TJ McCorvie
@allostericstate.bsky.social
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
Reposted by TJ McCorvie
The weird reality of 'rare' diseases is that almost everyone knows someone who is affected by one.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
1 in 10 Americans have a rare disease, but few have treatments
The scientific community has identified more than 10,000 rare diseases, but the path to accurately diagnosing and treating these illnesses has been
www.statnews.com
November 13, 2025 at 5:18 PM
The weird reality of 'rare' diseases is that almost everyone knows someone who is affected by one.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
Reposted by TJ McCorvie
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 9:57 AM
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
Reposted by TJ McCorvie
Very cool structures, congrats to all! #microsky
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 1:44 PM
Very cool structures, congrats to all! #microsky
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Reposted by TJ McCorvie
I find the premise that science should serve capital really troublesome to begin with
The UK government says it wants to make Britain one of the top three places in the world to create, invest in and scale-up a fast-growing technology business
go.nature.com/4ifRp9n
go.nature.com/4ifRp9n
Can UK science really spawn a $1-trillion company?
The British government wants the country to be home to a supersized tech firm within the next decade.
go.nature.com
November 12, 2025 at 4:57 PM
I find the premise that science should serve capital really troublesome to begin with
Reposted by TJ McCorvie
The entire interview is great, obviously. But, this is perhaps the best part.
November 10, 2025 at 7:35 PM
The entire interview is great, obviously. But, this is perhaps the best part.
Reposted by TJ McCorvie
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 12:48 PM
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 12:48 PM
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Reposted by TJ McCorvie
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
November 11, 2025 at 8:35 AM
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
Reposted by TJ McCorvie
Join us in a highly collaborative environment. At the IMP everything is possible.
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 11, 2025 at 9:56 AM
Join us in a highly collaborative environment. At the IMP everything is possible.
Reposted by TJ McCorvie
Using Leishmania as a model, we determined the cryo-EM structure of the doublet microtubule to pinpoint the position of each dynein. This gave us a detailed map of where every “rower” sits on the ciliary “boat.”
November 10, 2025 at 5:45 PM
Using Leishmania as a model, we determined the cryo-EM structure of the doublet microtubule to pinpoint the position of each dynein. This gave us a detailed map of where every “rower” sits on the ciliary “boat.”
Reposted by TJ McCorvie
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
November 10, 2025 at 9:30 PM
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
Reposted by TJ McCorvie
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
November 10, 2025 at 6:15 PM
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
Reposted by TJ McCorvie
Every day I understand the Butlerian Jihad more and more
November 10, 2025 at 4:26 PM
Every day I understand the Butlerian Jihad more and more
Reposted by TJ McCorvie
... a sharp image on a piece of film.
What it revealed was this: fuzzy edges with four distinct "spots" in an X pattern in the interior.
This was compared to the chemical structures worked out for the nucleotides themselves, suggesting a stacked pattern of interacting bases.
What it revealed was this: fuzzy edges with four distinct "spots" in an X pattern in the interior.
This was compared to the chemical structures worked out for the nucleotides themselves, suggesting a stacked pattern of interacting bases.
November 10, 2025 at 2:12 PM
... a sharp image on a piece of film.
What it revealed was this: fuzzy edges with four distinct "spots" in an X pattern in the interior.
This was compared to the chemical structures worked out for the nucleotides themselves, suggesting a stacked pattern of interacting bases.
What it revealed was this: fuzzy edges with four distinct "spots" in an X pattern in the interior.
This was compared to the chemical structures worked out for the nucleotides themselves, suggesting a stacked pattern of interacting bases.
