King Lab
@kinglabipd.bsky.social
News from the King Lab kinglab.ipd.uw.edu.
Part of @uwmedicine.bsky.social and @uwproteindesign.bsky.social.
Some assembly required.
Part of @uwmedicine.bsky.social and @uwproteindesign.bsky.social.
Some assembly required.
🚨 new paper alert 🚨
Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks.
Read more @pnas.org: doi.org/10.1073/pnas....
Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks.
Read more @pnas.org: doi.org/10.1073/pnas....
November 4, 2025 at 8:31 PM
🚨 new paper alert 🚨
Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks.
Read more @pnas.org: doi.org/10.1073/pnas....
Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks.
Read more @pnas.org: doi.org/10.1073/pnas....
Reposted by King Lab
Applying computational design, researchers in #ScienceTranslationalMedicine present an integrated vaccine platform that combines the strengths of mRNA and nanoparticle technologies, and show it elicits strong immune responses in a SARS-CoV-2 model system. https://scim.ag/3W9M09p
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.
scim.ag
October 16, 2025 at 3:27 PM
Applying computational design, researchers in #ScienceTranslationalMedicine present an integrated vaccine platform that combines the strengths of mRNA and nanoparticle technologies, and show it elicits strong immune responses in a SARS-CoV-2 model system. https://scim.ag/3W9M09p
🚨 new paper alert 🚨
Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.
Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.
bit.ly
October 15, 2025 at 11:16 PM
🚨 new paper alert 🚨
Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.
Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.
mRNA vaccines 🤝 designed nanoparticle immunogens
This week's issue of #ScienceTranslationalMedicine has arrived!
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
October 15, 2025 at 10:00 PM
mRNA vaccines 🤝 designed nanoparticle immunogens
Couldn't have asked for a lovelier day to break ground in our new lab downtown! 🌞
October 8, 2025 at 9:59 PM
Couldn't have asked for a lovelier day to break ground in our new lab downtown! 🌞
@uwproteindesign.bsky.social Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!
August 22, 2025 at 9:15 PM
@uwproteindesign.bsky.social Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!
Another day, another preprint on @biorxivpreprint.bsky.social!
Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. www.biorxiv.org/cgi/content/...
Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. www.biorxiv.org/cgi/content/...
From sequence to scaffold: computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and du...
www.biorxiv.org
August 22, 2025 at 5:29 PM
Another day, another preprint on @biorxivpreprint.bsky.social!
Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. www.biorxiv.org/cgi/content/...
Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. www.biorxiv.org/cgi/content/...
🚨 New paper alert! 🚨
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses
Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...
bit.ly
August 4, 2025 at 5:48 PM
🚨 New paper alert! 🚨
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
August 1, 2025 at 9:22 PM
🚨 new paper alert 🚨
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!
This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
@uwproteindesign.bsky.social We’re looking for early stage investigators (Sr. Postdocs, Instructors, Asst Profs, etc) to join our ReVAMPP Center designing vaccines and antibodies against paramyxoviruses and bunyaviruses! Read more and apply here: tinyurl.com/MLvax-ESI-app
tinyurl.com
August 1, 2025 at 9:19 PM
@uwproteindesign.bsky.social We’re looking for early stage investigators (Sr. Postdocs, Instructors, Asst Profs, etc) to join our ReVAMPP Center designing vaccines and antibodies against paramyxoviruses and bunyaviruses! Read more and apply here: tinyurl.com/MLvax-ESI-app
The IPD is hiring a new Assistant to the Director! This role provides complex administrative support to IPD leadership and is crucial to keeping operations running. Apply today! bit.ly/4kyguvn
UW Human Resources
University of Washington Human Resources
bit.ly
July 9, 2025 at 8:20 PM
The IPD is hiring a new Assistant to the Director! This role provides complex administrative support to IPD leadership and is crucial to keeping operations running. Apply today! bit.ly/4kyguvn
Congrats on graduating Priya! After working in the lab for 3 years on vaccine adjuvants targeting the CD40 signaling pathway in germinal centers, she earned a Distinguished Researcher in Biochemistry award! Now she's off to work on flu vaccine research at NIAID’s Vaccine Research Center.
