Professor Lesley Hoyles
@bugsinyourguts.bsky.social
And all this science I don't understand, it's just my job five days a week.
Professor of Microbiome and Systems Biology @ Nottingham Trent University. 🏳️🌈
Working predominantly on the human gut microbiota.
All views my own.
Professor of Microbiome and Systems Biology @ Nottingham Trent University. 🏳️🌈
Working predominantly on the human gut microbiota.
All views my own.
Reposted by Professor Lesley Hoyles
It’s a dark night when you look at the news and are forced to admit that you no longer believe in the power of the FIFA peace prize
January 3, 2026 at 7:06 AM
It’s a dark night when you look at the news and are forced to admit that you no longer believe in the power of the FIFA peace prize
Reposted by Professor Lesley Hoyles
Three million people live in Caracas, five million in the metro area. It's one of the densest cities in South America. Remember this in the morning when they try to spin this as anything other than a cold-blooded attack on a major civilian center.
January 3, 2026 at 7:20 AM
Three million people live in Caracas, five million in the metro area. It's one of the densest cities in South America. Remember this in the morning when they try to spin this as anything other than a cold-blooded attack on a major civilian center.
Reposted by Professor Lesley Hoyles
I know many of you know Joe James (of Binning Singletons)
Joe and his family had a terrible tragedy occur on Christmas. If you can give, this is a good family to help out
gofund.me/5cbfe22fe
Joe and his family had a terrible tragedy occur on Christmas. If you can give, this is a good family to help out
gofund.me/5cbfe22fe
Donate to Honoring Sarah James Through Education, organized by Joe James
Honoring Sarah James & Supporting Her Children’s Future
On Christmas, our com… Joe James needs your support for Honoring Sarah James Through Education
gofund.me
January 1, 2026 at 10:05 PM
I know many of you know Joe James (of Binning Singletons)
Joe and his family had a terrible tragedy occur on Christmas. If you can give, this is a good family to help out
gofund.me/5cbfe22fe
Joe and his family had a terrible tragedy occur on Christmas. If you can give, this is a good family to help out
gofund.me/5cbfe22fe
Reposted by Professor Lesley Hoyles
For those of you wanting to start a new project in the new year but afraid you're gonna suck, heed the words of the ancient texts:
December 31, 2025 at 11:14 PM
For those of you wanting to start a new project in the new year but afraid you're gonna suck, heed the words of the ancient texts:
Happy new year to you and yours.
Vaughan Williams - Fantasia on a Theme by Thomas Tallis
YouTube video by Philharmonia Orchestra
youtu.be
January 1, 2026 at 5:47 PM
Happy new year to you and yours.
Reposted by Professor Lesley Hoyles
New year, new PhD? 🧑🎓
If you’re fed up of leftovers, and out of ideas for festive fun, here’s a quick reminder to apply to these posts! 🧫 🧬
#PhD #Microbiology #Genomics
If you’re fed up of leftovers, and out of ideas for festive fun, here’s a quick reminder to apply to these posts! 🧫 🧬
#PhD #Microbiology #Genomics
We are recruiting for a number of PhDs in the HPRU in Public Health Genomics, based at @unibirmingham.bsky.social, in collaboration with UKHSA. 🦠🧬
Apply below to work on cutting-edge science and public health priorities! (NB deadline of 9th January / UK only due to funding restrictions)
(1/7)
Apply below to work on cutting-edge science and public health priorities! (NB deadline of 9th January / UK only due to funding restrictions)
(1/7)
December 31, 2025 at 10:17 AM
New year, new PhD? 🧑🎓
If you’re fed up of leftovers, and out of ideas for festive fun, here’s a quick reminder to apply to these posts! 🧫 🧬
#PhD #Microbiology #Genomics
If you’re fed up of leftovers, and out of ideas for festive fun, here’s a quick reminder to apply to these posts! 🧫 🧬
#PhD #Microbiology #Genomics
Reposted by Professor Lesley Hoyles
Here’s to 2026
