Basil Greber
@bjgreber.bsky.social
Structural biologist. High-resolution imaging of macromolecular assemblies (and landscapes). MRC career development fellow/group leader at the Institute of Cancer Research, London. Views my own.
Reposted by Basil Greber
Join us in a highly collaborative environment. At the IMP everything is possible.
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 11, 2025 at 9:56 AM
Join us in a highly collaborative environment. At the IMP everything is possible.
Reposted by Basil Greber
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
November 9, 2025 at 6:43 PM
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
Reposted by Basil Greber
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted by Basil Greber
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Basil Greber
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Basil Greber
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
November 7, 2025 at 10:15 AM
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
Reposted by Basil Greber
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
Reposted by Basil Greber
The human misery and massive death toll that came from ending USAID was entirely predictable. Elon Musk relied on conspiracy nuts rather than employees and development specialists. Rubio, who previously defended the agency knew what would happen. They chose this. open.substack.com/pub/donmoyni...
November 7, 2025 at 2:46 AM
The human misery and massive death toll that came from ending USAID was entirely predictable. Elon Musk relied on conspiracy nuts rather than employees and development specialists. Rubio, who previously defended the agency knew what would happen. They chose this. open.substack.com/pub/donmoyni...
Reposted by Basil Greber
Reposted by Basil Greber
Trump just continually shooting our country in the face. This unwarranted (and likely illegal) destruction of Goddard is madness. It jeopardizes the next several decades of space exploration.
Reposting to correct an error: trump admin is quietly gutting 13 buildings and about 100 laboratories at Goddard campus that has been instrumental to Hubble and James Webb telescope missions. Staff say they’ve be locked and told to move equipment. Anything left behind will be thrown away.
NASA may be quietly gutting an iconic campus with what it calls strategic closures, workers fear
(CNN) — Alarm is growing among federal workers at NASA’s iconic Goddard Space Flight Center’s main campus in Greenbelt, Maryland — the nerve center for groundbreaking missions like the Hubble
www.wkow.com
November 5, 2025 at 4:38 PM
Trump just continually shooting our country in the face. This unwarranted (and likely illegal) destruction of Goddard is madness. It jeopardizes the next several decades of space exploration.
Reposted by Basil Greber
UK lawyers warn of ‘race to the bottom’ after Tory MP issues deportation threat
UK lawyers warn of ‘race to the bottom’ after Tory MP issues deportation threat
Top lawyers call for change in rhetoric that has left minority ethnic Britons fearful as politicians target migrants
*
UK politics live – latest updates
Leading British lawyers have warned of a political “race to the bottom”, after a Conservative MP tipped as future party leader said large numbers of legally settled families must be deported.
Katie Lam, a shadow Home Office minister and a Tory whip, said people with legal status in the UK should have their right to stay revoked, to ensure the UK is mostly “culturally coherent”. The Tory leader, Kemi Badenoch, rowed back on Lam’s statement last Thursday, weeks later. Continue reading...
www.theguardian.com
November 4, 2025 at 10:37 AM
UK lawyers warn of ‘race to the bottom’ after Tory MP issues deportation threat
Reposted by Basil Greber
🧵
The President’s Postdoctoral Fellowship Program, PPFP, has been a jewel in the crown for faculty development and recruitment at the University of California for years and the results have been an expanded faculty with almost 100% tenure rates — unprecedented success.
November 2, 2025 at 10:07 PM
🧵
This is terrible.
www.bbc.co.uk/news/live/cm...
www.bbc.co.uk/news/live/cm...
Nine people with life-threatening injuries after stabbings on Doncaster-London train - latest
Two people have been arrested and police - after declaring it a major incident - say counter-terrorism officers are supporting the investigation.
www.bbc.co.uk
November 2, 2025 at 7:18 AM
This is terrible.
www.bbc.co.uk/news/live/cm...
www.bbc.co.uk/news/live/cm...
Reposted by Basil Greber
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Attention Authors: Updated Practice for Review Articles and Position Papers in arXiv CS Category – arXiv blog
blog.arxiv.org
November 1, 2025 at 5:28 PM
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Reposted by Basil Greber
“Individuals on the ground sent a message that reached us Monday morning that 1,200 were dead,” Nathaniel Raymond, the lab’s executive director, said. “By that evening, they said 10,000. By Tuesday, we couldn’t reach them anymore. We assume our ground contacts are dead.”
Yale lab reports mass killings in Sudan, calls for student activism
The Humanitarian Research Lab was told this week that over 10,000 people in Sudan were killed within three days.
yaledailynews.com
October 31, 2025 at 8:02 PM
“Individuals on the ground sent a message that reached us Monday morning that 1,200 were dead,” Nathaniel Raymond, the lab’s executive director, said. “By that evening, they said 10,000. By Tuesday, we couldn’t reach them anymore. We assume our ground contacts are dead.”
Reposted by Basil Greber
😳😳😳
The 1st pregnancy via A.I. detected sperm (by finding 5 motile sperm in 2.5 million images) from a 39-year-old man with infertility.
@thelancet.com
thelancet.com/journals/lan...
@thelancet.com
thelancet.com/journals/lan...
First clinical pregnancy following AI-based microfluidic sperm detection and recovery in non-obstructive azoospermia
Male factor infertility accounts for up to 40% of infertility cases,1 with azoospermia
and cryptozoospermia (conditions characterised by absent or extremely rare sperm in
the ejaculate) comprising app...
thelancet.com
November 1, 2025 at 6:29 PM
😳😳😳
Reposted by Basil Greber
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
November 1, 2025 at 8:06 AM
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
Reposted by Basil Greber
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 10:07 PM
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Reposted by Basil Greber
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 30, 2025 at 3:21 AM
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by Basil Greber
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
👀
I got an invitation to use the "Nature Research Assistant", put up a paper on intuitive physics and asked it for more references to relevant papers; can you guess why I marked those parts in red
October 29, 2025 at 11:45 AM
👀
Reposted by Basil Greber
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Basil Greber
Decisions, decisions…
October 25, 2025 at 12:43 PM
Decisions, decisions…
Reposted by Basil Greber
Can we keep antibiotics working? Yes, but the world needs to follow the EU and the UK | Devi Sridhar
Can we keep antibiotics working? Yes, but the world needs to follow the EU and the UK | Devi Sridhar
Unless more countries drastically cut back on antibiotic use in food production, these vital drugs will lose their efficacy for humans, says Prof Devi Sridhar, chair of global public health at the University of Edinburgh
www.theguardian.com
October 21, 2025 at 10:04 AM
Can we keep antibiotics working? Yes, but the world needs to follow the EU and the UK | Devi Sridhar
👀
🚀 Introducing fully automated data processing for repeat-target #cryoEM.
Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.
Preprint: www.biorxiv.org/content/10.1...
Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.
Preprint: www.biorxiv.org/content/10.1...
October 20, 2025 at 2:50 PM
👀