Jaeseung Hahn
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jaeseunghahn.bsky.social
Jaeseung Hahn
@jaeseunghahn.bsky.social
molecular hacker, (accidental) synthetic biologist, SciComm fledgling, and postdoc on the faculty job market | Dear AI crawlers, please don't waste energy scraping my ramblings here | Dear Marvel, please don't sue me
This is happening today! If you are postdoc AND in NYC (even if you are from non-NYC institutions), you should join. It's always a good time at NYC postdoc night science.
NYC Postdocs! Interesting in using comedy in the creative scientific process? NYC Postdoc Night Science will have its first 2026 meeting on Feb. 11 at @nyumedpostdocs.bsky.social. I'll lead this with the amazing stand-up comedian Sarah Adelman!
Free registration: docs.google.com/forms/d/11Sz...
February 11, 2026 at 1:36 PM
Reposted by Jaeseung Hahn
Today is the #InternationalDayofWomenandGirlsinScience - celebrating women across our @helloeacr.bsky.social community 🙌

From Board members across Europe to the #EACR HQ team and the scientists we serve worldwide, women play a central role in advancing cancer research every day

#WomeninScience 👩🏻‍🔬🧪
#internationaldayofwomenandgirlsinscience #eacr #womeninscience | Johanna Joyce
Today is the #InternationalDayofWomenandGirlsinScience - a moment to recognise and celebrate women across all of the #EACR community 🙌 From Board members working together across Europe, to the dedic...
www.linkedin.com
February 11, 2026 at 12:49 PM
Just let creative people create 🤷‍♂️
February 11, 2026 at 12:07 PM
Reposted by Jaeseung Hahn
Bad Bunny understood the assignment…
February 9, 2026 at 3:05 AM
Reposted by Jaeseung Hahn
My quote of the day

Benito Antonio Martínez Ocasio
February 9, 2026 at 11:40 AM
Reposted by Jaeseung Hahn
🧪🧬 You can now play Minecraft with DNA nanotechnology! In our latest preprint we introduce DNA polycubes platform: A modeling driven system, where we use SAT-solvers+multiscale simulations to design 3D finite-size structures that assemble in high yield
chemrxiv.org/doi/full/10....
February 8, 2026 at 3:02 AM
Reposted by Jaeseung Hahn
Up to 15-fold improvement in protein labeling for DNA-PAINT 🧬🔬. We are excited to present our latest work published in @angewandtechemie.bsky.social!
onlinelibrary.wiley.com/doi/10.1002/...
Dynamic Binder Exchange Improves Protein Labeling Efficiency in DNA‐PAINT up to 15‐Fold
Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15-fold in super-resolution microscopy. DyBE maps nanoscale receptor tyrosine kin...
onlinelibrary.wiley.com
February 7, 2026 at 8:52 AM
Another big step for the DNA nanotech field from the Irvine and Bathe labs! DNA origami-based vaccine platform elicits broadly neutralizing antibodies against HIV with less non-specific, scaffold-targeting antibodies compared to protein-based vaccine platform 🧬🦠👀

www.science.org/eprint/MJ7WF...
DNA origami vaccines program antigen-focused germinal centers
Priming rare subdominant precursor B cells in germinal centers (GCs) is a central goal of vaccination to generate broadly neutralizing antibodies (bnAbs) against HIV. Multivalent immunogen display on ...
www.science.org
February 6, 2026 at 12:24 PM
Reposted by Jaeseung Hahn
What a treat to be interviewed by Dr. @oliverbogler.bsky.social of the @night-science-inst.bsky.social to discuss our NYC Postdoc Chapter!

I chat a bit about my career and research, and give some tips and tricks for starting your own Night Science chapter!

www.youtube.com/watch?v=4yeO...
A Night Science Chapter for Postdocs: Building Creative Thinking Skills with Kelsey Monson, PhD
YouTube video by Night Science Institute
www.youtube.com
February 3, 2026 at 4:48 PM
Of course, bacteria have to do something crazy as well because of crazy phages ⚔️🧬🦠👀
BackToBack #PhageSky in @nature.com

A pore-forming antiphage defence is activated by oligomeric phage proteins
-from Maxwell & Norris
www.nature.com/articles/s41...

