Basil Greber
@bjgreber.bsky.social
Structural biologist. High-resolution imaging of macromolecular assemblies (and landscapes). MRC career development fellow/group leader at the Institute of Cancer Research, London. Views my own.
I leave the country for a conference, and of course THIS happens. 🙃
November 12, 2025 at 1:07 PM
I leave the country for a conference, and of course THIS happens. 🙃
To further support this idea, we determined structures of CAK-CDK1-cyclin B and CAK-CDK11. Which agreed with the predictions and our hypothesis. This suggests that we have uncovered a general mechanism for CDK activation by the CDK-activating kinase.
October 16, 2025 at 7:31 PM
To further support this idea, we determined structures of CAK-CDK1-cyclin B and CAK-CDK11. Which agreed with the predictions and our hypothesis. This suggests that we have uncovered a general mechanism for CDK activation by the CDK-activating kinase.
Does this arrangement also apply to other CDKs that are activated by the CAK? We ran AlphaFold3 predictions, which suggested that this architecture was indeed shared across multiple CAK-CDK complexes.
October 16, 2025 at 7:27 PM
Does this arrangement also apply to other CDKs that are activated by the CAK? We ran AlphaFold3 predictions, which suggested that this architecture was indeed shared across multiple CAK-CDK complexes.
We started out on this journey by determining structures of CAK-CDK2 and CAK-CDK2-cyclin A complexes. They revealed a pseudo-symmetric arrangement of CDK7 and its substrate, CDK2. Biochemical analysis demonstrated that contacts in both kinase lobes are important for this interaction.
October 16, 2025 at 7:22 PM
We started out on this journey by determining structures of CAK-CDK2 and CAK-CDK2-cyclin A complexes. They revealed a pseudo-symmetric arrangement of CDK7 and its substrate, CDK2. Biochemical analysis demonstrated that contacts in both kinase lobes are important for this interaction.
I guess I am late to the party, but the new Rainbow Rocket bouldering gym in Cambridge is pretty cool!
September 14, 2025 at 8:18 PM
I guess I am late to the party, but the new Rainbow Rocket bouldering gym in Cambridge is pretty cool!
Couple snaps from our recent family trip to the (very pretty) seaside in Dorset. #landscape #landscapephotography #nikon
August 23, 2025 at 2:05 PM
Couple snaps from our recent family trip to the (very pretty) seaside in Dorset. #landscape #landscapephotography #nikon
They also have mountains rising out of the sea in Norway. 😉
August 6, 2025 at 5:33 PM
They also have mountains rising out of the sea in Norway. 😉
And last but not least, some from team displays - the Frecce Tricolori and the Royal Jordanian Falcons - accompanied by a close-up of an F/A-18 front section.
July 28, 2025 at 10:04 PM
And last but not least, some from team displays - the Frecce Tricolori and the Royal Jordanian Falcons - accompanied by a close-up of an F/A-18 front section.
A few more - including the Danish F-16, a few Spitfires, a Hurricane, and a Lancaster.
July 28, 2025 at 9:57 PM
A few more - including the Danish F-16, a few Spitfires, a Hurricane, and a Lancaster.
A few photos from this year's @airtattoo.bsky.social (which took place 10 days ago not too far from home). The weather was highly variable, but it made for interesting backgrounds in the photos. Descriptions in alt text. #aviation #airshow #aviationphotography
July 28, 2025 at 9:51 PM
A few photos from this year's @airtattoo.bsky.social (which took place 10 days ago not too far from home). The weather was highly variable, but it made for interesting backgrounds in the photos. Descriptions in alt text. #aviation #airshow #aviationphotography
July 17, 2025 at 6:56 AM
Goodbye Nucleic Acids GRC, goodbye Tuscany - this was great! Thanks to Jane Jackman and Brandt Eichman for organising this fantastic conference!
June 27, 2025 at 6:09 AM
Goodbye Nucleic Acids GRC, goodbye Tuscany - this was great! Thanks to Jane Jackman and Brandt Eichman for organising this fantastic conference!
A new day at the Nucleic Acids GRC: Looking forward to great science, nice views, and lots of interesting conversations.
