Mariotti Genomics Lab
@mariottilab.bsky.social
Comparative genomics of gene expression lab at Universitat de Barcelona @geneticsub.bsky.social, led by Marco Mariotti.
Interests: Translational recoding, bioinformatics, evolution, biotech, rare diseases.
https://www.mariottigenomicslab.com/
Interests: Translational recoding, bioinformatics, evolution, biotech, rare diseases.
https://www.mariottigenomicslab.com/
Pinned
🔊We are excited to announce a new Associate Prof (Prof Agregat) at @geneticsub.bsky.social
👏Congratulations to Dr.Marco Mariotti on his new position!He leads the "Comparative Genomics of Gene expression Lab",where his team works to investigate the process of gene expression and protein synthesis.
👏Congratulations to Dr.Marco Mariotti on his new position!He leads the "Comparative Genomics of Gene expression Lab",where his team works to investigate the process of gene expression and protein synthesis.
I'm happy to announce that I obtained a tenured position at @geneticsub.bsky.social @biologiaub.bsky.social ! 🧬🎉
We will continue to advocate with public bioinformatics institutions to correct the annotation of selenoproteins, and eventually other cases of translational recoding, in public databases
January 14, 2026 at 8:59 AM
We will continue to advocate with public bioinformatics institutions to correct the annotation of selenoproteins, and eventually other cases of translational recoding, in public databases
To fix this issue, we present an upgraded version of our pipeline Selenoprofiles to automatically and accurately annotate selenoproteins at scale, matching manual curation quality. This may help to uncover overlooked biology tied to redox homeostasis and protein function.
January 14, 2026 at 8:59 AM
To fix this issue, we present an upgraded version of our pipeline Selenoprofiles to automatically and accurately annotate selenoproteins at scale, matching manual curation quality. This may help to uncover overlooked biology tied to redox homeostasis and protein function.
We show that the great majority of vertebrate selenoprotein genes are misannotated in major public databases, meaning that they appear often missing or incorrect. Since annotations are a foundational resource upon which much of bioinformatics is built, these flaws impact many downstream analysis.
January 14, 2026 at 8:59 AM
We show that the great majority of vertebrate selenoprotein genes are misannotated in major public databases, meaning that they appear often missing or incorrect. Since annotations are a foundational resource upon which much of bioinformatics is built, these flaws impact many downstream analysis.
Selenoproteins are special proteins incorporating the amino acid selenocysteine, which play many essential biological roles, most notably for antioxidant defense. Selenocysteine is encoded by the UGA stop codon via translational recoding, making selenoproteins notoriously hard to annotate.
January 14, 2026 at 8:59 AM
Selenoproteins are special proteins incorporating the amino acid selenocysteine, which play many essential biological roles, most notably for antioxidant defense. Selenocysteine is encoded by the UGA stop codon via translational recoding, making selenoproteins notoriously hard to annotate.
We're happy to share that our article "Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases" has been published:
journals.plos.org/ploscompbiol... #bioinformatics #recoding #selenoproteins #geneannotation Collab with @rodericguigo.bsky.social
journals.plos.org/ploscompbiol... #bioinformatics #recoding #selenoproteins #geneannotation Collab with @rodericguigo.bsky.social
Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases
Author summary Genome annotations serve as a map of the genetic information encoded in our DNA. They are essential for numerous applications, working as a reference to interpret high throughput experi...
journals.plos.org
January 14, 2026 at 8:59 AM
We're happy to share that our article "Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases" has been published:
journals.plos.org/ploscompbiol... #bioinformatics #recoding #selenoproteins #geneannotation Collab with @rodericguigo.bsky.social
journals.plos.org/ploscompbiol... #bioinformatics #recoding #selenoproteins #geneannotation Collab with @rodericguigo.bsky.social
Reposted by Mariotti Genomics Lab
🧬 Avui hem pogut gaudir del Simposi organitzat per @geneticsub.bsky.social sobre l’actualitat i les aplicacions de la tecnologia #CRISPR.
🗣️ L’acte ha comptat amb la participació dels ponents Anna Cereseto, @lluismontoliu.bsky.social, @vtoulis.bsky.social i Jean-Luc Gallois
🗣️ L’acte ha comptat amb la participació dels ponents Anna Cereseto, @lluismontoliu.bsky.social, @vtoulis.bsky.social i Jean-Luc Gallois
January 9, 2026 at 1:32 PM
🧬 Avui hem pogut gaudir del Simposi organitzat per @geneticsub.bsky.social sobre l’actualitat i les aplicacions de la tecnologia #CRISPR.