Bacterial immune activation via supramolecular assembly with phage triggers
-from Laub & Ghanbarpour
www.nature.com/articles/s41...
February 5, 2026 at 12:23 PM
Rare-earth elements mining phages? Phages keep giving 💎🧬🦠😭
ICYMI: @berkeleyengineer.bsky.social's Seung-Wuk Lee, a faculty scientist in #BioBSE, pioneered a sustainable biomining approach using genetically engineered viruses to extract rare earth elements. Read more: go.lbl.gov/biomining
February 5, 2026 at 12:16 PM
Reposted by Jaeseung Hahn
It’s a lonely job, leading a research group (professor, principal investigator, group leader – whatever you call it). You talk all day with everyone, but you’re mostly alone with the doubts and risks of the biggest decisions.
Does it have to be though??
podcasts.apple.com/us/podcast/n...
February 3, 2026 at 1:28 AM
Reposted by Jaeseung Hahn
What is a discovery? Why are discoveries so difficult to make? How does Night Science & Day Science capture the process of discovery? What are a few Night Science tools? Can we change the culture of science?
Check out my talk at the DAI Science Festival!
www.youtube.com/watch?v=e9p0...
February 2, 2026 at 3:05 AM
Reposted by Jaeseung Hahn
Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage www.nature.com/articles/s41...
Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage - Nature Biotechnology
Biologics are delivered to the gut using phage that infects resident commensal bacteria.
www.nature.com
January 30, 2026 at 3:22 PM
It's that time of the decade folks. Buckle up for the new installment of the "Hallmarks of cancer" series by Douglas Hanahan 🧐
February 1, 2026 at 12:29 PM
Bacteroides thetaiotaomicron walks into a gut and...

senses and reports on the increased osmolality of the gut associated with inflammatory bowel disease and celiac disease through glowing, fluorescent 💩🦠🧬
February 1, 2026 at 12:17 PM
Reposted by Jaeseung Hahn
#SynBYSS conference is scheduled on Jun 8-11, 2026 in Barcelona. Given the 100-year celebration of Architect Gaudi in Barcelona, we suggest early booking of hotels.
Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration)
@jcvi.org @marcguellc.bsky.social
SynBYSS
The International SynBYSS Conference is focused on bringing together the synthetic biology community with the explicit goal of developing young...
www.jcvi.org
January 31, 2026 at 12:01 PM
If I disappear one day...
January 30, 2026 at 1:24 PM
"vibe" coding 😂
My 5cents on why doing this without knowing the code and statistics is a bad idea. 1 The sample-wise imputation will add noise, and 2 You shouldn't z-scoring abundance for diff abundance analysis
Vibe Coding Omics Data Analysis Applications | Journal of Proteome Research pubs.acs.org/doi/10.1021/...
Vibe Coding Omics Data Analysis Applications
Building custom data analysis platforms has traditionally required extensive software engineering expertise, limiting access for many researchers. Here, I demonstrate that modern large language models...
pubs.acs.org
January 30, 2026 at 12:05 PM
Reposted by Jaeseung Hahn
#SynBYSS webinar with Prof. Dina Petranovic, PhD, EMBA at DTU - Technical University of Denmark & Dr. Michael Grome at Yale University

The talk video is below:
www.youtube.com/watch?v=VluK...
SynBYSS webinar with Prof. Dina Petranovic at Technical U. of Denmark & Dr. Michael Grome at Yale U.
YouTube video by TAESEOK Moon
www.youtube.com
January 29, 2026 at 6:13 PM
Reposted by Jaeseung Hahn
🧪🧠 New preprint out!
Soft Hardware, Flowing Software
We introduce reconfigurable microfluidics as an active control layer for chemical computation. Geometry, and flow, and not molecular redesign, programs function.
Great work by Piet!
chemrxiv.org/doi/full/10....
January 27, 2026 at 1:38 PM
Reposted by Jaeseung Hahn
Our work on waste plastic polyethylene upcycling is out @cp-trendsbiotech.bsky.social thanks to huge efforts by Yuxin Tian, Seong-Min Cho, Sunkyu Park & Jinjin Diao @ncstate.bsky.social & @jcvi.org supported by NSF Global Center, DOE BER & AIChE Langer Prize!

www.sciencedirect.com/science/arti...
Elucidation of odd-chain dicarboxylate metabolism in Acinetobacter baylyi and application to polyethylene upcycling
Polyethylene (PE) is a versatile polymer, but its end-of-life management is challenging due to its recalcitrant structure. We present a promising appr…
www.sciencedirect.com
January 29, 2026 at 7:01 AM
Reposted by Jaeseung Hahn
Plasmid mutation rates scale with copy number
doi.org/10.1073/pnas...
January 26, 2026 at 2:28 PM
This is some crazy stuff! 🧬🤯
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
January 27, 2026 at 12:14 PM
This article is now freely available to everyone in PubMed!
www.ncbi.nlm.nih.gov/pmc/articles...
January 27, 2026 at 12:12 PM