Pedro Friedmann Angeli
@angelifriedmann.bsky.social
Reposted by Pedro Friedmann Angeli
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
www.nature.com
November 5, 2025 at 4:11 PM
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
pubs.acs.org/doi/abs/10.1...
Congrats @theprattgroup.bsky.social for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
Congrats @theprattgroup.bsky.social for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
Intramolecular Hydrogen Atom Transfer Enables Hydroperoxyl Radical Formation during the Peroxidation of Unsaturated Lipids
Lipid peroxidation (autoxidation) is among the most well-studied free radical chain reactions and drives a cell death modality (ferroptosis) implicated in neurodegeneration and the damage resulting fr...
pubs.acs.org
November 1, 2025 at 10:25 PM
pubs.acs.org/doi/abs/10.1...
Congrats @theprattgroup.bsky.social for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
Congrats @theprattgroup.bsky.social for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
Reposted by Pedro Friedmann Angeli
Reposted by Pedro Friedmann Angeli
calling "Acetylysine" the 21st amino acid is a declaration of war
October 24, 2025 at 6:38 PM
calling "Acetylysine" the 21st amino acid is a declaration of war
Reposted by Pedro Friedmann Angeli
(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
doi.org
October 16, 2025 at 3:20 AM
(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
Reposted by Pedro Friedmann Angeli
REVIEW🚨
The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies.
@mdanderson.bsky.social
📖 ⬇️
https://bit.ly/3L3vN...
The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies.
@mdanderson.bsky.social
📖 ⬇️
https://bit.ly/3L3vN...
October 22, 2025 at 2:46 PM
REVIEW🚨
The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies.
@mdanderson.bsky.social
📖 ⬇️
https://bit.ly/3L3vN...
The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies.
@mdanderson.bsky.social
📖 ⬇️
https://bit.ly/3L3vN...
Reposted by Pedro Friedmann Angeli
Bayern und die Max-Planck-Gesellschaft @maxplanck.de haben sich darauf verständigt, in Würzburg ein Max-Planck-Institut 🔬 aufzubauen. Unipräsident Paul Pauli: "Das ist ein starkes Zeichen für den Wissenschaftsstandort Würzburg." go.uniwue.de/mpg-wue 📷 Mindcore
October 22, 2025 at 8:50 AM
Bayern und die Max-Planck-Gesellschaft @maxplanck.de haben sich darauf verständigt, in Würzburg ein Max-Planck-Institut 🔬 aufzubauen. Unipräsident Paul Pauli: "Das ist ein starkes Zeichen für den Wissenschaftsstandort Würzburg." go.uniwue.de/mpg-wue 📷 Mindcore
Reposted by Pedro Friedmann Angeli
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Reposted by Pedro Friedmann Angeli
We’re thrilled to announce this workshop! 🌟
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Starting your own lab is exciting—but challenging.
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉 gbm-online.de/de/young-inv...
Pls repost!
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉 gbm-online.de/de/young-inv...
Pls repost!
October 16, 2025 at 6:13 AM
We’re thrilled to announce this workshop! 🌟
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
doi.org
October 16, 2025 at 3:20 AM
(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
Reposted by Pedro Friedmann Angeli
One of the crazy things about the AI bubble bursting is that consumer sentiment toward AI has always leaned skeptical to outright negative but it’s an industry propped up by pure billionaire greed, sycophancy, and childish fantasy
October 9, 2025 at 2:14 PM
One of the crazy things about the AI bubble bursting is that consumer sentiment toward AI has always leaned skeptical to outright negative but it’s an industry propped up by pure billionaire greed, sycophancy, and childish fantasy
Reposted by Pedro Friedmann Angeli
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
October 9, 2025 at 6:42 AM
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Reposted by Pedro Friedmann Angeli
✨✨✨ Huge congratulations to the winners of the #NobelPrize in Physics: John Clarke, Michel H. Devoret and John M. Martinis. Clarke and Martinis are both members of the Humboldt Network – as hosts for Feodor Lynen Research Fellows! 💚
Picture: Ill. Niklas Elmehed © Nobel Prize Outreach
Picture: Ill. Niklas Elmehed © Nobel Prize Outreach
October 7, 2025 at 10:26 AM
✨✨✨ Huge congratulations to the winners of the #NobelPrize in Physics: John Clarke, Michel H. Devoret and John M. Martinis. Clarke and Martinis are both members of the Humboldt Network – as hosts for Feodor Lynen Research Fellows! 💚
Picture: Ill. Niklas Elmehed © Nobel Prize Outreach
Picture: Ill. Niklas Elmehed © Nobel Prize Outreach
www.theguardian.com/world/2025/o...
will be too late when people realise that is not about left and right
will be too late when people realise that is not about left and right
‘One rule for the rich’: the Salzburg mansion, the Porsche heir and the writer Stefan Zweig
The car magnate, who is restoring the Jewish author’s former villa, has been given permission to dig out a 500-metre road leading to a garage, causing consternation in the city
www.theguardian.com
October 4, 2025 at 6:19 AM
www.theguardian.com/world/2025/o...
will be too late when people realise that is not about left and right
will be too late when people realise that is not about left and right
Reposted by Pedro Friedmann Angeli
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 7:35 AM
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
Reposted by Pedro Friedmann Angeli
🚨Preprint alert 🚨
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...
www.biorxiv.org
August 6, 2025 at 8:38 AM
🚨Preprint alert 🚨
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
Reposted by Pedro Friedmann Angeli
very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
will there be a consensus? does it really matter? more studies definitely needed to settle this
Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry
Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.
www.nature.com
September 26, 2025 at 4:39 PM
very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
will there be a consensus? does it really matter? more studies definitely needed to settle this
very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
will there be a consensus? does it really matter? more studies definitely needed to settle this
Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry
Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.
www.nature.com
September 26, 2025 at 4:39 PM
very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
will there be a consensus? does it really matter? more studies definitely needed to settle this
meteoroptosis
A therapeutically targetable pathway promoting MASH fibrosis involving a non-apoptotic function of caspase-8 and a newly discovered HSC activator, meteorin.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosis - Nature Metabolism
Hepatocyte caspase-8 in MASH promotes the activation of hepatic stellate cells and liver fibrosis through an apoptosis-independent mechanism
www.nature.com
September 26, 2025 at 3:57 PM
meteoroptosis
Reposted by Pedro Friedmann Angeli
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
September 15, 2025 at 9:27 AM
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
Preach freedom of speech overseas, but ignore that weak institutions are what give clowns the spotligh
September 12, 2025 at 5:33 AM
Preach freedom of speech overseas, but ignore that weak institutions are what give clowns the spotligh
Reposted by Pedro Friedmann Angeli
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
September 10, 2025 at 4:56 AM
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
Reposted by Pedro Friedmann Angeli
🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science.
Application deadline: Sept 26
Link: www.mu-ds.de
Application deadline: Sept 26
Link: www.mu-ds.de
MUDS - Helmholtz Information & Data Science Academy
www.mu-ds.de
September 10, 2025 at 7:06 AM
🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science.
Application deadline: Sept 26
Link: www.mu-ds.de
Application deadline: Sept 26
Link: www.mu-ds.de