Joe Grove
@grovearmada.bsky.social
Investigating viruses, using pipettes, #AI and coffee.
Learn more at the lab website: https://grovelab.github.io/
Check out our database of viral protein structure predictions: https://viro3d.cvr.gla.ac.uk/
Based at: @cvrinfo.bsky.social
Learn more at the lab website: https://grovelab.github.io/
Check out our database of viral protein structure predictions: https://viro3d.cvr.gla.ac.uk/
Based at: @cvrinfo.bsky.social
Pinned
Joe Grove
@grovearmada.bsky.social
· Sep 26
Viro3D
viro3d.cvr.gla.ac.uk
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
www.nature.com
November 6, 2025 at 12:52 PM
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Reposted by Joe Grove
Always fun when the word "unusually" turns up in a UKHSA doc: "influenza activity increased, particularly among children, and is now above baseline. This is an unusually early start of the influenza season." www.gov.uk/government/s...
National flu and COVID-19 surveillance report: 30 October 2025 (week 44)
www.gov.uk
October 30, 2025 at 2:24 PM
Always fun when the word "unusually" turns up in a UKHSA doc: "influenza activity increased, particularly among children, and is now above baseline. This is an unusually early start of the influenza season." www.gov.uk/government/s...
Reposted by Joe Grove
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
October 1, 2025 at 7:08 AM
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Reposted by Joe Grove
Huge congratulations to Emma Davis, the winner of 2025's Early Career Microbiologist of the Year prize! We agree with Emma that all of the finalists' talks were brilliant and a massive well done to everyone involved!
October 7, 2025 at 5:17 PM
Huge congratulations to Emma Davis, the winner of 2025's Early Career Microbiologist of the Year prize! We agree with Emma that all of the finalists' talks were brilliant and a massive well done to everyone involved!
Reposted by Joe Grove
Viral AlphaFold Database (VAD) is live in Science Advances
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes
VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.
www.science.org
October 2, 2025 at 8:48 AM
Viral AlphaFold Database (VAD) is live in Science Advances
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
~27,000 predicted viral protein monomers & homodimers
Conserved folds across bacteria, archaea & eukaryotic viruses
New toxin–antitoxin system KreTA uncovered
Vast “functional darkness” remains uncharted
www.science.org/doi/10.1126/...
Reposted by Joe Grove
Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.
Check out this work co-led with @benadler.bsky.social here:
www.nature.com/articles/s41...
Check out this work co-led with @benadler.bsky.social here:
www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
October 2, 2025 at 3:01 AM
Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.
Check out this work co-led with @benadler.bsky.social here:
www.nature.com/articles/s41...
Check out this work co-led with @benadler.bsky.social here:
www.nature.com/articles/s41...
Reposted by Joe Grove
New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...
www.biorxiv.org
September 29, 2025 at 3:38 PM
New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
Reposted by Joe Grove
I made a sign for the lab with our informal lab motto, inspired by this convo between @itaiyanai.bsky.social and Martin Lercher: nightscience.buzzsprout.com/1744020/epis.... A good reminder that talking is among the best forms of thinking!
September 30, 2025 at 4:54 PM
I made a sign for the lab with our informal lab motto, inspired by this convo between @itaiyanai.bsky.social and Martin Lercher: nightscience.buzzsprout.com/1744020/epis.... A good reminder that talking is among the best forms of thinking!
Reposted by Joe Grove
Over the last year, Nature’s Careers team has been tapping into its global community of readers, writers, friends and colleagues to compile a list of laboratory hacks to help make scientists’ working lives easier. Here’s a list of 99 of those hacks. #Academicsky 🧪
These 99 'lab hacks' will make your scientific work easier
Nature asked contributors, editors and working researchers to share their best advice for scientists.
go.nature.com
September 28, 2025 at 7:11 PM
Over the last year, Nature’s Careers team has been tapping into its global community of readers, writers, friends and colleagues to compile a list of laboratory hacks to help make scientists’ working lives easier. Here’s a list of 99 of those hacks. #Academicsky 🧪
Reposted by Joe Grove
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
www.embopress.org
September 28, 2025 at 5:39 AM
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Reposted by Joe Grove
Reposted by Joe Grove
PhD position in my team!
Join me in the new Graduate School ACME (www.mhh.de/en/institute...). 65% TVL 13 for 4 years integrated into the Hannover Medical School; the ACME program starts in April 2026, but joining us earlier is possible.
1/3
@gesvirologie.bsky.social
@infect-net.bsky.social
Join me in the new Graduate School ACME (www.mhh.de/en/institute...). 65% TVL 13 for 4 years integrated into the Hannover Medical School; the ACME program starts in April 2026, but joining us earlier is possible.
1/3
@gesvirologie.bsky.social
@infect-net.bsky.social
September 27, 2025 at 2:48 PM
PhD position in my team!
Join me in the new Graduate School ACME (www.mhh.de/en/institute...). 65% TVL 13 for 4 years integrated into the Hannover Medical School; the ACME program starts in April 2026, but joining us earlier is possible.
1/3
@gesvirologie.bsky.social
@infect-net.bsky.social
Join me in the new Graduate School ACME (www.mhh.de/en/institute...). 65% TVL 13 for 4 years integrated into the Hannover Medical School; the ACME program starts in April 2026, but joining us earlier is possible.
