Jack Tierney
jackatierney.bsky.social
Jack Tierney
@jackatierney.bsky.social
Bioinformatician @ EMBL-EBI - Ensembl Genebuild

Formerly:

Post Doctoral Researcher @ UCC, Ireland

RNA Biology, Translation, Ribo-Seq

Bioinformatic Method Development & Research Infrastructure
Pinned
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features.

In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
Believe it or not, the term Translon as the translational unit predates Walter Gilberts 'Exon' (1978). In 1973 Suresh Goel had a letter published in Nature arguing for the establishment of units of Transcription (Transcon) and Translation (Translon).
www.nature.com/articles/245...
September 2, 2025 at 8:13 PM
Reposted by Jack Tierney
Here's an interesting paper @natmethods.nature.com introducing the term "Translon", filling a terminology gap in the field of gene expression. Kudos to Pasha Baranov for leading this initiative and gathering many contributors (including myself) for an healthy discussion on fundamental principles 👏
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features.

In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
September 2, 2025 at 11:00 AM
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features.

In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
September 1, 2025 at 3:37 PM