Michael Brockhurst
banner
brockhurstlab.bsky.social
Michael Brockhurst
@brockhurstlab.bsky.social
Microbial evolution / University of Manchester
Pinned
New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...
www.biorxiv.org
Over and out. See you in 2026.
December 22, 2025 at 5:49 PM
Reposted by Michael Brockhurst
Microbes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠

www.nature.com/articles/s41...
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology
A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
www.nature.com
December 19, 2025 at 3:03 PM
Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan.
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
Professorial Appointment within the Manchester Institute of Biotechnology:Manchester Institute of Biotechnology
Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.
www.jobs.manchester.ac.uk
December 20, 2025 at 12:21 PM
Reposted by Michael Brockhurst
New 2-year Postdoc: Ancient #Metagenomics & #Microbiome Sciences! 🧬🦷

Join Prof. @christinawarinner.bsky.social ’s group at @mpi-eva-leipzig.bsky.social to study the evolution and ecology of ancient oral microbiota.

📅 Apply by Jan 20, 2026: www.microverse-cluster.de/en/career/jo...
Jobs - Balance of the Microverse
www.microverse-cluster.de
December 20, 2025 at 10:59 AM
Reposted by Michael Brockhurst
so you're going into the piñata business too 😊
A minia­ture piñata
by Christoph — Can you imagine a chil­dren's par­ty in Me­xi­co with­out a piñata as the main at­trac­tion? One of the kids hits the sus­pend­ed piñata with a stick un­til it bursts and the en­tir…
smallthingsconsidered.blog
December 19, 2025 at 9:33 PM
This was nice. Thanks to the wonderful mentees who nominated me.
December 19, 2025 at 8:55 PM
Reposted by Michael Brockhurst
For the life of me, why do people submit manuscripts now? My EIC inbox has rarely been fuller, and there's no way I'm sending these to Associate Editors until 2026.

Friends don't let friends submit in late December.
barack obama is sitting in a chair making a funny face and asking why tho ?
ALT: barack obama is sitting in a chair making a funny face and asking why tho ?
media.tenor.com
December 19, 2025 at 7:57 PM
It’s official: we’ve been awarded a UKRI Engineering Biology Focal Award to train the next generation of microbial bioengineer PhDs. An exciting collaboration between @officialuom.bsky.social @liverpooluni.bsky.social
Projects will be advertised in February 2026!
www.ukri.org/news/ukri-do...
UKRI doctoral training investment set to power UK growth
UK Research and Innovation (UKRI) invests in next-generation doctoral training to boost UK innovation and economic growth.
www.ukri.org
December 19, 2025 at 8:26 PM
Reposted by Michael Brockhurst
We had two fantastic visiting speakers today

MERMan alumnus @rowancallumg.bsky.social spoke about his current work with viral cheating in influenza with @asherleeks.bsky.social

And @lavishaparab.bsky.social talked about phage infection trade-offs

Thanks to @microbesng.bsky.social for our snacks!
December 3, 2025 at 5:32 PM
Reposted by Michael Brockhurst
The last seminar of the year was another set of exciting talks from visitor @alekseiagapov.bsky.social and merfolk @sophiesomerville.bsky.social !

Thanks to @microbesng.bsky.social for the 🍪!

Have a happy and safe holiday! 🤶🏻 🎅🏻 🎄
December 11, 2025 at 4:30 PM
Reposted by Michael Brockhurst
Whelan lab cake for the win at the Division of Evolution, Infection and Genomics and MCF Winter Celebration 🥳
#bakeoff #whelanlab
December 11, 2025 at 5:29 PM
Reposted by Michael Brockhurst
Congratulations to PhD student Zahraa Albaqsami @zahraaalbaqsami.bsky.social for successfully defending her PhD today! Zahraa's thesis looked at thermal adaptation and mutation in the archaeon Sulfolobus acidocaldarious.

Thanks to examiners @rokkrasovec.bsky.social and Thorsten Allers!
December 17, 2025 at 8:13 PM
We did a genome. Not just any genome. A Eukaryote! Telomeres, centromeres, introns! What the hell?! With megabrains @guyleonard.bsky.social Tom Richards, Fiona Savory at Oxford. A fun collaboration! Keep em peeled for more algal preprints coming soon!
De novo genome sequence assembly of the model algal endosymbiont Micractinium conductrix derived from its host Paramecium bursaria 186b.