December 27, 2025 at 11:34 AM
Here’s to 2026
Reposted by Professor Lesley Hoyles
Repeat after me: GENE 👏 EXPRESSION 👏 PROFILING 👏 DOES 👏 NOT 👏 A 👏 VIRTUAL 👏 CELL 👏 MAKE 👏
December 26, 2025 at 12:11 PM
Repeat after me: GENE 👏 EXPRESSION 👏 PROFILING 👏 DOES 👏 NOT 👏 A 👏 VIRTUAL 👏 CELL 👏 MAKE 👏
Reposted by Professor Lesley Hoyles
Hey folks, am looking for examples of circularised/full plasmid sequences from "unusual " bacterial species, sequenced since 2020 (as independent validation for a plasmid identification tool that was trained on refseq2020+plsdb). Any tips? #microsky
December 22, 2025 at 11:03 PM
Hey folks, am looking for examples of circularised/full plasmid sequences from "unusual " bacterial species, sequenced since 2020 (as independent validation for a plasmid identification tool that was trained on refseq2020+plsdb). Any tips? #microsky
Reposted by Professor Lesley Hoyles
Systematic profiling of growth interactions in human gut microbiome species https://www.biorxiv.org/content/10.64898/2025.12.19.693361v1
December 22, 2025 at 10:17 AM
Systematic profiling of growth interactions in human gut microbiome species https://www.biorxiv.org/content/10.64898/2025.12.19.693361v1
Reposted by Professor Lesley Hoyles
🚨Only 2 weeks left to apply!
✨Join the HIS team! ✨
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #Hiring
✨Join the HIS team! ✨
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #Hiring
December 22, 2025 at 10:05 AM
🚨Only 2 weeks left to apply!
✨Join the HIS team! ✨
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #Hiring
✨Join the HIS team! ✨
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #Hiring
Reposted by Professor Lesley Hoyles
We would be very happy to host a #bioinformatics #postdoc within this call!
If you have expertise in #gutmicrobiota, #metagenomics, #machinelearning and/or #multiomics approaches, please get in touch to discuss potential 🧬& 🖥️ projects.
Please share!
@MicroSky
www.scilifelab.se/data-driven/...
If you have expertise in #gutmicrobiota, #metagenomics, #machinelearning and/or #multiomics approaches, please get in touch to discuss potential 🧬& 🖥️ projects.
Please share!
@MicroSky
www.scilifelab.se/data-driven/...
DDLS Research School Postdoc call 2026
Call for Academic and Industrial Postdoctoral Fellowships in Data-Driven Life Science 2026 Generic Description of the DDLS Postdoc Program The SciLifeLab and Wallenberg National Program for Data-Drive...
www.scilifelab.se
December 20, 2025 at 3:50 PM
We would be very happy to host a #bioinformatics #postdoc within this call!
If you have expertise in #gutmicrobiota, #metagenomics, #machinelearning and/or #multiomics approaches, please get in touch to discuss potential 🧬& 🖥️ projects.
Please share!
@MicroSky
www.scilifelab.se/data-driven/...
If you have expertise in #gutmicrobiota, #metagenomics, #machinelearning and/or #multiomics approaches, please get in touch to discuss potential 🧬& 🖥️ projects.
Please share!
@MicroSky
www.scilifelab.se/data-driven/...
Reposted by Professor Lesley Hoyles
Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan.
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
Professorial Appointment within the Manchester Institute of Biotechnology:Manchester Institute of Biotechnology
Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.
www.jobs.manchester.ac.uk
December 20, 2025 at 12:21 PM
Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan.
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Professor Lesley Hoyles
The experiment would not be allowed in Denmark or the US, where vaccination-at-birth is already the standard of care.
Withholding vaccination at birth lacks equipoise, given the high risk of lifelong chronic infection when acquired early in life.
As noted yesterday, it clearly violates Helsinki.
Withholding vaccination at birth lacks equipoise, given the high risk of lifelong chronic infection when acquired early in life.
As noted yesterday, it clearly violates Helsinki.
