Corey Watson
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cdubsig.bsky.social
Corey Watson
@cdubsig.bsky.social
680 followers 1K following 28 posts
Scientist with interests in immuno-, population, evolutionary, molecular, and disease genetics. IG for life.
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cdubsig.bsky.social
🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data.
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...
The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase
Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons
academic.oup.com
November 7, 2025 at 8:23 PM
Reposted by Corey Watson
ayeletperes.bsky.social
Query by ancestry, tissue, chain, or study.

Explore allele usage, haplotypes, and gene presence/absence with interactive tools.

Download via API or browser.

Fully FAIR, MiAIRR-compliant, open, and versioned.

vdjbase.org

#AIRR #Immunogenetics
VDJbase
vdjbase.org
November 7, 2025 at 2:19 PM
Reposted by Corey Watson
ayeletperes.bsky.social
New manuscript out in NAR! tinyurl.com/4rrbuesn
🧬 VDJbase and OGRDB now support 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. From population analysis to precision annotation. @guryaari.bsky.social @cdubsig.bsky.social @williamlees.bsky.social
The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase
Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons
academic.oup.com
November 7, 2025 at 2:19 PM
Reposted by Corey Watson
link-nky.bsky.social
LifeSciKY has welcomed three biotech startups to the new OneNKY Center in Covington. Learn more about the companies and their work in cancer research, immune profiling, and fertility innovation.
linknky.com/business/ent...
LifeSciKY welcomes three biotech startups to Covington’s new OneNKY Center
LifeSciKY’s new lab at the OneNKY Center in Covington welcomed three biotech startups focused on cancer therapy, genomics and fertility.
linknky.com
September 17, 2025 at 10:00 PM
Reposted by Corey Watson
ayeletperes.bsky.social
Excited to see our work on IGHC diversity out! Huge shoutout to @uddalok.bsky.social for leading this study.

🧬 The data is now available on VDJbase, our open resource for exploring B and T cell germline variation across populations. 🧑‍🔬 Go and Explore vdjbase.org!

#immunogenetics #VDJbase
October 28, 2025 at 4:26 PM
cdubsig.bsky.social
Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

www.cell.com/cell-genomic...
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations
Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the cleara...
www.cell.com
October 28, 2025 at 2:35 PM
Reposted by Corey Watson
cyrilpedia.bsky.social
'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'
Dynamic control of autoreactive B cells from spontaneous germinal centers
Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled
academic.oup.com
October 8, 2025 at 9:39 AM
Reposted by Corey Watson
jamieheather.bsky.social
I've got a PSA to the T cell receptor researchers of #immunosky to let you know about a new paper we've just got out: doi.org/10.1016/j.im...

This covers how our field is handling the sets of germline #TCR genes used in our research. Maybe not the most glamorous topic, but it’s kind of a big deal…
A screenshot of the old style '10 PM, do you know where your children are?' PSA poster, with the 'children are?' scribbled out and 'TCR germline gene reference comes from?' crudely pasted over the top.
September 1, 2025 at 3:18 PM
Reposted by Corey Watson
politicsgirl.bsky.social
FFS.
rbreich.bsky.social Robert Reich @rbreich.bsky.social · Aug 29
The CDC is gutting a program that monitors foodborne illnesses. The program will now only track infections caused by two pathogens, rather than eight.

Hello? How does this “Make America Healthy Again”?
The CDC quietly scaled back a surveillance program for foodborne illnesses
As of July 1, a critical surveillance program is monitoring for only two pathogens instead of the usual eight.
www.nbcnews.com
August 30, 2025 at 1:22 AM
cdubsig.bsky.social
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences
The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…
www.sciencedirect.com
August 29, 2025 at 4:49 PM
Reposted by Corey Watson
steen1969.bsky.social
Check out this week's newsletter, featuring @clareobio.bsky.social!
Clareo! Aging, RPM and more...
Neat!
liverpoollane.beehiiv.com
August 5, 2025 at 6:05 PM
Reposted by Corey Watson
clareobio.bsky.social
Thrilled to be featured in GenomeWeb! 🧬

Stuck behind the paywall? We got you. Here's the TL;DR on how Clareo is pioneering the next generation of immune profiling with full-length antibody sequencing.