Guy Leonard, Irma Vitonyte, Fiona R Savory, Erika M Hansson, Duncan D Cameron, Michael Brockhurst, Thomas A Richards
bioRxiv doi: doi.org/10.64898/202...
De novo genome sequence assembly of the model algal endosymbiont Micractinium conductrix derived from its host Paramecium bursaria 186b
Endosymbiosis is a major driver of evolutionary innovation and underpins the function of diverse ecosystems. The origins and evolution of endosymbiosis are challenging to study experimentally due to t...
doi.org
December 19, 2025 at 8:16 PM
Reposted by Michael Brockhurst
Congratulations to Dr Rana Alruthaya, who successfully defended her PhD today on AMR diversity in Pseudomonas aeruginosa isolates from non-CF bronchiectasis patients. She's the 10th PhD student from MERMan. Well done Rana! @dannagifford.bsky.social @brockhurstlab.bsky.social @knightjar.bsky.social
December 18, 2025 at 5:41 PM
Reposted by Michael Brockhurst
Back home from the #MicroEvo25 conference in the heartwarming city of Liverpool 🥰 We had fun, made new friends, and discussed science and future projects. Thank you @microbiologysociety.org for these amazing days! Can’t wait for the next edition!
November 28, 2025 at 10:22 PM
Reposted by Michael Brockhurst
Come work with us!! 2.5 year postdoc on HGT in plants.

Please share and get in touch if interested

www.jobs.ac.uk/job/DPQ418/r...
Research Associate: Horizontal Gene Transfer at University of Sheffield
Searching for an academic job? Explore this Research Associate: Horizontal Gene Transfer opening on jobs.ac.uk! Click to view more details and browse other academic jobs.
www.jobs.ac.uk
November 28, 2025 at 8:06 PM
Reposted by Michael Brockhurst
And that’s a wrap for #MicroEvo25! Thank you to @microbiologysociety.org for organising such a fantastic event & to everyone in attendance for sharing such exciting science! Let’s do it again soon?
November 28, 2025 at 9:24 AM
Reposted by Michael Brockhurst
P.S. if you were at #MicroEvo25 and didn’t get chance to scan the QR code on my poster, but would like to see some videos from our Iceland fieldwork 🌋 you can find them all here linktr.ee/magdalenakur...
Magdalena Kurteu | Instagram | Linktree
Microbiologist, PhD student studying eco-evolutionary dynamics of microbial communities in hot springs 🧫🧬🌋
linktr.ee
November 28, 2025 at 10:20 AM
Reposted by Michael Brockhurst
Back in Oxford, but still buzzing with excitement from #MicroEvo25 ! Great science, friendly and relaxed atmosphere, and a brilliant opportunity to catch up with friends and colleagues.

Liverpool is a good place for scientific meetings.
November 28, 2025 at 5:45 PM
Reposted by Michael Brockhurst
On the plane after a fantastic few days in Liverpool at #MicroEvo25 organised by the @microbiologysociety.org. The science, the people, and the city were all way above expectations. I’m definitely coming back. Had an absolute blast!
November 28, 2025 at 6:20 PM
Reposted by Michael Brockhurst
Winning the poster prize was an amazing way to end #MicroEvo25 🎉

Absolutely loved sharing (the start of!) my PhD research! Thanks to @brockhurstlab.bsky.social @coytelab.bsky.social and Sophie for the encouragement & to @microbiologysociety.org for organising such a fantastic event!
Massive congratulations to our own @magdalenakurteu.bsky.social for winning the poster prize at #MicroEvo25!! Her poster describes coalescence dynamics in hot spring microbial communities, and featured wonderful photos from Icelandic field work
November 28, 2025 at 10:17 AM
Reposted by Michael Brockhurst
Had an amazing time at #MicroEvo25 in Liverpool learning all about phages and evolution of antimicrobial resistance. Was great to present my first ever poster and met some lovely people!
November 27, 2025 at 9:59 PM
Reposted by Michael Brockhurst
Had a great time at #MicroEvo25 soaking up some inspiring science from lots of amazing people. Even networked! Very well organised by @microbiologysociety.org. Next time hopefully more of the work presented is published in society journals! If we don't use it we will lose it!
November 27, 2025 at 10:17 PM
What a week! Thanks to everyone who attended the UK Phage Therapy workshop and #MicroEvo25 in Liverpool… every talk, poster, question, chat, and round of applause helps to build our microbial evolution community! Thanks to @microbiologysociety.org and @ukri.org for support
November 27, 2025 at 9:34 PM