June 25, 2025 at 8:17 AM
A new day at the Nucleic Acids GRC: Looking forward to great science, nice views, and lots of interesting conversations.
Enjoying great science in a beautiful setting at the Nucleic Acids GRC: View of a distant hilltop village in Tuscany after sunset.
June 23, 2025 at 9:04 PM
Enjoying great science in a beautiful setting at the Nucleic Acids GRC: View of a distant hilltop village in Tuscany after sunset.
Snapped a few snaps of heavies coming in to land at Heathrow. Clouds and the setting sun provided a nicely lit backdrop.
June 22, 2025 at 3:03 PM
Snapped a few snaps of heavies coming in to land at Heathrow. Clouds and the setting sun provided a nicely lit backdrop.
Delighted to hear that post-doc @natalia-mg.bsky.social has received the Short Talk Award for her #cryoEM studies of DNA repair at the conference on "Machines Acting on DNA and RNA, a molecular mechanistic perspective" at CNIO Madrid. Congratulations, Natàlia!
Photo courtesy of @amunts.bsky.social.
Photo courtesy of @amunts.bsky.social.
June 2, 2025 at 1:36 PM
Delighted to hear that post-doc @natalia-mg.bsky.social has received the Short Talk Award for her #cryoEM studies of DNA repair at the conference on "Machines Acting on DNA and RNA, a molecular mechanistic perspective" at CNIO Madrid. Congratulations, Natàlia!
Photo courtesy of @amunts.bsky.social.
Photo courtesy of @amunts.bsky.social.
Today, I went to the airfield. The jets were really fast, really low, really close - and occasionally upside down.
April 11, 2025 at 9:31 PM
Today, I went to the airfield. The jets were really fast, really low, really close - and occasionally upside down.
Some spectacular flying to be witnessed around the house, courtesy of the Patrouille Suisse. Glad I brought proper camera gear to (hopefully) do it justice. 😉
April 9, 2025 at 8:47 PM
Some spectacular flying to be witnessed around the house, courtesy of the Patrouille Suisse. Glad I brought proper camera gear to (hopefully) do it justice. 😉
OMG! 😀 Several days late, but it made it!
March 28, 2025 at 10:01 AM
OMG! 😀 Several days late, but it made it!
These findings provide important new insights into how CDK7, which also functions as the CDK-activating kinase and as a transcriptional RNA Pol II CTD kinase, acts as a master regulator of cell growth and proliferation.
Congratulations & a big thank you to everyone involved!
Congratulations & a big thank you to everyone involved!
February 28, 2025 at 9:56 PM
These findings provide important new insights into how CDK7, which also functions as the CDK-activating kinase and as a transcriptional RNA Pol II CTD kinase, acts as a master regulator of cell growth and proliferation.
Congratulations & a big thank you to everyone involved!
Congratulations & a big thank you to everyone involved!
Same. Orion Nebula, also 2022. 😄
November 20, 2024 at 6:21 PM
Same. Orion Nebula, also 2022. 😄
Dubai & Oman - a real desert adventure! Amazing landscapes, endless dunes, and occasional surprise encounters. #nikon #photography
November 19, 2024 at 9:37 PM
Dubai & Oman - a real desert adventure! Amazing landscapes, endless dunes, and occasional surprise encounters. #nikon #photography
And yes, there are things other than waterfalls in Iceland. 😉 #nikon #photography
November 18, 2024 at 9:42 PM
And yes, there are things other than waterfalls in Iceland. 😉 #nikon #photography
Iceland - the one place where I thought "wow, today was even crazier than yesterday!" every day, for two weeks straight. #photography #nikon
November 18, 2024 at 9:37 PM
Iceland - the one place where I thought "wow, today was even crazier than yesterday!" every day, for two weeks straight. #photography #nikon
Lofoten in northern Norway. Epic landscapes, midnight sun, snow capped peaks. What more could one ask for? #photography #nikon
November 17, 2024 at 10:34 PM
Lofoten in northern Norway. Epic landscapes, midnight sun, snow capped peaks. What more could one ask for? #photography #nikon