Elisa Rosati Scalchi
@elisarosix.bsky.social
👩🔬 ImmunOmics scientist.
💻 Immune repertoire geek.
🧡 Work at GSK.
💙 IUIS TR-IG NRC committee co-chair.
🐈⬛🍼Mother of 3 (2 cats + 1 human)
🍕 Foodie.
💻 Immune repertoire geek.
🧡 Work at GSK.
💙 IUIS TR-IG NRC committee co-chair.
🐈⬛🍼Mother of 3 (2 cats + 1 human)
🍕 Foodie.
Pinned
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
As many said, I also think @wikipedia.org is one of the rare good places remained on the internet.
Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25
Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25
Make your donation now - Wikimedia Foundation
Donate to the Wikimedia Foundation, the nonprofit that hosts Wikipedia and other crucial free knowledge projects. Each year, the generosity of the 2% of readers who donate allows us to expand the reac...
donate.wikipedia25.org
January 15, 2026 at 9:44 AM
As many said, I also think @wikipedia.org is one of the rare good places remained on the internet.
Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25
Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25
Reposted by Elisa Rosati Scalchi
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 8, 2025 at 1:39 PM
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Reposted by Elisa Rosati Scalchi
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
October 25, 2025 at 6:37 PM
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
Reposted by Elisa Rosati Scalchi
@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 24, 2025 at 7:14 PM
@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Elisa Rosati Scalchi
Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ
Integrated epigenetic and genetic programming of primary human T cells - Nature Biotechnology
Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
go.nature.com
October 21, 2025 at 3:57 PM
Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ
Reposted by Elisa Rosati Scalchi
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Credit: @integralanswers.bsky.social
October 18, 2025 at 1:30 PM
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Credit: @integralanswers.bsky.social
Reposted by Elisa Rosati Scalchi
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
www.science.org
October 11, 2025 at 3:11 PM
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Statistics on 100 million people
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
www.nature.com
October 8, 2025 at 6:37 AM
Statistics on 100 million people
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
Reposted by Elisa Rosati Scalchi
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences
The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…
www.sciencedirect.com
August 29, 2025 at 4:49 PM
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
June 28, 2025 at 8:42 AM
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
Reposted by Elisa Rosati Scalchi
This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!
We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 9, 2025 at 2:43 PM
This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!
And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉
I love the location in Antwerp too 😍
I love the location in Antwerp too 😍
May 28, 2025 at 4:28 PM
And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉
I love the location in Antwerp too 😍
I love the location in Antwerp too 😍
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
May 27, 2025 at 4:06 PM
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Reposted by Elisa Rosati Scalchi
Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n
May 2, 2025 at 2:50 PM
Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n
Reposted by Elisa Rosati Scalchi
'Unparalleled' snake antivenom made from man bitten 200 times
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
'Unparalleled' snake antivenom made from man bitten 200 times
Scientists hope to make a universal antivenom from the extraordinary blood of a man exposed to snake venom for decades.
www.bbc.com
May 3, 2025 at 2:59 PM
'Unparalleled' snake antivenom made from man bitten 200 times
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
Reposted by Elisa Rosati Scalchi
New @science.org
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
May 1, 2025 at 6:00 PM
New @science.org
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
Reposted by Elisa Rosati Scalchi
Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Differential T cell receptor gene expression analysis using the Wilcoxon test with similarity-based weighting
To better understand immune responses, comparing the abundance of T cell receptors (TCRs) between conditions can provide insights into which T cells have proliferated or were involved in immune activa...
www.biorxiv.org
April 9, 2025 at 3:19 PM
Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Elisa Rosati Scalchi
This looks super interesting www.biorxiv.org/content/10.1...
Ultra long-lived plasma cells in the human small intestine produce microbiota-reactive IgA antibodies
A large fraction of the intestinal microbiota is highly coated with secretory IgA, and bacteria-specific IgA is believed to shape the composition of the microbiota. A hallmark of the adaptive immune s...
www.biorxiv.org
March 22, 2025 at 8:54 AM
This looks super interesting www.biorxiv.org/content/10.1...
Reposted by Elisa Rosati Scalchi
Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses
doi.org/10.1101/2025...
doi.org/10.1101/2025...
March 17, 2025 at 6:48 PM
Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Elisa Rosati Scalchi
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...
doi.org/10.1002/cyto...
March 18, 2025 at 4:36 PM
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...
doi.org/10.1002/cyto...
Reposted by Elisa Rosati Scalchi
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Self-peptide-dependent autoproliferation (AP) of B and T cells i…
www.sciencedirect.com
March 18, 2025 at 5:19 PM
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Elisa Rosati Scalchi
check out our new manuscript (led by Gian Marco Visani):
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
March 4, 2025 at 4:29 AM
check out our new manuscript (led by Gian Marco Visani):
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
Reposted by Elisa Rosati Scalchi
Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 20, 2025 at 10:50 AM
Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously.
www.nature.com/articles/s41...
www.nature.com/articles/s41...