Jeff Mold
@jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Pinned
Jeff Mold
@jeffmold.bsky.social
· Nov 15
My policy on this app is to follow as many scientists as possible. I want a robust, highly varied network of people to discuss all biological research. Especially students
I had no idea this was a thing… my god open.spotify.com/episode/0T6E...
How Peptides Conquered the Internet
open.spotify.com
February 13, 2026 at 11:15 AM
I had no idea this was a thing… my god open.spotify.com/episode/0T6E...
This actually looks pretty neat - but if you wanted to do a comprehensive assessment of visual diversity among a cell type T cells must be the hardest to do, tiny round mostly nucleus... like if you wanted to assess visual diversity in a species and chose chipmunks www.biorxiv.org/content/10.6...
www.biorxiv.org
February 12, 2026 at 8:06 AM
This actually looks pretty neat - but if you wanted to do a comprehensive assessment of visual diversity among a cell type T cells must be the hardest to do, tiny round mostly nucleus... like if you wanted to assess visual diversity in a species and chose chipmunks www.biorxiv.org/content/10.6...
This guy is killing it now. youtu.be/vfpQbv7CmeE?...
Trump Defends Racist Obama Meme & MAGA Rages Over Bad Bunny’s Spanish Halftime Show | The Daily Show
YouTube video by The Daily Show
youtu.be
February 10, 2026 at 6:24 AM
This guy is killing it now. youtu.be/vfpQbv7CmeE?...
Reposted by Jeff Mold
Not something you see in textbooks very often: tripolar mitosis.
February 7, 2026 at 8:00 AM
Not something you see in textbooks very often: tripolar mitosis.
Reposted by Jeff Mold
A near-complete map of human cytosolic degrons and their relevance for disease
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
February 7, 2026 at 7:42 AM
A near-complete map of human cytosolic degrons and their relevance for disease
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
Skiing in Kosovo not bad!
February 3, 2026 at 12:26 PM
Skiing in Kosovo not bad!
This literally can be said of anything this man has touched since 1980…
“.. for most Trump investors, the year has been brutal. But .. for the President and his family, the money-making shows no sign of slowing.”
@newyorker.com
www.newyorker.com/news/a-repor...
@newyorker.com
www.newyorker.com/news/a-repor...
January 31, 2026 at 4:50 PM
This literally can be said of anything this man has touched since 1980…
This fits my biases in how I imagine tissues age www.science.org/doi/10.1126/...
Cellular survivorship bias as a mechanistic driver of muscle stem cell aging
Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) ...
www.science.org
January 29, 2026 at 8:24 PM
This fits my biases in how I imagine tissues age www.science.org/doi/10.1126/...
I doubt I’ll understand this but I’ll try - www.science.org/doi/10.1126/...
Heritability of intrinsic human life span is about 50% when confounding factors are addressed
How heritable is human life span? If genetic heritability is high, longevity genes can reveal aging mechanisms and inform medicine and public health. However, current estimates of heritability are low...
www.science.org
January 29, 2026 at 8:22 PM
I doubt I’ll understand this but I’ll try - www.science.org/doi/10.1126/...
Reposted by Jeff Mold
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
January 28, 2026 at 4:10 PM
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
Reposted by Jeff Mold
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 5:07 PM
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Reposted by Jeff Mold
This article is now freely available to everyone in PubMed!
www.ncbi.nlm.nih.gov/pmc/articles...
www.ncbi.nlm.nih.gov/pmc/articles...
January 27, 2026 at 12:12 PM
This article is now freely available to everyone in PubMed!
www.ncbi.nlm.nih.gov/pmc/articles...
www.ncbi.nlm.nih.gov/pmc/articles...
Reposted by Jeff Mold
For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!)
www.youtube.com/watch?v=o_X4...
www.youtube.com/watch?v=o_X4...
