Daniel Hurdiss
@danielhurdiss.bsky.social
Assistant Professor at Utrecht University 🇳🇱
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
We use #cryoEM and molecular #virology techniques to study the infection mechanisms of +ssRNA viruses.
https://www.uu.nl/medewerkers/DLHurdiss
Views are my own.
Pinned
Daniel Hurdiss
@danielhurdiss.bsky.social
· Jun 18
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Daniel Hurdiss
IsoNet2 determines cellular structures at submolecular resolution without averaging pubmed.ncbi.nlm.nih.gov/41415472/ #cryoem
December 21, 2025 at 4:59 AM
IsoNet2 determines cellular structures at submolecular resolution without averaging pubmed.ncbi.nlm.nih.gov/41415472/ #cryoem
Reposted by Daniel Hurdiss
Molecular mechanisms of receptor recognition and antibody neutralization of coxsackievirus A6 pubmed.ncbi.nlm.nih.gov/41413343/ #cryoem
December 19, 2025 at 1:55 PM
Molecular mechanisms of receptor recognition and antibody neutralization of coxsackievirus A6 pubmed.ncbi.nlm.nih.gov/41413343/ #cryoem
Reposted by Daniel Hurdiss
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
December 19, 2025 at 4:45 PM
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Reposted by Daniel Hurdiss
Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem
December 19, 2025 at 8:10 AM
Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem
Reposted by Daniel Hurdiss
BBC News - Drones detect deadly virus in Arctic whales' breath
www.bbc.co.uk/news/article... (it is, in case you're wondering, cetacean morbillivirus)
www.bbc.co.uk/news/article... (it is, in case you're wondering, cetacean morbillivirus)
Drones detect deadly virus in Arctic whales' breath
Whale breath collected by drones is giving clues to the health of wild humpbacks and other whales.
www.bbc.co.uk
December 19, 2025 at 8:19 AM
BBC News - Drones detect deadly virus in Arctic whales' breath
www.bbc.co.uk/news/article... (it is, in case you're wondering, cetacean morbillivirus)
www.bbc.co.uk/news/article... (it is, in case you're wondering, cetacean morbillivirus)
Reposted by Daniel Hurdiss
The EMDB wishes you a very Merry Christmas, a Happy New Year and we are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, we look forward to seeing you in the New Year here! Card: A mixture of #cryoEM and X-ray diffraction structures.
December 18, 2025 at 2:01 PM
The EMDB wishes you a very Merry Christmas, a Happy New Year and we are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, we look forward to seeing you in the New Year here! Card: A mixture of #cryoEM and X-ray diffraction structures.
Reposted by Daniel Hurdiss
In our new preprint, we show how fibril-dynamics of signaling component TIRAP supports sensitive & fast sensing of endotoxin LPS. Congrats to co-lead @arthurfelker.bsky.social. @piehlerlab.bsky.social @arnemoeller.bsky.social #TLR #cryoEM #blender doi.org/10.64898/202...
December 17, 2025 at 4:00 PM
In our new preprint, we show how fibril-dynamics of signaling component TIRAP supports sensitive & fast sensing of endotoxin LPS. Congrats to co-lead @arthurfelker.bsky.social. @piehlerlab.bsky.social @arnemoeller.bsky.social #TLR #cryoEM #blender doi.org/10.64898/202...
Reposted by Daniel Hurdiss
A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion pubmed.ncbi.nlm.nih.gov/41402251/ #cryoem
December 17, 2025 at 9:58 PM
A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion pubmed.ncbi.nlm.nih.gov/41402251/ #cryoem
Reposted by Daniel Hurdiss
A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion - Nature Communications
Alphaherpesvirus infections pose a health challenge due to the lack of effective broad-spectrum antiviral strategies. Here, the authors identify a broadly neutralizing antibody, 16F9, which targets gl...
www.nature.com
December 17, 2025 at 2:20 PM
A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Daniel Hurdiss
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 4:29 PM
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Daniel Hurdiss
Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification pubmed.ncbi.nlm.nih.gov/41387700/ #cryoem
December 13, 2025 at 3:50 PM
Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification pubmed.ncbi.nlm.nih.gov/41387700/ #cryoem
Reposted by Daniel Hurdiss
Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin pubmed.ncbi.nlm.nih.gov/41390501/ #cryoem
December 14, 2025 at 3:50 PM
Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin pubmed.ncbi.nlm.nih.gov/41390501/ #cryoem
Reposted by Daniel Hurdiss
Tracking SARSCoV2 Lineage BA.3.2* ( #Cicada) over time | 12/15/25
Total BA.3.2* seqs: 184 (+4)
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA, #Germany, #Mozambique, #Slovenia, #UK, #Denmark, #Ireland, #Singapore
Tracker: public.tableau.com/app/profile/...
Total BA.3.2* seqs: 184 (+4)
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA, #Germany, #Mozambique, #Slovenia, #UK, #Denmark, #Ireland, #Singapore
Tracker: public.tableau.com/app/profile/...
December 16, 2025 at 6:16 AM
Tracking SARSCoV2 Lineage BA.3.2* ( #Cicada) over time | 12/15/25
Total BA.3.2* seqs: 184 (+4)
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA, #Germany, #Mozambique, #Slovenia, #UK, #Denmark, #Ireland, #Singapore
Tracker: public.tableau.com/app/profile/...
Total BA.3.2* seqs: 184 (+4)
Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA, #Germany, #Mozambique, #Slovenia, #UK, #Denmark, #Ireland, #Singapore
Tracker: public.tableau.com/app/profile/...
