Jeff Mold
@jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Pinned
Jeff Mold
@jeffmold.bsky.social
· Nov 15
My policy on this app is to follow as many scientists as possible. I want a robust, highly varied network of people to discuss all biological research. Especially students
I wish there was an AI tool where one could give it IF microscopy images from a known tissue and get a list of likely proteins that have the precise distribution of the fluorescent signal
November 9, 2025 at 4:08 PM
I wish there was an AI tool where one could give it IF microscopy images from a known tissue and get a list of likely proteins that have the precise distribution of the fluorescent signal
Reposted by Jeff Mold
Have you no decency?
It's time to start asking questions
open.substack.com
October 27, 2025 at 3:03 AM
Reposted by Jeff Mold
There is something deeply rotten at the heart of modern tech that goes well beyond the corruptions produced by capitalism.
“authors & publishers who filed a lawsuit against the Sam Altman-led firm have secured access to internal Slack messages… discussing the mass deletion of a pirated books dataset… A NY district court ordered OpenAI to hand over the communications regarding data deletion”
futurism.com/artificial-i...
futurism.com/artificial-i...
OpenAI in Danger After Authors Suing It Gain Access to Its Internal Slack Messages
Authors and publishers, who are suing OpenAI, secured access to internal Slack messages and emails discussing the deletion of pirated books.
futurism.com
November 9, 2025 at 12:00 PM
There is something deeply rotten at the heart of modern tech that goes well beyond the corruptions produced by capitalism.
Reposted by Jeff Mold
I like "audio documentary"
thank you for listening!
thank you for listening!
There needs to be a new word for radio journalism to distinguish incredible outfits like @onthemedia.bsky.social from “podcasts”. This series on the trump’s war on academia is phenomenal- open.spotify.com/episode/729x...
S2 - Episode 2: The Harvard Plan
open.spotify.com
November 8, 2025 at 3:53 PM
I like "audio documentary"
thank you for listening!
thank you for listening!
Americans are concerned with competition in academic science by China… they should be concerned about Europe. We still value science quite a lot here
There needs to be a new word for radio journalism to distinguish incredible outfits like @onthemedia.bsky.social from “podcasts”. This series on the trump’s war on academia is phenomenal- open.spotify.com/episode/729x...
S2 - Episode 2: The Harvard Plan
open.spotify.com
November 8, 2025 at 12:43 PM
Americans are concerned with competition in academic science by China… they should be concerned about Europe. We still value science quite a lot here
There needs to be a new word for radio journalism to distinguish incredible outfits like @onthemedia.bsky.social from “podcasts”. This series on the trump’s war on academia is phenomenal- open.spotify.com/episode/729x...
S2 - Episode 2: The Harvard Plan
open.spotify.com
November 8, 2025 at 6:59 AM
There needs to be a new word for radio journalism to distinguish incredible outfits like @onthemedia.bsky.social from “podcasts”. This series on the trump’s war on academia is phenomenal- open.spotify.com/episode/729x...
Reposted by Jeff Mold
Cryptic multicellularity in wild yeast brings selective advantages under stress https://www.biorxiv.org/content/10.1101/2025.11.06.687064v1
November 8, 2025 at 5:17 AM
Cryptic multicellularity in wild yeast brings selective advantages under stress https://www.biorxiv.org/content/10.1101/2025.11.06.687064v1
Atlases are like really great reviews of a massive field without the fuss of “citing relevant literature”
November 7, 2025 at 3:24 PM
Atlases are like really great reviews of a massive field without the fuss of “citing relevant literature”
Looks neat but the idea that fetal T cells are naive or quiescent has looooooooong been disproven. No need for red herrings on that one: www.cell.com/cell/fulltex...
Systemic immune activity occurs during human immune system maturation
Profiling of immune cells from consecutive developmental time points in second-trimester
fetuses and adults reveals that immune activation, immune tolerance, and hematopoiesis
occur in a systemic way ...
www.cell.com
November 6, 2025 at 4:11 PM
Looks neat but the idea that fetal T cells are naive or quiescent has looooooooong been disproven. No need for red herrings on that one: www.cell.com/cell/fulltex...
Reposted by Jeff Mold
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
This is interesting for a number of reasons. www.nature.com/articles/s41...
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity - Nature Biotechnology
T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.
www.nature.com
November 3, 2025 at 4:05 PM
This is interesting for a number of reasons. www.nature.com/articles/s41...
