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sbgrid.bsky.social
SBGrid Consortium
@sbgrid.bsky.social
1.6K followers 190 following 470 posts
Harvard-based consortium curating structural biology (CryoEM Crystallography NMR Tomography) software, hosting educational webinars, supporting reproducibility, validation, reprocessing of data, & access to scientific resources sbgrid.org / biogrids.org
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sbgrid.bsky.social
SBGrid's eLife paper received a citation in January from @bhartisingal.bsky.social , at @stanford.edu SLAC CryoEM Initiative contributing in @nature.com Chemical Engineering

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#SBGrid #ScienceMatters
A synthetic cell-free pathway for biocatalytic upgrading of formate from electrochemically reduced CO2 - Nature Chemical Engineering
Cost-effective, environmentally sustainable and energy-efficient ways to address rising atmospheric CO2 levels are urgently needed. Here the authors combine electrochemical reduction of CO2 to…
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February 10, 2026 at 6:04 PM
sbgrid.bsky.social
New Title Alert: ConSurf- is a bioinformatics tool designed for estimating the evolutionary conservation of amino and nucleic acid positions in protein, DNA, and RNA molecules.

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#SBGrid #SBGridSoftware #StructuralBiology
GitHub - Rostlab/ConSurf: Evolutionary conservation estimation of residues or nucleotides
Evolutionary conservation estimation of residues or nucleotides - Rostlab/ConSurf
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February 10, 2026 at 5:04 PM
sbgrid.bsky.social
New Member Alert: James Chen from University of California, San Francisco joined SBGrid in January! Welcome.
February 9, 2026 at 5:30 PM
sbgrid.bsky.social
Join our software webinar on February 10th to hear from Alyssa Travitz of the @omsf.io on @openfree.energy: An Open Source Ecosystem for Calculating Free Energies.

Tuesday, February 10, 2026 - 12:00pm ET

Register here: buff.ly/N7AYdjp

#SBGrid #Webinars #StructuralBiology
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
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February 9, 2026 at 5:06 PM
sbgrid.bsky.social
New Member Alert: Javid Babak from University of California, San Francisco joined SBGrid in January. Welcome!
February 6, 2026 at 5:30 PM
sbgrid.bsky.social
Fisk University student Cariuna Ellison's highlight features a JCI Insight publication from the lab of Charles Sanders at @vanderbilt.edu in which the authors describe a small molecule that may change the trajectory of LQTS intervention research.

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Promising small molecule may help with sudden cardiac death
SBGrid Member Chuck Sanders reports on a small molecule that may change the trajectory of LQTS intervention research.
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February 6, 2026 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in January from @mclellanlab.bsky.social from @utaustin.bsky.social in @nature.com : Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen.

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#SBGrid #ScienceMatters
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen - Nature Communications
Epstein–Barr virus (EBV) is a widespread herpesvirus linked to cancer and autoimmune disease. The authors in this work design and characterize a stabilized prefusion form of gB, an essential viral…
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February 5, 2026 at 6:03 PM
sbgrid.bsky.social
New Title Alert: Calc_level_chimeraX- is a ChimeraX plugin to predict and visualize isosurface levels for 3D density maps.

Learn more here: buff.ly/8tWjgTF

#SBGridSoftware #SBGrid #StructuralBiology
GitHub - mariacarreira/calc_level_ChimeraX: ChimeraX command to predict isosurface levels for 3D density maps
ChimeraX command to predict isosurface levels for 3D density maps - mariacarreira/calc_level_ChimeraX
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February 5, 2026 at 5:05 PM
sbgrid.bsky.social
New Title Alert: ThermoMPNN-D- is a Siamese neural network designed to predict stability changes from protein double point mutations.

Learn more here: buff.ly/rogxB7G

#SBGrid #SBGridSoftware #StructuralBiology
GitHub - Kuhlman-Lab/ThermoMPNN-D: Extension of ThermoMPNN for double mutant predictions
Extension of ThermoMPNN for double mutant predictions - Kuhlman-Lab/ThermoMPNN-D
buff.ly
February 4, 2026 at 6:05 PM
sbgrid.bsky.social
Our January member tale features Jean-Philippe Julien from @sickkidsto.bsky.social in Toronto, who interrogates antibodies in the science of global heath, following their stories to guide interventions against infectious diseases like malaria.

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#SBGridTales
The Stories Antibodies Tell
Jean-Philippe Julien from The Hospital for Sick Children interrogate antibodies that arise from natural infections and vaccine trials.
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February 4, 2026 at 5:02 PM
sbgrid.bsky.social
If you missed Alice-Roza Eruera's January webinar on Building CryoET Training Workflows Using the SBGrid Ecosystem, we will have the video posted to the SBGrid YouTube channel soon.

You can subscribe at buff.ly/RTDvlIb to receive alerts when new videos are added.

#SBGrid #Webinars #ScienceMatters
SBGrid Consortium
For structural biologists, by structural biologists! The SBGrid TV channel was developed with participation from many members of the structural biology community. We welcome suggestions for topics to…
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February 3, 2026 at 5:01 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in December from @sachsegroup.bsky.social from @fz_juelich in @natcomms.nature.com: Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo.