🗣️ L’acte ha comptat amb la participació dels ponents Anna Cereseto, @lluismontoliu.bsky.social, @vtoulis.bsky.social i Jean-Luc Gallois
🗣️ L’acte ha comptat amb la participació dels ponents Anna Cereseto, @lluismontoliu.bsky.social, @vtoulis.bsky.social i Jean-Luc Gallois
Reposted by Mariotti Genomics Lab
Mañana estaré en Barcelona @biologiaub.bsky.social @unibarcelonathe.bsky.social participando en este simposio sobre actualidad y aplicaciones #CRISPR que organizan desde el departamento de @geneticsub.bsky.social junto a Anna Cereseto @vtoulis.bsky.social y Jean-Luc Gallois
ub.edu/portal/web/bio…
ub.edu/portal/web/bio…
January 8, 2026 at 10:48 AM
Mañana estaré en Barcelona @biologiaub.bsky.social @unibarcelonathe.bsky.social participando en este simposio sobre actualidad y aplicaciones #CRISPR que organizan desde el departamento de @geneticsub.bsky.social junto a Anna Cereseto @vtoulis.bsky.social y Jean-Luc Gallois
ub.edu/portal/web/bio…
ub.edu/portal/web/bio…
Reposted by Mariotti Genomics Lab
🧬 Year after year, @geneticsub.bsky.social remains firmly committed to continuous improvement.
🥇 This year has been highly rewarding and we look forward to the opportunities that 2026 will bring.
🎉 Thanks to all our members for your hard work and dedication! Together, we make a strong team.
🥇 This year has been highly rewarding and we look forward to the opportunities that 2026 will bring.
🎉 Thanks to all our members for your hard work and dedication! Together, we make a strong team.
December 29, 2025 at 8:49 AM
🧬 Year after year, @geneticsub.bsky.social remains firmly committed to continuous improvement.
🥇 This year has been highly rewarding and we look forward to the opportunities that 2026 will bring.
🎉 Thanks to all our members for your hard work and dedication! Together, we make a strong team.
🥇 This year has been highly rewarding and we look forward to the opportunities that 2026 will bring.
🎉 Thanks to all our members for your hard work and dedication! Together, we make a strong team.
Reposted by Mariotti Genomics Lab
📢 Our beloved symposium on #CRISPR is scheduled earlier than usual this year.
‼️ It's open without registration.
🗓 Mark your calendars: 9th January
📍 @biologiaub.bsky.social
👥 Organizers: Marco Mariotti, Marc Valls, Jesús Lozano, Mercedes Rocafort, from @geneticsub.bsky.social
‼️ It's open without registration.
🗓 Mark your calendars: 9th January
📍 @biologiaub.bsky.social
👥 Organizers: Marco Mariotti, Marc Valls, Jesús Lozano, Mercedes Rocafort, from @geneticsub.bsky.social
December 19, 2025 at 9:35 AM
📢 Our beloved symposium on #CRISPR is scheduled earlier than usual this year.
‼️ It's open without registration.
🗓 Mark your calendars: 9th January
📍 @biologiaub.bsky.social
👥 Organizers: Marco Mariotti, Marc Valls, Jesús Lozano, Mercedes Rocafort, from @geneticsub.bsky.social
‼️ It's open without registration.
🗓 Mark your calendars: 9th January
📍 @biologiaub.bsky.social
👥 Organizers: Marco Mariotti, Marc Valls, Jesús Lozano, Mercedes Rocafort, from @geneticsub.bsky.social
We welcome feedback and contributions! Use GitHub to report issues or request features, and to follow our Continuous-Integration-compliant development: github.com/pyranges/pyr...
Wannabe contributors can find guidelines here: pyranges1.readthedocs.io/en/latest/de...
Wannabe contributors can find guidelines here: pyranges1.readthedocs.io/en/latest/de...
GitHub - pyranges/pyranges_1.x: Pyranges: a Python framework for ultrafast sequence interval operations
Pyranges: a Python framework for ultrafast sequence interval operations - pyranges/pyranges_1.x
github.com
December 15, 2025 at 4:59 PM
We welcome feedback and contributions! Use GitHub to report issues or request features, and to follow our Continuous-Integration-compliant development: github.com/pyranges/pyr...
Wannabe contributors can find guidelines here: pyranges1.readthedocs.io/en/latest/de...
Wannabe contributors can find guidelines here: pyranges1.readthedocs.io/en/latest/de...
Pyranges works best as python library, but if you are a die-hard bash enthusiast that despises Python for some reason, you may access its functionalities from the command line, thanks to pyranger, a Pyranges wrapper based on Google Python Fire library.
pyranges1.readthedocs.io/en/latest/py...
pyranges1.readthedocs.io/en/latest/py...
Command-line interface: pyranger — pyranges documentation
pyranges1.readthedocs.io
December 15, 2025 at 4:59 PM
Pyranges works best as python library, but if you are a die-hard bash enthusiast that despises Python for some reason, you may access its functionalities from the command line, thanks to pyranger, a Pyranges wrapper based on Google Python Fire library.
pyranges1.readthedocs.io/en/latest/py...
pyranges1.readthedocs.io/en/latest/py...
