Richard Leggett
@richardmleggett.bsky.social
Bioinformatics/Nanopore/Metagenomics person at the Earlham Institute. This is my (unofficial) work related account - I do inane non-work stuff elsewhere!
https://www.earlham.ac.uk/leggett-group
https://www.earlham.ac.uk/leggett-group
Know metagenomics and could spare 2 mins? I'm applying for funding to build a visual repository for metagenomic classification data (not sequence data). To support the application, I have a short 2 minute survey and it would be a big help if you could fill it in: docs.google.com/forms/d/e/1F...
November 12, 2025 at 12:01 PM
Know metagenomics and could spare 2 mins? I'm applying for funding to build a visual repository for metagenomic classification data (not sequence data). To support the application, I have a short 2 minute survey and it would be a big help if you could fill it in: docs.google.com/forms/d/e/1F...
Know metagenomics and could spare 2 mins? I'm applying for funding to build a visual repository for metagenomic classification data (not sequence data). To support the application, I have a short 2 minute survey and it would be a big help if you could fill it in: docs.google.com/forms/d/e/1F...
Metagenomic classification survey
Background: We're seeking the views of researchers on the possibility of a repository for metagenomic classification data, which we're hoping to build. The rationale is that people are familiar with t...
docs.google.com
November 10, 2025 at 6:24 PM
Know metagenomics and could spare 2 mins? I'm applying for funding to build a visual repository for metagenomic classification data (not sequence data). To support the application, I have a short 2 minute survey and it would be a big help if you could fill it in: docs.google.com/forms/d/e/1F...
Reposted by Richard Leggett
Exciting news! We are pleased to announce the call for abstracts for our 2nd Aerosols and Microbiology Meeting, taking place from 9–11 June 2026 at the Leeds Marriott Hotel: microb.io/Aerosols2026... #Aerosols2026
November 3, 2025 at 4:30 PM
Exciting news! We are pleased to announce the call for abstracts for our 2nd Aerosols and Microbiology Meeting, taking place from 9–11 June 2026 at the Leeds Marriott Hotel: microb.io/Aerosols2026... #Aerosols2026
Hey @moderation.bsky.app I set up a new account @martisoftware.bsky.social to give updates on a piece of open source scientific software and you've flagged it as spam because I followed 9 people and made 1 post. You've then failed to respond to my appeal. What is going on?
November 5, 2025 at 8:41 AM
Hey @moderation.bsky.app I set up a new account @martisoftware.bsky.social to give updates on a piece of open source scientific software and you've flagged it as spam because I followed 9 people and made 1 post. You've then failed to respond to my appeal. What is going on?
Our MARTi @nanoporetech.com paper is now out in @genomeresearch.bsky.social after several years of development (particularly Ned Peel and Sam Martin). We'd love to hear from users about how you're using it, or suggestions for new features. @earlhaminst.bsky.social
genome.cshlp.org/content/earl...
genome.cshlp.org/content/earl...
Real-time analysis and visualization of nanopore metagenomic samples with MARTi
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
October 28, 2025 at 9:36 AM
Our MARTi @nanoporetech.com paper is now out in @genomeresearch.bsky.social after several years of development (particularly Ned Peel and Sam Martin). We'd love to hear from users about how you're using it, or suggestions for new features. @earlhaminst.bsky.social
genome.cshlp.org/content/earl...
genome.cshlp.org/content/earl...
Reposted by Richard Leggett
💬 “It’s operationally very lightweight, you can use it in-field for taxonomic classification on a standard laptop, or undertake larger, complex analysis using HPC.”
💻🧬 Scientists at Earlham Institute introduce MARTi, a new tool for real-time #nanopore #metagenomics.
@genomeresearch.bsky.social
💻🧬 Scientists at Earlham Institute introduce MARTi, a new tool for real-time #nanopore #metagenomics.
@genomeresearch.bsky.social
New software tool MARTi fast-tracks identification and response to microbial threats.
An open-source software tool that powers real-time analysis and visualisation of metagenomic data
buff.ly
October 28, 2025 at 9:02 AM
💬 “It’s operationally very lightweight, you can use it in-field for taxonomic classification on a standard laptop, or undertake larger, complex analysis using HPC.”
