@tafesselab.bsky.social
Reposted
Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
www.jbc.org
November 5, 2025 at 10:31 PM
Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
Reposted
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 3:48 PM
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Reposted
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 25, 2025 at 1:11 PM
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
August 12, 2025 at 2:13 PM
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Reposted
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 7, 2025 at 4:10 PM
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Reposted
🌶️ Lipids bring the heat 🔥
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism
The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...
www.biorxiv.org
September 24, 2025 at 2:40 PM
🌶️ Lipids bring the heat 🔥
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Reposted
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
www.nature.com
August 21, 2025 at 4:19 AM
Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
August 12, 2025 at 2:13 PM
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Reposted
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
August 1, 2025 at 9:22 PM
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Reposted
Great news!!
Does anyone know what bill will determine NIH funding levels?
Does anyone know what bill will determine NIH funding levels?
🧪 Good news, for now at least.
Senate Appropriations Committee passes the Commerce, Justice and Science Bill.
NSF: flat funding, not -55% as requested by Trump!
NIST, NOAA, NASA get strong support, R's push back cuts requested by Trump.
Summary:
www.appropriations.senate.gov/imo/media/do...
Senate Appropriations Committee passes the Commerce, Justice and Science Bill.
NSF: flat funding, not -55% as requested by Trump!
NIST, NOAA, NASA get strong support, R's push back cuts requested by Trump.
Summary:
www.appropriations.senate.gov/imo/media/do...
www.appropriations.senate.gov
July 18, 2025 at 12:25 PM
Great news!!
Does anyone know what bill will determine NIH funding levels?
Does anyone know what bill will determine NIH funding levels?
Promoted to Full Professor with tenure!
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
July 2, 2025 at 1:23 PM
Promoted to Full Professor with tenure!
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.
Excited for what’s next- here to the future! 🙌
Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 18, 2025 at 11:03 PM
Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It’s finally out!
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed
Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...
pubmed.ncbi.nlm.nih.gov
June 10, 2025 at 2:20 AM
It’s finally out!
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...
www.biorxiv.org
June 4, 2025 at 3:45 PM
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
Excellent new study from the Catteruccia lab, co-led by Alexandra Probst and Douglas Paton www.nature.com/articles/s41...
In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature
An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...
www.nature.com
May 23, 2025 at 11:40 PM
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work!
@ohsunews.bsky.social @ohsummi.bsky.social
www.nature.com/articles/s43...
@ohsunews.bsky.social @ohsummi.bsky.social
www.nature.com/articles/s43...
Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination - Communications Medicine
Wrynla et al. assess humoral immunity elicited by the monovalent XBB.1.5 COVID-19 vaccine in participants who did or did not previously receive the bivalent Wuhan-Hu-1/BA.4-5 vaccine. They find that i...
www.nature.com
May 19, 2025 at 11:27 AM
Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work!
@ohsunews.bsky.social @ohsummi.bsky.social
www.nature.com/articles/s43...
@ohsunews.bsky.social @ohsummi.bsky.social
www.nature.com/articles/s43...
Reposted
Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...
Analysis of Factors That Regulate HIV-1 Fusion in Reverse
Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...
pmc.ncbi.nlm.nih.gov
April 30, 2025 at 2:25 PM
Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...
Excellent work!
New work out from my lab by my graduate student Isobel in collaboration with Josh Pemberton and Tamas Balla. Provides some new cool tools to manipulate PI3,5P2 levels, as well as some new insight into PIKfyve regulation.
rupress.org/jcb/article-...
rupress.org/jcb/article-...
An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate
In this paper, Pemberton et al. describe the generation and characterization of an engineered active fragment of the PIKfyve enzyme and its use to generate
rupress.org
April 1, 2025 at 4:38 AM
Excellent work!
I had an amazing time visiting University of Victoria @uvic.ca It was wonderful meeting students and faculty- thank you so much, John Burke @jburkevic.bsky.social, for hosting me!
#lipids and #nanobodies
#lipids and #nanobodies
March 4, 2025 at 4:06 PM
I had an amazing time visiting University of Victoria @uvic.ca It was wonderful meeting students and faculty- thank you so much, John Burke @jburkevic.bsky.social, for hosting me!
#lipids and #nanobodies
#lipids and #nanobodies
Reposted
The early bird deadline may have passed but there is still plenty of time to register and submit abstracts for the 2025 FEBS/ICC! Come to historic Varna for sun, sea, and sphingolipid science!!
February 4, 2025 at 9:30 PM
The early bird deadline may have passed but there is still plenty of time to register and submit abstracts for the 2025 FEBS/ICC! Come to historic Varna for sun, sea, and sphingolipid science!!
Reposted
The Obeid award was created to honor the legacy of the late, great Lina Obeid, a giant of the Sphingolipid field and a strong proponent of women in science. We are privileged to present this award at FEBS/ICC 2025 and are very grateful to CaymanChemical for their sponsorship.
February 20, 2025 at 1:30 PM
The Obeid award was created to honor the legacy of the late, great Lina Obeid, a giant of the Sphingolipid field and a strong proponent of women in science. We are privileged to present this award at FEBS/ICC 2025 and are very grateful to CaymanChemical for their sponsorship.
Reposted
The Kester award honors the legacy of Mark Kester, a sphingolipid researcher with an entreprenurial drive, and a leader in sphingolipid therapies, particularly ceramide nanoliposomes. We will present the award at FEBS/ICC 13 2025 and thank CaymanChemical for their sponsorship.
February 21, 2025 at 4:19 PM
The Kester award honors the legacy of Mark Kester, a sphingolipid researcher with an entreprenurial drive, and a leader in sphingolipid therapies, particularly ceramide nanoliposomes. We will present the award at FEBS/ICC 13 2025 and thank CaymanChemical for their sponsorship.