June 27, 2025 at 9:44 PM
Congrats on graduating Priya! After working in the lab for 3 years on vaccine adjuvants targeting the CD40 signaling pathway in germinal centers, she earned a Distinguished Researcher in Biochemistry award! Now she's off to work on flu vaccine research at NIAID’s Vaccine Research Center.
🚨 new paper alert 🚨
Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform!
This collaborative project was led by Dr. Mark Langowski
and is out now in npj Vaccines: www.nature.com/articles/s41...
Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform!
This collaborative project was led by Dr. Mark Langowski
and is out now in npj Vaccines: www.nature.com/articles/s41...
Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens - npj Vaccines
npj Vaccines - Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens
www.nature.com
June 27, 2025 at 9:43 PM
🚨 new paper alert 🚨
Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform!
This collaborative project was led by Dr. Mark Langowski
and is out now in npj Vaccines: www.nature.com/articles/s41...
Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform!
This collaborative project was led by Dr. Mark Langowski
and is out now in npj Vaccines: www.nature.com/articles/s41...
There's a new doctor in town, Cameron Criswell defended her PhD thesis last week! 🥳
Congratulations on all your hard work Dr. Criswell!
Congratulations on all your hard work Dr. Criswell!
June 6, 2025 at 9:12 PM
There's a new doctor in town, Cameron Criswell defended her PhD thesis last week! 🥳
Congratulations on all your hard work Dr. Criswell!
Congratulations on all your hard work Dr. Criswell!
Our very own Grace Hendricks gave an excellent talk about her work on mRNA-launched nanoparticles at the Keystone Symposium on Vaccinology in Washington, DC today!
June 5, 2025 at 9:52 PM
Our very own Grace Hendricks gave an excellent talk about her work on mRNA-launched nanoparticles at the Keystone Symposium on Vaccinology in Washington, DC today!
Reposted by King Lab
Delighted to share our most recent work on designing broadly protective sarbecovirus vaccines and defining the path forward for other coronaviruses.
Led by @aminaddetia.bsky.social
@hhmi.org
www.biorxiv.org/content/10.1...
Led by @aminaddetia.bsky.social
@hhmi.org
www.biorxiv.org/content/10.1...
Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines
Vaccines against emerging SARS-CoV-2 variants and sarbecoviruses with pandemic potential must elicit a robust humoral immune response in a population imprinted with the SARS-CoV-2 spike (S) protein. H...
www.biorxiv.org
May 14, 2025 at 2:21 PM
Delighted to share our most recent work on designing broadly protective sarbecovirus vaccines and defining the path forward for other coronaviruses.
Led by @aminaddetia.bsky.social
@hhmi.org
www.biorxiv.org/content/10.1...
Led by @aminaddetia.bsky.social
@hhmi.org
www.biorxiv.org/content/10.1...
On Monday the lab celebrated "Cinco de Cara" in honor of Dr. Cara Chao successfully defending her PhD thesis! 🥂
In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter.
Congratulations!
In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter.
Congratulations!
May 8, 2025 at 10:02 PM
On Monday the lab celebrated "Cinco de Cara" in honor of Dr. Cara Chao successfully defending her PhD thesis! 🥂
In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter.
Congratulations!
In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter.
Congratulations!
The IPD is hiring a new Executive Director! This senior leadership role guides institutional strategy, builds research partnerships, drives fundraising, and directs operations at the world’s top center for computational protein design. Apply today! bit.ly/3Z99PA1
UW Human Resources
University of Washington Human Resources
bit.ly
May 8, 2025 at 9:48 PM
The IPD is hiring a new Executive Director! This senior leadership role guides institutional strategy, builds research partnerships, drives fundraising, and directs operations at the world’s top center for computational protein design. Apply today! bit.ly/3Z99PA1
Enjoying the cherry blossoms and blue skies in Seattle today 🌞
April 4, 2025 at 10:10 PM
Enjoying the cherry blossoms and blue skies in Seattle today 🌞