💻🧬 Scientists at Earlham Institute introduce MARTi, a new tool for real-time #nanopore #metagenomics.
@genomeresearch.bsky.social
💻🧬 Scientists at Earlham Institute introduce MARTi, a new tool for real-time #nanopore #metagenomics.
@genomeresearch.bsky.social
Excellently led by Mia Berelson.
📄 A new review from scientists at the Earlham Institute, @johninnescentre.bsky.social and @nhm-london.bsky.social discusses the developments, methodology, and applications of airborne #DNA #sequencing. 🍃
➡️ buff.ly/adMCpPd
@richardmleggett.bsky.social
🖥️ 🧬
➡️ buff.ly/adMCpPd
@richardmleggett.bsky.social
🖥️ 🧬
From air to insight: the evolution of airborne DNA sequencing technologies
Historically, the analysis of airborne biological organisms relied on microscopy and culture-based techniques. However, technological advances such as PCR and next-generation sequencing now provide…
buff.ly
May 29, 2025 at 2:50 PM
Excellently led by Mia Berelson.
Reposted by Richard Leggett
🆕 Registration has is open for our training course '#Nanopore #Metagenomics: from sample to analysis.
The course provides a thorough overview of lab and in-field, real-time
@nanoporetech.com #sequencing, including DNA extraction, library preparation, and data analysis and visualisation. 🖥️ 🧬
The course provides a thorough overview of lab and in-field, real-time
@nanoporetech.com #sequencing, including DNA extraction, library preparation, and data analysis and visualisation. 🖥️ 🧬
Nanopore metagenomics: from sample to analysis 2025
Learn how to extract DNA from metagenomic samples, prepare libraries, carry out nanopore sequencing and analyse data.
buff.ly
May 8, 2025 at 11:01 AM
🆕 Registration has is open for our training course '#Nanopore #Metagenomics: from sample to analysis.
The course provides a thorough overview of lab and in-field, real-time
@nanoporetech.com #sequencing, including DNA extraction, library preparation, and data analysis and visualisation. 🖥️ 🧬
The course provides a thorough overview of lab and in-field, real-time
@nanoporetech.com #sequencing, including DNA extraction, library preparation, and data analysis and visualisation. 🖥️ 🧬
A few places remaining for EI's latest "Nanopore metagenomics: from sample to analysis" course, running 8-9 July 2025. Will hopefully be a good introduction to wet lab and bioinformatics, plus the opportunity to discuss your projects.
@nanoporetech.com
www.earlham.ac.uk/events/nanop...
@nanoporetech.com
www.earlham.ac.uk/events/nanop...
Nanopore metagenomics: from sample to analysis 2025
In this in-person workshop, learn how to extract DNA from metagenomic samples, prepare libraries, carry out nanopore sequencing and analyse data.
www.earlham.ac.uk
May 9, 2025 at 9:57 AM
A few places remaining for EI's latest "Nanopore metagenomics: from sample to analysis" course, running 8-9 July 2025. Will hopefully be a good introduction to wet lab and bioinformatics, plus the opportunity to discuss your projects.
@nanoporetech.com
www.earlham.ac.uk/events/nanop...
@nanoporetech.com
www.earlham.ac.uk/events/nanop...
Reposted by Richard Leggett
At the Earlham Institute, we develop tools that help researchers share, access, and use large #genomic datasets. 🖥️🧬
One of those is Grassroots Genomics - an open-source platform supporting the plant genomic community. #FAIRdata #OpenScience
➡️ buff.ly/CRUNCDr
@richardmleggett.bsky.social
One of those is Grassroots Genomics - an open-source platform supporting the plant genomic community. #FAIRdata #OpenScience
➡️ buff.ly/CRUNCDr
@richardmleggett.bsky.social
Threshing out the grains of FAIR data with Grassroots
In an era of cheaper and faster sequencing, genomics can mean having to find a needle-sized piece of vital information in a haystack-sized wealth of data. Our Grassroots tool helps you sort the wheat…
buff.ly
April 1, 2025 at 8:00 AM
At the Earlham Institute, we develop tools that help researchers share, access, and use large #genomic datasets. 🖥️🧬
One of those is Grassroots Genomics - an open-source platform supporting the plant genomic community. #FAIRdata #OpenScience
➡️ buff.ly/CRUNCDr
@richardmleggett.bsky.social
One of those is Grassroots Genomics - an open-source platform supporting the plant genomic community. #FAIRdata #OpenScience
➡️ buff.ly/CRUNCDr
@richardmleggett.bsky.social
Reposted by Richard Leggett
Keen to understand more about #Nanopore #metagenomics?