Reposted by Daniel Hurdiss
Current H5N1 avian influenza viruses replicate better in human respiratory tissues than a historic one, warranting "the urgency to prevent cross-species transmission to humans by controlling spillover events to mammals and limiting viral spread in farmed mammals." www.thelancet.com/journals/lan...
December 16, 2025 at 5:54 AM
Current H5N1 avian influenza viruses replicate better in human respiratory tissues than a historic one, warranting "the urgency to prevent cross-species transmission to humans by controlling spillover events to mammals and limiting viral spread in farmed mammals." www.thelancet.com/journals/lan...
Reposted by Daniel Hurdiss
Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome pubmed.ncbi.nlm.nih.gov/41379934/ #cryoem
December 12, 2025 at 6:47 PM
Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome pubmed.ncbi.nlm.nih.gov/41379934/ #cryoem
Reposted by Daniel Hurdiss
I am happy to share our new preprint about the #cryoEM #structure of the AAV2 Rep-Capsid complex. Congratulations to the team. A great collaboration with the Kaelber Lab at Rutgers.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex
The Adeno-associated virus (AAV) has become the most used viral vector for gene therapy applications to treat monogenic diseases, with over 250 clinical trials and six FDA-approved biologics. AAV has ...
www.biorxiv.org
December 12, 2025 at 2:19 AM
I am happy to share our new preprint about the #cryoEM #structure of the AAV2 Rep-Capsid complex. Congratulations to the team. A great collaboration with the Kaelber Lab at Rutgers.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Daniel Hurdiss
Important work that supports the ongoing vaccination trial throughput Europe by the EEHV research group @utrechtvirology.bsky.social
@utrechtuniversity.bsky.social
#EEHV
@utrechtuniversity.bsky.social
#EEHV
How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬
Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉
www.biorxiv.org/content/10.6...
Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉
www.biorxiv.org/content/10.6...
December 4, 2025 at 10:32 AM
Important work that supports the ongoing vaccination trial throughput Europe by the EEHV research group @utrechtvirology.bsky.social
@utrechtuniversity.bsky.social
#EEHV
@utrechtuniversity.bsky.social
#EEHV
Reposted by Daniel Hurdiss
We were well represented at the Science for Life Conference this week!
Sypke van Terwisga gave a fantastic talk on his coronavirus research, and for the 3rd year in a row our team brought home a poster prize — this year thanks to Víctor Pisabarro Montoro and his enterovirus imaging work! 🏆
Sypke van Terwisga gave a fantastic talk on his coronavirus research, and for the 3rd year in a row our team brought home a poster prize — this year thanks to Víctor Pisabarro Montoro and his enterovirus imaging work! 🏆
December 11, 2025 at 9:35 AM
We were well represented at the Science for Life Conference this week!
Sypke van Terwisga gave a fantastic talk on his coronavirus research, and for the 3rd year in a row our team brought home a poster prize — this year thanks to Víctor Pisabarro Montoro and his enterovirus imaging work! 🏆
Sypke van Terwisga gave a fantastic talk on his coronavirus research, and for the 3rd year in a row our team brought home a poster prize — this year thanks to Víctor Pisabarro Montoro and his enterovirus imaging work! 🏆
Reposted by Daniel Hurdiss
BBC News - Flu wave hits England's busiest A&E - hundreds of patients are arriving a day - BBC News
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Flu wave hits England's busiest A&E - hundreds of patients are arriving a day
The BBC visits Leicester Royal Infirmary to witness first-hand how it's coping with an early surge in cases of winter bugs.
www.bbc.co.uk
December 11, 2025 at 8:43 AM
BBC News - Flu wave hits England's busiest A&E - hundreds of patients are arriving a day - BBC News
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted by Daniel Hurdiss
Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex www.biorxiv.org/content/10.64898/2025.12.09.693273v1 #cryoem
December 10, 2025 at 8:10 AM
Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex www.biorxiv.org/content/10.64898/2025.12.09.693273v1 #cryoem
Reposted by Daniel Hurdiss
Cryo-ET Reveals Distinct Gag Lattice Architectures in Virus-like Particles and Immature HIV-1 www.biorxiv.org/content/10.64898/2025.12.08.693107v1 #cryoem
December 10, 2025 at 9:49 AM
Cryo-ET Reveals Distinct Gag Lattice Architectures in Virus-like Particles and Immature HIV-1 www.biorxiv.org/content/10.64898/2025.12.08.693107v1 #cryoem
Reposted by Daniel Hurdiss
I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab
The article is open access and available at:
www.nature.com/articles/s41...
The article is open access and available at:
www.nature.com/articles/s41...
Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria - Nature Communications
The study reveals the structure of ArnC, a membrane glycosyltransferase that modifies undecaprenyl phosphate with aminoarabinose (L-Ara4N), leading to polymyxin resistance. The structure of ArnC in tw...
www.nature.com
December 9, 2025 at 9:56 PM
I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab
The article is open access and available at:
www.nature.com/articles/s41...
The article is open access and available at:
www.nature.com/articles/s41...
Reposted by Daniel Hurdiss
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
Recovery of infectious recombinant human norovirus using zebrafish embryos | PNAS www.pnas.org/doi/abs/10.1...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 9, 2025 at 6:07 PM
Recovery of infectious recombinant human norovirus using zebrafish embryos | PNAS www.pnas.org/doi/abs/10.1...
Reposted by Daniel Hurdiss
Structural and catalytic diversity of coronavirus proofreading exoribonuclease pubmed.ncbi.nlm.nih.gov/41361186/ #cryoem
December 9, 2025 at 3:15 PM
Structural and catalytic diversity of coronavirus proofreading exoribonuclease pubmed.ncbi.nlm.nih.gov/41361186/ #cryoem