Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...

Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.

Cryo-EM structures of the stabilized prefusion conformation of the glycoprotein B ectodomain—the HSV-1 entry machine—identify a prefusion-specific neutralizing antibody and reveal how prefusion glycop...

Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...

The cryo-EM structure of the herpes simplex virus helicase–primase (HP) complex informs about the mechanism of action of HP inhibitors pritelivir and amenamevir, which are drugs of clinical relevance.

Japanese encephalitis virus (JEV), a member of the Flaviviridae family and Orthoflavivirus genus, is one of the leading causes of viral encephalitis in Asia. According to the World Health Organization (WHO), JEV circulates in 24 countries across the WHO South-East Asia Region and Western Pacific Region, causing approximately 20,000 infections annually and placing over 3 billion people at risk of infection (1, 2). The majority of infected individuals are asymptomatic, while a small proportion develop Japanese encephalitis (JE), a severe neurological disease with a fatality rate of ~30%. Moreover, ~50% of JE survivors experience permanent neurological, cognitive, and behavioral sequelae. However, no specific antiviral treatments are currently available for JE (3). Fortunately, JE is a vaccine-preventable disease, and the widespread promotion and accessibility of vaccination programs have significantly reduced the incidence of JE globally over the past two decades (4).

A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

Eleven consortia from various scientific disciplines are set to launch projects of great value to science. But also to the economic and social prosperity of the Netherlands. For example, a consortium led by TU Delft will start work on a detailed virtual model of the Dutch energy system. In another project, a consortium of UMC Utrecht is developing an MRI scanner that can scan people in motion.

A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

C10, a potent non-nucleoside inhibitor targeting NSP14’s SAM-binding pocket, suppresses viral translation, exhibits immunostimulatory effects, and reverses NSP14-induced transcriptome alterations, off...

Rhinoviruses (RVs) are the most common cause of upper respiratory infections, yet RV-C is particularly associated with severe respiratory disease, including exacerbations of asthma and chronic obstruc...

We discover and study reverse transcriptases