Mariotti Genomics Lab
@mariottilab.bsky.social
Comparative genomics of gene expression lab at Universitat de Barcelona @geneticsub.bsky.social, led by Marco Mariotti.
Interests: Translational recoding, bioinformatics, evolution, biotech, rare diseases.
https://www.mariottigenomicslab.com/
Interests: Translational recoding, bioinformatics, evolution, biotech, rare diseases.
https://www.mariottigenomicslab.com/
Learn more on the wiki: 2025.igem.wiki/barcelona-ub/
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
November 5, 2025 at 9:22 AM
Learn more on the wiki: 2025.igem.wiki/barcelona-ub/
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
Video presentation (15 min): video.igem.org/w/c6034b4e-8...
Skippit fuses a SECIS element (readthrough driver) with a theophylline-binding aptamer, yielding the first readthrough-based riboswitch.
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
Barcelona-UB: switch scr (2025) [English]
Accessory Video for explanations https://2025.igem.wiki/barcelona-ub/index.html
video.igem.org
November 5, 2025 at 9:22 AM
Skippit fuses a SECIS element (readthrough driver) with a theophylline-binding aptamer, yielding the first readthrough-based riboswitch.
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
By changing ligand concentration, you can flip between producing the canonical protein isoform or the readthrough isoform:
video.igem.org/w/rDM2PWQi8Y...
The project Skippit uses stop codon readthrough as a synthetic biology control knob. In readthrough, the ribosome occasionally ignores a stop codon and keeps translating — extending the protein instead of terminating it:
video.igem.org/w/9U3qG3tzMA...
video.igem.org/w/9U3qG3tzMA...
Barcelona-UB: SCR Translational influence (2025)
SCR Translational influence https://2025.igem.wiki/barcelona-ub
video.igem.org
November 5, 2025 at 9:22 AM
The project Skippit uses stop codon readthrough as a synthetic biology control knob. In readthrough, the ribosome occasionally ignores a stop codon and keeps translating — extending the protein instead of terminating it:
video.igem.org/w/9U3qG3tzMA...
video.igem.org/w/9U3qG3tzMA...
It was my pleasure!
April 9, 2025 at 12:02 PM
It was my pleasure!