1/3
@gesvirologie.bsky.social
@infect-net.bsky.social
Reposted by Joe Grove
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
September 27, 2025 at 3:31 AM
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
Reposted by Joe Grove
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
AussiERV 2025
AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!
events.humanitix.com
September 27, 2025 at 7:28 AM
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Congratulations to @ulad-litvin.bsky.social for this! He performed the vast majority of data curation and analysis, made the majority of figures for the manuscript AND drafted the text. An AMAZING effort!
Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
doi.org
September 26, 2025 at 2:50 PM
Congratulations to @ulad-litvin.bsky.social for this! He performed the vast majority of data curation and analysis, made the majority of figures for the manuscript AND drafted the text. An AMAZING effort!
Reposted by Joe Grove
Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
doi.org
September 26, 2025 at 2:06 PM
Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk
Reposted by Joe Grove
Our ELP winner @grovearmada.bsky.social and his team have launched Viro3D, an AI-powered virus protein database, which will help scientists understand and combat emerging viral threats more efficiently.
Read more here: https://bit.ly/3IIfND1
@cvrinfo.bsky.social @uofglasgow.bsky.social
Read more here: https://bit.ly/3IIfND1
@cvrinfo.bsky.social @uofglasgow.bsky.social
Researchers launch world’s most comprehensive human virus protein database
A look at new Foundation-funded research by Dr Joe Grove and his team at the MRC-University of Glasgow Centre for Virus Research.
bit.ly
September 26, 2025 at 1:54 PM
Our ELP winner @grovearmada.bsky.social and his team have launched Viro3D, an AI-powered virus protein database, which will help scientists understand and combat emerging viral threats more efficiently.
Read more here: https://bit.ly/3IIfND1
@cvrinfo.bsky.social @uofglasgow.bsky.social
Read more here: https://bit.ly/3IIfND1
@cvrinfo.bsky.social @uofglasgow.bsky.social
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
Viro3D
viro3d.cvr.gla.ac.uk
September 26, 2025 at 11:36 AM
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
Reposted by Joe Grove
Reposted by Joe Grove
See our ELP winner Dr Joe Grove discussing his work with Dr Chris van Tulleken at 9pm tonight on BBC2, or right now on BBC iPlayer: bbc.in/47WjAXM
Joe and his team at @cvrinfo.bsky.social @uofglasgow.bsky.social are using #AI to better understand how viruses evolve and function.
Joe and his team at @cvrinfo.bsky.social @uofglasgow.bsky.social are using #AI to better understand how viruses evolve and function.
September 22, 2025 at 4:13 PM
See our ELP winner Dr Joe Grove discussing his work with Dr Chris van Tulleken at 9pm tonight on BBC2, or right now on BBC iPlayer: bbc.in/47WjAXM
Joe and his team at @cvrinfo.bsky.social @uofglasgow.bsky.social are using #AI to better understand how viruses evolve and function.
Joe and his team at @cvrinfo.bsky.social @uofglasgow.bsky.social are using #AI to better understand how viruses evolve and function.
Reposted by Joe Grove
Three jobs in our shiny new building:
Oxford Biology is growing 📢
We’re appointing 3 Associate Professors in:
🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology
3 fields. 3 opportunities. One new home for Oxford Biology.
Learn more 👉 bit.ly/41S2Tc7
Apply now 👉 bit.ly/488CNW3
We’re appointing 3 Associate Professors in:
🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology
3 fields. 3 opportunities. One new home for Oxford Biology.
Learn more 👉 bit.ly/41S2Tc7
Apply now 👉 bit.ly/488CNW3
September 22, 2025 at 11:03 AM
Three jobs in our shiny new building:
Check out this new BBC documentary on Disease X and pandemic preparedness, broadcast tonight (22/09) and on BBC iPlayer.
It features @cvrinfo.bsky.social's work using #AI to investigate #virology and much, much more. 🧪🦠🤖
It was a real pleasure working with Chris VT and the team. Thank you!
It features @cvrinfo.bsky.social's work using #AI to investigate #virology and much, much more. 🧪🦠🤖
It was a real pleasure working with Chris VT and the team. Thank you!
September 22, 2025 at 10:50 AM
Check out this new BBC documentary on Disease X and pandemic preparedness, broadcast tonight (22/09) and on BBC iPlayer.
It features @cvrinfo.bsky.social's work using #AI to investigate #virology and much, much more. 🧪🦠🤖
It was a real pleasure working with Chris VT and the team. Thank you!
It features @cvrinfo.bsky.social's work using #AI to investigate #virology and much, much more. 🧪🦠🤖
It was a real pleasure working with Chris VT and the team. Thank you!
Reposted by Joe Grove
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
September 17, 2025 at 8:56 AM
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
Reposted by Joe Grove
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
📄 www.nature.com/articles/s41...
💿 mmseqs.com
GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
www.nature.com
September 21, 2025 at 8:06 AM
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
📄 www.nature.com/articles/s41...
💿 mmseqs.com
Excellent work @cb99-lewis.bsky.social. But you seem to have neglected to mention the prize you received for the best PhD student presentation! 🎉🎊👏
Had a brilliant time at the 9th International Calicivirus Conference in Banff (www.calicivirusconference.com) - phenomenal science in a phenomenal setting! It was great to present my PhD work so far (thanks @dbhella.bsky.social for the pic). Here's to many more!
September 20, 2025 at 8:06 PM
Excellent work @cb99-lewis.bsky.social. But you seem to have neglected to mention the prize you received for the best PhD student presentation! 🎉🎊👏