Sam J Wilson
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samjwilsonphd.bsky.social
Sam J Wilson
@samjwilsonphd.bsky.social
How does fever work?

Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.

This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵

www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 7:55 PM
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.

I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.

(whiteboard art from Zhuonan Li)
November 26, 2025 at 5:12 PM