RNA Society Journal
@rnajournal.bsky.social
The official journal of the RNA Society. Featuring cutting edge research in RNA biology.
https://rnajournal.cshlp.org
https://rnajournal.cshlp.org
IsoformMapper creates protein networks from AlphaFold models and uses InfoMap community detection to compare isoform structures and visualize alternative splicing consequences via alluvial diagrams bit.ly/49n4USa
November 18, 2025 at 2:32 PM
IsoformMapper creates protein networks from AlphaFold models and uses InfoMap community detection to compare isoform structures and visualize alternative splicing consequences via alluvial diagrams bit.ly/49n4USa
Conserved protein Seb1 that interacts with RNA polymerase II and RNA is an anti-pausing transcription elongation factor bit.ly/4pbUQzQ
November 17, 2025 at 12:57 PM
Conserved protein Seb1 that interacts with RNA polymerase II and RNA is an anti-pausing transcription elongation factor bit.ly/4pbUQzQ
LC-MS based quantification of m6A, m6Am and inosine challenges the view of m6A as a dynamic modification and shows m6Am potential as a dynamic, reversible RNA methylation mark in total poly(A) RNA bit.ly/4hnU4vI
November 14, 2025 at 7:29 PM
LC-MS based quantification of m6A, m6Am and inosine challenges the view of m6A as a dynamic modification and shows m6Am potential as a dynamic, reversible RNA methylation mark in total poly(A) RNA bit.ly/4hnU4vI
Ordered Two-Template Relay (OTTR) appends adapters to RNA end-to-end cDNA during reverse transcription. We optimized end-precision and low-input, gel-based or automation-compatible protocols bit.ly/4gRL6al
November 13, 2025 at 3:57 PM
Ordered Two-Template Relay (OTTR) appends adapters to RNA end-to-end cDNA during reverse transcription. We optimized end-precision and low-input, gel-based or automation-compatible protocols bit.ly/4gRL6al
The methylation status of protein DRBD18 influences its role in the U-indel RNA editing of A6 and COIII mRNAs bit.ly/4jrnQ4P
November 12, 2025 at 3:50 PM
The methylation status of protein DRBD18 influences its role in the U-indel RNA editing of A6 and COIII mRNAs bit.ly/4jrnQ4P
Welcome to rRFtargetDB! It is a database of rRNA-derived fragments, a novel class of emerging post-transcriptional regulators of gene expression likely binding to transcripts of their target genes bit.ly/40kAqtH
November 12, 2025 at 3:47 PM
Welcome to rRFtargetDB! It is a database of rRNA-derived fragments, a novel class of emerging post-transcriptional regulators of gene expression likely binding to transcripts of their target genes bit.ly/40kAqtH
Intra-host quasispecies as disease determinant, and precursor of a diversifying virosphere bit.ly/3Cbc0uN
November 10, 2025 at 3:15 PM
Intra-host quasispecies as disease determinant, and precursor of a diversifying virosphere bit.ly/3Cbc0uN
A genome-wide screen revealed that proteins lacking stable structures can be just as essential as folded ones. Among them, FAM32A plays a crucial role in RNA splicing bit.ly/4o7muy3
November 7, 2025 at 8:27 PM
A genome-wide screen revealed that proteins lacking stable structures can be just as essential as folded ones. Among them, FAM32A plays a crucial role in RNA splicing bit.ly/4o7muy3
A PLP-RCA method enables simultaneous, in situ detection of AAV transgene DNA and mRNA at single-cell resolution, enabling the analysis of genome processing and transduction efficiency bit.ly/4qoAR2g
November 5, 2025 at 5:16 PM
A PLP-RCA method enables simultaneous, in situ detection of AAV transgene DNA and mRNA at single-cell resolution, enabling the analysis of genome processing and transduction efficiency bit.ly/4qoAR2g
By analyzing the subcellular localization of various UPF1 mutants, we show that UPF1’s nuclear-cytoplasmic shuttling is independent of its ATPase and RNA binding activities, with RNA binding itself being a key determinant of its cytoplasmic retention bit.ly/3IFlQII
November 4, 2025 at 3:07 PM
By analyzing the subcellular localization of various UPF1 mutants, we show that UPF1’s nuclear-cytoplasmic shuttling is independent of its ATPase and RNA binding activities, with RNA binding itself being a key determinant of its cytoplasmic retention bit.ly/3IFlQII
Molecular dynamics reveal how Mg²⁺, K⁺ and Gdm⁺ synergistically drive allosteric changes in the ykkC-I riboswitch aptamer, fine-tuning the RNA conformational landscape for function bit.ly/4hgs9ze
November 3, 2025 at 6:26 PM
Molecular dynamics reveal how Mg²⁺, K⁺ and Gdm⁺ synergistically drive allosteric changes in the ykkC-I riboswitch aptamer, fine-tuning the RNA conformational landscape for function bit.ly/4hgs9ze
NMR structures and ³J couplings combined with MD and maximum entropy refinement yield ensembles consistent with experiment, revealing dynamic conformations of Omicron s2m RNA bit.ly/4nUTycB
October 31, 2025 at 5:45 PM
NMR structures and ³J couplings combined with MD and maximum entropy refinement yield ensembles consistent with experiment, revealing dynamic conformations of Omicron s2m RNA bit.ly/4nUTycB
DEAD-box protein Prp5 hydrolyzes ATP/ATPγS to drive prespliceosome formation. ATP is dispensable in the absence of Sub2, which is not essential, but facilitates splicing by stabilizing Msl5 binding bit.ly/4nw3sB3
October 30, 2025 at 8:40 PM
