Elisa Rosati Scalchi
@elisarosix.bsky.social
👩🔬 ImmunOmics scientist.
💻 Immune repertoire geek.
🧡 Work at GSK.
💙 IUIS TR-IG NRC committee co-chair.
🐈⬛🍼Mother of 3 (2 cats + 1 human)
🍕 Foodie.
💻 Immune repertoire geek.
🧡 Work at GSK.
💙 IUIS TR-IG NRC committee co-chair.
🐈⬛🍼Mother of 3 (2 cats + 1 human)
🍕 Foodie.
6/6 📄 Read the full commentary:
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social
Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era
For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has …
www.sciencedirect.com
June 28, 2025 at 8:42 AM
6/6 📄 Read the full commentary:
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social
5/6 What can we do now?
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍
iuis.org/committees/n...
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍
iuis.org/committees/n...
T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee » IUIS
Since this Sub-Committee has not addressed MHC/HLA nomenclature for several decades, the name of the Sub-Committee has been changed to “T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee”…
iuis.org
June 28, 2025 at 8:42 AM
5/6 What can we do now?
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍
iuis.org/committees/n...
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍
iuis.org/committees/n...
4/6 Look up the work of the @iuis-online.bsky.social IG/TR Nomenclature Sub-Committee.
They’re urging caution and precision:
➡️ Don’t rush to name
➡️ Wait for sufficient genomic context
➡️ Use consistent interim strategies for gene reporting
#IUIS #GenomicsPolicy
They’re urging caution and precision:
➡️ Don’t rush to name
➡️ Wait for sufficient genomic context
➡️ Use consistent interim strategies for gene reporting
#IUIS #GenomicsPolicy
June 28, 2025 at 8:42 AM
4/6 Look up the work of the @iuis-online.bsky.social IG/TR Nomenclature Sub-Committee.
They’re urging caution and precision:
➡️ Don’t rush to name
➡️ Wait for sufficient genomic context
➡️ Use consistent interim strategies for gene reporting
#IUIS #GenomicsPolicy
They’re urging caution and precision:
➡️ Don’t rush to name
➡️ Wait for sufficient genomic context
➡️ Use consistent interim strategies for gene reporting
#IUIS #GenomicsPolicy
3/6 The problem?
Old naming rules assumed gene order and structure were mostly conserved.
Now we know that’s not always true.
Assigning permanent names too soon could mislead downstream research.
#NomenclatureMatters #IGTR
Old naming rules assumed gene order and structure were mostly conserved.
Now we know that’s not always true.
Assigning permanent names too soon could mislead downstream research.
#NomenclatureMatters #IGTR
June 28, 2025 at 8:42 AM
3/6 The problem?
Old naming rules assumed gene order and structure were mostly conserved.
Now we know that’s not always true.
Assigning permanent names too soon could mislead downstream research.
#NomenclatureMatters #IGTR
Old naming rules assumed gene order and structure were mostly conserved.
Now we know that’s not always true.
Assigning permanent names too soon could mislead downstream research.
#NomenclatureMatters #IGTR
2/6 For 30+ years, the IG/TR gene naming system worked well—standardized, community-supported, and extended across species.
But things have changed…
Genomic sequencing is exposing extreme structural variation across individuals and species.
🧬🔍
But things have changed…
Genomic sequencing is exposing extreme structural variation across individuals and species.
🧬🔍
June 28, 2025 at 8:42 AM
2/6 For 30+ years, the IG/TR gene naming system worked well—standardized, community-supported, and extended across species.
But things have changed…
Genomic sequencing is exposing extreme structural variation across individuals and species.
🧬🔍
But things have changed…
Genomic sequencing is exposing extreme structural variation across individuals and species.
🧬🔍