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sbgrid.bsky.social
SBGrid Consortium
@sbgrid.bsky.social
1.5K followers 190 following 440 posts
Harvard-based consortium curating structural biology (CryoEM Crystallography NMR Tomography) software, hosting educational webinars, supporting reproducibility, validation, reprocessing of data, & access to scientific resources sbgrid.org / biogrids.org
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sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from @cijilim.bsky.social from University of Wisconsin-Madison in @science.org : Human RPA is an essential telomerase processivity factor for maintaining telomeres.

Read more here: buff.ly/83Fx3qA

#SBGrid #Stayconnected
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical…
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December 25, 2025 at 5:03 PM
sbgrid.bsky.social
New Title Alert: Protein-Hunter- a tool for exploiting structure hallucination within diffusion for protein design. A fast, fine-tuning-free framework for de novo protein design.

Learn more here: buff.ly/DrCDsKH

#SBGrid #StructuralBiology #SBGridSoftware
GitHub - yehlincho/Protein-Hunter
Contribute to yehlincho/Protein-Hunter development by creating an account on GitHub.
buff.ly
December 24, 2025 at 5:05 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Andrew Kruse from @harvardmed.bsky.social in @pnas.org : Conformational regulation of two essential activators of bacterial cell elongation.

Read more here: buff.ly/fKVkrjw

#SBGrid #ScienceMatters
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly…
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December 23, 2025 at 5:05 PM
sbgrid.bsky.social
New Member Alert: Wayne Patrick from @vicuniwgtn.bsky.social joined SBGrid in November. Welcome!
December 22, 2025 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Jean-Philippe Julien from
@sickkidsto.bsky.social in Journal of Virology.

Read more here: buff.ly/08Bai02

#SBGrid #ScienceMatters
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions | Journal of Virology
Bats and pangolins are natural reservoirs of betacoronaviruses (β-CoVs) and continue to pose a significant risk for future outbreaks through zoonotic transmissions. This highlights the need for…
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December 19, 2025 at 5:06 PM
sbgrid.bsky.social
New Title Alert: CryoSiam- a self-supervised deep learning framework that works on dense and subtomogram levels.

Learn more here: buff.ly/xt1uGJt

#SBGrid #SBGridSoftware
CryoSiam Documentation
Welcome to the official documentation for the CryoSiam method. This guide will help to use this tool effectively.
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December 18, 2025 at 5:05 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Seth Darst at @rockefelleruniv.bsky.social in @nature.com Communications: Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.

Read more here: buff.ly/VXkYTjT

#SBGrid #ScienceMatters
Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase - Nature Communications
Promoter escape is a key step in bacterial transcription and a target of the antibiotic rifampicin. Here, the authors use cryo-EM to explore this step, finding seven structural intermediates of M.…
buff.ly
December 17, 2025 at 5:04 PM
sbgrid.bsky.social
New Title Alert: CryoLithe- a supervised machine learning method to directly reconstruct the tomogram from aligned cryo-ET tilt series. The methods is trained on real measurements using FBP+cryo-CARE+IsoNet reconstructions as the reference.

Learn more here: buff.ly/3jxoax3

#SBGrid #Software
GitHub - swing-research/CryoLithe
Contribute to swing-research/CryoLithe development by creating an account on GitHub.
github.com
December 16, 2025 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Titus Boggon from Yale University in Protein and Peptide Letters: Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization.

Read more here: buff.ly/diXPL4b

#SBGrid #ScienceMatters
Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization
Introduction: Numerous X-ray crystal structures of the c-Src SH3 domain have provided a large sampling of atomic-level information for this important signaling domain. Multiple crystal forms have…
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December 15, 2025 at 5:04 PM
sbgrid.bsky.social
New Title Alert: CryoCAT- an open source, GPL-3.0+ licensed library providing contextual analysis tools for cryo electron tomography and subtomogram averaging.

Learn more here: buff.ly/ug59jUR

#SBGrid #SBGridSoftware #StructuralBiology
cryoCAT: Contextual Analysis Tools for cryo electron tomography — cryoCAT 0.2.2 documentation
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December 12, 2025 at 5:02 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from @demet-arac.bsky.social from the University of Chicago in @pnas.org : The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.

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#SBGrid #ScienceMatters
The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling | PNAS
Adhesion G protein–coupled receptors (aGPCRs) transduce extracellular adhesion events into cytoplasmic signaling pathways. ADGRG6/GPR126 is an aGPC...
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December 11, 2025 at 5:03 PM
sbgrid.bsky.social
New Title Alert: CryoAtom- is a software that automatically constructs full-atom 3D structural models of proteins based on cryo-EM density maps and sequence information.

Learn more here: buff.ly/gjVyH1m

#SBGrid #SBGridSoftware #StructuralBiology
GitHub - YangLab-SDU/CryoAtom: From cryo-EM density map to atomic structure
From cryo-EM density map to atomic structure. Contribute to YangLab-SDU/CryoAtom development by creating an account on GitHub.
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December 10, 2025 at 5:05 PM
sbgrid.bsky.social
Technical Notes: This month's software push includes updates to BCFTools, BioXTAS RAW 2, CCPEM-Pipeliner, CNIO relion_tools, COOT, Doppio, OpenEye, RDKit, Scipion, and Surface-morphometrics.