Developed for max speed, Pyranges is also suitable for interactive data exploration, supported by convenient data access functions and intuitive Jupyter-compatible representations, including an early prototype of the companion graphics library Pyrangeyes 🐍👀(pyrangeyes.readthedocs.io).
Pyrangeyes documentation — pyrangeyes documentation
pyrangeyes.readthedocs.io
December 15, 2025 at 4:59 PM
Developed for max speed, Pyranges is also suitable for interactive data exploration, supported by convenient data access functions and intuitive Jupyter-compatible representations, including an early prototype of the companion graphics library Pyrangeyes 🐍👀(pyrangeyes.readthedocs.io).
Pyranges is ready for AI-assisted coding. It provides utilities to turn chatbots (e.g. ChatGPT, Gemini) into specialized coding assistants that can build readable Pyranges-based workflows from simple user requests. Guide: pyranges1.readthedocs.io/en/latest/tu...
Examples of AI-generated workflows:
Examples of AI-generated workflows:
December 15, 2025 at 4:59 PM
Pyranges is ready for AI-assisted coding. It provides utilities to turn chatbots (e.g. ChatGPT, Gemini) into specialized coding assistants that can build readable Pyranges-based workflows from simple user requests. Guide: pyranges1.readthedocs.io/en/latest/tu...
Examples of AI-generated workflows:
Examples of AI-generated workflows:
Our library is designed to be user-friendly. The PyRanges object (representing a table of genomic interval-based data) is a subclass of pandas.DataFrame, allowing users to seamlessly leverage the familiar pandas API while combining it with Pyranges-specific methods. See how in our linked tutorial!
Tutorial — pyranges documentation
pyranges1.readthedocs.io
December 15, 2025 at 4:59 PM
Our library is designed to be user-friendly. The PyRanges object (representing a table of genomic interval-based data) is a subclass of pandas.DataFrame, allowing users to seamlessly leverage the familiar pandas API while combining it with Pyranges-specific methods. See how in our linked tutorial!
With big data, Pyranges is ~5× faster than BEDTools and ~3× faster than GenomicRanges, largely due to its Rust-based core engine, ruranges. In addition, Pyranges uses about half the memory required by these alternative tools. See the preprint for details.
December 15, 2025 at 4:59 PM
With big data, Pyranges is ~5× faster than BEDTools and ~3× faster than GenomicRanges, largely due to its Rust-based core engine, ruranges. In addition, Pyranges uses about half the memory required by these alternative tools. See the preprint for details.
This library allows you to read lots of diverse omics data (e.g. gene annotations, mapped NGS reads, chromosome and protein domains, in many file formats) and readily build complex pipelines by combining efficient methods for overlapping, counting, slicing intervals, and much more. Cheatsheet below.
December 15, 2025 at 4:59 PM
This library allows you to read lots of diverse omics data (e.g. gene annotations, mapped NGS reads, chromosome and protein domains, in many file formats) and readily build complex pipelines by combining efficient methods for overlapping, counting, slicing intervals, and much more. Cheatsheet below.
Bioinformaticians, spread the word! Pyranges v1 is here: a Python framework for ultrafast sequence interval operations (aka genome arithmetic). Documentation (installation, tutorial, API, how-to-pages): pyranges1.readthedocs.io
Preprint: doi.org/10.64898/202... #bioinformatics #genomics #python 🧬💻🐍
Preprint: doi.org/10.64898/202... #bioinformatics #genomics #python 🧬💻🐍
Pyranges v1: a Python framework for ultrafast sequence interval operations
Sequence interval algebra is key to modern bioinformatics. Pyranges v1 offers a Python Pandas-based interface to a comprehensive palette of Rust-powered operations (e.g., overlap, count, slice interva...
doi.org
December 15, 2025 at 4:59 PM
Bioinformaticians, spread the word! Pyranges v1 is here: a Python framework for ultrafast sequence interval operations (aka genome arithmetic). Documentation (installation, tutorial, API, how-to-pages): pyranges1.readthedocs.io
Preprint: doi.org/10.64898/202... #bioinformatics #genomics #python 🧬💻🐍
Preprint: doi.org/10.64898/202... #bioinformatics #genomics #python 🧬💻🐍
I'm happy to announce that I obtained a tenured position at @geneticsub.bsky.social @biologiaub.bsky.social ! 🧬🎉
🔊We are excited to announce a new Associate Prof (Prof Agregat) at @geneticsub.bsky.social
👏Congratulations to Dr.Marco Mariotti on his new position!He leads the "Comparative Genomics of Gene expression Lab",where his team works to investigate the process of gene expression and protein synthesis.