Join our course in July for hands-on training covering experimental methods, sample collection, #DNA extraction and library preparation.
buff.ly/jX87IHb
@richardmleggett.bsky.social
Join our course in July for hands-on training covering experimental methods, sample collection, #DNA extraction and library preparation.
buff.ly/jX87IHb
@richardmleggett.bsky.social
Nanopore metagenomics: from sample to analysis 2025
In this in-person workshop, learn how to extract DNA from metagenomic samples, prepare libraries, carry out nanopore sequencing and analyse data.
buff.ly
March 24, 2025 at 4:00 PM
Keen to understand more about #Nanopore #metagenomics?
Join our course in July for hands-on training covering experimental methods, sample collection, #DNA extraction and library preparation.
buff.ly/jX87IHb
@richardmleggett.bsky.social
Join our course in July for hands-on training covering experimental methods, sample collection, #DNA extraction and library preparation.
buff.ly/jX87IHb
@richardmleggett.bsky.social
Reposted by Richard Leggett
Great talk at #CMINorwich25 from Mia Berelson on sequencing fungal pathogens from the air using AirSeq @richardmleggett.bsky.social @norwichmicro.bsky.social @earlhaminst.bsky.social
February 27, 2025 at 5:40 PM
Great talk at #CMINorwich25 from Mia Berelson on sequencing fungal pathogens from the air using AirSeq @richardmleggett.bsky.social @norwichmicro.bsky.social @earlhaminst.bsky.social
It’s nice to be attending the first annual conference of the Centre for Microbial Interactions, to which I am affiliated. So many Norwich researchers are involved in this great initiative.
Also amused to discover my new Spanish naming on the name badge! #cminorwich25 @norwichmicro.bsky.social
Also amused to discover my new Spanish naming on the name badge! #cminorwich25 @norwichmicro.bsky.social
February 26, 2025 at 10:18 AM
It’s nice to be attending the first annual conference of the Centre for Microbial Interactions, to which I am affiliated. So many Norwich researchers are involved in this great initiative.
Also amused to discover my new Spanish naming on the name badge! #cminorwich25 @norwichmicro.bsky.social
Also amused to discover my new Spanish naming on the name badge! #cminorwich25 @norwichmicro.bsky.social
Reposted by Richard Leggett
Happy to share our latest paper led by Will Boulton just out in 'Scientific Data'. Significant effort including #Alfred-Wegener-Institute, @jgi.doe.gov, @uniofeastanglia.bsky.social ++
Metagenome-assembled-genomes recovered from the #Arctic drift expedition #MOSAiC
www.nature.com/articles/s41...
Metagenome-assembled-genomes recovered from the #Arctic drift expedition #MOSAiC
www.nature.com/articles/s41...
February 4, 2025 at 2:18 PM
Happy to share our latest paper led by Will Boulton just out in 'Scientific Data'. Significant effort including #Alfred-Wegener-Institute, @jgi.doe.gov, @uniofeastanglia.bsky.social ++
Metagenome-assembled-genomes recovered from the #Arctic drift expedition #MOSAiC
www.nature.com/articles/s41...
Metagenome-assembled-genomes recovered from the #Arctic drift expedition #MOSAiC
www.nature.com/articles/s41...
Reposted by Richard Leggett
We're really excited to be part of Norwich Science Festival next month! Thanks to our PhD intern @rapher97.bsky.social we're running a poster trail around Norwich city centre from 1-22 February and an interactive stand at The Forum on 21 February: norwichsciencefestival.co.uk/whats-on/mar...
Marvellous Microbes Trail | Norwich Science Festival
norwichsciencefestival.co.uk
January 20, 2025 at 11:50 AM
We're really excited to be part of Norwich Science Festival next month! Thanks to our PhD intern @rapher97.bsky.social we're running a poster trail around Norwich city centre from 1-22 February and an interactive stand at The Forum on 21 February: norwichsciencefestival.co.uk/whats-on/mar...