Lung Treg seminar
YouTube video by Adrian Liston
www.youtube.com
January 26, 2026 at 1:49 PM
For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!)
www.youtube.com/watch?v=o_X4...
www.youtube.com/watch?v=o_X4...
Reposted by Jeff Mold
Last term I tried an experiment: I walked into my Tech and Design Ethics class, admitted that I had *no idea* what to do about ChatGPT - so I would let them figure it out.
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
January 22, 2026 at 11:36 PM
Last term I tried an experiment: I walked into my Tech and Design Ethics class, admitted that I had *no idea* what to do about ChatGPT - so I would let them figure it out.
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
Reposted by Jeff Mold
Towards the end of typological thinking in cell biology?
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
January 22, 2026 at 3:33 PM
Towards the end of typological thinking in cell biology?
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
I have a serious question for the bioinformatics community - it is now very trendy to assign genes to modules or groups and then annotate those groups using various strategies. When I read the methods for papers it is unclear to me how one comes up with the strategy they use - see below:
January 22, 2026 at 9:18 AM
I have a serious question for the bioinformatics community - it is now very trendy to assign genes to modules or groups and then annotate those groups using various strategies. When I read the methods for papers it is unclear to me how one comes up with the strategy they use - see below:
Few will get this but watching Trump at Davos gave me flashbacks to Mario Incandenza’s puppet show explanatory chapter of the origins of ONAN in Infinite Jest…
January 21, 2026 at 7:14 PM
Few will get this but watching Trump at Davos gave me flashbacks to Mario Incandenza’s puppet show explanatory chapter of the origins of ONAN in Infinite Jest…
Wow what a paper - www.nature.com/articles/s41...
Critical role for a high-plasticity cell state in lung cancer - Nature
The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...
www.nature.com
January 21, 2026 at 6:26 PM
Wow what a paper - www.nature.com/articles/s41...
As more and more high dimensional datasets are generated it seems like everyone is starting to discover that things form a 'continuum'. I bet once people adopt more barcoding tools we will move back towards a world where things fall in buckets but just a lot more than we thought.
January 21, 2026 at 1:55 PM
As more and more high dimensional datasets are generated it seems like everyone is starting to discover that things form a 'continuum'. I bet once people adopt more barcoding tools we will move back towards a world where things fall in buckets but just a lot more than we thought.
Holy crap - is China going to take the USA position as the global peacemaker?! Remember they own an enormous amount of USA debt… edition.cnn.com/2026/01/21/c...
Analysis: As Trump sows division, China says it’s the calm, dependable leader the world needs | CNN
As US President Donald Trump primed his arrival in Davos by sowing discord with allies – ramping up threats to take control of Greenland, vowing to levy tariffs on opponents of that bid, and leaking p...
edition.cnn.com
January 21, 2026 at 8:19 AM
Holy crap - is China going to take the USA position as the global peacemaker?! Remember they own an enormous amount of USA debt… edition.cnn.com/2026/01/21/c...
Remember that Michael Burry who called the financial crisis in 2008 long before everyone else is currently investing everything in clean water…. edition.cnn.com/2026/01/20/c...
The world has entered a new era of ‘water bankruptcy’ with irreversible consequences | CNN
Over-allocation of water, chronic groundwater depletion, pollution and climate change have pushed the world into a drastic situation, a new United Nations report finds.
edition.cnn.com
January 20, 2026 at 8:44 PM
Remember that Michael Burry who called the financial crisis in 2008 long before everyone else is currently investing everything in clean water…. edition.cnn.com/2026/01/20/c...
Trump keeps complaining to the Norwegian government about his lack of prizes…. “https://edition.cnn.com/2026/01/19/europe/trump-norway-nobel-prize-snub-intl”
January 20, 2026 at 4:45 AM
Trump keeps complaining to the Norwegian government about his lack of prizes…. “https://edition.cnn.com/2026/01/19/europe/trump-norway-nobel-prize-snub-intl”