December 18, 2025 at 9:33 PM
The experiment would not be allowed in Denmark or the US, where vaccination-at-birth is already the standard of care.
Withholding vaccination at birth lacks equipoise, given the high risk of lifelong chronic infection when acquired early in life.
As noted yesterday, it clearly violates Helsinki.
Withholding vaccination at birth lacks equipoise, given the high risk of lifelong chronic infection when acquired early in life.
As noted yesterday, it clearly violates Helsinki.
Reposted by Professor Lesley Hoyles
🚨 Postdoctoral Opportunity for Female Scientists🚨
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
December 19, 2025 at 12:24 AM
🚨 Postdoctoral Opportunity for Female Scientists🚨
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
Reposted by Professor Lesley Hoyles
Now published 🔥 Feeding your gut microbes with complex carbohydrates can help preventing colorectal cancer by reducing the production of secondary bile acids. Perhaps NiMe diet @jenswalter15.bsky.social? THX team & Sören Ocvirk ⭐ Thx www.sfb.tum.de/1371/microbi.... Article 👉 doi.org/10.1136/gutj...
Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
Background Western diet and associated production of secondary bile acids (BAs) have been linked to the development of sporadic colorectal cancer (CRC). Despite observational studies showing that seco...
doi.org
December 19, 2025 at 7:50 AM
Now published 🔥 Feeding your gut microbes with complex carbohydrates can help preventing colorectal cancer by reducing the production of secondary bile acids. Perhaps NiMe diet @jenswalter15.bsky.social? THX team & Sören Ocvirk ⭐ Thx www.sfb.tum.de/1371/microbi.... Article 👉 doi.org/10.1136/gutj...
Reposted by Professor Lesley Hoyles
In case anyone needed any more reasons NOT to engage with Frontiers 🤪
"Ask AI to summarize long sections, clarify jargon, or outline the structure. Always verify summaries against the original."
Frontiers guidance on AI in peer review for ECRs optimistically expects them to "verify summaries" of things they couldn't be bothered to read it in the first place.
Frontiers guidance on AI in peer review for ECRs optimistically expects them to "verify summaries" of things they couldn't be bothered to read it in the first place.
AI in peer review: what early-career researchers should know (and how to use it wisely)
For early-career researchers, AI has become part of everyday work, whether in drafting manuscripts, organizing ideas, or exploring literature. A survey of 1,645
www.frontiersin.org
December 17, 2025 at 8:22 PM
In case anyone needed any more reasons NOT to engage with Frontiers 🤪
Reposted by Professor Lesley Hoyles
If you missed the 2025 @isbscience.org Virtual Microbiome Symposium (theme: how microbial metabolites influence the brain, the immune system, & metabolism), the videos of the talks and the panel discussion are now available here:
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
2025 ISB Microbiome Symposium - YouTube
The 2025 ISB Microbiome Symposium was a virtual scientific event hosted by the Institute for Systems Biology (ISB) on December 12, 2025. The symposium brough...
youtube.com
December 17, 2025 at 4:34 PM
If you missed the 2025 @isbscience.org Virtual Microbiome Symposium (theme: how microbial metabolites influence the brain, the immune system, & metabolism), the videos of the talks and the panel discussion are now available here:
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
Reposted by Professor Lesley Hoyles
Our preprint on predicting drug resistance in bacteria is now out in @plosbiology.org. We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. Work from @yanyingyu.bsky.social with @nwheeler443.bsky.social.
Biased sampling driven by bacterial population structure confounds machine learning prediction of antimicrobial resistance
Machine learning methods have emerged as promising tools to predict antimicrobial resistance (AMR) and uncover resistance determinants from genomic data. This study shows that sampling biases driven b...
journals.plos.org
December 17, 2025 at 2:55 PM
Our preprint on predicting drug resistance in bacteria is now out in @plosbiology.org. We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. Work from @yanyingyu.bsky.social with @nwheeler443.bsky.social.