For a slightly more sober analysis of Nvidia's new Project Digits "super" personal computer, see this great article at
@theregister.com www.theregister.com/2025/01/07/n...
@theregister.com www.theregister.com/2025/01/07/n...
Nvidia unveils cut-down Grace-Blackwell Superchip
Tuned for running chunky models on the desktop with 128GB of RAM, custom Ubuntu
www.theregister.com
January 7, 2025 at 9:26 PM
For a slightly more sober analysis of Nvidia's new Project Digits "super" personal computer, see this great article at
@theregister.com www.theregister.com/2025/01/07/n...
@theregister.com www.theregister.com/2025/01/07/n...
Reposted by Richard Leggett
New year, new assemblies!
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)
Home
A tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler
github.com
December 31, 2024 at 11:43 PM
New year, new assemblies!
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)
It certainly is! But there is even more to it than scientists and data centres! 😃 🧬🔬🥼
Never been to Norwich, but sounds like the place to visit.
🆕 New Data Centre at Norwich Research Park set to bolster UK’s bioscience capability
@earlhaminst.bsky.social John Innes Centre @thesainsburylab.bsky.social
https://buff.ly/3ZHEVQ4
@earlhaminst.bsky.social John Innes Centre @thesainsburylab.bsky.social
https://buff.ly/3ZHEVQ4
December 10, 2024 at 12:32 PM
It certainly is! But there is even more to it than scientists and data centres! 😃 🧬🔬🥼
Do get in contact with me, or even better, Simon Tyrrell (not of this platform) if you want to know more!
We're recruiting for a Research #SoftwareEngineer to work on the Earlham Institute's Grassroots Genomics Platform - supporting #FAIRdata access and sharing across the #wheatgenomics community. @richardmleggett.bsky.social
📅 Apply by: 29 January
ℹ️ Full-time, part-time, or job-share considered
🖥️🧬
📅 Apply by: 29 January
ℹ️ Full-time, part-time, or job-share considered
🖥️🧬
Research Software Engineer
www.earlham.ac.uk
December 10, 2024 at 12:26 PM
Do get in contact with me, or even better, Simon Tyrrell (not of this platform) if you want to know more!
Reposted by Richard Leggett
And support to deposit long read technology data was added relatively recently!
November 28, 2024 at 3:55 PM
And support to deposit long read technology data was added relatively recently!
I would guess deposits at SRA are typically delayed 1-many years from start of work, so not so much the state of sequencing in 2024, but fascinating figure nonetheless!
🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐
November 28, 2024 at 3:49 PM
I would guess deposits at SRA are typically delayed 1-many years from start of work, so not so much the state of sequencing in 2024, but fascinating figure nonetheless!
Reposted by Richard Leggett
Exciting news! The latest hifiasm release from Haoyu Cheng and Heng Li adds beta support for @nanoporetech.com simplex R10 reads. Initial results look very promising. 🚀
Check it out: github.com/chhylp123/hi...
Check it out: github.com/chhylp123/hi...
Release Hifiasm-0.21.0-r686 · chhylp123/hifiasm
Since Hifiasm-0.20.0 (r639):
New Feature: Introduced a beta module for ONT assembly using ONT simplex R10 reads. To enable this feature, add the --ont option as shown below:
hifiasm -t64 --ont -o...
github.com
November 27, 2024 at 7:11 PM
Exciting news! The latest hifiasm release from Haoyu Cheng and Heng Li adds beta support for @nanoporetech.com simplex R10 reads. Initial results look very promising. 🚀
Check it out: github.com/chhylp123/hi...
Check it out: github.com/chhylp123/hi...
Reposted by Richard Leggett
If you haven't seen this, an interesting analysis (uk based) peerj.com/articles/989/
Research groups: How big should they be?
Understanding the relationship between scientific productivity and research group size is important for deciding how science should be funded. We have investigated the relationship between these varia...
peerj.com
November 27, 2024 at 9:29 PM
If you haven't seen this, an interesting analysis (uk based) peerj.com/articles/989/