DEAD-box protein Prp5 hydrolyzes ATP/ATPγS to drive prespliceosome formation. ATP is dispensable in the absence of Sub2, which is not essential, but facilitates splicing by stabilizing Msl5 binding bit.ly/4nw3sB3
SpDis3L2-U13 RNA crystal structure further unveils its degradation mechanism. A single substitution at A756 disrupts Dis3L2’s ability to process structured RNAs, highlighting a key functional residue bit.ly/4pTuJyO
October 29, 2025 at 2:10 PM
SpDis3L2-U13 RNA crystal structure further unveils its degradation mechanism. A single substitution at A756 disrupts Dis3L2’s ability to process structured RNAs, highlighting a key functional residue bit.ly/4pTuJyO
Tiny ocean creatures called diplonemids bend the rules of genetics! Their genes are packed with unusual introns, yet their editing system works fine, showing the flexibility of life bit.ly/3KUBOPC
Splice site diversity and abundance of non-canonical introns in diplonemids (Diplonemea, Euglenozoa)
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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October 28, 2025 at 9:06 PM
Tiny ocean creatures called diplonemids bend the rules of genetics! Their genes are packed with unusual introns, yet their editing system works fine, showing the flexibility of life bit.ly/3KUBOPC
This work highlights the conserved role of NMD in the degradation of lncRNAs in an RNAi-capable budding yeast and provides insight into the functional impact of endogenous RNAi on the transcriptome bit.ly/3IvOmwj
October 27, 2025 at 3:21 PM
This work highlights the conserved role of NMD in the degradation of lncRNAs in an RNAi-capable budding yeast and provides insight into the functional impact of endogenous RNAi on the transcriptome bit.ly/3IvOmwj
Crystal structure of the LIG-KIN domains of fungal tRNA ligase Trl1 reveals interdomain assembly and RNA transfer model, offering insight into a possible antifungal target bit.ly/3IZ7SBn
October 24, 2025 at 5:40 PM
Crystal structure of the LIG-KIN domains of fungal tRNA ligase Trl1 reveals interdomain assembly and RNA transfer model, offering insight into a possible antifungal target bit.ly/3IZ7SBn
Loss of a base (A3027) in the sarcin/ricin loop (PDB 4V7R) of 25S rRNA is sensed by factors detecting slow-moving ribosomes. Ubiquitination of the small subunit occurs, despite large subunit damage bit.ly/4pRJfHD
October 23, 2025 at 4:29 PM
Loss of a base (A3027) in the sarcin/ricin loop (PDB 4V7R) of 25S rRNA is sensed by factors detecting slow-moving ribosomes. Ubiquitination of the small subunit occurs, despite large subunit damage bit.ly/4pRJfHD
Desthiobiotin (DTB)-modified and TAMRA-modified 2''OMeNAD+ are RNA 2'-phosphotransferase (Tpt1) poisons that enable affinity-tagging and fluorescence-tagging of internal RNA 2'-phosphate groups bit.ly/46dMUHZ
October 22, 2025 at 4:10 PM
Desthiobiotin (DTB)-modified and TAMRA-modified 2''OMeNAD+ are RNA 2'-phosphotransferase (Tpt1) poisons that enable affinity-tagging and fluorescence-tagging of internal RNA 2'-phosphate groups bit.ly/46dMUHZ
The #RNA editing enzyme ADAR1 is an important target for many cancers. This study evaluated ZYS-1, a recently reported ADAR1 inhibitor, and found no evidence supporting ZYS-1 as an ADAR1 inhibitor bit.ly/4nEK7xc
October 21, 2025 at 4:01 PM
The #RNA editing enzyme ADAR1 is an important target for many cancers. This study evaluated ZYS-1, a recently reported ADAR1 inhibitor, and found no evidence supporting ZYS-1 as an ADAR1 inhibitor bit.ly/4nEK7xc
T-box-i is a novel, effective inhibitor of T-box riboswitches with antimicrobial activity against Staphylococcus aureus bit.ly/4nyMmSE
October 20, 2025 at 6:51 PM
T-box-i is a novel, effective inhibitor of T-box riboswitches with antimicrobial activity against Staphylococcus aureus bit.ly/4nyMmSE
HPV E6 exploits codon usage to reduce antigen presentation and evade immunity; combinations of synonymous substitutions restore E6 expression and T cell activation bit.ly/3VUKzvo
October 3, 2025 at 3:02 PM
HPV E6 exploits codon usage to reduce antigen presentation and evade immunity; combinations of synonymous substitutions restore E6 expression and T cell activation bit.ly/3VUKzvo
HRV-B3 IRES acts as a position-dependent negative regulator of RNA abundance from the upstream promoter. We found that this effect can be mitigated by inserting a spacer between IRES and the promoter bit.ly/4nEhYGA
October 3, 2025 at 3:01 PM
HRV-B3 IRES acts as a position-dependent negative regulator of RNA abundance from the upstream promoter. We found that this effect can be mitigated by inserting a spacer between IRES and the promoter bit.ly/4nEhYGA
Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery bit.ly/4n38pB3
September 30, 2025 at 4:51 PM
Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery bit.ly/4n38pB3
CSDE1 is present at low levels in healthy melanocytes, but upon transformation its expression rises and it becomes phosphorylated, promoting stronger interactions with ribosomes, possibly at membrane bit.ly/3JOdi2c
September 29, 2025 at 6:11 PM
CSDE1 is present at low levels in healthy melanocytes, but upon transformation its expression rises and it becomes phosphorylated, promoting stronger interactions with ribosomes, possibly at membrane bit.ly/3JOdi2c