Kay Schink
@kschink.bsky.social
Cell Biologist interested in membrane trafficking, phosphoinositides, macropinosomes and fancy microscopes.
Associate Professor, UiO
Associate Professor, UiO
Reposted by Kay Schink
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Kay Schink
• you don’t care about publishing in our crappy predatory journal
@andrewplested.bsky.social would have enjoyed this
@andrewplested.bsky.social would have enjoyed this
November 20, 2025 at 6:53 PM
• you don’t care about publishing in our crappy predatory journal
@andrewplested.bsky.social would have enjoyed this
@andrewplested.bsky.social would have enjoyed this
Reposted by Kay Schink
Recent interview for @jcellsci.bsky.social. Thx for important services JCS & @biologists.bsky.social provide to the cell science community. Glad we could share aspects on #50yearDGZ @dgz.bsky.social, @dfg.de @hetcci.bsky.social SPP2493, #CGBM & my great team @uni-saarland.de
shorturl.at/rCQg5
shorturl.at/rCQg5
Interview with Sandra Iden – President of the German Society for Cell Biology
ABSTRACT. Sandra Iden is Professor and Chair of Cell and Developmental Biology at Saarland University in Homburg, Germany. Her research focuses on cell–cell communication in epithelial tissue homeosta...
journals.biologists.com
October 16, 2025 at 6:13 AM
Recent interview for @jcellsci.bsky.social. Thx for important services JCS & @biologists.bsky.social provide to the cell science community. Glad we could share aspects on #50yearDGZ @dgz.bsky.social, @dfg.de @hetcci.bsky.social SPP2493, #CGBM & my great team @uni-saarland.de
shorturl.at/rCQg5
shorturl.at/rCQg5
Reposted by Kay Schink
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 6, 2025 at 5:52 PM
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kay Schink
New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure
Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...
www.biorxiv.org
May 13, 2025 at 12:07 PM
New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kay Schink
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kay Schink
big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv
Quantitative imaging of lipid transport in mammalian cells
Nature - Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
rdcu.be
August 21, 2025 at 8:51 AM
big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv
Reposted by Kay Schink
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
August 12, 2025 at 2:13 PM
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Reposted by Kay Schink
We are hiring! A 3-year postdoc in #Chromatin #Cancer #Epigenetics at University of Oslo, Norway and co-supervised by @amathelier.bsky.social You will be part of @cancelluio.bosky.social. We focus on #Sarcoma #Epigenome #CRISPR and Drug screen studies. Find out more and apply here: shorturl.at/DtLHM
Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381) | University of Oslo
Job title: Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381), Employer: University of Oslo, Deadline: Wednesday, August 20, 2025
shorturl.at
August 12, 2025 at 9:08 AM
We are hiring! A 3-year postdoc in #Chromatin #Cancer #Epigenetics at University of Oslo, Norway and co-supervised by @amathelier.bsky.social You will be part of @cancelluio.bosky.social. We focus on #Sarcoma #Epigenome #CRISPR and Drug screen studies. Find out more and apply here: shorturl.at/DtLHM
Reposted by Kay Schink
🚨 We're hiring! NCMBM @ncmbm.bsky.social is looking for 2 new group leaders to join our vibrant research community. Ready to build your own group with strong support and a solid startup package?
Interested and attending #ISMBECCB2025? Let’s connect!
🔗 www.jobbnorge.no/en/available...
Interested and attending #ISMBECCB2025? Let’s connect!
🔗 www.jobbnorge.no/en/available...
Group Leader (282908) | University of Oslo
Job title: Group Leader (282908), Employer: University of Oslo, Deadline: Monday, September 8, 2025
www.jobbnorge.no
July 22, 2025 at 6:12 AM
🚨 We're hiring! NCMBM @ncmbm.bsky.social is looking for 2 new group leaders to join our vibrant research community. Ready to build your own group with strong support and a solid startup package?
Interested and attending #ISMBECCB2025? Let’s connect!
🔗 www.jobbnorge.no/en/available...
Interested and attending #ISMBECCB2025? Let’s connect!
🔗 www.jobbnorge.no/en/available...
Reposted by Kay Schink
The power of basic optical design knowledge and CAD!
-> Here's a fast laser point scanner that connects to a commercial microscope. The design, build and alignment are relatively simple. Much harder is agile software control that integrates with the existing system... Custom hardware is hard!
-> Here's a fast laser point scanner that connects to a commercial microscope. The design, build and alignment are relatively simple. Much harder is agile software control that integrates with the existing system... Custom hardware is hard!
July 7, 2025 at 3:51 PM
The power of basic optical design knowledge and CAD!
-> Here's a fast laser point scanner that connects to a commercial microscope. The design, build and alignment are relatively simple. Much harder is agile software control that integrates with the existing system... Custom hardware is hard!
-> Here's a fast laser point scanner that connects to a commercial microscope. The design, build and alignment are relatively simple. Much harder is agile software control that integrates with the existing system... Custom hardware is hard!
Reposted by Kay Schink
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Reposted by Kay Schink
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
Reposted by Kay Schink
De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy by Bo Huang and team: www.biorxiv.org/content/10.1...
June 26, 2025 at 1:50 PM
De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy by Bo Huang and team: www.biorxiv.org/content/10.1...
Reposted by Kay Schink
🔎 Looking to start a PhD in Sept 2025?
The Crick Institute spring round for PhD recruitment is open!
If you are interested in actin cytoskeleton and imaging 🔬 then check out my project on role of Arp2/3 iso-complexes in regulating invadopodia👇please RT
www.crick.ac.uk/careers-stud...
The Crick Institute spring round for PhD recruitment is open!
