The origin story of MARQO, our tool to analyze multiplex imaging technologies. (Multiplex-imaging Analysis, Registration, Quantification, and Overlaying)

Chatbots and AI models are challenging ideas about who — or what — can create art, music and more.

Recent advances in forensic genetics have improved the range, precision and reliability of forensic information obtainable from biological trace material. The author reviews how non-targeted and targeted omics approaches and methods are improving crime scene analyses being applied for the identification of perpetrators and their relatives or victims, the prediction of phenotypic traits, and the determination of trace characteristics.

With the US government absent from the COP30 global climate summit, it will be up to others to avert catastrophe.

In a phase 1 trial, intramuscular injection of synthetic plasmid DNA encoding monoclonal antibodies against SARS-CoV-2 was safe and well tolerated and did not elicit antidrug antibodies.

From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the country is losing.

Expanding cell-type atlases to include developing human, mouse and non-human primate brains using multimodal genomics.

Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered brain activity, pupil size and brain fluid movement.

To understand how life began on Earth billions of years ago, a global community must work collaboratively to study the emergence of the necessary molecular building blocks and how they evolved into complex life in different environments.

As machines get better at data analysis and writing tasks, doctoral training must evolve to make the most of artificial-intelligence outputs.

Recent studies integrating multi-omics data with cell atlases across development for brains of humans and model organisms are revealing conserved and divergent patterns of brain development at the molecular and cellular levels, and linking these to complex behavioural and neuropsychiatric phenotypes.

Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.

The Roman Empire’s road system was critical for structuring the movement of people, goods and ideas, and sustaining imperial control. Yet, it remains incompletely mapped and poorly integrated across sources despite centuries of research. We present Itiner-e, the most detailed and comprehensive open digital dataset of roads in the entire Roman Empire. It was created by identifying roads from archaeological and historical sources, locating them using modern and historical topographic maps and remote sensing, and digitising them with road segment-level metadata and certainty categories. The dataset nearly doubles the known length of Roman roads through increased coverage and spatial precision, and reveals that the location of only 2.737% are known with certainty. This resource is transformative for understanding how mobility shaped connectivity, administration, and even disease transmission in the ancient world, and for studies of the millennia-long development of terrestrial mobility in the region.

Here, the authors find that relative abundances of stress-sensitive gastrointestinal microbes at age 2 years predicts internalizing symptoms in middle childhood through altered emotion-related brain network connectivity.

Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...

Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...