Reposted by Jeff Mold
Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.
Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...
www.biorxiv.org
October 31, 2025 at 5:24 PM
Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.
Reposted by Jeff Mold
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 5:56 AM
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Controversial idea - aging won’t be figured out anytime soon with multiomic profiling of a few 100,000 or even million cells…
October 29, 2025 at 8:58 PM
Controversial idea - aging won’t be figured out anytime soon with multiomic profiling of a few 100,000 or even million cells…
Reposted by Jeff Mold
Say what?
This ignoramus is harming Science and people.
This papers shows that your immune response, particularly your T cells, respond very good and are on good shape after SARS-COV-2 infection! It provides good evidence there is no immune damage‼️
1/9
This ignoramus is harming Science and people.
This papers shows that your immune response, particularly your T cells, respond very good and are on good shape after SARS-COV-2 infection! It provides good evidence there is no immune damage‼️
1/9
October 26, 2025 at 5:44 PM
Say what?
This ignoramus is harming Science and people.
This papers shows that your immune response, particularly your T cells, respond very good and are on good shape after SARS-COV-2 infection! It provides good evidence there is no immune damage‼️
1/9
This ignoramus is harming Science and people.
This papers shows that your immune response, particularly your T cells, respond very good and are on good shape after SARS-COV-2 infection! It provides good evidence there is no immune damage‼️
1/9
Reposted by Jeff Mold
Have you considered submitting a paper to @jhumimmunity.org ?
To know more about us, please read our inaugural editorial: rupress.org/jhi/article/...
To know more about us, please read our inaugural editorial: rupress.org/jhi/article/...
Human immunity | Journal of Human Immunity | Rockefeller University Press
Human immunity is often insufficient against infectious agents and sometimes over-reactive to innocuous components of the environment or the human body. Ge
rupress.org
October 26, 2025 at 8:09 AM
Have you considered submitting a paper to @jhumimmunity.org ?
To know more about us, please read our inaugural editorial: rupress.org/jhi/article/...
To know more about us, please read our inaugural editorial: rupress.org/jhi/article/...
Infinite Jest is a book written in the 1990s that was meant to be read in the 2020s…
October 25, 2025 at 4:17 PM
Infinite Jest is a book written in the 1990s that was meant to be read in the 2020s…
Reposted by Jeff Mold
Failure of DNA repair leads to the tumorigenic transformation of a regenerating blastema in Drosophila imaginal discs https://www.biorxiv.org/content/10.1101/2025.10.24.684460v1
October 25, 2025 at 10:31 AM
Failure of DNA repair leads to the tumorigenic transformation of a regenerating blastema in Drosophila imaginal discs https://www.biorxiv.org/content/10.1101/2025.10.24.684460v1
What’s the alternative? Have PhD students that you don’t mentor? Is an unmentored PhD student really a student?
"...researchers who invest time in their students tend to lead more-productive, more-collaborative groups and attract stronger future students than those who do not." "Time spent with the next generation of scientists is an investment."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
www.nature.com
October 25, 2025 at 5:23 AM
What’s the alternative? Have PhD students that you don’t mentor? Is an unmentored PhD student really a student?
Reposted by Jeff Mold
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
October 24, 2025 at 10:57 AM
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
Reposted by Jeff Mold
Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...
Cell-stereotyped DNA repair outcomes are widespread during genome editing
Genome editing outcomes are governed by DNA repair pathways that vary with cell type and state. We developed scOUT-seq (single-cell Outcomes Using Transcript sequencing), a scalable approach that join...
www.biorxiv.org
October 24, 2025 at 8:44 AM
Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...
Nature... you belittle yourself. Next time just go for the '10 reasons why the COVID vaccine might cure your cancer - you won't believe number 7!'
October 23, 2025 at 10:38 AM
Nature... you belittle yourself. Next time just go for the '10 reasons why the COVID vaccine might cure your cancer - you won't believe number 7!'
Another interesting paper to check on later - www.nature.com/articles/s41...
Parity and lactation induce T cell mediated breast cancer protection - Nature
Nature - Parity and lactation induce T cell mediated breast cancer protection
www.nature.com
October 22, 2025 at 8:21 PM
Another interesting paper to check on later - www.nature.com/articles/s41...
This seems very interesting - www.nature.com/articles/s41...
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 22, 2025 at 8:20 PM
This seems very interesting - www.nature.com/articles/s41...