As far as I understand leads me to ask why merge the same micelle density twice into a map? This is an unusual map of a cytosolic protein embedded in the membrane of a liposome. There is no explanation for how this map was derived in the associated paper. www.ebi.ac.uk/emdb/EMD-47001
November 10, 2025 at 11:24 AM
As far as I understand leads me to ask why merge the same micelle density twice into a map? This is an unusual map of a cytosolic protein embedded in the membrane of a liposome. There is no explanation for how this map was derived in the associated paper. www.ebi.ac.uk/emdb/EMD-47001
Reposted by TJ McCorvie
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
November 9, 2025 at 5:20 PM
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
pubpeer.com/publications... Unfortunately, I am having a hard time believing the authors were told the FSC plot from CryoSPARC was not acceptable for publication during peer review. Does this usually happen? #CryoEM
PubPeer - High-resolution cryo-EM analysis of a Streptococcus pyogenes...
There are comments on PubPeer for publication: High-resolution cryo-EM analysis of a Streptococcus pyogenes M-protein/human plasminogen complex (2024)
pubpeer.com
November 9, 2025 at 9:06 PM
pubpeer.com/publications... Unfortunately, I am having a hard time believing the authors were told the FSC plot from CryoSPARC was not acceptable for publication during peer review. Does this usually happen? #CryoEM
Reposted by TJ McCorvie
How did @biorxivpreprint make it this far without a #StructuralBiology "subject area"? 🤔
I will choose "biophysics" as the closest one, but this feels inexact for this paper...
I will choose "biophysics" as the closest one, but this feels inexact for this paper...
November 9, 2025 at 5:53 PM
How did @biorxivpreprint make it this far without a #StructuralBiology "subject area"? 🤔
I will choose "biophysics" as the closest one, but this feels inexact for this paper...
I will choose "biophysics" as the closest one, but this feels inexact for this paper...
Reposted by TJ McCorvie
Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3!
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
Mei5–Sae3 stabilizes both active and inactive forms of Dmc1 filaments independently of its impact on ATP hydrolysis
Abstract. In budding yeast, Dmc1’s recombinogenic activity is controlled by the meiosis-specific heterodimer Mei5–Sae3. Mei5–Sae3 is required for assembly
doi.org
November 9, 2025 at 2:19 PM
Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3!
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
Reposted by TJ McCorvie
New guest post on my blog: Csaba Szabo plays cat and mouse with a paper mill
deevybee.blogspot.com/2025/11/the-...
#fraud #publishing
deevybee.blogspot.com/2025/11/the-...
#fraud #publishing
The inner workings of a paper mill:
My Wuxi sting operation Guest post by Csaba Szabo Chair of Pharmacology, University of Fribourg, Switzerland After the limited success of...
deevybee.blogspot.com
November 8, 2025 at 5:57 PM
New guest post on my blog: Csaba Szabo plays cat and mouse with a paper mill
deevybee.blogspot.com/2025/11/the-...
#fraud #publishing
deevybee.blogspot.com/2025/11/the-...
#fraud #publishing
Reposted by TJ McCorvie
This is a really remarkable piece of writing and in its particulars it describes so, so many people
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 1:31 AM
This is a really remarkable piece of writing and in its particulars it describes so, so many people
Reposted by TJ McCorvie
CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!
November 7, 2025 at 4:58 PM
CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!
Finally the architecture of the KICSTOR complex has been determined:
ICYMI: New online: Architecture of the human KICSTOR and GATOR1–KICSTOR complexes
Architecture of the human KICSTOR and GATOR1–KICSTOR complexes
Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01693-4Teng and Zeng et al. use cryo-electron microscopy to show that the crescent scaffold of KICSTOR anchors GATOR1 to lysosomes and disruption of the interaction causes mTORC1 hyperactivation and TFE3 mislocalization. KICSTOR enables nutrient-dependent mTORC1 regulation by binding anionic lipids for lysosomal targeting.
go.nature.com
November 8, 2025 at 10:36 AM
Finally the architecture of the KICSTOR complex has been determined:
Reposted by TJ McCorvie
As James Watson dies, let's remember Rosalind Franklin's contribution to the discovery of DNA.
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 7, 2025 at 10:27 PM
As James Watson dies, let's remember Rosalind Franklin's contribution to the discovery of DNA.