.at
Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹
Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna.
👉 cryoem-symposium.pages.ist.ac.at
Reposted by Wilson Lab
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...
www.uni-hamburg.de/en/stellenan...
Job advertisement
www.uni-hamburg.de
October 16, 2025 at 4:02 PM
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...
www.uni-hamburg.de/en/stellenan...
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...
www.uni-hamburg.de/en/stellenan...
Job advertisement
www.uni-hamburg.de
October 16, 2025 at 4:02 PM
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...
www.uni-hamburg.de/en/stellenan...
Reposted by Wilson Lab
Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
October 13, 2025 at 4:26 PM
Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
Reposted by Wilson Lab
Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation | Open Biology
Transfer RNAs (tRNAs) and their modifications are central to bacterial translation
and physiology, yet their roles in stress adaptation remain underexplored. While extensively
studied in eukaryotes, a...
doi.org
October 8, 2025 at 2:02 PM
Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
Reposted by Wilson Lab
The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
The mechanistic basis of cargo selection during Golgi maturation
Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.
www.science.org
October 6, 2025 at 11:39 AM
The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
Reposted by Wilson Lab
Reposted by Wilson Lab
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 3, 2025 at 11:02 AM
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
Reposted by Wilson Lab
We combine our yeast genetics experiments with the massive body of literature data to make a case for 40S scanning of 5’UTRs of by 1D diffusion (finalised version): m.rnajournal.cshlp.org/content/31/1...
RNA | Mobile
https://m.rnajournal.cshlp.org/content/31/10/…
October 4, 2025 at 2:05 AM
We combine our yeast genetics experiments with the massive body of literature data to make a case for 40S scanning of 5’UTRs of by 1D diffusion (finalised version): m.rnajournal.cshlp.org/content/31/1...
Reposted by Wilson Lab
Giant DNA viruses taking on translation factors!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...
www.biorxiv.org
October 4, 2025 at 1:42 PM
Giant DNA viruses taking on translation factors!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Wilson Lab
Finally! This was really missing.
wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports
Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report
Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric
www.rcsb.org
September 26, 2025 at 7:09 PM
Finally! This was really missing.