Reposted by Professor Lesley Hoyles
✨Join the HIS team! ✨
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #GuidelinesDevelopment #Hiring
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #GuidelinesDevelopment #Hiring
December 17, 2025 at 12:05 PM
✨Join the HIS team! ✨
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #GuidelinesDevelopment #Hiring
We’re recruiting a Researcher in Evidence Synthesis to drive guideline development, rapid reviews and knowledge mobilisation in IPC.
Deadline: 5 Jan 2026.
Details: https://ow.ly/o0zV50Xz0g1
#ResearchJobs #GuidelinesDevelopment #Hiring
Reposted by Professor Lesley Hoyles
In partnership with the University of Manchester, we've secured a prestigious Doctoral Focal Award from UK Research and Innovation for a new PhD programme aimed at shaping the future of bioengineering in the UK
📅 Applications will open on 6 February 2026
🔗 bit.ly/3MyLwIy
#TeamLivUni #EPSRC #NERC
📅 Applications will open on 6 February 2026
🔗 bit.ly/3MyLwIy
#TeamLivUni #EPSRC #NERC
December 17, 2025 at 10:51 AM
In partnership with the University of Manchester, we've secured a prestigious Doctoral Focal Award from UK Research and Innovation for a new PhD programme aimed at shaping the future of bioengineering in the UK
📅 Applications will open on 6 February 2026
🔗 bit.ly/3MyLwIy
#TeamLivUni #EPSRC #NERC
📅 Applications will open on 6 February 2026
🔗 bit.ly/3MyLwIy
#TeamLivUni #EPSRC #NERC
Reposted by Professor Lesley Hoyles
I wrote a piece on LLMs, citation metrics, and the institution of science. It's been up for a couple of days, but it is officially "out" now.
Context Widows
or, of GPUs, LPUs, and Goal Displacement
artificialbureaucracy.substack.com
December 15, 2025 at 4:19 PM
I wrote a piece on LLMs, citation metrics, and the institution of science. It's been up for a couple of days, but it is officially "out" now.
Reposted by Professor Lesley Hoyles
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
December 16, 2025 at 11:41 PM
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
Had to take obligatory AI training. The answers to most of the course questions essentially summarised all the reasons why generative AI is rubbish. I dread to think how much cash-strapped institutions have invested in the Emperor's new clothes.
December 17, 2025 at 7:28 AM
Had to take obligatory AI training. The answers to most of the course questions essentially summarised all the reasons why generative AI is rubbish. I dread to think how much cash-strapped institutions have invested in the Emperor's new clothes.
Reposted by Professor Lesley Hoyles
(1/7) Really pleased to have this published in @natcomms.nature.com
We looked at all public genomes encoding blaIMP (carbapenem #AMR ) 🦠🧫🧬💊. We show 5 IMP variants achieved global endemicity while 2 are regionally endemic.
www.nature.com/articles/s41...
#MicroSky #microbiology #IDSky #EpiSky 🧪
We looked at all public genomes encoding blaIMP (carbapenem #AMR ) 🦠🧫🧬💊. We show 5 IMP variants achieved global endemicity while 2 are regionally endemic.
www.nature.com/articles/s41...
#MicroSky #microbiology #IDSky #EpiSky 🧪
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study - Nature Communications
Carbapenemase blaIMP genes between 1996-2023 were analysed across 4,556 genomes, revealing variant-specific epidemiologies and endemicities. Horizontal gene transfer enabled broad inter-species transm...
www.nature.com
December 17, 2025 at 4:30 AM
(1/7) Really pleased to have this published in @natcomms.nature.com
We looked at all public genomes encoding blaIMP (carbapenem #AMR ) 🦠🧫🧬💊. We show 5 IMP variants achieved global endemicity while 2 are regionally endemic.
www.nature.com/articles/s41...
#MicroSky #microbiology #IDSky #EpiSky 🧪
We looked at all public genomes encoding blaIMP (carbapenem #AMR ) 🦠🧫🧬💊. We show 5 IMP variants achieved global endemicity while 2 are regionally endemic.
www.nature.com/articles/s41...
#MicroSky #microbiology #IDSky #EpiSky 🧪