👏Congratulations to Dr.Marco Mariotti on his new position!He leads the "Comparative Genomics of Gene expression Lab",where his team works to investigate the process of gene expression and protein synthesis.
November 19, 2025 at 10:26 AM
I'm happy to announce that I obtained a tenured position at @geneticsub.bsky.social @biologiaub.bsky.social ! 🧬🎉
Reposted by Mariotti Genomics Lab
calling "Acetylysine" the 21st amino acid is a declaration of war
October 24, 2025 at 6:38 PM
calling "Acetylysine" the 21st amino acid is a declaration of war
Reposted by Mariotti Genomics Lab
The iGEM UB team has come back from the competition with amazing results!🥇🤩
The team worked in developing a first prototype of an inducible stop codon readthrough riboswitch in Marco Mariotti's lab, here at @geneticsub.bsky.social 🧬1/2
The team worked in developing a first prototype of an inducible stop codon readthrough riboswitch in Marco Mariotti's lab, here at @geneticsub.bsky.social 🧬1/2
November 5, 2025 at 1:07 PM
The iGEM UB team has come back from the competition with amazing results!🥇🤩
The team worked in developing a first prototype of an inducible stop codon readthrough riboswitch in Marco Mariotti's lab, here at @geneticsub.bsky.social 🧬1/2
The team worked in developing a first prototype of an inducible stop codon readthrough riboswitch in Marco Mariotti's lab, here at @geneticsub.bsky.social 🧬1/2
Learn more on the wiki: 2025.igem.wiki/barcelona-ub/
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
November 5, 2025 at 9:22 AM
Learn more on the wiki: 2025.igem.wiki/barcelona-ub/
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
Skippit fuses a SECIS element (readthrough driver) with a theophylline-binding aptamer, yielding the first readthrough-based riboswitch.
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
Barcelona-UB: switch scr (2025) [English]
Accessory Video for explanations https://2025.igem.wiki/barcelona-ub/index.html
video.igem.org
November 5, 2025 at 9:22 AM
Skippit fuses a SECIS element (readthrough driver) with a theophylline-binding aptamer, yielding the first readthrough-based riboswitch.
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
The project Skippit uses stop codon readthrough as a synthetic biology control knob. In readthrough, the ribosome occasionally ignores a stop codon and keeps translating — extending the protein instead of terminating it:
video.igem.org/w/9U3qG3tzMA...
video.igem.org/w/9U3qG3tzMA...
Barcelona-UB: SCR Translational influence (2025)
SCR Translational influence https://2025.igem.wiki/barcelona-ub
video.igem.org
November 5, 2025 at 9:22 AM
The project Skippit uses stop codon readthrough as a synthetic biology control knob. In readthrough, the ribosome occasionally ignores a stop codon and keeps translating — extending the protein instead of terminating it:
video.igem.org/w/9U3qG3tzMA...
video.igem.org/w/9U3qG3tzMA...
Ecstatic about the success of our iGEM Barcelona-UB team at the 2025 Jamboree!
Gold medal 🥇 + 5 Special Prize nominations 🏆 + TOP TEN overall 🔝🤯
#iGEM2025 #iGEM
@geneticsub.bsky.social @biologiaub.bsky.social @ub.edu
Short explanation below 👇
Gold medal 🥇 + 5 Special Prize nominations 🏆 + TOP TEN overall 🔝🤯
#iGEM2025 #iGEM
@geneticsub.bsky.social @biologiaub.bsky.social @ub.edu
Short explanation below 👇
November 5, 2025 at 9:22 AM
Ecstatic about the success of our iGEM Barcelona-UB team at the 2025 Jamboree!
Gold medal 🥇 + 5 Special Prize nominations 🏆 + TOP TEN overall 🔝🤯
#iGEM2025 #iGEM
@geneticsub.bsky.social @biologiaub.bsky.social @ub.edu
Short explanation below 👇
Gold medal 🥇 + 5 Special Prize nominations 🏆 + TOP TEN overall 🔝🤯
#iGEM2025 #iGEM
@geneticsub.bsky.social @biologiaub.bsky.social @ub.edu
Short explanation below 👇
Reposted by Mariotti Genomics Lab
The @geneticsub.bsky.social section, was well represented at #EDRC2025 @edrc2025.bsky.social by Nadia and Marco @mariottilab.bsky.social Sofia @sofiajaraujo.bsky.social and Núria @nuriacorbella.bsky.social @araujolabub.bsky.social and Ivan from the Serras’ lab who presented their results
September 28, 2025 at 3:33 PM
The @geneticsub.bsky.social section, was well represented at #EDRC2025 @edrc2025.bsky.social by Nadia and Marco @mariottilab.bsky.social Sofia @sofiajaraujo.bsky.social and Núria @nuriacorbella.bsky.social @araujolabub.bsky.social and Ivan from the Serras’ lab who presented their results