If you are interested in actin cytoskeleton and imaging 🔬 then check out my project on role of Arp2/3 iso-complexes in regulating invadopodia👇please RT
www.crick.ac.uk/careers-stud...
February 20, 2025 at 3:25 PM
🔎 Looking to start a PhD in Sept 2025?
The Crick Institute spring round for PhD recruitment is open!
If you are interested in actin cytoskeleton and imaging 🔬 then check out my project on role of Arp2/3 iso-complexes in regulating invadopodia👇please RT
www.crick.ac.uk/careers-stud...
The Crick Institute spring round for PhD recruitment is open!
If you are interested in actin cytoskeleton and imaging 🔬 then check out my project on role of Arp2/3 iso-complexes in regulating invadopodia👇please RT
www.crick.ac.uk/careers-stud...
nature.com/articles/s41467-025-57053-9
Finally this work is out - we show that short sequence motifs direct proteins to specific peroxisomal sub-domains. Fantastic collaboration with @bangebalcony.bsky.social , Johannes Freitag @unimarburg.bsky.social and many more! @uio.no @cancelluio.bsky.social
Finally this work is out - we show that short sequence motifs direct proteins to specific peroxisomal sub-domains. Fantastic collaboration with @bangebalcony.bsky.social , Johannes Freitag @unimarburg.bsky.social and many more! @uio.no @cancelluio.bsky.social
Peroxisomal core structures segregate diverse metabolic pathways - Nature Communications
Peroxisomes contain detergent resistant core structures. Bäcker et al. show that these core structures contain diverse enzymes and serve to enable metabolic compartmentalization of the peroxisome lume...
nature.com
February 20, 2025 at 5:02 PM
nature.com/articles/s41467-025-57053-9
Finally this work is out - we show that short sequence motifs direct proteins to specific peroxisomal sub-domains. Fantastic collaboration with @bangebalcony.bsky.social , Johannes Freitag @unimarburg.bsky.social and many more! @uio.no @cancelluio.bsky.social
Finally this work is out - we show that short sequence motifs direct proteins to specific peroxisomal sub-domains. Fantastic collaboration with @bangebalcony.bsky.social , Johannes Freitag @unimarburg.bsky.social and many more! @uio.no @cancelluio.bsky.social
Very proud to be part of that team - this was a really long term project with lots of amazing people!
www.nature.com/articles/s41... Great Joint Venture with Johannes Freitag @synmikro.bsky.social @unimarburg.bsky.social
Peroxisomal core structures segregate diverse metabolic pathways - Nature Communications
Peroxisomes contain detergent resistant core structures. Bäcker et al. show that these core structures contain diverse enzymes and serve to enable metabolic compartmentalization of the peroxisome lume...
www.nature.com
February 20, 2025 at 4:54 PM
Very proud to be part of that team - this was a really long term project with lots of amazing people!
Reposted by Kay Schink
www.nature.com/articles/s41... Great Joint Venture with Johannes Freitag @synmikro.bsky.social @unimarburg.bsky.social
Peroxisomal core structures segregate diverse metabolic pathways - Nature Communications
Peroxisomes contain detergent resistant core structures. Bäcker et al. show that these core structures contain diverse enzymes and serve to enable metabolic compartmentalization of the peroxisome lume...
www.nature.com
February 20, 2025 at 4:20 PM
www.nature.com/articles/s41... Great Joint Venture with Johannes Freitag @synmikro.bsky.social @unimarburg.bsky.social
Reposted by Kay Schink
Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n
Fast Antibiotic resistance-Based gene editing of mammalian cells with CRISPR-Cas9 (FAB-CRISPR)
Protein tagging with CRISPR-Cas9 enables the investigation of protein function in its native environment but is limited by low homology-directed repair (HDR) efficiency causing low knock-in rates. We ...
arxiv.org
February 19, 2025 at 8:43 AM
Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n
Reposted by Kay Schink
Molecular force measurements in vivo are notoriously difficult. We present a new class of programmable force sensors based on engineered coiled-coils, with modular readouts, including fluorescence and luminescence. doi.org/10.1101/2025...
Genetically encoded mechano-sensors with versatile readouts and compact size
Mechanical forces are critical for virtually all fundamental biological processes, yet quantification of mechanical forces at the molecular scale in vivo remains challenging. Here, we present a new st...
doi.org
January 20, 2025 at 9:41 PM
Molecular force measurements in vivo are notoriously difficult. We present a new class of programmable force sensors based on engineered coiled-coils, with modular readouts, including fluorescence and luminescence. doi.org/10.1101/2025...
Reposted by Kay Schink
Welcome to the official Bluesky page of the Institut Pasteur!
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
January 14, 2025 at 9:10 AM
Welcome to the official Bluesky page of the Institut Pasteur!
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
Reposted by Kay Schink
Pasteur is on bluesky!
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Institut Pasteur decides to leave X
The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...
www.pasteur.fr
January 16, 2025 at 9:30 AM
Pasteur is on bluesky!
Reposted by Kay Schink
Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells
Genetically encoded fluorescent protein and fluorogenic RNA sensors are indispensable tools for imaging biomolecules in cells. To expand the toolboxes and improve the generalizability and stability of...
pubs.acs.org
January 14, 2025 at 9:34 PM
Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Kay Schink
Very nice
We made a photoswitchable HaloTag (psHaloTag), which can reversibly turn-on fluorogenic dyes upon illumination 💡. Congrats to Franzi, Bego and all co-authors, check out our preprint below 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 7, 2025 at 5:49 PM
Very nice
Reposted by Kay Schink
How it started How it's going
January 6, 2025 at 5:04 PM
How it started How it's going