It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation

When MORC3 is SUMOylated, this MORC Regulated Element (MRE) is repressed. Removal of SUMO drastically increases MORC3 binding, turning on its enhancer function. But not only that: the element acquires insulator / boundary activity as well.

Very happy to participate in the 8th Brazilian Cytogenetics and Cytogenomics meeting in beautiful Brasília. A great opportunity to present our recent work and discussing with the Brazilian research community

Looking forward to talking about our recent Capture multi-omics work and how its helping us to understand the molecular mechanisms of genomic imprinting #GenomicImprinting25

Our study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/...
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.

Not our usual topic, but exciting results from this collaborative work! www.biorxiv.org/content/10.1... Perturbed spindle pole dissociation during mitotic exit causes lasting nuclear and chromatin reorganization. A tour-de-force from the Kotak lab at the IISc in Bangalore, happy to have contributed

We hypothesize that one-sides blocking of loop extrusion at boundaries promotes a reeling-in of the adjacent TAD. At narrow boundaries this promotes intermingling of the neighboring TADs. Spreading of loop extrusion blocking in extended boundaries counters this by introducing distance between TADs.

Boundary width is diverse and can go >150 kb. CTCF peaks can be found anywhere, regardless of width, indicating that loop extrusion is blocked throughout. Interestingly, CTCF sites within boundaries tend to be convergent, suggesting boundary regions share structural characteristics with TADs.

Boundaries between TADs often extend over considerable distance. But how variable is this width of boundaries? And does it matter? Find out in our new pre-print with the group of David Holcman. www.biorxiv.org/content/10.1...

First snow of the year on campus

The Noordermeer lab has installed itself in its new rooms at the I2BC / University Paris-Saclay. Exciting times ahead of us. Come for the science 👩‍🔬👨‍🔬, stay for the view 🏞️. Or vice-versa of course

🚨🚨🚨🤝🧬🔍 We are recruiting group leaders for the #GenomeBiologyDepartment at the I2BC (France). Open to all relevant topics, with particular interest in RNA biology, chromatin organization, genome stability and gene expression. i2bc.paris-saclay.fr/jobs/ DM me for info! Please RT🙏

We're very that our study about clustering of CTCF binding at TAD boundaries, is now published: www.nature.com/articles/s41.... Individual CTCF binding sites contribute to insulation but not perfectly. Clustering of multiple CTCF sites thus creates redundancy, thereby allowing strong separation.