TJ McCorvie
@allostericstate.bsky.social
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
All nose and instinct
December 29, 2025 at 3:03 PM
All nose and instinct
Reposted by TJ McCorvie
Merry Christmas! 🎄✨
🔭🧪🐡🎨
🔭🧪🐡🎨
December 25, 2025 at 4:19 PM
Merry Christmas! 🎄✨
🔭🧪🐡🎨
🔭🧪🐡🎨
Reposted by TJ McCorvie
Ulster University senior management spends freely in the skies
Three trips to Qatar cost £83114, attended by Vice-Chancellor & other senior figures including pro-VCs
St Patrick’s Day visit to Washington added another £61000 — or ~£12400 per head
www.belfasttelegraph.co.uk/news/educati...
Three trips to Qatar cost £83114, attended by Vice-Chancellor & other senior figures including pro-VCs
St Patrick’s Day visit to Washington added another £61000 — or ~£12400 per head
www.belfasttelegraph.co.uk/news/educati...
Ulster University under fire for £83k cost of Qatar trips after telling Stormont it is ‘feeling the squeeze’ of cuts
Ulster University has been criticised over an £83,000 bill for trips to Qatar.
www.belfasttelegraph.co.uk
December 24, 2025 at 10:43 AM
Ulster University senior management spends freely in the skies
Three trips to Qatar cost £83114, attended by Vice-Chancellor & other senior figures including pro-VCs
St Patrick’s Day visit to Washington added another £61000 — or ~£12400 per head
www.belfasttelegraph.co.uk/news/educati...
Three trips to Qatar cost £83114, attended by Vice-Chancellor & other senior figures including pro-VCs
St Patrick’s Day visit to Washington added another £61000 — or ~£12400 per head
www.belfasttelegraph.co.uk/news/educati...
Reposted by TJ McCorvie
This is exactly why people claiming "it came up with a new set of experiments/ideas/concepts" are carrying water for the weasels trying to put genAI on everything. This is how we get science defunded. This is how your colleagues lose their jobs 🧪
Suppose you ask #AI for improvements to your writing.
The #LLM was trained on, but doesn’t mention, Smith’s work.
You adopt the suggestions containing Smith’s ideas.
You don’t even realize YOU’VE PLAGIARIZED because you’ve never read or heard of Smith.
The #LLM was trained on, but doesn’t mention, Smith’s work.
You adopt the suggestions containing Smith’s ideas.
You don’t even realize YOU’VE PLAGIARIZED because you’ve never read or heard of Smith.
LLM use in scholarly writing poses a provenance problem
Nature Machine Intelligence - LLM use in scholarly writing poses a provenance problem
doi.org
December 23, 2025 at 2:55 PM
This is exactly why people claiming "it came up with a new set of experiments/ideas/concepts" are carrying water for the weasels trying to put genAI on everything. This is how we get science defunded. This is how your colleagues lose their jobs 🧪
Reposted by TJ McCorvie
We have an opening for a research support officer. Come and join us! Please share.
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
December 22, 2025 at 12:09 PM
We have an opening for a research support officer. Come and join us! Please share.
It’s hazelnut bread wreath time. Recipe: www.cookingaffair.de/kuchen/nussk...
December 22, 2025 at 5:05 PM
It’s hazelnut bread wreath time. Recipe: www.cookingaffair.de/kuchen/nussk...
Reposted by TJ McCorvie
Reinke crystals are immunoreactive for purine-synthesizing metabolic enzymes https://www.biorxiv.org/content/10.64898/2025.12.18.695235v1
December 22, 2025 at 11:00 AM
Reinke crystals are immunoreactive for purine-synthesizing metabolic enzymes https://www.biorxiv.org/content/10.64898/2025.12.18.695235v1
Reposted by TJ McCorvie
A.I. Slop - Beyond the Black Void
A.I. Slop - Beyond the Black Void
YouTube video by RedLetterMedia
youtu.be
December 16, 2025 at 3:55 PM
A.I. Slop - Beyond the Black Void
Reposted by TJ McCorvie
The Max Planck Society has begun an exploratory round table for open science. We are drafting some recommendations to leadership. Still a long way to go! But here are my notes on the most recent draft, just so you all know how I am trying to steer things.
December 17, 2025 at 11:33 AM
The Max Planck Society has begun an exploratory round table for open science. We are drafting some recommendations to leadership. Still a long way to go! But here are my notes on the most recent draft, just so you all know how I am trying to steer things.
Reposted by TJ McCorvie
Great to see new data coming out already from the Tundra :)
A 8 Å resolution map of filamentous cystathionine beta-synthase from a test collection on our Tundra when it was being installed. Though the resolution is limited because the microscope had not been fully set up it was nice to determine a structure again of one of my favourite enzymes. #CryoEM
December 17, 2025 at 2:24 PM
Great to see new data coming out already from the Tundra :)
Reposted by TJ McCorvie
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 4:29 PM
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by TJ McCorvie
In my case, this painstaking labor in the process through which the science gets done. Science isn't measuring stuff in a lab. It's thinking deeply, extracting the heart of idea from the soup of thoughts running through my mind, molding it, and finding a way to communicate that idea to others.
