Mike Bottery
@mbottery.bsky.social
Microbial Evolution - AMR - University of Manchester
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech.
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
November 5, 2025 at 3:35 PM
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech.
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Reposted by Mike Bottery
Currently hosting event on antifungals in medicine and agriculture, focusing on #AntiMicrobialResistance #AMR. With 6.5 million invasive infections globally each year, and 3.8 million deaths attributable to them. Area of fast-rising concern!
September 16, 2025 at 10:35 AM
Currently hosting event on antifungals in medicine and agriculture, focusing on #AntiMicrobialResistance #AMR. With 6.5 million invasive infections globally each year, and 3.8 million deaths attributable to them. Area of fast-rising concern!
Reposted by Mike Bottery
Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.
July 4, 2025 at 8:59 AM
Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.
Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
July 8, 2025 at 10:06 AM
Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
Reposted by Mike Bottery
The MHRA today released new guidance for #Phage therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪
🔗 www.gov.uk/government/n...
🔗 www.gov.uk/government/n...
June 4, 2025 at 2:36 PM
The MHRA today released new guidance for #Phage therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪
🔗 www.gov.uk/government/n...
🔗 www.gov.uk/government/n...
Reposted by Mike Bottery
New preprint with nice detective work by PhD student Khadija Hanga: gain of pOXA MDR plasmid is facilitated by chromosomal mutations affecting OmpF which act synergistically with the plasmid’s carbapenamase to give high level resistance. Led by @mbottery.bsky.social www.biorxiv.org/content/10.1...
Chromosomal resistance mutations facilitate acquisition of multidrug-resistance plasmids in Escherichia coli
Bacteria can gain multiple resistance mechanisms in a single step by the acquisition of multidrug-resistance (MDR) plasmids, but it is unclear how antibiotic selection during the acquisition of MDR pl...
www.biorxiv.org
April 16, 2025 at 9:58 AM
New preprint with nice detective work by PhD student Khadija Hanga: gain of pOXA MDR plasmid is facilitated by chromosomal mutations affecting OmpF which act synergistically with the plasmid’s carbapenamase to give high level resistance. Led by @mbottery.bsky.social www.biorxiv.org/content/10.1...
@wellcometrust.bsky.social Thanks for organizing the ERC meeting. I found the research culture activity really helpful, so many great thought-provoking ideas
April 1, 2025 at 5:53 PM
@wellcometrust.bsky.social Thanks for organizing the ERC meeting. I found the research culture activity really helpful, so many great thought-provoking ideas
Beautiful day to get out of the office and do some fieldwork! Soil samples + 🍄 #failsafe #mycology @normanvanrhijn.bsky.social
December 19, 2024 at 3:13 PM
Beautiful day to get out of the office and do some fieldwork! Soil samples + 🍄 #failsafe #mycology @normanvanrhijn.bsky.social
New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr
Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance
Nature Communications - Here, Bottery et al show that resistance to next generation antifungals is more likely to occur within azole resistant Aspergillus fumigatus due to the close linkage between...
rdcu.be
December 16, 2024 at 12:04 PM
New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr
Reposted by Mike Bottery
In case you missed it: @matthewjshepherd.bsky.social surveyed the clinical literature to reveal how #AMR evolves within patients, why eco/evo mechanisms vary among infections, & what we can do better to improve treatments www.nature.com/articles/s41... #MicroSky
Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance - Nature Reviews Microbiology
In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence i...
www.nature.com
December 4, 2024 at 2:58 PM
In case you missed it: @matthewjshepherd.bsky.social surveyed the clinical literature to reveal how #AMR evolves within patients, why eco/evo mechanisms vary among infections, & what we can do better to improve treatments www.nature.com/articles/s41... #MicroSky
It was great fun to be part of this project! Super cool to see Rock-Paper-Scissors dynamics in real microbial populations
🆕New in @plosbiology.bsky.social: we show compensatory mutations make plasmids play Rock-Paper-Scissors and turn conjugation into a weapon🛡️💫✂️🦠
w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky
w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky
A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation
Plasmids spread important traits in microbiomes but impose fitness costs on their hosts. This study of the ecological consequences of plasmid-bacterial compensatory evolution reveals benefits to bacte...
journals.plos.org
December 3, 2024 at 10:36 AM
It was great fun to be part of this project! Super cool to see Rock-Paper-Scissors dynamics in real microbial populations
PhD studentship alert!
Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester
Exploring routes of horizontal gene transfer in pathogenic fungi
Exciting project, will be a bunch of fun! Come & join us 🔬
www.findaphd.com/phds/project...
Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester
Exploring routes of horizontal gene transfer in pathogenic fungi
Exciting project, will be a bunch of fun! Come & join us 🔬
www.findaphd.com/phds/project...
www.findaphd.com
November 28, 2024 at 3:06 PM
PhD studentship alert!
Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester
Exploring routes of horizontal gene transfer in pathogenic fungi
Exciting project, will be a bunch of fun! Come & join us 🔬
www.findaphd.com/phds/project...
Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester
Exploring routes of horizontal gene transfer in pathogenic fungi
Exciting project, will be a bunch of fun! Come & join us 🔬
www.findaphd.com/phds/project...
Reposted by Mike Bottery
Soil microbiomes show consistent and predictable responses to extreme events
We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social
We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social
Soil microbiomes show consistent and predictable responses to extreme events - Nature
Soils from 30 grasslands across Europe were subjected to 4 contrasting extreme climatic events under drought, flood, freezing and heat conditions, with the results suggesting that soil microbiomes fro...
doi.org
November 27, 2024 at 6:29 PM
Soil microbiomes show consistent and predictable responses to extreme events
We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social
We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social
Fungal Genetics Stock Centre, there's something fishy going on here...
November 23, 2024 at 8:33 PM
Fungal Genetics Stock Centre, there's something fishy going on here...
Excited to be giving a talk this afternoon on the risk of AMR evolution in fungal pathogens @newcastleuni.bsky.social #WAAW #AMR
November 21, 2024 at 10:37 AM
Excited to be giving a talk this afternoon on the risk of AMR evolution in fungal pathogens @newcastleuni.bsky.social #WAAW #AMR