Find it here: lnk.bio/clareobio

#Biotech #Genomics #LongReads #Immunology
August 6, 2025 at 7:51 PM
Reposted by Corey Watson
clareobio.bsky.social
🌟 Meet "Rosie" - our new @pacbio.bsky.social Vega sequencer! Named after Rosalind Franklin, she'll supercharge our ProfilAIR & GenotypAIR services with faster, more comprehensive B & T cell receptor profiling. Better data = better biomarkers, faster vaccine design, and more precise therapeutics!
August 13, 2025 at 9:35 PM
Reposted by Corey Watson
dnascience.bsky.social
Big win for science: The US senate rejects 40% cuts to NIH funding and instead proposes $400M increase. A clear sign that Congresd is standing behind biomedical research www.nature.com/articles/d41...
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.
www.nature.com
August 4, 2025 at 12:02 AM
Reposted by Corey Watson
molbioevol.bsky.social
Pospelova et al. present a comparative analysis of full-length sequences of IG/TR loci across 46 mammalian species, demonstrating these as rapidly evolving genomic regions, with implications for immunogenomics.

🔗 doi.org/10.1093/molbev/msaf152

#evobio #molbio
Pospelova et al. present a comparative analysis of adaptive immune loci across diverse mammalian species, uncovering relationships between locus architecture, characteristics of immune genes, and population dynamics. The artwork illustrates how the structure of immunoglobulin heavy chain loci influences gene variability in three representative species from the study – the mountain lion, the ring-tailed lemur, and European hedgehog.
July 30, 2025 at 10:36 PM
Reposted by Corey Watson
mossplants.bsky.social
Know an Evolutionary Genomicist looking for a faculty position? Join us in EEB @utknoxville.bsky.social Position is open for studying any organism, but personally I have some botany bias. 🌱 Apply before Sept 19 for full consideration. apply.interfolio.com/170735 Please share widely. Thanks!
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
August 2, 2025 at 4:16 PM
Reposted by Corey Watson
labwaggoner.bsky.social
Are you an immunologist working towards your first R01?

Please join @aai.org and take advantage of programs like our Grant Review for Immunologists Program www.aai.org/Careers/GRIP

We pair early career principal investigators with established mentors. Send me a chat for more info
June 25, 2025 at 3:57 PM
Reposted by Corey Watson
elisarosix.bsky.social
5/6 What can we do now?
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍

iuis.org/committees/n...
T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee » IUIS
Since this Sub-Committee has not addressed MHC/HLA nomenclature for several decades, the name of the Sub-Committee has been changed to “T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee”…
iuis.org
June 28, 2025 at 8:42 AM
Reposted by Corey Watson
elisarosix.bsky.social
6/6 📄 Read the full commentary:
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social
Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era
For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has …
www.sciencedirect.com
June 28, 2025 at 8:42 AM
Reposted by Corey Watson
elisarosix.bsky.social
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
June 28, 2025 at 8:42 AM
cdubsig.bsky.social
An overview of the future of IG and TR gene nomenclature www.immunoinformaticsjournal.com/article/S266...

@yanasafonova.bsky.social @elisarosix.bsky.social
Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era
Antibodies were at the forefront of protein and gene research in the 1970s and 1980s [1–3]. At that time, every report of a new antibody gene or even a partial antibody gene was eagerly awaited, and s...
www.immunoinformaticsjournal.com
June 27, 2025 at 9:48 PM
Reposted by Corey Watson
sten.linnarsson.org
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
ki.se Karolinska Institutet @ki.se · Jun 25
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:08 AM
cdubsig.bsky.social
@guryaari.bsky.social giving awesome overview of ML approaches for AIRR-seq data - FOCiS 2025
@airr-community.bsky.social
June 24, 2025 at 8:38 PM
cdubsig.bsky.social
@ayeletperes.bsky.social providing excellent overview of AIRR-seq tools at FOCiS 2025
@airr-community.bsky.social
June 24, 2025 at 8:01 PM