December 16, 2025 at 11:46 PM
In my case, this painstaking labor in the process through which the science gets done. Science isn't measuring stuff in a lab. It's thinking deeply, extracting the heart of idea from the soup of thoughts running through my mind, molding it, and finding a way to communicate that idea to others.
A 8 Å resolution map of filamentous cystathionine beta-synthase from a test collection on our Tundra when it was being installed. Though the resolution is limited because the microscope had not been fully set up it was nice to determine a structure again of one of my favourite enzymes. #CryoEM
December 16, 2025 at 8:18 PM
A 8 Å resolution map of filamentous cystathionine beta-synthase from a test collection on our Tundra when it was being installed. Though the resolution is limited because the microscope had not been fully set up it was nice to determine a structure again of one of my favourite enzymes. #CryoEM
Reposted by TJ McCorvie
📽️Please allow us to present our latest Lee lab production: Holding lab equipment like men hold their fish 🪝🐟
Is it just us, or do y'all also get unreasonably attached to your favorite tools of the trade??
(all credit to @kcs-umasslowell.bsky.social for giving us this idea for a REEL good time🎣)
Is it just us, or do y'all also get unreasonably attached to your favorite tools of the trade??
(all credit to @kcs-umasslowell.bsky.social for giving us this idea for a REEL good time🎣)
December 16, 2025 at 2:11 PM
📽️Please allow us to present our latest Lee lab production: Holding lab equipment like men hold their fish 🪝🐟
Is it just us, or do y'all also get unreasonably attached to your favorite tools of the trade??
(all credit to @kcs-umasslowell.bsky.social for giving us this idea for a REEL good time🎣)
Is it just us, or do y'all also get unreasonably attached to your favorite tools of the trade??
(all credit to @kcs-umasslowell.bsky.social for giving us this idea for a REEL good time🎣)
Reposted by TJ McCorvie
Reposted by TJ McCorvie
Reposted by TJ McCorvie
Trump's comment about Rob Reiner, a beloved American, really demonstrates the rottenness of his character.
December 15, 2025 at 7:42 PM
Trump's comment about Rob Reiner, a beloved American, really demonstrates the rottenness of his character.
Reposted by TJ McCorvie
Elon's little serfs are quite literally begging journalists to come back because every publicly available source of data shows people have fled the platform and young people won't use it.
They are literally begging regular people to come back. Don't do it! It is a website by and for actual Nazis!
They are literally begging regular people to come back. Don't do it! It is a website by and for actual Nazis!
December 15, 2025 at 1:27 AM
Elon's little serfs are quite literally begging journalists to come back because every publicly available source of data shows people have fled the platform and young people won't use it.
They are literally begging regular people to come back. Don't do it! It is a website by and for actual Nazis!
They are literally begging regular people to come back. Don't do it! It is a website by and for actual Nazis!
Reposted by TJ McCorvie
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com
PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
December 15, 2025 at 12:15 PM
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Reposted by TJ McCorvie
I’ve said it before: peer review at good journals can be good and valuable, but at the system level, “peer reviewed” [alone] does not convey any level of validity.
Springer-Nature statement
“Whilst the details of peer review are confidential, we can confirm that the article underwent two rounds of review from two independent peer reviewers, supporting an accept decision.”
How am I now expected to believe that two people looked at the paper twice and DGAF?
“Whilst the details of peer review are confidential, we can confirm that the article underwent two rounds of review from two independent peer reviewers, supporting an accept decision.”
How am I now expected to believe that two people looked at the paper twice and DGAF?
Riding the Autism Bicycle to Retraction Town
Does anyone *really* know their Factor Fexcectorn?
nobreakthroughs.substack.com
December 11, 2025 at 1:18 PM
I’ve said it before: peer review at good journals can be good and valuable, but at the system level, “peer reviewed” [alone] does not convey any level of validity.
Reposted by TJ McCorvie
An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoem
December 11, 2025 at 9:16 AM
An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoem
Reposted by TJ McCorvie
Join us, it will be fun! 😀 Postdoc position in our lab
@giuliazanetti.bsky.social at the Crick&UCL working on #membranetrafficking using biochemical reconstitution and #cryoET is now open! #cellbiology
Email Giulia directly/follow the link to apply: www.ucl.ac.uk/work-at-ucl/...
@giuliazanetti.bsky.social at the Crick&UCL working on #membranetrafficking using biochemical reconstitution and #cryoET is now open! #cellbiology
Email Giulia directly/follow the link to apply: www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
December 10, 2025 at 8:06 PM
Join us, it will be fun! 😀 Postdoc position in our lab
@giuliazanetti.bsky.social at the Crick&UCL working on #membranetrafficking using biochemical reconstitution and #cryoET is now open! #cellbiology
Email Giulia directly/follow the link to apply: www.ucl.ac.uk/work-at-ucl/...
@giuliazanetti.bsky.social at the Crick&UCL working on #membranetrafficking using biochemical reconstitution and #cryoET is now open! #cellbiology
Email Giulia directly/follow the link to apply: www.ucl.ac.uk/work-at-ucl/...
Reposted by TJ McCorvie
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
mrc.tal.net
December 10, 2025 at 2:28 PM
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...