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#SBGrid
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo - Nature Communications
The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of…
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January 30, 2026 at 5:07 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in December from Catherine Drennan from @mit.edu in Science Advances: How ATP and dATP reposition class III ribonucleotide reductase cone domains to regulate enzyme activity.

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#SBGrid #ScienceMatters
How ATP and dATP reposition class III ribonucleotide reductase cone domains to regulate enzyme activity
Structural snapshots reveal how ATP and dATP reposition class III RNR cone domains to control substrate binding and activity.
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January 28, 2026 at 5:04 PM
sbgrid.bsky.social
New Member Alert: In December, Paul Seidler from @usc.edu joined SBGrid. Welcome!!
January 26, 2026 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in December from David Jeruzalmi atThe City College of New York in @narjournal.bsky.social

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#SBGrid #ScienceMatters
Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage λP helicase loader
Abstract. Replicative helicases need loader proteins to assemble at DNA replication origins. Multiple copies of the bacteriophage λP (P) loader bind and lo
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January 23, 2026 at 5:04 PM
sbgrid.bsky.social
New Member Alert: Vera Moiseenkova-Bell from @isbupenn.bsky.social joined SBGrid in December!. Welcome!!
January 22, 2026 at 5:06 PM
sbgrid.bsky.social
New Title Alert: REPIC- REliable PIcking by Consensus (REPIC) is a consensus methodology for harnessing multiple cryogenic-electron microscopy (cryo-EM) particle picking algorithms.

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#SBGrid #SBGridSoftware #StructuralBiology
GitHub - ccameron/REPIC: REliable PIcking by Consensus (REPIC) - an ensemble learning methodology for cryo-EM particle picking
REliable PIcking by Consensus (REPIC) - an ensemble learning methodology for cryo-EM particle picking - ccameron/REPIC
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January 20, 2026 at 5:06 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in December from Elizabeth Campbell from @rockefeller.edu in @natmicrobiol.nature.com: Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.

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#SBGrid
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology
Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.
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January 16, 2026 at 5:03 PM
sbgrid.bsky.social
New Title Alert: cryomaskR- is a desktop application that provides WYSIWYG mask generation for cryo-electron microscopy data analysis.

Learn more here: buff.ly/MC0uNqR

#SBGrid #SBGridSoftware #StructuralBiology
CryomaskR - Matthew Byrne
WYSIWYG CRYO-EM MASK GENERATION
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January 14, 2026 at 5:05 PM
sbgrid.bsky.social
Our January software webinar will feature Sliz Lab postdoc Alice-Roza Eruera on Building CryoET Training Workflows Using the SBGrid Ecosystem. Be sure to join us on January 13th!

Register here: buff.ly/wwNF6Zh

#SBGrid #StructuralBiology #Webinars
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
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January 12, 2026 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Rick Page from Miami University Ohio in Biochemical and Biophysical Research Communications: Functional and structural analyses of UbcH5 mutants with enhanced binding to the E3 ubiquitin ligase CHIP.

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#SBGrid
Functional and structural analyses of UbcH5 mutants with enhanced binding to the E3 ubiquitin ligase CHIP
The E3 ubiquitin ligase CHIP ubiquitinates substrates in chaperone-dependent or -independent manners. Structural studies, particularly by cryo-electro…
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January 9, 2026 at 5:31 PM
sbgrid.bsky.social
New Title Alert: meteor- a tool for computing crystallographic difference maps that specializes in robust identification of weak signals from minor populations such as bound ligands or time-resolved experimental changes.

Learn more here: buff.ly/bgJYF9N

#SBGrid #SBGridSoftware #StructuralBiology
GitHub - rs-station/meteor: bringing you the best difference maps
bringing you the best difference maps. Contribute to rs-station/meteor development by creating an account on GitHub.
github.com
January 9, 2026 at 5:03 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from @palencialab.bsky.social from @ugrenoblealpes.bsky.social in @natcomms.nature.com Hierarchical folding-upon-binding of an intrinsically disordered protein.

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#SBGrid #Stayconnected
January 6, 2026 at 6:39 PM
sbgrid.bsky.social
Technical Notes: This month's software push includes updates to BioEmu, BoltzGen, ChimeraX, DOCK, Google Cloud SDK, HADDOCK3, NAMD, OpenFold, ORCA, pytom-match-pick, pyTME, SamTOOLS, Schrödinger 2025-3 and 2025-4, and Topaz.

More information here: buff.ly/lgtNHCd

#SBGrid #SBGridSoftware
SBGrid Consortium - Software Updates
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
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January 6, 2026 at 5:02 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from@sshaolab.bsky.social from @harvardmed.bsky.social in@natcomms.nature.com : Structures of human organellar SPFH protein complexes.

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#SBGrid #ScienceMatters
Structures of human organellar SPFH protein complexes - Nature Communications
SPFH proteins oligomerize with distinct stoichiometries in all kingdoms of life. Here, Gao et al. determine cryo-EM structures to elucidate the compositions of the ER-resident Erlin and the…
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December 31, 2025 at 5:02 PM