More here: buff.ly/SS4Qn0w

#SBGrid #SBGridSoftware
SBGrid Consortium - Software Updates
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
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December 9, 2025 at 5:04 PM
sbgrid.bsky.social
Mark your calendars for January 13th when our own Alice-Roza Eruera will give a primer on Building CryoET Training Workflows Using the SBGrid Ecosystem.

Register here: buff.ly/AaZQlJL

#SBGrid #Structuralbiology #Webinars
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
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December 8, 2025 at 5:05 PM
sbgrid.bsky.social
Mapping bacteriophages: a publication highlight from @keandreyam.bsky.social featuring a new article from the lab of Mihnea Bostina at the @universityofotago.bsky.social & colleagues.

Read more here: buff.ly/Wgfu3bt

#SBGrid #cryoem
Mapping bacteriophages
SBGrid member Mihnea Bostina helps to uncover the first high-resolution, head-to-tail structural map of a Felixounavirus bacteriophage.
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December 5, 2025 at 5:04 PM
sbgrid.bsky.social
Melanie Ohi from @umich.edu is the focus of our November member tale. Ohi stuck with cryoEM, despite warnings that becoming a "blobologist" would limit her options.

Read more here: buff.ly/nPzs4rm

#SBGridTales #Stayconnected
Reshaping membranes
Melanie Ohi from the University of Michigan studies membrane proteins that work together as complex molecular machines.
buff.ly
December 4, 2025 at 5:04 PM
sbgrid.bsky.social
For our November software webinar we heard from Hui Wang from UCLA on TomoNet - Automatic Particle Picking of Flexible Lattice-Like Structures for CryoET.

If you missed it, you can watch it on SBGrid's YouTube channel:

buff.ly/gnhR2AV

#SBGrid #Webinars
TomoNet
SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont University.…
youtu.be
December 3, 2025 at 5:04 PM
sbgrid.bsky.social
COOT Update: We have added a stand-alone versions of & Coot for Linux and for ARM & Intel-based Macs that are available for academic, non-profit, commercial members to download. These versions will work with MacOS Tahoe & are not dependent on other applications.

#SBGrid #SoftwareUpdates
December 2, 2025 at 5:15 PM
sbgrid.bsky.social
Technical Notes: MacOS 26 Tahoe issues--We recommend that users hold off upgrading to MacOS Tahoe since XQuartz-based OpenGL acceleration is partly broken. These issues impact software that rely on XQuartz, such as Coot.

#SBGrid #SoftwareUpdates
December 2, 2025 at 5:00 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in October from George Phillips Jr. in Journal of Natural Products: Functional and Structural Studies on the Esperamicin Thioesterase and Progress toward Understanding Enediyne Core Biosynthesis.

Read more here: buff.ly/Exh9hxZ

#SBGrid #ScienceMatters
Functional and Structural Studies on the Esperamicin Thioesterase and Progress toward Understanding Enediyne Core Biosynthesis
Enediynes are among the most potent antitumor and antibacterial natural products. Studies on their biosynthetic pathways have identified a shared, linear polyene precursor generated from an iterative…
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November 28, 2025 at 5:05 PM
sbgrid.bsky.social
New Title Alert: Pom- a tool for scaling data analyses in cellular cryoET using comprehensive segmentation.

Learn more here: buff.ly/qisPeYQ

#SBGrid #SBGridSoftware #StructuralBiology
GitHub - bionanopatterning/Pom: Scaling data analyses in cellular cryoET using comprehensive segmentation.
Scaling data analyses in cellular cryoET using comprehensive segmentation. - bionanopatterning/Pom
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November 27, 2025 at 5:03 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in October from Jean-Philippe Julien from @sickkidsto.bsky.social Research Institute in Immunity.

Read more here: buff.ly/aXP3Rl3

#SBGrid #StructuralBiology
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
The Pfs230:Pfs48/45 complex is the target of leading anti-malaria transmission-blocking vaccine candidates, yet its molecular assembly is poorly understood. Bekkering, Yoo, Hailemariam, et al.…
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November 26, 2025 at 5:05 PM
sbgrid.bsky.social
New Title Alert: OpenEye Academic Package- tools to help design potent and selective bioactive molecules.

Learn more here: buff.ly/SMacQQa

#SBGrid #SBGridSoftware #StructuralBiology
Molecular Modeling Software | OpenEye Scientific
Molecular modeling and cheminformatics software tools built in the cloud to accelerate lead discovery and optimization in drug development.
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November 25, 2025 at 5:05 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in October from Kevin Campbell from University of Iowa in Nature Magazine: LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan.

Read more here: buff.ly/wg8IVnm

#SBGrid #StayConnected
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan - Nature Communications
LARGE1 glycosyltransferase synthesizes matriglycan (xylose-glucuronate)n on dystroglycan, and short matriglycan can cause neuromuscular disorders. Authors show that LARGE1 processively polymerizes…
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November 24, 2025 at 5:06 PM
sbgrid.bsky.social
New Title Alert: nvMolKit- is a CUDA-backed Python library for accelerating common RDKit molecular operations through batch-oriented GPU processing.

Learn more here: buff.ly/pqV1HiF

#SBGrid #SBGridSoftware #StructuralBiology
NVIDIA nvMolKit Documentation — nvMolKit
nvMolKit
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November 21, 2025 at 5:04 PM