@tafesselab.bsky.social
It was fun writing this book chapter on methods to trace #lipid metabolism.
Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social
www.sciencedirect.com/science/chap...
Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social
www.sciencedirect.com/science/chap...
January 21, 2026 at 2:59 PM
It was fun writing this book chapter on methods to trace #lipid metabolism.
Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social
www.sciencedirect.com/science/chap...
Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social
www.sciencedirect.com/science/chap...
Reposted
Reposted
Can GLP-1 drugs reduce the incidence of cancer, independent of weight loss? Results from cohort studies are encouraging for many types (Figure) and clinical trials are ongoing
nature.com/articles/s43...
nature.com/articles/s43...
January 17, 2026 at 5:45 PM
Can GLP-1 drugs reduce the incidence of cancer, independent of weight loss? Results from cohort studies are encouraging for many types (Figure) and clinical trials are ongoing
nature.com/articles/s43...
nature.com/articles/s43...
Excited to share our first collaborative paper of the year- a review on the emerging roles of lipids in flavivirus infection, now published in @cp-trendsmicrobiol.bsky.social. Congrats to Judah (postdoc) for spearheading the work!
@ohsunews.bsky.social
www.sciencedirect.com/science/arti...
@ohsunews.bsky.social
www.sciencedirect.com/science/arti...
January 12, 2026 at 8:12 PM
Excited to share our first collaborative paper of the year- a review on the emerging roles of lipids in flavivirus infection, now published in @cp-trendsmicrobiol.bsky.social. Congrats to Judah (postdoc) for spearheading the work!
@ohsunews.bsky.social
www.sciencedirect.com/science/arti...
@ohsunews.bsky.social
www.sciencedirect.com/science/arti...
Reposted
@tafesselab.bsky.social Ronald Schnaar Julie Saba Ashley Cowart @gioelelamanno.bsky.social @nadlerlab.bsky.social Jurgen Seibel Markus Wenk
December 19, 2025 at 9:14 AM
@tafesselab.bsky.social Ronald Schnaar Julie Saba Ashley Cowart @gioelelamanno.bsky.social @nadlerlab.bsky.social Jurgen Seibel Markus Wenk
Reposted
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
December 19, 2025 at 9:09 AM
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
Reposted
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
December 14, 2025 at 1:54 PM
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
Reposted
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
November 27, 2025 at 10:41 AM
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Beautiful work! Congrats @abdourachidthiam.bsky.social and the team!
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 18, 2025 at 2:37 PM
Beautiful work! Congrats @abdourachidthiam.bsky.social and the team!
Reposted
Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
www.jbc.org
November 5, 2025 at 10:31 PM
Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
Reposted
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 3:48 PM
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Reposted
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 25, 2025 at 1:11 PM
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
August 12, 2025 at 2:13 PM
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Reposted
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 7, 2025 at 4:10 PM
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Reposted
🌶️ Lipids bring the heat 🔥
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism
The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...
www.biorxiv.org
September 24, 2025 at 2:40 PM
🌶️ Lipids bring the heat 🔥
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Reposted
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
www.nature.com
August 21, 2025 at 4:19 AM
Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
August 12, 2025 at 2:13 PM
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Reposted
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
August 1, 2025 at 9:22 PM
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Reposted
Great news!!
Does anyone know what bill will determine NIH funding levels?
Does anyone know what bill will determine NIH funding levels?
🧪 Good news, for now at least.
Senate Appropriations Committee passes the Commerce, Justice and Science Bill.
NSF: flat funding, not -55% as requested by Trump!
NIST, NOAA, NASA get strong support, R's push back cuts requested by Trump.
Summary:
www.appropriations.senate.gov/imo/media/do...
Senate Appropriations Committee passes the Commerce, Justice and Science Bill.
NSF: flat funding, not -55% as requested by Trump!
NIST, NOAA, NASA get strong support, R's push back cuts requested by Trump.
Summary:
www.appropriations.senate.gov/imo/media/do...
www.appropriations.senate.gov
July 18, 2025 at 12:25 PM
Great news!!
Does anyone know what bill will determine NIH funding levels?
Does anyone know what bill will determine NIH funding levels?
Promoted to Full Professor with tenure!
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
July 2, 2025 at 1:23 PM
Promoted to Full Professor with tenure!
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 18, 2025 at 11:03 PM
Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It’s finally out!
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed
Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...
pubmed.ncbi.nlm.nih.gov
June 10, 2025 at 2:20 AM
It’s finally out!
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/